Also known as: 144481-98-1, Landiolol hcl, Ono 1101 hydrochloride, Ono-1101 hydrochloride, Onoact, Unii-g8hq634y17

Molecular Formula

C₂₅H₄₀ClN₃O₈

Molecular Weight

546.1 g/mol

InChI Key

DLPGJHSONYLBKP-IKGOIYPNSA-N

FDA UNII

G8HQ634Y17

LANDIOLOL HYDROCHLORIDE is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 3 investigational indications.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate;hydrochloride

2.1.2 InChI

InChI=1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1

2.1.3 InChI Key

DLPGJHSONYLBKP-IKGOIYPNSA-N

2.2 Other Identifiers

2.2.1 UNII

G8HQ634Y17

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 144481-98-1

2. Landiolol Hcl

3. Ono 1101 Hydrochloride

4. Ono-1101 Hydrochloride

5. Onoact

6. Unii-g8hq634y17

7. Onoact (tn)

8. Dtxsid3048605

9. G8hq634y17

10. Dtxcid0028531

11. Landiolol Hydrochloride [mi]

12. Landiolol Hydrochloride [jan]

13. Landiolol Hydrochloride [mart.]

14. Landiolol Hydrochloride [who-dd]

15. Benzenepropanoic Acid, 4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl Ester, (s-(r*,r*))-, Hydrochloride

16. Landiolol Hydrochloride (jan)

17. Landiolol Hydrochloride (mart.)

18. ((s)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((s)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino)propoxy)phenylpropionate Monohydrochloride

19. [(s)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(s)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino]propoxy]phenylpropionate Monohydrochloride

20. 4-((s)-2-hydroxy-3-((2-((morpholinocarbonyl)amino)ethyl)amino)propoxy)benzenepropanoic Acid ((s)-2,2-dimethyl-1,3-dioxolane-4alpha-yl)methyl Hydrochloric Acid

21. 833-743-1

22. Landiolol (hydrochloride)

23. Landiolol Hydrochloride [usan]

24. Benzenepropanoic Acid, 4-[(2s)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4s)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl Ester, Hydrochloride (1:1)

25. Rapiblyk

26. ((s)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((s)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate Hydrochloride

27. [(4s)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2s)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate;hydrochloride

28. Cas-144481-98-1

29. Ncgc00182709-01

30. Ncgc00182709-02

31. Rapiblyk (tn)

32. Mfcd01937430

33. Ono 1101;ono-1101;ono1101

34. Chembl2362410

35. Chebi:31760

36. Glxc-05109

37. Hy-100607ar

38. Landiolol Hydrochloride (jan/usan)

39. Tox21_112940

40. Tox21_113021

41. Landiolol (hydrochloride) (standard)

42. S5540

43. Akos025311253

44. Tox21_113021_1

45. Ccg-269982

46. Hy-100607a

47. Ncgc00182709-03

48. Ac-22604

49. As-17684

50. Da-54781

51. Landiolol Hydrochloride, >=98% (hplc)

52. Cs-0019761

53. L0296

54. D01847

55. Sbi-0654179.0001

56. Q27278937

57. [(4s)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-{(2s)-2-hydroxy-3-[{2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino]propoxy}phenyl)propanoate Hydrochloride

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₄₀ClN₃O₈
Molecular Weight	546.1 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	14
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	128
Heavy Atom Count	37
Formal Charge	0
Complexity	666
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Treatment of supraventricular arrhythmias

Rapiblyk

Rapiblyk

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