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    Technical details about Benziodarone, learn more about the structure, uses, toxicity, action, side effects and more

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    Benziodarone

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    PharmaCompass

    Biopharma Group offers CDMO services with expertise in contract R&D for dried products & liquid formulations.

    Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

    2D Structure
    1. Also known as: 68-90-6, Amplivix, Dilafurane, Cardivix, Dila-vasal, Corofam
    Molecular Formula
    C17H12I2O3
    Molecular Weight
    518.08  g/mol
    InChI Key
    CZCHIEJNWPNBDE-UHFFFAOYSA-N
    FDA UNII
    75CL65GTYR
    Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone
    2.1.2 InChI
    InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
    2.1.3 InChI Key
    CZCHIEJNWPNBDE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)O)I
    2.2 Other Identifiers
    2.2.1 UNII
    75CL65GTYR
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-ethyl-3-benzofuranyl-4-hydroxy-3,5-diiodophenyl Ketone

    2. Algocor

    3. Amplivix

    4. Cardivix

    5. Dila-vasal

    6. Dilafurane

    2.3.2 Depositor-Supplied Synonyms

    1. 68-90-6

    2. Amplivix

    3. Dilafurane

    4. Cardivix

    5. Dila-vasal

    6. Corofam

    7. Coronal-crinos

    8. Retrangor

    9. Benziodaron

    10. Carofam

    11. Dilacoron

    12. L 2329

    13. 2329 Labaz

    14. Nsc 82133

    15. 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl Ketone

    16. Nsc-82133

    17. 75cl65gtyr

    18. 2-ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)-cumarone

    19. Benzofuran, 3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-

    20. 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl Ketone

    21. Chembl232201

    22. Corofam;dilacoron;nsc 82133

    23. (2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone

    24. Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)-

    25. Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 Cumaron

    26. Ncgc00160408-01

    27. Plexocardio

    28. Flanicone

    29. Ketone, 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl

    30. Ketone, 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl

    31. Uricor

    32. L-2329

    33. Dsstox_cid_26134

    34. Dsstox_rid_81367

    35. Dsstox_gsid_46134

    36. Benziodarona

    37. Benziodaronum

    38. Benzoiodarone

    39. Benziodaronum [inn-latin]

    40. Cas-68-90-6

    41. Benziodarona [inn-spanish]

    42. Einecs 200-695-2

    43. Unii-75cl65gtyr

    44. Brn 1257683

    45. Amplivix (tn)

    46. Benziodarone [inn:ban:dcf:jan]

    47. Ketone,5-diiodophenyl

    48. Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 Cumaron [german]

    49. Benziodarone (jan/inn)

    50. Benziodarone [mi]

    51. Benziodarone [inn]

    52. Benziodarone [jan]

    53. Methanone,5-diiodophenyl)-

    54. Benziodarone [mart.]

    55. Benziodarone [who-dd]

    56. Schembl308541

    57. Dtxsid1046134

    58. Chebi:135814

    59. Nsc82133

    60. Zinc3875456

    61. Tox21_111793

    62. (2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone

    63. Bdbm50209206

    64. Mfcd00868246

    65. Akos015994715

    66. Tox21_111793_1

    67. Db13277

    68. Ks-1133

    69. Ncgc00160408-02

    70. Ncgc00160408-03

    71. Ncgc00160408-06

    72. E1290

    73. Ft-0662545

    74. D01833

    75. T72830

    76. Q4890775

    77. 2-ethylbenzofuranyl 4-hydroxy-3,5-diiodophenyl Ketone

    78. (2-ethyl-1-benzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone #

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 518.08 g/mol
    Molecular Formula C17H12I2O3
    XLogP35.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass517.88759 g/mol
    Monoisotopic Mass517.88759 g/mol
    Topological Polar Surface Area50.4 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity405
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Uricosuric Agents

    Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)

    4.2 ATC Code

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01D - Vasodilators used in cardiac diseases

    C01DX - Other vasodilators used in cardiac diseases

    C01DX04 - Benziodarone

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