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1. Cp 89044
2. Cp 90033
3. Cp-89044
4. Cp-90033
5. Cp89044
6. Cp90033
7. Gonadotropin, Human Menopausal
8. Gonadotropins, Human Menopausal
9. Hmg Ferring
10. Hmg Lepori
11. Hmg Massone
12. Human Menopausal Gonadotropin
13. Human Menopausal Gonadotropins
14. Humegon
15. Lepori, Hmg
16. Menogon
17. Menopausal Gonadotropin, Human
18. Menopur
19. Menotrophin
20. Menotropins
21. Normegon
22. Org 31338
23. Org-31338
24. Org31338
25. Pergonal
26. Pergonal 500
27. Pergonal-500
28. Pergonal500
1. 6,6-dimethylheptanal
2. Menotrophin
3. 61489-71-2
4. Menotropins
5. Schembl1784550
6. Akos013847259
7. Gonadotropin From Human Menopausal Urine
| Molecular Weight | 142.24 g/mol |
|---|---|
| Molecular Formula | C9H18O |
| XLogP3 | 3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 5 |
| Exact Mass | 142.135765193 g/mol |
| Monoisotopic Mass | 142.135765193 g/mol |
| Topological Polar Surface Area | 17.1 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 89.4 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
MENOTROPINS FOR INJECTION (PERGONAL)... WHILE FSH & LH ACTIVITIES ARE PRESENT IN EQUAL UNITAGE, CHORIONIC GONADOTROPIN IS USUALLY REQUIRED IN CONJUNCTION WITH MENOTROPINS TO INDUCE OVULATION.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1388
WIDEST POTENTIAL USEFULNESS OF GONADOTROPINS IS IN INDUCTION OF OVULATION IN WOMEN WHO ARE INFERTILE BECAUSE OF INSUFFICIENT GONADOTROPINS. ...OCCURRENCE OF OVULATION IN 75% OF PT TREATED WITH DRUGS. /GONADOTROPINS/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1388
WHILE OVULATION WAS OCCASIONALLY SEEN DURING ADMIN OF MENOTROPINS BEFORE HUMAN CHORIONIC GONADOTROPIN...GIVEN, IT USUALLY TOOK PLACE ABOUT 18 HR AFTER ADMIN OF LATTER HORMONE. PREGNANCY RESULTED IN APPROX 25% OF PT... 20% OF PREGNANCIES RESULTED IN MULTIPLE BIRTHS...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1388
GROWTH & DEVELOPMENT OF CHILDREN BORN OF MOTHERS RECEIVING GONADOTROPIN TREATMENT HAVE BEEN NORMAL... /GONADOTROPINS/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1388
For more Therapeutic Uses (Complete) data for MENOTROPINS (6 total), please visit the HSDB record page.
...ABORTION RATE...25% & FETAL ABNORMALITIES...IN 2%.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1388
For the treatment of female infertility
FDA Label
Treatment of female infertility
Used to treat female infertility, Menotropins stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Menotropins bind to the LH/hCG/FSH receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.
Fertility Agents, Female
Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)
G - Genito urinary system and sex hormones
G03 - Sex hormones and modulators of the genital system
G03G - Gonadotropins and other ovulation stimulants
G03GA - Gonadotropins
G03GA02 - Human menopausal gonadotrophin
LENGTH OF SURVIVAL OF INJECTED & PRESUMABLY OF ENDOGENOUSLY SECRETED HORMONES IS DETERMINED LARGELY BY RATE OF DEGRADATION IN BODY, BECAUSE LITTLE IS EXCRETED IN URINE...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1387
STUDIES ON RATE OF DISAPPEARANCE OF ENDOGENOUS HUMAN...FSH...INDICATE REMOVAL FROM PLASMA WITH @ LEAST 2 DISTINCT HALF-TIMES. SHORTER HALF-LIVES...APPROX 4 HR...WHILE LONGER HALF-LIVES APPEAR TO BE 70 /HR/...ONLY 5% OF SECRETED FSH IS FOUND IN URINE IN ACTIVE FORM...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1387
MEASUREMENTS OF GONADOTROPINS IN PLASMA THROUGHOUT MENSTRUAL CYCLE SHOW THAT FSH IS ELEVATED DURING FOLLICULAR PHASE & SLOWLY FALLS BEFORE IT RISES AGAIN AT MIDCYCLE; IT IS LOWEST DURING LUTEAL PHASE. .../AT MIDCYCLE/ FSH IS HIGHEST.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1386
Being a combination drug, Menotropins bind to the follicle stimulating hormone receptor (FSH), which results in ovulation in the absence of sufficient endogenous luteinizing hormone (LH). It also binds the LH receptor, thereby stimulating proper hormone release. The drug contains both FSH and LH, therefore, it induces ovarian follicular growth and development as well as gonadal steroid production in women who do not have ovarian failure. FSH is the primary driver of follicular recruitment and growth in early folliculogenesis, while LH is important for ovarian steroidogenesis and is involved in the physiological events leading to development of a competent pre-ovulatory follicle.
...LH & FSH BIND WITH APPARENT SPECIFICITY TO VARIOUS PARTICULATE FRACTIONS DERIVED FROM TESTIS & OVARY. ...BOTH GONADOTROPINS ARE KNOWN TO STIMULATE CYCLIC AMP SYNTHESIS IN APPROPRIATE GONADAL PREPN. CYCLIC AMP THEN STIMULATES SEX STEROID BIOSYNTHESIS BY MECHANISMS APPARENTLY ANALOGOUS TO THOSE OPERATIVE IN ADRENAL CORTEX.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1387
.../FSH/ CONSISTS OF NONIDENTICAL, NON-COVALENTLY LINKED SUBUNITS... WHILE THE ALPHA SUBUNIT OF FSH IS SIGNIFICANTLY DIFFERENT FROM THAT OF LH OR TSH...THERE IS EVIDENCE THAT FSH ALPHA SUBUNIT CAN COMBINE WITH BETA SUBUNIT OF CHORIONIC GONADOTROPIN WITH RESTORATION OF CHORIONIC GONADODTROPIN ACTIVITY...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1385
DURING FOLLICULAR PHASE OF OVARIAN CYCLE SUCCESSIVE GROUPS OF SMALL FOLLICLES START TO GROW, & BY TIME OVULATION IS IMMINENT FOLLICLES IN ALL STAGES OF DEVELOPMENT ARE FOUND. THIS OVARIAN RESPONSE REPRESENTS PREDOMINANT ACTION OF FSH, IT IS DURING THIS PHASE THAT ESTROGEN IS MAIN OVARIAN SECRETORY PRODUCT...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1386
FSH IS PRIMARILY A GAMETOGENIC HORMONE IN MALES; IT IS RESPONSIBLE FOR ANATOMICAL INTEGRITY OF SEMINIFEROUS TUBULES & ONLY UNDER ITS INFLUENCE ARE COMPLEX STAGES OF GAMETOGENESIS CARRIED THROUGH TO PRODUCTION OF SPERMATOZOA.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1386
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