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Suanfarma Suanfarma

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    Technical details about Tavapadon, learn more about the structure, uses, toxicity, action, side effects and more

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    Tavapadon

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    Inke S.A: APIs manufacturing plant.

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    2D Structure
    1. Also known as: 1643489-24-0, (rac)-tavapadon, Tavapadon [usan], Pf-06649751, Pt4p8mjp8l, Cvl-751
    Molecular Formula
    C19H16F3N3O3
    Molecular Weight
    391.3  g/mol
    InChI Key
    AKQXQLUNFKDZBN-UHFFFAOYSA-N
    FDA UNII
    PT4P8MJP8L
    Tavapadon is under investigation in clinical trial NCT02262767 (A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 Co-administered With Trimethobenzamide Hydrochloride in Healthy Subjects).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrimidine-2,4-dione
    2.1.2 InChI
    InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
    2.1.3 InChI Key
    AKQXQLUNFKDZBN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C
    2.2 Other Identifiers
    2.2.1 UNII
    PT4P8MJP8L
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 1643489-24-0

    2. (rac)-tavapadon

    3. Tavapadon [usan]

    4. Pf-06649751

    5. Pt4p8mjp8l

    6. Cvl-751

    7. Tavapadon (usan)

    8. 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrimidine-2,4-dione

    9. 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione

    10. 2,4(1h,3h)-pyrimidinedione, 1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)-2-pyridinyl)oxy)phenyl)-, (-)-

    11. Tavapadon [inn]

    12. Unii-pt4p8mjp8l

    13. Chembl3697617

    14. Schembl16334991

    15. Dtxsid301337071

    16. Bcp32804

    17. Ex-a3416

    18. Db14899

    19. Hy-119486a

    20. Ac-36997

    21. Cs-0131271

    22. D11431

    23. (-)-1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)-2-pyridinyl)oxy)phenyl)-2,4(1h,3h)-pyrimidinedione

    24. (-)-1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-2,4(1h,3h)-pyrimidinedione

    25. (-)-1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrimidine-2,4(1h,3h)-dione

    26. 1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrimidine-2,4(1h,3h)-dione

    27. 86w

    28. Pf-06649751;pf 06649751;pf-6649751;pf-06649751;pf06649751;pf 06649751

    2.4 Create Date
    2015-02-02
    3 Chemical and Physical Properties
    Molecular Weight 391.3 g/mol
    Molecular Formula C19H16F3N3O3
    XLogP33.3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass391.11437587 g/mol
    Monoisotopic Mass391.11437587 g/mol
    Topological Polar Surface Area71.5 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity665
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of Parkinson's disease

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