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    Loprazolam Mesilate

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Loprazolam mesilate, Dormonoct, Loprazolam methanesulfonate, Somnovit, Sonin, Havlane
    Molecular Formula
    C24H25ClN6O6S
    Molecular Weight
    561.0  g/mol
    InChI Key
    DDSDPQHQLNAGLJ-YEBWQKSTSA-N
    FDA UNII
    VKF8383J65
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2Z)-6-(2-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one;methanesulfonic acid
    2.1.2 InChI
    InChI=1S/C23H21ClN6O3.CH4O3S/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24;1-5(2,3)4/h2-7,12,14H,8-11,13H2,1H3;1H3,(H,2,3,4)/b19-14-;
    2.1.3 InChI Key
    DDSDPQHQLNAGLJ-YEBWQKSTSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C=C2C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl.CS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl.CS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    VKF8383J65
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 8-nitro-6-(o-chlorophenyl)-1,2-dihydro-2-(n-methylpiperazin-1-yl)methylene-1h,4h-imidazo (1,2-a)(1,4)benzodiazepin-1-one Methanesulfonate

    2. Hr 158

    3. Hr 458

    4. Loprazolam

    5. Ru 31158

    6. Triazulenone

    7. Triazulenone Mesylate

    8. Triazulenone, (z)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. Loprazolam Mesilate

    2. Dormonoct

    3. Loprazolam Methanesulfonate

    4. Somnovit

    5. Sonin

    6. Havlane

    7. 70111-54-5

    8. Ru-31158

    9. Vkf8383j65

    10. Hr-158

    11. Triazulenone Mesylate

    12. Unii-vkf8383j65

    13. Havlane (tn)

    14. Hr 158

    15. Schembl352745

    16. 61197-93-1

    17. Loprazolam Mesilate [mart.]

    18. Loprazolam Mesilate [who-dd]

    19. Loprazolam Methanesulfonate [mi]

    20. D08145

    21. Q27291872

    22. (2z)-6-(2-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4h-imidazo[1,2-a][1,4]benzodiazepin-1-one;methanesulfonic Acid

    23. (z)-6-(2-chlorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-2,4-dihydro-1h-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one Methanesulfonate

    24. 1h-imidazo(1,2-a)(1,4)benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-, (2z)-, Methanesulfonate (1:1)

    25. 1h-imidazo(1,2-a)(1,4)benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-, Monomethanesulfonate

    2.4 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 561.0 g/mol
    Molecular Formula C24H25ClN6O6S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count2
    Exact Mass560.1244814 g/mol
    Monoisotopic Mass560.1244814 g/mol
    Topological Polar Surface Area160 Ų
    Heavy Atom Count38
    Formal Charge0
    Complexity984
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)