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    Technical details about 111Indium Trichloride, learn more about the structure, uses, toxicity, action, side effects and more

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    111Indium Trichloride

    APIs // Active Pharmaceutical Ingredients

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    2D Structure
    1. Also known as: 111indium trichloride, Indium chloride in-111, Indium chloride (111incl3), Indium in-111 chloride, 50800-85-6, Unii-58td96h03i
    Molecular Formula
    Cl3In
    Molecular Weight
    217.26  g/mol
    InChI Key
    PSCMQHVBLHHWTO-FZTWWWDYSA-K
    Indium In-111 Chloride is a radioactive salt that is used as a reagent in the preparation of indium 111-labeled radiopharmaceuticals. Indium 111-labeled radioconjugates are used as radioactive tracers in nuclear medicine that detect malignant lesions and inflammatory tissues probably due to an increased capillary permeability. Indium-111 chloride is particularly used in the radiolabeling of the monoclonal antibodies satumomab pendetide, 7E11-C5.3 (CYT-356), and ibritumomab tiuxetan. (NCI05)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    trichloro(111In)indigane
    2.1.2 InChI
    InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
    2.1.3 InChI Key
    PSCMQHVBLHHWTO-FZTWWWDYSA-K
    2.1.4 Canonical SMILES
    Cl[In](Cl)Cl
    2.1.5 Isomeric SMILES
    Cl[111In](Cl)Cl
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. 111indium Trichloride

    2. Indium Chloride In-111

    3. Indium Chloride (111incl3)

    4. Indium In-111 Chloride

    5. 50800-85-6

    6. Unii-58td96h03i

    7. Dtxsid90965038

    8. Db09490

    9. Q27098008

    2.3 Create Date
    2010-12-22
    3 Chemical and Physical Properties
    Molecular Weight 217.26 g/mol
    Molecular Formula Cl3In
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass215.81167 g/mol
    Monoisotopic Mass215.81167 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count4
    Formal Charge0
    Complexity8
    Isotope Atom Count1
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone

    5.2 Absorption, Distribution and Excretion

    Absorption

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone

    Route of Elimination

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone

    Volume of Distribution

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone

    Clearance

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone

    5.3 Metabolism/Metabolites

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone

    5.4 Biological Half-Life

    2.8 days

    5.5 Mechanism of Action

    Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone

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