Please Wait
Applying Filters...
menu
    • menu
    Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

    Virtual Booth

    Contact Supplier

    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    pharmacompass-1-m-2025-12-22

    Virtual Booth

    An Enquiry

    AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

    Virtual Booth

    Contact Supplier

    HTL Biotechnology is a French biotech & a global leader in the responsible development & production of pharma-grade biopolymers.

    Virtual Booth

    Contact Supplier

    pharmacompass-2-m-2025-11-03

    Virtual Booth

    An Enquiry

    Menu

    Solabegron

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 252920-94-8, (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic acid, Solabegron [inn], Gw427353, 451470-34-1, Gw 427353
    Molecular Formula
    C23H23ClN2O3
    Molecular Weight
    410.9  g/mol
    InChI Key
    LLDXOPKUNJTIRF-QFIPXVFZSA-N
    FDA UNII
    55P6YH9O6N
    Solabegron (GW-427,353) is a selective 3 adrenoceptor agonist being developed for the treatment of overactive bladder and irritable bowel syndrome.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethylamino]phenyl]benzoic acid
    2.1.2 InChI
    InChI=1S/C23H23ClN2O3/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29/h1-9,12-14,22,25-27H,10-11,15H2,(H,28,29)/t22-/m0/s1
    2.1.3 InChI Key
    LLDXOPKUNJTIRF-QFIPXVFZSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
    2.1.5 Isomeric SMILES
    C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O
    2.2 Other Identifiers
    2.2.1 UNII
    55P6YH9O6N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

    2. 3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

    3. Gw 427353

    4. Gw-427353

    5. Gw427353

    6. Solabegron Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 252920-94-8

    2. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic Acid

    3. Solabegron [inn]

    4. Gw427353

    5. 451470-34-1

    6. Gw 427353

    7. Gw-427353

    8. 55p6yh9o6n

    9. 3-[3-[2-[[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethylamino]phenyl]benzoic Acid

    10. [1,1'-biphenyl]-3-carboxylicacid,3'-[[2-[[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-

    11. (1,1'-biphenyl)-3-carboxylic Acid, 3'-((2-(((2r)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-

    12. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

    13. Solabegronum

    14. Unii-55p6yh9o6n

    15. Solabegron-13c6

    16. (r)-3'-[[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3-carboxylic Acid

    17. Solabegron [who-dd]

    18. Chembl208427

    19. Gtpl9512

    20. Schembl2596555

    21. Dtxsid50179932

    22. Chebi:141346

    23. Cka92094

    24. Zinc1547346

    25. Bdbm50002595

    26. Db06190

    27. Compound 38 [pmid: 16640337]

    28. As-74724

    29. Hy-19436

    30. Cs-0015536

    31. Gw 427353gw 427353

    32. D93408

    33. (r)-3'-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethylamino)biphenyl-3-carboxylic Acid

    34. 3'-((2-(((2r)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)biphenyl-3-carboxylic Acid

    35. 3'-[(2-{[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino]-[1,1'-biphenyl]-3-carboxylic Acid

    36. 3'-[(2-{[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino][biphenyl]-3-carboxylic Acid

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 410.9 g/mol
    Molecular Formula C23H23ClN2O3
    XLogP31.8
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count9
    Exact Mass410.1397203 g/mol
    Monoisotopic Mass410.1397203 g/mol
    Topological Polar Surface Area81.6 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity507
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic beta-3 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS. (See all compounds classified as Adrenergic beta-3 Receptor Agonists.)

    • Privacy policy
    • Terms and conditions
    • Disclaimers
    • LinkedIn
    • Product listings are provided for informational purposes only. We do not supply or sell any products. Any products that may be covered by patent(s) are supplied solely for uses permitted under Section 107A of the Indian Patents Act and not for commercial sale.