1. Cx717
1. Cx717
2. 867276-98-0
3. Cx-717
4. Unii-7i12yta3qm
5. 7i12yta3qm
6. Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone
7. 2,1,3-benzoxadiazol-5-yl-4-morpholinylmethanone
8. Cx 717
9. Morpholine, 4-(2,1,3-benzoxadiazol-5-ylcarbonyl)-
10. 211735-82-9
11. Starbld0003244
12. Cx 717 (pharmaceutical)
13. Oprea1_513346
14. Schembl243542
15. Chembl4791762
16. Dtxsid301241632
17. Ex-a6414
18. Db05047
19. Bs-47001
20. Cs-0256234
| Molecular Weight | 233.22 g/mol |
|---|---|
| Molecular Formula | C11H11N3O3 |
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 1 |
| Exact Mass | 233.08004122 g/mol |
| Monoisotopic Mass | 233.08004122 g/mol |
| Topological Polar Surface Area | 68.5 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 294 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.
CX-717 is an ampakine compound. It is a positive allosteric modulator of AMPA receptors. Its action is theorized to be due to the facilitation of transmission at cortical synapses that use glutamate as a neurotransmitter. This in turn may promote plasticity at the synapse, which could translate into better cognitive performance. CX-717 works by allosterically binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. In addition, CX717 could potentially strongly impact the up-regulation of BDNF (brain-derived neurotrophic factor) or NGF (nerve growth factor), two growth factors known to stimulate the formation of new circuitry in the brain associated with forming memory and cognition.
