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ACTIVE PHARMA INGREDIENTS

59 API Suppliers, 15 USDMF, 11 CEP/COS, 2 JDMF, 5 EU WC, 4 KDMF, 19 NDC API, 32 Listed Suppliers, $ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

151 FDF Dossiers, 55 FDA Orange Book, 58 Europe, 13 Canada, 13 Australia, 6 South Africa, 6 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

AEROSOL, METERED;RECTAL - 10%, CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML, AEROSOL, METERED;TOPICAL - 1%;1%

RELATED EXCIPIENT COMPANIES

2 EUROAPI, 3 Rochem International Inc, 4 SPI Pharma, 10 DKSH, 1 Pharm-RX Chemical, 1 Boai NKY Pharmaceuticals Ltd, 1 Gangwal Healthcare, 13 Nanjing Well Pharmaceutical, 10 Kirsch Pharma, 1 ACG Worldwide, 18 Actylis, 1 Aeon Procare, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Ashland, 42 BASF, 8 Beneo, 1 BioSpectra, 3 CD Formulation, 15 Corel Pharma Chem, 1 Doshion Polyscience, 3 Esteem Industries, 4 Finar, 13 Gangwal Chemicals, 3 Ideal Cures, 9 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 7 Lubrizol Life Science Health, 7 Microlex e.U, 2 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 16 Roquette, 21 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries, 1 Symrise, 2 The Dow Chemical Company, 2 Valens Pharmachem, 1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

65 Topical, 51 Solubilizers, 45 Coating Systems & Additives, 38 Thickeners and Stabilizers, 33 Parenteral, 26 Fillers, Diluents & Binders, 25 Emulsifying Agents, 25 Controlled & Modified Release, 21 Film Formers & Plasticizers, 20 Taste Masking, 16 Surfactant & Foaming Agents, 16 Granulation, 14 Direct Compression, 10 Lubricants & Glidants, 9 Rheology Modifiers, 7 API Stability Enhancers, 5 Empty Capsules, 5 Chewable & Orodispersible Aids, 4 Co-Processed Excipients, 4 Vegetarian Capsules, 4 Coloring Agents, 2 Disintegrants & Superdisintegrants, 1 Soft Gelatin

DIGITAL CONTENT

1 Data Compilation #PharmaFlow, 7 News #PharmaBuzz

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions, 7 Regulatory FDF Prices

MARKET PLACE

20 APIs, 2 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM, 1 JP, 1 Others

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Filters

Also known as: Mls002637530, Hydrocortisoni acetas, Ncgc00183367-01, Chembl1715636, Schembl13026148, Hms2232p13

Molecular Formula

C₂₃H₃₂O₆

Molecular Weight

404.5 g/mol

InChI Key

ALEXXDVDDISNDU-UHFFFAOYSA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate

2.1.2 InChI

InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3

2.1.3 InChI Key

ALEXXDVDDISNDU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Mls002637530

2. Hydrocortisoni Acetas

3. Ncgc00183367-01

4. Chembl1715636

5. Schembl13026148

6. Hms2232p13

7. Hms3373l06

8. Bbl033683

9. Stl301800

10. Akos001582713

11. Akos021734921

12. [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] Acetate

13. Ac-12502

14. Smr001317857

15. Vs-12217

16. Ft-0627126

17. Ft-0667894

18. Ah-034/06873032

19. Pregn-4-ene-3,20-dione,11beta,17alpha,21-trihydroxy-,21 Acetate

20. 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate

21. 2-{1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl Acetate

2.3 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₃₂O₆
Molecular Weight	404.5 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	404.21988874 g/mol
Monoisotopic Mass	404.21988874 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	786
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	7
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Hydrocortisone acetate
Drug Label	Epifoam (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam containing: hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a base containing: propylene glycol, cetyl alcohol, glyceryl monostearate and PEG 1...
Active Ingredient	Hydrocortisone acetate
Dosage Form	Cream; Powder
Route	For rx compounding; Topical
Strength	100%; 2.5%
Market Status	Prescription
Company	X Gen Pharms; Ferndale Labs

2 of 2
Drug Name	Hydrocortisone acetate
Drug Label	Epifoam (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam containing: hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a base containing: propylene glycol, cetyl alcohol, glyceryl monostearate and PEG 1...
Active Ingredient	Hydrocortisone acetate
Dosage Form	Cream; Powder
Route	For rx compounding; Topical
Strength	100%; 2.5%
Market Status	Prescription
Company	X Gen Pharms; Ferndale Labs

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

59 API Suppliers

15 USDMF

11 CEP/COS

2 JDMF

5 EU WC

4 KDMF

19 NDC API

32 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

151 FDF Dossiers

55 FDA Orange Book

58 Europe

13 Canada

13 Australia

6 South Africa

6 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

AEROSOL, METERED;RECTAL - 10%

CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML

AEROSOL, METERED;TOPICAL - 1%;1%

RELATED EXCIPIENT COMPANIES

2 EUROAPI

3 Rochem International Inc

4 SPI Pharma

10 DKSH

1 Pharm-RX Chemical

1 Boai NKY Pharmaceuticals Ltd

1 Gangwal Healthcare

13 Nanjing Well Pharmaceutical

10 Kirsch Pharma

1 ACG Worldwide

18 Actylis

1 Aeon Procare

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Ashland

42 BASF

8 Beneo

1 BioSpectra

3 CD Formulation

15 Corel Pharma Chem

1 Doshion Polyscience

3 Esteem Industries

4 Finar

13 Gangwal Chemicals

3 Ideal Cures

9 Kerry

3 Kima Chemical

6 Lonza Capsugel

7 Lubrizol Life Science Health

7 Microlex e.U

2 Nanjing Bold Chemical

2 Nomisma Healthcare

2 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

16 Roquette

21 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Sigachi Industries

1 Symrise

2 The Dow Chemical Company

2 Valens Pharmachem

1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

65 Topical

51 Solubilizers

CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons