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    List of all Manufacturers, Suppliers & Exporters of Pacritinib API listed on PharmaCompass with details of regulatory filings

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      Looking for 937272-79-2 / Pacritinib API manufacturers, exporters & distributors?

      Pacritinib manufacturers, exporters & distributors 1

      18

      PharmaCompass offers a list of Pacritinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pacritinib manufacturer or Pacritinib supplier for your needs.

      Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pacritinib manufacturer or Pacritinib supplier.

      PharmaCompass also assists you with knowing the Pacritinib API Price utilized in the formulation of products. Pacritinib API Price is not always fixed or binding as the Pacritinib Price is obtained through a variety of data sources. The Pacritinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

      API | Excipient name

      Pacritinib

      Synonyms

      937272-79-2, Pacritinib (sb1518), Sb1518, Sb-1518, Pacritinib(sb1518), Onx-0803

      Cas Number

      937272-79-2

      Unique Ingredient Identifier (UNII)

      G22N65IL3O

      About Pacritinib

      Pacritinib is an orally bioavailable inhibitor of Janus kinase 2 (JAK2), the JAK2 mutant JAK2V617F and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration, pacritinib competes with JAK2 and the JAK2 mutant JAK2V617F for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-signal transducer and activator of transcription (STAT) signaling pathway, and the induction of apoptosis. In addition, pacritinib targets, binds to and inhibits the activity of FLT3. This inhibits FLT3-mediated signaling and the proliferation of FLT3-expressing cancer cells. JAK2, often upregulated or mutated in a variety of cancer cells, plays a key role in tumor cell proliferation and survival. The JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. In addition, JAK2 and FLT3 play a key role in the regulation of the inflammatory response and dendritic cell (DC) proliferation, differentiation and function. Inhibition of JAK2- and FLT3-mediated signaling may suppress the generation and differentiation of DCs, and may regulate inflammatory and immune responses.

      Pacritinib Manufacturers

      A Pacritinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pacritinib, including repackagers and relabelers. The FDA regulates Pacritinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pacritinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

      click here to find a list of Pacritinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

      Pacritinib Suppliers

      A Pacritinib supplier is an individual or a company that provides Pacritinib active pharmaceutical ingredient (API) or Pacritinib finished formulations upon request. The Pacritinib suppliers may include Pacritinib API manufacturers, exporters, distributors and traders.

      click here to find a list of Pacritinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

      Pacritinib Manufacturers | Traders | Suppliers

      Pacritinib Manufacturers, Traders, Suppliers 1
      11

      We have 2 companies offering Pacritinib

      Get in contact with the supplier of your choice:

      1. Aspen API
      2. Sun-shine Chem
      Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
      For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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