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Lagevrio (molnupiravir) is an investigational, orally administered nucleoside analog that accumulates errors in the viral genome leading in inhibition of SARS-CoV-2 replication, the causative agent of COVID-19.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: Lagevrio

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Merck Group

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 24, 2023

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A preliminary analysis in highly-vaccinated adults mostly <65 years of age, showed no evidence of difference between LAGEVRIO (molnupiravir) added to usual care compared to usual care alone for reduction of hospitalizations and deaths through Day 28.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: Lagevrio

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 06, 2022

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Under the terms of the contemplated collaboration, Emergent will be responsible for the manufacturing, sale, and distribution of Ebanga (Ansuvimab-zykl) in the United States and Canada, and Ridgeback Bio will serve as the global access partner for Ebanga™.


Lead Product(s): Ansuvimab-zykl

Therapeutic Area: Infections and Infectious Diseases Product Name: Ebanga

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Emergent BioSolutions

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration July 07, 2022

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Analyses of pre-specied exploratory endpoints indicate that a lower proportion of LAGEVRIO (Molnupiravir)-treated participants in MTT population had an acute care visit or a COVID-19-related acute care visit versus placebo-treated participants in the MITT population.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: Lagevrio

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 07, 2022

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Lagevrio (molnupiravir), an investigational oral antiviral medicine, cleared infectious SARS-CoV-2 faster than placebo among patients who had infectious virus at baseline, resulting in no infectious virus detected at Day 3, 5 or 10.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: Lagevrio

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 01, 2022

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The studies used established cell-based assays to evaluate the antiviral activity of molnupiravir and other COVID-19 antiviral agents against SARS-CoV-2 variants of concern, including Omicron.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: MK-4482

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 28, 2022

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The approval is based on positive results from a planned interim analysis from Phase 3 MOVe-OUT clinical trial by Japan’s Ministry of Health, Labor and Welfare, in Japan LAGEVRIO® (molnupiravir) is planned trademark for molnupiravir.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: MK-4482

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 24, 2021

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Merck’s submission to the FDA for EUA is based on the positive results of Molnupiravir an investigational oral antiviral medicine, for the treatment of mild to moderate COVID-19 in adults.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: MK-4482

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 30, 2021

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Molnupiravir investigational, orally administered form of a potent ribonucleoside analog that inhibits the replication of SARS-CoV-2, the causative agent of COVID-19.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: MK-4482

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 26, 2021

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MK-4482 or EIDD-2801 (Molnupiravir) is an investigational, orally administered form of a potent ribonucleoside analog that inhibits the replication of SARS-CoV-2, the causative agent of COVID-19.


Lead Product(s): Molnupiravir

Therapeutic Area: Infections and Infectious Diseases Product Name: MK-4482

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Merck & Co

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 04, 2021

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