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Industries"},{"orgOrder":0,"company":"Alvotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"ICELAND","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Ustekinumab","moa":"IL-12 receptor","graph1":"Dermatology","graph2":"Approved FDF","graph3":"Alvotech","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Alvotech \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Alvotech \/ Inapplicable"},{"orgOrder":0,"company":"Alvotech","sponsor":"ATP Holdings","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"ICELAND","productType":"Antibody","year":"2023","type":"Private Placement","leadProduct":"Ustekinumab","moa":"IL-12 receptor","graph1":"Dermatology","graph2":"Approved FDF","graph3":"Alvotech","amount2":0.10000000000000001,"highestDevelopmentShortName":"Approved 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Disease","graph2":"Undisclosed","graph3":"Alvotech","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Alvotech \/ Advanz Pharma","highestDevelopmentStatusID":"1","companyTruncated":"Alvotech \/ Advanz Pharma"},{"orgOrder":0,"company":"Alvotech","sponsor":"Dr. Reddy's Laboratories","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ICELAND","productType":"Antibody","year":"2025","type":"Collaboration","leadProduct":"Pembrolizumab","moa":"PD-1","graph1":"Oncology","graph2":"Preclinical","graph3":"Alvotech","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Alvotech \/ Dr. Reddy's Laboratories","highestDevelopmentStatusID":"4","companyTruncated":"Alvotech \/ Dr. Reddy's Laboratories"},{"orgOrder":0,"company":"Alvotech","sponsor":"Advanz Pharma","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"ICELAND","productType":"Antibody-drug Conjugate","year":"2025","type":"Agreement","leadProduct":"Certolizumab Pegol","moa":"TNF-alpha receptor","graph1":"Immunology","graph2":"Preclinical","graph3":"Alvotech","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Alvotech \/ Advanz Pharma","highestDevelopmentStatusID":"4","companyTruncated":"Alvotech \/ Advanz Pharma"},{"orgOrder":0,"company":"Alvotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"ICELAND","productType":"Protein","year":"2025","type":"Inapplicable","leadProduct":"Aflibercept","moa":"VEGF-A receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Alvotech","amount2":0,"highestDevelopmentShortName":"Approved 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III","therapeuticAreaShortName":"Immunology","amount2New":0.080000000000000002,"dosageForm":"Subcutaneous Injection","sponsorNew":"Alvotech \/ Citigroup","highestDevelopmentStatusID":"10","companyTruncated":"Alvotech \/ Citigroup"}]

Find Clinical Drug Pipeline Developments & Deals by Alvotech

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The agreement aims for the supply and commercialization of AVT10, Alvotech’s biosimilar candidate to Cimzia (certolizumab pegol).

                          Product Name : AVT10

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          July 01, 2025

                          Lead Product(s) : Certolizumab Pegol

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : Advanz Pharma

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          02

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : Aflivu (aflibercept) is a biosimilar to Eyelea which is ndicated for the treatment of patients with Neovascular (Wet) Age-Related Macular Degeneration.

                          Product Name : Aflivu

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          June 23, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : Under the terms of the agreement, the parties will be jointly responsible for developing and manufacturing the biosimilar candidate, AVT33 (pembrolizumab).

                          Product Name : AVT33

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 05, 2025

                          Lead Product(s) : Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Dr. Reddy\'s Laboratories

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : Through the acquisition, Alvotech leverages R&D operations and a biosimilar candidate of Xbrane XB003 (certolizumab pegol). It is being evluated for treating crohn disease.

                          Product Name : XB003

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : $10.1 million

                          June 04, 2025

                          Lead Product(s) : Certolizumab Pegol

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Xbrane Biopharma

                          Deal Size : $10.1 million

                          Deal Type : Acquisition

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                          05

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The proceeds will be used for accelerating Alvotech’s R&D activities, including AVT23, a proposed biosimilar to Xolair (omalizumab) in chronic spontaneous urticaria.

                          Product Name : AVT23

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 04, 2025

                          Lead Product(s) : Omalizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Citigroup

                          Deal Size : $78.2 million

                          Deal Type : Private Placement

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                          06

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The proceeds will be used for accelerating Alvotech’s R&D activities, including AVT23, a proposed biosimilar to Xolair (omalizumab) in chronic spontaneous urticaria.

                          Product Name : AVT23

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 04, 2025

                          Lead Product(s) : Omalizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Citigroup

                          Deal Size : $78.2 million

                          Deal Type : Private Placement

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                          07

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : Advanz secures exclusive rights from Alvotech to commercialize three biosimilar candidates, Ilaris (canakinumab), Kesimpta (ofatumumab) and an undiclosed biosimilar in Europe.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          May 28, 2025

                          Lead Product(s) : Canakinumab

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Undisclosed

                          Sponsor : Advanz Pharma

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          08

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : Selarsdi (ustekinumab) is a human interleukin-12 and -23 antagonist indicated for the treatment of adult patients with moderate to severe plaque psoriasis & active psoriatic arthritis.

                          Product Name : Selarsdi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 05, 2025

                          Lead Product(s) : Ustekinumab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Approved FDF

                          Recipient : Teva Pharmaceutical Industries

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : AVT03 (denosumab) is a human monoclonal antibody and a biosimilar candidate to Prolia & Xgeva. It is a RANK ligand inhibitor, which is being evaluated in phase 1 trials for bone loss in adult men.

                          Product Name : AVT03

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 17, 2025

                          Lead Product(s) : Denosumab

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase III

                          Sponsor : Dr. Reddy's Laboratories

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : AVT06 (aflibercept) is a PGF & VEGF-A inhibitor, indicated for the treatment of patients with neovascular (wet) age-related macular degeneration.

                          Product Name : AVT06

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 18, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Teva Pharmaceutical Industries

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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