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    Selonsertib

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    INTERMEDIATES

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    Sun-shine Chem

    China

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AMWC Asia-TDAC
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    Looking for 1448428-04-3 / Selonsertib API manufacturers, exporters & distributors?

    Selonsertib manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Selonsertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Selonsertib manufacturer or Selonsertib supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Selonsertib manufacturer or Selonsertib supplier.

    API | Excipient name

    Selonsertib

    Synonyms

    1448428-04-3, Gs-4997, Selonsertib [inn], 5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-n-(6-(4-isopropyl-4h-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide, Selonsertib(gs-4997), 5-(4-cyclopropylimidazol-1-yl)-2-fluoro-4-methyl-n-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide

    Cas Number

    1448428-04-3

    Unique Ingredient Identifier (UNII)

    NS3988A2TC

    About Selonsertib

    Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Upon oral administration, selonsertib targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. This prevents the phosphorylation of downstream kinases, such as c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK). By preventing the activation of ASK1-dependent signal transduction pathways, GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. ASK1, also called mitogen-activated protein kinase kinase kinase 5 (MAP3K5), is activated in response to oxidative and endoplasmic reticulum (ER) stress, calcium influx and infection. It plays a key role in the development of certain cardiovascular and neurodegenerative diseases, diabetes, as well as certain types of cancer.

    Selonsertib Manufacturers

    A Selonsertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Selonsertib, including repackagers and relabelers. The FDA regulates Selonsertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Selonsertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Selonsertib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

    Selonsertib Suppliers

    A Selonsertib supplier is an individual or a company that provides Selonsertib active pharmaceutical ingredient (API) or Selonsertib finished formulations upon request. The Selonsertib suppliers may include Selonsertib API manufacturers, exporters, distributors and traders.

    click here to find a list of Selonsertib suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

    Selonsertib Manufacturers | Traders | Suppliers

    Selonsertib Manufacturers, Traders, Suppliers 1
    70

    We have 1 companies offering Selonsertib

    Get in contact with the supplier of your choice:

    1. Sun-shine Chem
    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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