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Technical details about Nebivolol, learn more about the structure, uses, toxicity, action, side effects and more

Nebivolol

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

40 Suppliers, 14 USDMF, 4 CEP/COS, 7 EU WC, 11 KDMF, 9 NDC API, 30 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

21 Suppliers

21 Suppliers

DOSSIERs // Finished Dosage Forms

229 Dossiers, 72 FDA Orange Book, 77 Europe, 4 Canada, 30 Australia, 2 South Africa, 44 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - EQ 5MG BASE;80MG, TABLET;ORAL - EQ 10MG BASE, TABLET;ORAL - EQ 2.5MG BASE, TABLET;ORAL - EQ 20MG BASE, TABLET;ORAL - EQ 5MG BASE

RELATED EXCIPIENT COMPANIES

Suppliers, 31 Kerry, 16 Roquette, 13 Seppic, 11 Microlex e.U, 11 Sigachi Industries, 10 Corel Pharma Chem, 10 Gangwal Chemicals, 9 BASF, 8 Gangwal Healthcare, 7 Ideal Cures Pvt Ltd, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Lonza Capsugel, 5 DFE Pharma, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 SPI Pharma, 3 Ingredion Pharma Solutions, 3 Kima Chemical, 3 Prachin Chemical, 3 Vasa Pharmachem, 3 Nanjing Well Pharmaceutical, 2 The Dow Chemical Company, 2 Jai Radhe Sales, 2 Actylis, 1 DKSH, 1 Aeon Procare, 1 Huzhou Sunflower Pharmaceutical Co. Ltd, 1 Alcedo Pharmachem, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 ACG Worldwide, 1 Qualicaps, 1 Nanjing Bold Chemical, 1 Pharmatrans-Sanaq, 1 Boai NKY Pharmaceuticals Ltd

EXCIPIENTS BY APPLICATIONS

58 Fillers, Diluents & Binders, 49 Coating Systems & Additives, 27 Direct Compression, 26 Controlled & Modified Release, 21 Disintegrants & Superdisintegrants, 17 Granulation, 15 Lubricants & Glidants, 13 Solubilizers, 13 Thickeners and Stabilizers, 12 Film Formers & Plasticizers, 11 Co-Processed Excipients, 10 Taste Masking, 8 Parenteral, 6 Chewable & Orodispersible Aids, 6 API Stability Enhancers, 6 Emulsifying Agents, 6 Topical, 5 Empty Capsules, 4 Vegetarian Capsules, 4 Rheology Modifiers, 2 Surfactant & Foaming Agents, 2 Coloring Agents

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions, 69 Finished Drug Prices

MARKET PLACE

24 APIs, 5 DOSSIERS // FDF, 1 EXCIPIENTS

PATENTS

2 US Patents

2 US Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 6 USP Standards, 6 Other Ref. Standards

DIGITAL CONTENT

2 Data Compilation & Company Tracker #PharmaFlow, 23 News

Also known as: 169293-50-9, Nebivolol hcl, 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethanol) hydrochloride, 152520-56-4, Rac nebivolol hydrochloride, R 065824 hydrochloride

Molecular Formula

C₂₂H₂₆ClF₂NO₄

Molecular Weight

441.9 g/mol

InChI Key

JWEXHQAEWHKGCW-UHFFFAOYSA-N

A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol;hydrochloride

2.1.2 InChI

InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H

2.1.3 InChI Key

JWEXHQAEWHKGCW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 67555, R

2. Alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2h-1-benzopyran-2-methanol

3. Bystolic

4. Hydrochloride, Nebivolol

5. Lobivon

6. Nebilet

7. Nebivolol

8. R 67555

9. R-67555

10. R67555

11. Silostar

2.2.2 Depositor-Supplied Synonyms

1. 169293-50-9

2. Nebivolol Hcl

3. 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethanol) Hydrochloride

4. 152520-56-4

5. Rac Nebivolol Hydrochloride

6. R 065824 Hydrochloride

7. Nebilox

8. Rac-nebivolol Hcl

9. R-067555

10. Schembl514784

11. N-phenyliminodiaceticacid

12. Chembl1201731

13. Akos016006035

14. Ac-4233

15. Ac-5636

16. Ccg-214847

17. Ro67555

18. As-12100

19. Cs-0362720

20. Ft-0652243

21. Ft-0655833

22. 520n564

23. W-60374

24. J-010524

25. 1-(6-fluoro-3,4-dihydro-2h-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2h-chromen-2-yl)-2-hydroxyethyl]amino]ethanol;hydrochloride

26. 2h-1-benzopyran-2-methanol,a,a'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride(1:1)

27. Alpha,alpha'[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2h-1-benzopyran-2-methanol]hydrochloride

2.3 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₆ClF₂NO₄
Molecular Weight	441.9 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	441.1518423 g/mol
Monoisotopic Mass	441.1518423 g/mol
Topological Polar Surface Area	71 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	483
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic beta-1 Receptor Agonists

Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Agonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

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