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    Istisociclib

    ACTIVE PHARMA INGREDIENTS

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    01 1Flamma SpA

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    Flamma SpA

    Italy

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    Flamma SpA

    Italy

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    NDC Package Code : 54236-110

    Start Marketing Date : 2024-06-19

    End Marketing Date : 2026-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

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    Looking for 2416873-83-9 / Istisociclib API manufacturers, exporters & distributors?

    Istisociclib manufacturers, exporters & distributors 1

    92

    PharmaCompass offers a list of Istisociclib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Istisociclib manufacturer or Istisociclib supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Istisociclib manufacturer or Istisociclib supplier.

    API | Excipient name

    Istisociclib

    Synonyms

    Kb-0742, 2416873-83-9, Chembl5199065, Kb0742, Istisociclib (usan), Istisociclib [usan]

    Cas Number

    2416873-83-9

    Unique Ingredient Identifier (UNII)

    F7J6KSY5I8

    About Istisociclib

    Istisociclib is an orally bioavailable, selective inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b; PTEFb), with potential antineoplastic activity. Upon oral administration, istisociclib targets, binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins and oncogenic transcription factors including MYC and androgen receptor (AR). This induces cell cycle arrest and apoptosis and prevents tumor cell proliferation. CDK9 regulates elongation of transcription through phosphorylation of RNA Pol II at serine 2 (p-Ser2-RNAPII), and is an important cofactor for various oncogenic transcription factors. It is upregulated in various tumor cell types and plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.

    Istisociclib Manufacturers

    A Istisociclib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Istisociclib, including repackagers and relabelers. The FDA regulates Istisociclib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Istisociclib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Istisociclib Suppliers

    A Istisociclib supplier is an individual or a company that provides Istisociclib active pharmaceutical ingredient (API) or Istisociclib finished formulations upon request. The Istisociclib suppliers may include Istisociclib API manufacturers, exporters, distributors and traders.

    click here to find a list of Istisociclib suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

    Istisociclib Manufacturers | Traders | Suppliers

    Istisociclib Manufacturers, Traders, Suppliers 1
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    We have 1 companies offering Istisociclib

    Get in contact with the supplier of your choice:

    1. Flamma SpA
    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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