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Technical details about Phenmetrazine, learn more about the structure, uses, toxicity, action, side effects and more

Phenmetrazine

Synopsis, Chemistry

DOSSIERs // Finished Dosage Forms

3 Dossiers, 3 FDA Orange Book

ANALYTICAL SOLUTION(s)

1 USP Standards

1 USP Standards

1. Also known as: Mefolin, Preludin, Marsin, 1707-14-8, Usaf ge-1, Phenmetraline hydrochloride

Molecular Formula

C₁₁H₁₆ClNO

Molecular Weight

213.70 g/mol

InChI Key

VJNXVAVKCZJOFQ-UHFFFAOYSA-N

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-methyl-2-phenylmorpholine;hydrochloride

2.1.2 InChI

InChI=1S/C11H15NO.ClH/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10;/h2-6,9,11-12H,7-8H2,1H3;1H

2.1.3 InChI Key

VJNXVAVKCZJOFQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1C(OCCN1)C2=CC=CC=C2.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Defenmetrazin

2. Fenmetrazin

3. Hydrochloride, Phenmetrazine

4. Oxazimedrine

5. Phenmetraline

6. Phenmetrazine

7. Preludin

2.2.2 Depositor-Supplied Synonyms

1. Mefolin

2. Preludin

3. Marsin

4. 1707-14-8

5. Usaf Ge-1

6. Phenmetraline Hydrochloride

7. Morpholine, 3-methyl-2-phenyl-, Hydrochloride

8. 3-methyl-2-phenylmorpholine Hydrochloride

9. Chebi:8068

10. Phenmetrazine Hydrochloride [usp]

11. Neo-zine

12. Nsc-405728

13. Dea No. 1631

14. Nsc 405728

15. Dsstox_cid_27799

16. Dsstox_rid_82571

17. Dsstox_gsid_47822

18. A 66 Hydrochloride

19. Phenmetrazine Hydrochloride (usp)

20. Probese-p Hydrochloride

21. 3-methyl-2-phenyl-morpholine

22. Cas-1707-14-8

23. Psychamine A 66 Hydrochloride

24. Ncgc00164535-01

25. Ncgc00164535-02

26. Einecs 216-950-6

27. 2-phenyl-3-methyltetrahydro-1,4-oxazine Hydrochloride

28. Preludin (tn)

29. Phenmetrazine Chloride

30. 3-methyl-2-phenyltetrahydro-2h-1,4-oxazine Hydrochloride

31. Schembl121536

32. Chembl1200483

33. Dtxsid0047822

34. Phenmetrazine Methylchloride

35. Tox21_112166

36. Wln: T6m Dotj B1 Cr &gh

37. Nsc405728

38. Akos022181094

39. Tox21_112166_1

40. 1707-14-8 (hcl)

41. 3-methyl-2-phenylmorpholine;hydrochloride

42. Phenmetrazinehydrochloridecii(200mg)

43. D05454

44. Q27107702

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₆ClNO
Molecular Weight	213.70 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	213.0920418 g/mol
Monoisotopic Mass	213.0920418 g/mol
Topological Polar Surface Area	21.3 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	154
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

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