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    Pharma Services Category of Menadiona

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    HTL Biotechnology is the world leader in the responsible development and production of pharmaceutical-grade biopolymers.
    Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.
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    01 API Development (2)

    02 Analytical Method Development (1)

    03 Contract Manufacturing (1)

    04 Controlled Substance (1)

    05 Custom Synthesis & Manufacturing (1)

    06 Distillation / Liquid API (1)

    07 Fine Chemical / Intermediate (1)

    08 GMP Manufacturing (1)

    09 Halogenation (1)

    10 Hazardous Chemistry (1)

    11 High Temperature Reaction (> 200 °C) (1)

    12 Hydrogenation (1)

    13 Process Development & Optimization (1)

    14 Scale Up (1)

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    01 Menadiona (15)

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    Menadiona

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    ANALYTICAL METHOD DEVELOPMENT & VALIDATION

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    Menadiona offers process development and validation of analytical methods, feasibility evaluations, pilot plant batches, validation batches, regulatory support and commercial production for APIs and advanced intermediates.

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    Pharma Service: Analytical

    Category: Analytical Method Development

    Sub Category: Method Development and Validation
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    PROCESS DEVELOPMENT

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    Menadiona delivers cost-efficient synthesis, process development & life-cycle management solutions to customers within the pharmaceutical value chain. Their R&D laboratory team is not only developing new processes, they also work in process optimization.

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    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: Process Development & Optimization
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    SCALE-UP CAPABILITIES

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    Menadiona offers synthesis development with process engineering, scale up, analytical development & testing, validation, regulatory support and commercial production for APIs and advanced intermediates.

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    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: Scale-Up Capabilities
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    API CONTRACT MANUFACTURING SERVICES

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    Menadiona's fine chemical division offers custom & contract manufacturing services. They are specialized in manufacturing APIs & key intermediates for the pharmaceutical, veterinary, plant health and nutraceutical industries.

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    Pharma Service: API Manufacturing

    Category: Contract Manufacturing

    Sub Category: Overview
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    FINE CHEMICALS & KEY INTERMEDIATES

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    Menadiona, an independent privately-owned company, specializes in manufacturing active ingredients (APIs) and key intermediates for the pharmaceutical, veterinary, plant health and nutraceutical industries, in addition to aziridine and its derivatives.

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    Pharma Service: API Manufacturing

    Category: Fine Chemical / Intermediate

    Sub Category: Overview
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    HALOGENATION REACTIONS

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    Menadiona manufactures active ingredients and key intermediates through various reactions such as bromination, chlorination, amidation, cyclization, grignard, hydrogenation, methylation, nitration, diazotization, friedel craft, oxidation, reduction, etc.

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    Pharma Service: API Manufacturing

    Category: Halogenation

    Sub Category: Overview
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    HYDROGENATION REACTIONS

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    Menadiona uses various key reactions such as hydrogenation, bromination, chlorination, amidation, cyclization, grignard, methylation, nitration, diazotization, friedel craft, oxidation, reduction, etc. for manufacturing APIs & and key intermediates.

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    Pharma Service: API Manufacturing

    Category: Hydrogenation

    Sub Category: Overview
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    HAZARDOUS MATERIALS HANDLING

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    Menadiona offers vast experience & capability to work with hazardous raw materials and controlled substances. Their key technologies include handling of hazardous materials such as PCl3, PBr3, Br2, POCl3, Cl2, Me2SO4, NH2NH2 & high temperature reactions.

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    Pharma Service: API Manufacturing

    Category: Hazardous Chemistry

    Sub Category: Overview
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    HIGH TEMPERATURE REACTIONS SERVICES

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    Menadiona's key technologies include high temperature reactions from -80ºC to 250ºC, handling of hazardous materials such as PCl3, PBr3, Br2, POCl3, Cl2, Me2SO4, NH2NH2 and fractionated distillations up to 15 theoretical plates.

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    Pharma Service: API Manufacturing

    Category: High Temperature Reaction (> 200 °C)

    Sub Category: Overview
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    DISTILLATION CAPABILITIES

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    Menadiona's key technologies include fractionated distillations up to 15 theoretical plates, handling of hazardous materials such as PCl3, PBr3, Br2, POCl3, Cl2, Me2SO4, NH2NH2 and high temperature reactions from -80ºC to 250ºC.

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    Pharma Service: API Manufacturing

    Category: Distillation / Liquid API

    Sub Category: Overview
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    GMP COMPLIANT API MANUFACTURING

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    Menadiona's two manufacturing plants are equipped with modern GMP production facilities for both liquid and solid products. The manufacturing operations are carried out according to the current good manufacturing practices (GMP) and environmental laws.

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    Pharma Service: API Manufacturing

    Category: GMP Manufacturing

    Sub Category: Overview
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    CUSTOM SYNTHESIS OF APIs

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    Menadiona offers custom & contract manufacturing services through their fine chemical division. They specialize in manufacturing active ingredients (APIs) & key intermediates for the pharmaceutical, veterinary, plant health and nutraceutical industries.

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    Pharma Service: API Manufacturing

    Category: Custom Synthesis & Manufacturing

    Sub Category: Overview
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    PROCESS DEVELOPMENT & OPTIMIZATION

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    Menadiona offers contract development & full contract manufacturing services for APIs, advanced intermediates, starting materials and industrial products. They also deliver cost-efficient synthesis, process development & life-cycle management solutions.

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    Pharma Service: API Manufacturing

    Category: Process Development & Optimization

    Sub Category: Overview
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    COMMERCIAL SCALE PRODUCTION

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    Menadiona's facilities are multipurpose, flexible and allow a rapid response to changing customer requirements. After numerous validation runs have been completed, large commercial scale batches are produced at Menadiona’s manufacturing plant.

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    Pharma Service: API Manufacturing

    Category: Scale Up

    Sub Category: Overview
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    CONTROLLED SUBSTANCE MANUFACTURING

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    Menadiona offers vast experience and capabilities to work with hazardous materials and controlled substances.

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    Pharma Service: API Manufacturing

    Category: Controlled Substance

    Sub Category: Overview
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