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    Technical details about GLUCONOLACTONE, learn more about the structure, uses, toxicity, action, side effects and more

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    GLUCONOLACTONE

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: Delta-gluconolactone, 90-80-2, D-glucono-1,5-lactone, Gluconic acid lactone, D-gluconolactone, 1,5-gluconolactone
    Molecular Formula
    C6H10O6
    Molecular Weight
    178.14  g/mol
    InChI Key
    PHOQVHQSTUBQQK-SQOUGZDYSA-N
    FDA UNII
    WQ29KQ9POT
    Gluconolactone is a naturally occurring polyhydroxy acid (PHA) with metal chelating, moisturizing and antioxidant activity. Gluconolactone can be produced by enzymatic oxidation of D-glucose oxidation. Its ability in free radicals scavenging accounts for its antioxidant property. It is used in cosmetic product and as a coagulant in tofu processing. (NCI05)
    Gluconolactone is a Calculi Dissolution Agent. The mechanism of action of gluconolactone is as an Irrigation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
    2.1.2 InChI
    InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
    2.1.3 InChI Key
    PHOQVHQSTUBQQK-SQOUGZDYSA-N
    2.1.4 Canonical SMILES
    C(C1C(C(C(C(=O)O1)O)O)O)O
    2.1.5 Isomeric SMILES
    C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    WQ29KQ9POT
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Beta-glucono-1,5-lactone

    2. Delta-gluconolactone

    3. Gdl (gluconate)

    4. Gluconic Lactone

    5. Glucono-delta-lactone

    6. Gulonic Acid Gamma-lactone

    2.3.2 Depositor-Supplied Synonyms

    1. Delta-gluconolactone

    2. 90-80-2

    3. D-glucono-1,5-lactone

    4. Gluconic Acid Lactone

    5. D-gluconolactone

    6. 1,5-gluconolactone

    7. Glucono Delta-lactone

    8. D-(+)-glucono-1,5-lactone

    9. D-gluconic Acid Lactone

    10. D-gluconic Acid Delta-lactone

    11. 1,5-d-gluconolactone

    12. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one

    13. Gluconic Lactone

    14. Glucono Delta Lactone

    15. Gluconic Delta-lactone

    16. Fujiglucon

    17. D-delta-gluconolactone

    18. Delta-d-gluconolactone

    19. Deltagluconolactone

    20. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one

    21. D-gluconic Delta-lactone

    22. D-(+)-gluconic Acid Delta-lactone

    23. Glucarolactone

    24. Glucono-delta-lactone

    25. D-aldonolactone

    26. Beta-glucono-1,5-lactone

    27. D-gluconic Acid-delta-lactone

    28. Gluconolactone [usp]

    29. Lysactone

    30. Riken Lactone

    31. D-threo-aldono-1,5-lactone

    32. 1335-57-5

    33. Ai3-19578

    34. Gluconic Acid Anhydride

    35. Gluconic Acid, Delta-lactone, D-

    36. Glucono .delta. Lactone

    37. Glucono .delta.-lactone

    38. .delta.-d-gluconolactone

    39. Wq29kq9pot

    40. 4253-68-3

    41. Gluconic Acid Delta-lactone

    42. Ins No.575

    43. Chebi:16217

    44. D-gluconic Acid .delta.-lactone

    45. Ins-575

    46. Nsc-34393

    47. Nsc-758238

    48. Gluconolactone (usp)

    49. E-575

    50. Nsc 34393

    51. Dsstox_cid_6549

    52. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one

    53. Dsstox_rid_78147

    54. Dsstox_gsid_26549

    55. 135820-79-0

    56. D-gluconic Acid, .delta.-lactone

    57. Glucolactone

    58. D-gluconic Acid D-lactone

    59. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-one

    60. Cas-90-80-2

    61. .delta.-gluconolactone

    62. D-glucono-delta-lactone

    63. Lgc

    64. Hsdb 488

    65. D-gluconic Acid-1,5-lactone

    66. Einecs 202-016-5

    67. Unii-wq29kq9pot

    68. Gluconic Acid Lactone (6ci)

    69. Nsc34393

    70. Delta-gluconic Acid Delta-lactone

    71. Glucono--lactone

    72. Gluconodeltalactone

    73. Delta-aldonolactone

    74. Gluconate, Lactone

    75. Ncgc00095002-01

    76. Delta Gluconolactone

    77. Gamma-gluconolactone

    78. Gdl

    79. D-glucono-d-lactone

    80. Mfcd00006647

    81. Glucono Gamma-lactone

    82. Glucono-1,5-lactone

    83. Glucono 1,5-lactone

    84. D-glucono1,5-lactone

    85. Gluconic Acid D-lactone

    86. Delta-delta-gluconolactone

    87. 1,5-delta-gluconolactone

    88. Bmse000230

    89. Delta-gluconic Acid Lactone

    90. Delta-glucono-delta-lactone

    91. Ec 202-016-5

    92. Gluconolactone [ii]

    93. Gluconolactone [mi]

    94. Delta-glucono-1,5-lactone

    95. Delta-gluconic Delta-lactone

    96. Glucono-delta-lactone(gdl)

    97. Schembl15320

    98. Gluconolactone [hsdb]

    99. Gluconolactone [inci]

    100. Delta-gluconic Acid D-lactone

    101. Mls002207105

    102. D-gluconic Acid 1,5-lactone

    103. Gluconolactone [mart.]

    104. Gluconolactone [usp-rs]

    105. Gluconolactone [who-dd]

    106. Chembl1200829

    107. D-(+)-gluconic Acid D-lactone

    108. Dtxsid0026549

    109. Delta-gluconic Acid 1,5-lactone

    110. Delta-gluconic Acid-1,5-lactone

    111. Delta-gluconic Acid-delta-lactone

    112. D(+)-gluconic Acid Gamma-lactone

    113. Glucono-

    114. A-lactone Usp26 Fcciv

    115. Cs-m3768

    116. D-(+)-gluconic Acid-delta Lactone

    117. Delta-(+)-gluconic Acid D-lactone

    118. Glucono Delta-lactone [fcc]

    119. Hy-i0301

    120. Zinc2539702

    121. Gluconolactone [orange Book]

    122. Tox21_111383

    123. Tox21_200429

    124. Bdbm50366565

    125. Glucono-delta-lactone [vandf]

    126. Gluconolactone [usp Monograph]

    127. Akos016843888

    128. Tox21_111383_1

    129. Db04564

    130. Delta-(+)-gluconic Acid-delta Lactone

    131. Ds-4779

    132. Ncgc00257983-01

    133. Ncgc00344522-01

    134. Renacidin Component Gluconolactone

    135. Ac-13150

    136. E575

    137. Smr001306715

    138. Gluconolactone Component Of Renacidin

    139. G0039

    140. C00198

    141. D04332

    142. P19765

    143. D-(+)-gluconic Acid Delta-lactone, >=99.0%

    144. Gluconolactone, Meets Usp Testing Specifications

    145. Q114174

    146. W-100325

    147. 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one

    148. 3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-one

    149. D-(+)-gluconic Acid Delta-lactone, Analytical Standard

    150. Wurcs=2.0/1,1,0/[a2122h_1-5]/1/

    151. A88519cb-a562-4c9c-b925-0a6b1701f841

    152. Gluconolactone, United States Pharmacopeia (usp) Reference Standard

    153. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydropyran-2-one

    154. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one (non-preferred Name)

    155. (3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one; Gluconolactone

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 178.14 g/mol
    Molecular Formula C6H10O6
    XLogP3-2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count1
    Exact Mass178.04773803 g/mol
    Monoisotopic Mass178.04773803 g/mol
    Topological Polar Surface Area107 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity181
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MEDICATION (VET): ...Mixture in urine helps dissolve urinary tract stones containing calcium carbonate, tricalcium phosphate, calcium oxalates, & magnesium ammonium phosphates but usually none containing uric acid, urates, cystineine, or some oxalates.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 240

    MEDICATION (VET): 0.5% Solution can be used for irrigating the urethra & bladder when indicated. Similar strength as a rinse can help maintain in dwelling urethral catheters free of calcification.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 240

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Active Moiety
    GLUCONOLACTONE
    5.1.2 FDA UNII
    WQ29KQ9POT
    5.1.3 Pharmacological Classes
    Mechanisms of Action [MoA] - Irrigation
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