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    Nedaplatin

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Nedaplatin, 95734-82-0, Nsc 375101d, Azane;2-hydroxyacetic acid;platinum, C2h8n2o3pt, C2-h8-n2-o3-pt
    Molecular Formula
    C2H10N2O3Pt
    Molecular Weight
    305.20  g/mol
    InChI Key
    ZAXCMPAWRCMABN-UHFFFAOYSA-N
    Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    azane;2-hydroxyacetic acid;platinum
    2.1.2 InChI
    InChI=1S/C2H4O3.2H3N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H3;
    2.1.3 InChI Key
    ZAXCMPAWRCMABN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(C(=O)O)O.N.N.[Pt]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (glycolato-o,o')diammineplatinum Ii

    2. 254-s

    3. Cgdp-ii

    4. Cis-diammine(glycolato)platinum Ii

    5. Nedaplatin

    6. Nsc 375101d

    7. Nsc-375101d

    2.2.2 Depositor-Supplied Synonyms

    1. Nedaplatin

    2. 95734-82-0

    3. Nsc 375101d

    4. Azane;2-hydroxyacetic Acid;platinum

    5. C2h8n2o3pt

    6. C2-h8-n2-o3-pt

    7. Nsc-375101d

    8. Cis-diammine(glycolato)platinum(ii)

    9. (glycolato-o,o')diammineplatinum(ii)

    10. Hms2089p16

    11. Akos025311233

    2.3 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 305.20 g/mol
    Molecular Formula C2H10N2O3Pt
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count0
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area59.5
    Heavy Atom Count8
    Formal Charge0
    Complexity44.1
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)