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Technical details about Pantoprazole, learn more about the structure, uses, toxicity, action, side effects and more

Pantoprazole

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

138 Suppliers, 58 USDMF, 46 CEP/COS, 42 EU WC, 18 KDMF, 29 NDC API, 80 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

29 Suppliers

29 Suppliers

DOSSIERs // Finished Dosage Forms

806 Dossiers, 61 FDA Orange Book, 429 Europe, 39 Canada, 62 Australia, 61 South Africa, 154 Listed Dossiers

DRUG PRODUCT COMPOSITION

POWDER;INTRAVENOUS - EQ 40MG BASE/VIAL, TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE, TABLET, DELAYED RELEASE;ORAL - EQ 40MG BASE, INJECTABLE;INTRAVENOUS - EQ 40MG BASE/VIAL

RELATED EXCIPIENT COMPANIES

Suppliers, 39 Kerry, 35 BASF, 21 Roquette, 20 SPI Pharma, 16 Corel Pharma Chem, 15 Ideal Cures Pvt Ltd, 14 Microlex e.U, 14 Seppic, 13 Gangwal Chemicals, 11 Sigachi Industries, 11 Gangwal Healthcare, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 Nanjing Well Pharmaceutical, 7 Boai NKY Pharmaceuticals Ltd, 6 Lonza Capsugel, 6 DFE Pharma, 6 Actylis, 5 Pharmatrans-Sanaq, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 DKSH, 4 Ingredion Pharma Solutions, 3 Prachin Chemical, 3 Doshion Polyscience, 3 Evonik, 3 Alcedo Pharmachem, 3 Ulanqab Kema New Material, 3 Kima Chemical, 3 Vasa Pharmachem, 2 Clariant, 2 Pfanstiehl, 2 Nomisma Healthcare, 2 Seqens, 2 Finar, 2 The Dow Chemical Company, 2 Aeon Procare, 2 Jai Radhe Sales, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 ACG Worldwide, 1 Shijiazhuang Huaxu Pharmaceutical, 1 NEWEDGE Overseas, 1 Qualicaps, 1 Chynops Pharma, 1 Rochem International Inc, 1 Nanjing Bold Chemical, 1 Minakem, 1 Vertellus, 1 Avesta Pharma

EXCIPIENTS BY APPLICATIONS

85 Fillers, Diluents & Binders, 75 Coating Systems & Additives, 48 Direct Compression, 45 Controlled & Modified Release, 38 Disintegrants & Superdisintegrants, 31 Solubilizers, 30 Thickeners and Stabilizers, 28 Granulation, 27 Taste Masking, 22 Lubricants & Glidants, 21 Chewable & Orodispersible Aids, 21 Film Formers & Plasticizers, 20 Parenteral, 19 Topical, 17 Co-Processed Excipients, 7 Emulsifying Agents, 7 API Stability Enhancers, 5 Empty Capsules, 5 Surfactant & Foaming Agents, 4 Rheology Modifiers, 4 Vegetarian Capsules, 2 Coloring Agents

GLOBAL SALES INFORMATION

23 US Medicaid Prescriptions, 387 Finished Drug Prices

MARKET PLACE

58 APIs, 55 DOSSIERS // FDF

PATENTS

8 US Patents, 22 Health Canada Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 2 EDQM Standards, 3 USP Standards, 21 Other Ref. Standards

DIGITAL CONTENT

4 Data Compilation & Company Tracker #PharmaFlow, 55 News

Also known as: 138786-67-1, Pantoloc, Protonix, Pantecta, Zurcal, Pantoprazole sodium salt

Molecular Formula

C₁₆H₁₄F₂N₃NaO₄S

Molecular Weight

405.4 g/mol

InChI Key

YNWDKZIIWCEDEE-UHFFFAOYSA-N

2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

2.1.2 InChI

InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1

2.1.3 InChI Key

YNWDKZIIWCEDEE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. By 1023

2. By-1023

3. By1023

4. Pantoprazole

5. Protonix

6. Sk And F 96022

7. Sk And F-96022

8. Sk And F96022

9. Skf 96022

10. Skf-96022

11. Skf96022

2.2.2 Depositor-Supplied Synonyms

1. 138786-67-1

2. Pantoloc

3. Protonix

4. Pantecta

5. Zurcal

6. Pantoprazole Sodium Salt

7. Skf96022 Sodium

8. By-1023 Sodium

9. Chebi:50270

10. Sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

11. Pantozol Control

12. 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) Sulfinyl)-1h-benzimidazole Sodium

13. Dsstox_cid_24215

14. Dsstox_rid_80123

15. Dsstox_gsid_44215

16. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

17. Sodium 5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)benzo[d]imidazol-1-ide

18. Cas-138786-67-1

19. Anagastra

20. Inipomp

21. Pantorc

22. Peptazol

23. Ulcotenal

24. Citrel

25. Apton

26. Rifun

27. Pantoprazole Sodium;

28. By1023 (sodium)

29. Pantoprazole Sodium,(s)

30. Skf96022 (sodium)

31. Schembl3543

32. Mls001424073

33. Pantoprazole Sodium Monohydrate

34. Chembl1200408

35. Dtxsid7044215

36. Dz-2352a

37. Hms2051l19

38. Hms3393l19

39. Hms3715d12

40. Act02633

41. Tox21_112996

42. Tox21_302362

43. Mfcd01658543

44. S4538

45. Akos015994677

46. Ccg-100980

47. Ks-1093

48. Nc00230

49. S86p671

50. Sb17369

51. By-1023/sk&f-96022

52. Ncgc00255835-01

53. Smr000469592

54. Ft-0602602

55. Ft-0673508

56. A807440

57. B-8610-23/sk&f-96022-z

58. J-516336

59. B-8510-29

60. Q27122012

61. Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl] Benzimidazol-1-ide

62. 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1h-benzo[d]imidazole, Sodium Salt

63. 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]benzimidazol-1-ide; Sodium;pantoprazole Sodium

64. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole

65. Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide

2.2.3 Other Synonyms

1. Pantozol

2. S-pantoprazole

3. Pantoprazole

2.3 Create Date

2007-02-09

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₄F₂N₃NaO₄S
Molecular Weight	405.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	405.05707772 g/mol
Monoisotopic Mass	405.05707772 g/mol
Topological Polar Surface Area	90.8 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	497
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Pantoprazole sodium
Drug Label	The active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
Active Ingredient	Pantoprazole sodium
Dosage Form	Injectable; Tablet, delayed release
Route	injection; Iv (infusion); Oral
Strength	eq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
Market Status	Tentative Approval; Prescription
Company	Wockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

2 of 4
Drug Name	Protonix iv
Active Ingredient	Pantoprazole sodium
Dosage Form	Injectable
Route	Iv (infusion)
Strength	eq 40mg base/vial
Market Status	Prescription
Company	Wyeth Pharms

3 of 4
Drug Name	Pantoprazole sodium
Drug Label	The active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
Active Ingredient	Pantoprazole sodium
Dosage Form	Injectable; Tablet, delayed release
Route	injection; Iv (infusion); Oral
Strength	eq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
Market Status	Tentative Approval; Prescription
Company	Wockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

4 of 4
Drug Name	Protonix iv
Active Ingredient	Pantoprazole sodium
Dosage Form	Injectable
Route	Iv (infusion)
Strength	eq 40mg base/vial
Market Status	Prescription
Company	Wyeth Pharms

4.2 Drug Indication

Short-term treatment of reflux symptoms (e. g. heartburn, acid regurgitation) in adults.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Proton Pump Inhibitors [MoA]; Proton Pump Inhibitor [EPC]

5.3 ATC Code

A02BC02

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