1. 4-aminobenzoic Acid Ethyl Ester
2. Acetate, Benzocaine
3. Americaine
4. Anaesthesin
5. Anesthesin
6. Bensokain
7. Benzocaine Acetate
8. Benzocaine Formate
9. Benzocaine Hydrobromide
10. Benzocaine Hydrochloride
11. Benzocaine Methanesulfonate
12. Ethoform
13. Ethyl Aminobenzoate
14. Formate, Benzocaine
15. Hydrobromide, Benzocaine
16. Hydrochloride, Benzocaine
17. Methanesulfonate, Benzocaine
1. Ethyl 4-aminobenzoate
2. Ethyl P-aminobenzoate
3. Parathesin
4. Norcaine
5. Anesthesin
6. Parathesine
7. Amben Ethyl Ester
8. P-carbethoxyaniline
9. Anaesthin
10. Anesthesine
11. Dermoplast
12. Hurricaine
13. Identhesin
14. Norcain
15. Baby Anbesol
16. Anaesthan-syngala
17. Ora-jel
18. Benzocainum
19. Solu H
20. 4-carbethoxyaniline
21. P-ethoxycarboxylic Aniline
22. Benzocaina
23. P-(ethoxycarbonyl)aniline
24. Ethyl P-aminophenylcarboxylate
25. Ethyl Paba
26. 4-(ethoxycarbonyl)aniline
27. Anaesthesinum
28. Ethoforme
29. Norcainum
30. Ethylis Aminobenzoas
31. Otocain
32. Outgro
33. Aethylium Paraminobenzoicum
34. Subcutin
35. Caswell No. 430a
36. Benzocainum [inn-latin]
37. Benzocaina [inn-spanish]
38. Hsdb 7225
39. Chebi:116735
40. Unii-u3rsy48jw5
41. Nsc-4688
42. Einecs 202-303-5
43. U3rsy48jw5
44. Nsc 41531
45. Nsc-41531
46. Epa Pesticide Chemical Code 097001
47. Brn 0638434
48. Ar01
49. Dtxsid8021804
50. Ai3-02081
51. Ar-01
52. Benzocaine [usp:inn:ban]
53. Dtxcid301804
54. Bensokain
55. 4-14-00-01129 (beilstein Handbook Reference)
56. Nsc41531
57. Benzocainum (inn-latin)
58. Benzocaina (inn-spanish)
59. Benzocaine (mart.)
60. Benzocaine [mart.]
61. Benzocaine (usp-rs)
62. Benzocaine [usp-rs]
63. Benzocaine (usp:inn:ban)
64. Benzocaine (ep Monograph)
65. Benzocaine [ep Monograph]
66. Benzocaine (usp Monograph)
67. Benzocaine [usp Monograph]
68. Desensitizer
69. Anesgerm
70. Anestenka
71. Athoforme
72. Benzocain
73. Benzodent
74. Chiggerex
75. Goodwinol
76. Preboost
77. Stallion
78. Topexraspberry
79. Topexstrawberry
80. Topicale
81. Defend
82. Ioline
83. Iolite
84. Rexall
85. Topexcherry
86. Cainetips
87. Opahl
88. Topexmint
89. Ultracare
90. Neuromed
91. Baby Anestenka
92. Benzocaine Gel
93. Benzocaine Wipes
94. Chigger Relief
95. Climax Control
96. Lollicaine Mint
97. Stingx
98. Benzo-jelcherry
99. Brace Relief
100. Dental Relief
101. Finaftamultioral
102. Intimate Wipe
103. Pleasure Balm
104. Prolong Plus
105. Roman Swipes
106. Topexbubble Gum
107. Topicale Xtra
108. Benzo-jel
109. Gingicaine Gel
110. Neuromedfa
111. Allegenal-m
112. Alpha-caine
113. Benzo-jelmint
114. Chigg Away
115. Delay Creme
116. Instant Erection
117. Nene Dente
118. Precaine B
119. Zilactin-b
120. Topexpina Colada
121. Benzo Jel
122. Boil Ease
123. Prime-gel
124. Sting And Bite
125. Anal Blu
126. Franklynumb 1
127. Lollicaine Cherry
128. Salivacaine
129. Assist Ii
130. Benz O Sthetic
131. Gingicaine Fusion
132. Men Delay Wipe
133. Nbe Anbesol
134. Blistex Kank-eze
135. Hims Delay Wipes
136. Benzocaine 6%
137. Cream Desensitizer
138. Topical Anesthetic
139. Benzo-jelraspberry
140. Kank-amouth Pain
141. Anadent Kanka Gel
142. Anal Glide
143. Kank-a
144. Mouth Sore Relief
145. Xpect Sting Wipes
146. Benzocaine 10%
147. Benzocaine 20%
148. Benzocainecherry
149. Benzocainemint
150. Blistex Baby Kanka
151. Magic Stamina
152. Oral Pain Reliever
153. Olp Baby Teething
154. Ejectdelaygel
155. Myderm Bite Relief
156. Aethylis Aminobenzoas
157. Benzocaine 3.5%
158. Benzocaine 7.5%
159. Comfortox Benzocaine
160. Cvs Oral Anesthetic
161. Shungasensation Balm
162. Anesgerm La Muela
163. Benzo-jelbubble Gum
164. Mckesson Orasol Gel
165. Mark 3
166. Precaine B Bubblegum
167. Prolong
168. Realtree
169. Benzocaineraspberry
170. Benzo-jelpina Colada
171. Ky Duration For Him
172. Ky Duration For Men
173. Benzocaine 10.0%
174. Benzocaine 5.00%
175. Benzocaine-5.00%
176. Endless Lovefor Men
177. Family Wellnessregular
178. Iodent Oral Analgesic
179. Leader Oral Analgesic
180. Lollicaine Bubble Gum
181. Mouth Sore Medication
182. Ms Topical Anesthetic
183. Orajelmaximum Strength
184. Rexallmaximum Strength
185. Sheffield Pain Relief
186. Topical Anestheticmint
187. Walgreens Pain Relief
188. Benzocainestrawberry
189. Endless Love For Men
190. Oral Pain Relief Gel
191. Anestesico Topical Gel
192. Bite And Sting Relief
193. Desensitizing Lubricant
194. Ez Access
195. Gps Topical Anesthetic
196. Lollicaine Pina Colada
197. Nrg Topical Anesthetic
198. Promescent Delay Wipes
199. Stay Hard
200. Anal-ese
201. Anbesolmaximum Strength
202. Benzo-jelstrawberry
203. Red Cross Canker Sore
204. Sta-hard
205. Sting Relief Prep Pad
206. Topcaremaximum Strength
207. Benzocainebubble Gum
208. Bite Reliefscherer Labs
209. Chiggerex 2x Medicated
210. Gingicaine Gel, Cherry
211. Makesensepain Relief
212. Climax Controlbenzocaine
213. Topical Anestheticbanana
214. Topical Anestheticcherry
215. Pleasure Balmkama Sutra
216. Benzocainepina Colada
217. Equate Oral Pain Relief
218. Optimum Rock Hard Cream
219. Primo Topical Anesthetic
220. Trojan Extended Pleasure
221. Walgreensmaximum Strength
222. Warrior Chiggerex Relief
223. Chigger Reliefevora Labs
224. Ombre Men Overtime Wipes
225. Oral Gelmaximum Strength
226. Ultracare Anesthetic Gel
227. Atopalm Oral Pain Relief
228. Gelato Topical Anesthetic
229. Gingicaine Gel Strawberry
230. Ismile Topical Anesthetic
231. Jianze Sting Relief Pads
232. Tokisansore Throat Relief
233. Topcare Oral Pain Relief
234. Bite And Sting Reliefgnp
235. 20/20topical Anesthetic
236. Gingicaine Liquid, Cherry
237. Good Neighbor Pain Relief
238. Gumnumb Topical Anesthetic
239. Precaine B Chocolate Mint
240. Terrasil Boil Pain Relief
241. Topical Anestheticraspberry
242. Ultimate Erection Enhancer
243. Massage Men Gel Max Size
244. Massage Men Gel Max Time
245. Tanac Oral Pain Reliever
246. Burkhart Topical Anesthetic
247. Dentek Instant Pain Relief
248. Gingicaine Gel Variety Pak
249. Goodsense Oral Pain Relief
250. Orajel Instant Pain Relief
251. Purelife Topical Anesthetic
252. Massage Men Gel Max Delay
253. Massage Men Gel Max Power
254. Topical Anestheticstrawberry
255. Bactimicina For Sore Throat
256. Dzeus Climax Control Wipes
257. Eclipse Topical Analgesicfa
258. Hurricainetopical Anesthetic
259. Gingicaine Gel, Mint Julep
260. Oral B Instant Pain Relief
261. Oralabs Cold Sore Treatment
262. Red Cross Oral Pain Relief
263. Topical Anestheticbubble Gum
264. Blt 1
265. Bencocaine Topical Anesthetic
266. Benzocaine Topical Anesthetic
267. Budpak Oral Maximum Strength
268. Cvs Pharmacymaximum Strength
269. Gingicaine Gel Banana Flavor
270. Gingicaine Gel, Pina Colada
271. Jo Prolonger With Benzocaine
272. Mouth Sore Relief Applicator
273. Precaine B Chocolate Vanilla
274. Quala Topical Anesthetic Gel
275. Alpha-cainetopical Anesthetic
276. Rite Aidprofessional Strength
277. Topical Anestheticpina Colada
278. Vistacaine Topical Anesthetic
279. Certus Sting Relief Prep Pad
280. Gelato Anestesico Topical Gel
281. Health-tec Topical Anesthetic
282. Makesensejunior Pain Relief
283. Sorbet Anestesico Topical Gel
284. Family Dollaroral Pain Relief
285. Gingicaine Gel, Cherry Flavor
286. Lubelife Climax Control Delay
287. Male Desensitizerpleasure Balm
288. Advance Topical Anesthetic Gel
289. Chloraseptic Warming Green Tea
290. Cvs Fast Acting Baby Teething
291. Dental City Topical Anesthetic
292. Ipana 20% Benzocaine Topical
293. Comfortcaine Topical Anesthetic
294. Mint Rx Endurance Wipes
295. Shungamale Genital Desensitizer
296. Candee Caine Topical Anesthetic
297. Gingicaine Gel, Chocolate Mint
298. Intimale Benzocaine Delay Gel
299. Lights Sting Relief Prep Pad
300. Kolorz Topical Anesthetic
301. Magic Stamina Climax Control
302. Chloraseptic Warming Honey Lemon
303. Gingicaine Gel Strawberry Flavor
304. Hurricainetopical Anesthetic Gel
305. Midway Select Topical Anesthetic
306. Scotts Select Topical Anesthetic
307. Zip Topical Anesthetic Gel Mint
308. Boy Butterdesensitizing Lubricant
309. Gingicaine Liquid, Cherry Flavor
310. Mandelaymale Genital Desensitizer
311. My Fair Babyinstant Pain Relief
312. Sally Hansen Ouch-reliefwax Kit
313. Baby Teething Oral Pain Reliever
314. C05ad03
315. Cvs Maximum Strength Boil Relief
316. D04ab04
317. Leader Oral Pain Reliefanesthetic
318. N01ba05
319. Orajel Instant Pain Reliefregular
320. R02ad01
321. Assist Iianorectal (hemorrhoidal)
322. Astra-dent Topical Anesthetic Gel
323. Monistat Care Instant Itch Relief
324. Walgreenssevere Oral Pain Reliever
325. Hurricainetopical Anesthetic Liquid
326. Patterson Dental Topical Anesthetic
327. Walgreens Pain Relieving For Boils
328. Adventure Medical Kits Dental Medic
329. Anesgerm La Muelafast Pain Relief
330. Bite And Sting Reliefsignature Care
331. Dermawound Wound Care Venous Stasis
332. Gingicaine Gel, Mint Julep Flabvor
333. Gingicaine Gel, Pina Colada Flavor
334. Tiger Supply Inc Topical Anesthetic
335. Ultracareoral Anesthetic Bubble Gum
336. Ultracareoral Anesthetic Walterberry
337. Goyescas 7 Syrupssore Throat Relief
338. Orajel For Toothachemaximum Strength
339. Powerect Benzocaine Male Delay Gel
340. Rite Aid Tooth And Gum Pain Relief
341. Top Quality Mfg. Topical Anesthetic
342. Gingicaine Gel, Cotton Candy Flavor
343. Onetouch Revolutiontopical Anesthetic
344. Sensicaine Tm Extratopical Anesthetic
345. Signature Care Bite And Sting Relief
346. Ultracareoral Anesthetic Orange Cream
347. Zip Topical Anesthetic Gel Strawberry
348. Gingicaine Gel, Chocolate Mint Flavor
349. Mouth Sore Reliefprofessional Strength
350. Sally Hansen Ouch-reliefwax Strip Kit
351. Bite And Sting Reliefwell At Walgreens
352. Goyescas Broncovac 5sore Throat Relief
353. Sally Hansen Ouch-relief Numbing Wipes
354. Budpak Baby Teething Oral Pain Reliever
355. Sally Hansen Ouch-relief Wax Strip Kit
356. Smartpractice Topical Anesthetic Gelmint
357. Bite And Sting Medicated Relief Padscvs
358. Boy Butterextreme Desensitizing Lubricant
359. Topcare Oral Pain Reliefmaximum Strength
360. Body Action Products Anal Glide Extra
361. Herbasoul Male Genital Desensitizer Cream
362. My Fair Baby Oral Gelinstant Pain Relief
363. Smartpractice Topical Anesthetic Gelcherry
364. Dentek Instant Pain Reliefmaximum Strength
365. Kolorz Topical Anestheticpina Colada
366. Kolorz Topical Anesthetictriple Mint
367. 7 Select Oral Pain Maximum Strength Relief
368. Body Action Products Butt Eze Benzocaine
369. Body Action Products Climax Control Gel
370. Body Action Products Prolong Lubricating
371. Kolorz Topical Anestheticcherry Burst
372. Kolorz Topical Anestheticcotton Candy
373. Little Colds Sore Throat Relief Melt Aways
374. Rite Aid Tooth And Gum Pain Reliefcushions
375. Skins Delay Climax Control Benzocaine Gel
376. Winco Foods Maximum Strength Oral Analgesic
377. Kolorz Topical Anestheticblue Rasberry
378. Rite Aid Liquid Anesthetic Oral Pain Relief
379. Smartpractice Topical Anesthetic Gelraspberry
380. Body Action Products Endless Love For Men
381. Boy Butterextreme H2o Desensitizing Lubricant
382. Carmex Cold Sore Treatment External Analgesic
383. Safco Sensicaine Ultra Topical Anesthetic Gel
384. Smartpractice Topical Anesthetic Gelbubble Gum
385. Smartpractice Topical Anesthetic Gelstrawberry
386. Smartpractice Topical Anesthetic Gelpina Colada
387. Higher Control Male Climax Control Lubricating
388. Sally Hansen Ouch-relief Stripless Hard Wax Kit
389. Body Action Products Higher Control Male Climax
390. Quality Choice Maximum Strength Oral Pain Relieving
391. Sally Hansen Microwavable Eybrow, Face And Lip Wax Kit
392. Orajel Severe Toothachemaximum Strength Fast-acting Formula
393. 202-303-5
394. 94-09-7
395. Ethyl Aminobenzoate
396. Americaine
397. Anaesthesin
398. 4-aminobenzoic Acid Ethyl Ester
399. Ethoform
400. Topcaine
401. Dextran Sulfate Sodium
402. Anestezin
403. Anesthone
404. Keloform
405. Orthesin
406. Benzoic Acid, 4-amino-, Ethyl Ester
407. Aethoform
408. P-aminobenzoic Acid Ethyl Ester
409. Benzoic Acid, P-amino-, Ethyl Ester
410. 4-aminobenzoic Acid, Ethyl Ester
411. Ethylester Kyseliny P-aminobenzoove
412. Dextran Sulfate
413. Flavamed
414. P-aminobenzoic Acid, Ethyl Ester
415. 4-amino-benzoic Acid Ethyl Ester
416. Ethyl-p-aminobenzoate
417. Mfcd00007892
418. Dextran Sulfate Sodium Salt
419. Dextran Sulfates
420. 4-aminobenzoic Acid-ethyl Ester
421. Dextran, Hydrogen Sulfate, Sodium Salt
422. Cas-94-09-7
423. Ncgc00016352-01
424. Anestezin [russian]
425. Chloraseptic
426. Ethyl4-aminobenzoate
427. Wln: Zr Dvo2
428. Aniline, 4-ethoxycarbonyl-
429. Ethyl Aminobenzoate (van)
430. Finafta
431. Parathesin (tn)
432. Smr000059025
433. Ethylester Kyseliny P-aminobenzoove [czech]
434. Benzocaine (usp/inn)
435. Sr-05000001573
436. P-aminobenzoic Ethyl Ester
437. Benzoak
438. Vagisil
439. Diet Ayds
440. Orabase-b
441. Prestwick_991
442. 4-carboethoxyaniline
443. Ethyl 4aminobenzoate
444. Ethyl 4-aminobenzate
445. Ethyl 4-aminobezoate
446. Outgro (salt/mix)
447. Anbesol (salt/mix)
448. Vagisil (salt/mix)
449. Ethyl-4-aminobenzoate
450. P-ethoxycarbonylaniline
451. Benzocaine (standard)
452. 4-ethoxycarbonylaniline
453. Dextransulfatesodiumsalt
454. Ethyl P-amino-benzoate
455. Ethyl-p-amino-benzoate
456. Ethyl Aminobenzoic Acid
457. Cough-x (salt/mix)
458. Spectrum_000074
459. Ethyl 4-amino-benzoate
460. Benzocaine [mi]
461. Ethyl 4-(amino)benzoate
462. Benzocaine [inn]
463. Ethyl P-aminobenzoic Acid
464. Prestwick0_000712
465. Prestwick1_000712
466. Prestwick2_000712
467. Prestwick3_000712
468. Spectrum2_000117
469. Spectrum3_000314
470. Spectrum4_000249
471. Spectrum5_000860
472. Benzocaine [hsdb]
473. Ethyl 4-aminobenzoic Acid
474. Benzocaine [vandf]
475. Epitope Id:114084
476. Benzocaine [who-dd]
477. Benzocaine [who-ip]
478. Sampl3, G4
479. Ethyl Aminobenzoate (jp18)
480. Oprea1_750694
481. Oprea1_827402
482. Schembl25100
483. Bspbio_000923
484. Bspbio_001908
485. Kbiogr_000658
486. Kbioss_000474
487. 4-(ethoxycarbonyl)phenylamine
488. Ae-562/40377256
489. Mls001331704
490. Mls002153970
491. Divk1c_000932
492. Ethyl 4-aminobenzoate, 98%
493. Spectrum1500139
494. (p-(ethoxycarbonyl)phenylamine
495. Ethyl P-aminobenzenecarboxylate
496. Spbio_000134
497. Spbio_002844
498. Bpbio1_001017
499. Chembl278172
500. Schembl2453474
501. Schembl6848539
502. Benzocaine, 1mg/ml In Methanol
503. Dextran Sulfate,from Leuconostoc
504. Schembl25289477
505. Dextran Sulfate Sodium (dst-h)
506. Ethyl Para-amino Benzoate
507. Hms502o14
508. Hy-y0258r
509. Kbio1_000932
510. Kbio2_000474
511. Kbio2_003042
512. Kbio2_005610
513. Kbio3_001408
514. P-amino Benzoic Acid Ethyl Ester
515. 4-amino Benzoic Acid Ethyl Ester
516. Ethyl Aminobenzoate [jan]
517. Msk8036
518. Nsc4688
519. Dextran Sulfate Sodium (kmds-h)
520. Ninds_000932
521. Bdbm197282
522. Dextran Sulfate Sodium (ds-m-1)
523. Hms1570o05
524. Hms1920g09
525. Hms2091m11
526. Hms2097o05
527. Hms2233h21
528. Hms3371d08
529. Hms3652h13
530. Hms3714o05
531. Hms3885b11
532. Hms5082f12
533. Pharmakon1600-01500139
534. Benzocainum [who-ip Latin]
535. Component Of Tympagesic (salt/mix)
536. Cs-b0934
537. Hy-y0258
538. Rfc05461
539. Str01509
540. Tox21_110391
541. Tox21_301149
542. Ccg-38918
543. Nsc755909
544. S4210
545. Sbb028356
546. Stk043620
547. Akos000119763
548. Benzocaine 1.0 Mg/ml In Acetonitrile
549. Tox21_110391_1
550. Ac-8127
551. Db01086
552. Nsc-755909
553. Idi1_000932
554. Benzocaine, Purum, >=99.0% (hplc)
555. Benzocaine, Tested According To Ph.eur.
556. Ncgc00016352-02
557. Ncgc00016352-03
558. Ncgc00016352-04
559. Ncgc00016352-07
560. Ncgc00094598-01
561. Ncgc00094598-02
562. Ncgc00255047-01
563. Da-72708
564. Ethyl 4-aminobenzoate, 98.0-101.0%
565. Sbi-0051293.p003
566. Component Of Solarcaine Aerosol (salt/mix)
567. Dextran Sulfate Sodium Salt, Mw ~ 8,000
568. Dextran Sulfate Sodium Salt, Mw ~ 80000
569. A0271
570. Ab00051923
571. Ns00001814
572. St45255315
573. Sw197074-3
574. Dextran Sulfate Sodium Salt, Mw ~ 500,000
575. En300-16170
576. C07527
577. D00552
578. Ab00051923_09
579. Ab00051923_10
580. Component Of Anbesol Maximum Strength (salt/mix)
581. A860898
582. A930377
583. Aminobenzoic Acid Impurity B [ep Impurity]
584. Q422745
585. Ethyl 4-aminobenzoate, Saj First Grade, >=99.0%
586. Sr-05000001573-1
587. Sr-05000001573-3
588. Brd-k75466013-001-05-2
589. Brd-k75466013-001-08-6
590. Brd-k75466013-001-13-6
591. Brd-k75466013-001-14-4
592. Z54178706
593. F2190-0448
594. Benzocaine, European Pharmacopoeia (ep) Reference Standard
595. Benzocaine, United States Pharmacopeia (usp) Reference Standard
596. Benzocaine, Pharmaceutical Secondary Standard; Certified Reference Material
597. Dextran Sulfate Sodium Salt From Leuconostoc Spp., Average Mol Wt 9,000-20,000
| Molecular Weight | 165.19 g/mol |
|---|---|
| Molecular Formula | C9H11NO2 |
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | Da |
| Monoisotopic Mass | Da |
| Topological Polar Surface Area | 52.3 |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 151 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Indicated for the relief of: canker sores, cold sores, or fever blisters: benzocaine (gel and topical solution); gingival or oral mucosal pain (i.e., pain caused by mouth or gum irritation, inflammation, lesions, or minor dental procedures): benzocaine (gel, dental paste, lozenges, and topical solution); dental prosthetic pain (i.e., pain or irritation caused by dentures or other dental or orthodontic appliances): benzocaine (dental paste, gel ointment, and topical solution); teething pain: benzocaine (7.5% and 10% gel); and toothache: benzocaine (10% and 20% gel and topical solution).
Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 153
Indicated to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation: benzocaine (gel, topical aerosol, and topical solution). /Included in US product labeling/
Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 153
Indicated to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the: esophagus: benzocaine (gel and topical solution)); larynx: benzocaine (gel and topical solution); mouth, In dental procedures and oral surgery: benzocaine (gel, topical aerosol, and topical solution); nasal cavity: benzocaine (gel); pharynx or throat: benzocaine (gel, topical aerosol, and topical solution); rectum: benzocaine (gel); respiratory tract or trachea: benzocaine (gel, topical aerosol, and topical solution); urinary tract: benzocaine (gel); and vagina: benzocaine (gel).
Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 153
Anesthetic (local).
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 186
(VET): Local (usually surface) anesthetic.
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 186
Infants and the elderly were more likely to develop toxic methemoglobinemia after benzocaine exposure. Other risk factors included genetic reductase deficiencies, exposure to high doses of anesthetic, and presence of denuded skin and mucous membranes. Because of the potential for severe complications, methemoglobinemia should be corrected promptly in compromised patients and those with toxic benzocaine concentrations. The possibility of masking symptoms during general anesthesia carries special risk of use of this agent in the preanesthesia setting.
PMID:8069004 Rodriguez LF et al; Ann Pharmacother 28 (5): 643-9 (1994)
Use of otic anesthetics may mask symptoms of a fulminating middle ear infection (acute otitis media). Otic solutions containing benzocaine should not be used in the presence of a perforated tympanic membrane.
McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 2695
When applied topically as recommended, benzocaine is relatively nontoxic, however, sensitization may occur.
McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 3411
When used as a male genital desensitizer, benzocaine generally does not adversely affect orgasm in female sexual partners and does not appear to anesthetize the clitoris or vagina.
McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 3411
For more Drug Warnings (Complete) data for BENZOCAINE (9 total), please visit the HSDB record page.
Benzocaine is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia. Benzocaine products are indicated for topical anesthesia in a wide variety of conditions including skin irritation, oral pain, and hemorrhoids.
Treatment of oropharyngeal pain
FDA-Approved Indications
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)
C05AD03
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N01 - Anesthetics
N01B - Anesthetics, local
N01BA - Esters of aminobenzoic acid
N01BA05 - Benzocaine
D - Dermatologicals
D04 - Antipruritics, incl. antihistamines, anesthetics, etc.
D04A - Antipruritics, incl. antihistamines, anesthetics, etc.
D04AB - Anesthetics for topical use
D04AB04 - Benzocaine
C - Cardiovascular system
C05 - Vasoprotectives
C05A - Agents for treatment of hemorrhoids and anal fissures for topical use
C05AD - Local anesthetics
C05AD03 - Benzocaine
R - Respiratory system
R02 - Throat preparations
R02A - Throat preparations
R02AD - Anesthetics, local
R02AD01 - Benzocaine
Branchial and urinary elimination of benzocaine residues was evaluated in adult rainbow trout, Oncorhynchus mykiss, given a single dorsal aortic dose of 14(C)-benzocaine hydrochloride. Branchial elimination of benzocaine residues was rapid and accounted for 59.2% of the dose during the first 3 h after dosing. Renal elimination of radioactivity was considerably slower; the kidney excreted 2.7% dose within 3 h and 9.0% within 24 hr. Gallbladder bile contained 2.0% dose 24 hr after injection. Of the radioactivity in radiochromatograms from water taken 3 min after injection, 87.3% was benzocaine and 12.7% was N-acetylated benzocaine. After 60 min, 32.7% was benzocaine and 67.3% was N-acetylated benzocaine. Of the radioactivity in radiochromatograms from urine taken 1 hr after dosing, 7.6% was para-aminobenzoic acid, 59.7% was N-acetylated para-aminobenzoic acid, 19.5% was benzocaine, and 8.0% was N-acetylated benzocaine. The proportion of the radioactivity in urine changed with time so that by 20 hr, 1.0% was para-aminobenzoic acid and 96.6% was N-acetylated para-aminobenzoic acid. Benzocaine and a more hydrophobic metabolite, N-acetylated benzocaine, were eliminated primarily through the gills; renal and biliary pathways were less significant elimination routes for benzocaine residues.
PMID:1897251 Meinertz JR et al; Xenobiotica 21 (4): 525-33 (1991)
Benzocaine undergoes ester hydrolysis to form 4-aminobenzoic acid, acetylation to form acetylbenzocaine, or N-hydroxylation to form benzocaine hydroxide. 4-aminobenzoic acid can be acetylated or acetylbenzocaine can undergo ester hydrolysis to form 4-acetaminobenzoic acid.
The effect of dose and enzymatic inhibition on the percutaneous absorption and metabolism of benzocaine was studied in vitro in the hairless guinea pig. At the dose level of 2 ug/sq cm, benzocaine was rapidly absorbed and extensively metabolized (80%) by acetyltransferase. As the applied dose of benzocaine was increased to 40 and 200 ug/sq cm, N-acetylation of benzocaine decreased to 44 and 34%, respectively, suggesting saturation of the acetyltransferase system. Total 14(C) absorption after benzocaine application was not significantly different between control and enzyme-inhibited skin and therefore does not appear to be affected by the extent of benzocaine metabolism during percutaneous penetration. Skin provides a significant first-pass metabolic effect for therapeutic doses of percutaneously absorbed benzocaine, and the primary metabolite formed, acetylbenzocaine, is biologically active.
PMID:8737920 Kraeling ME et al; Skin Pharmacol 9 (3): 221-30 (1996)
Hepatic (to a lesser extent) and plasma via hydrolysis by cholinesterase. Excretion trhough urine (as metabolites) (L1861)
Benzocaine diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses.
Benzocaine reversibly stabilizes the neuronal membrane with decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Physicians Desk Reference. 58th ed. Thomson PDR. Montvale, NJ 2004., p. 1130
BUILDING BLOCK
