loader
Please Wait
Applying Filters...
Close
4

Seqens Seqens

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about 042LAQ1IIS, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    042LAQ1IIS

    APIs // Active Pharmaceutical Ingredients

    DEVELOPMENTS

    PRICE INFORMATION

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    DRUG PRODUCT COMPOSITION

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

    PharmaCompass

    PharmaCompass Sponsored Ads

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 100286-90-6, Irinotecan hcl, Topotecin, Campto, Camptothecin 11 hydrochloride, Camptosar
    Molecular Formula
    C33H39ClN4O6
    Molecular Weight
    623.1  g/mol
    InChI Key
    GURKHSYORGJETM-WAQYZQTGSA-N
    FDA UNII
    06X131E4OE
    A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
    2.1.3 InChI Key
    GURKHSYORGJETM-WAQYZQTGSA-N
    2.1.4 Canonical SMILES
    CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
    2.1.5 Isomeric SMILES
    CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    06X131E4OE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 7 Ethyl 10 Hydroxycamptothecin

    2. 7-ethyl-10-hydroxycamptothecin

    3. Camptosar

    4. Camptothecin 11

    5. Camptothecin-11

    6. Cpt 11

    7. Cpt-11

    8. Cpt11

    9. Irinotecan

    10. Irrinotecan

    11. Nk012 Compound

    12. Sn 38

    13. Sn 38 11

    14. Sn-38

    15. Sn-38-11

    16. Sn3811

    2.3.2 Depositor-Supplied Synonyms

    1. 100286-90-6

    2. Irinotecan Hcl

    3. Topotecin

    4. Campto

    5. Camptothecin 11 Hydrochloride

    6. Camptosar

    7. Cpt 11

    8. Cpt-11

    9. Irinotecan (hydrochloride)

    10. Camptothecin 11

    11. U 101440e

    12. Chebi:5971

    13. (s)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate Hydrochloride

    14. Camptothecin Analog

    15. 06x131e4oe

    16. 7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxy Camptothecin Hydrochloride

    17. Nsc616348

    18. Nsc-616348

    19. Ncgc00095190-01

    20. Dsstox_cid_25953

    21. Dsstox_rid_81249

    22. Dsstox_gsid_45953

    23. [(19s)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydrochloride

    24. Irinotecan Hydrochloride Anhydrous

    25. Cas-100286-90-6

    26. U-101440e

    27. Unii-06x131e4oe

    28. Irinotecan Hydrochloride [usan:jan]

    29. Mfcd01862255

    30. Irinotecanhydrochloride

    31. Cpt-11 Hydrochloride

    32. Irinotecan Monohydrochloride

    33. Schembl4033

    34. Camptosar (tn) (pharmacia)

    35. (s)-[1,4'-bipiperidine]-1'-carboxylic Acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester Hydrochloride

    36. Spectrum1505821

    37. Chembl541887

    38. Dtxsid6045953

    39. Hms1922j04

    40. Pharmakon1600-01505821

    41. Amy24895

    42. Bcp17234

    43. Irinotecan Hydrochloride (anhydrous)

    44. Tox21_111479

    45. Hy-16562a

    46. Nsc759878

    47. S5026

    48. Akos015901921

    49. Tox21_111479_1

    50. Ccg-213561

    51. Irinotecan Hydrochloride [who-dd]

    52. Ncgc00095190-02

    53. Ncgc00178697-04

    54. (1,4'-bipiperidine)-1'-carboxylic Acid, (4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl Ester, Monohydrochloride

    55. (1,4'-bipiperidine)-1'-carboxylic Acid, 3,4,12,14-tetrahydro-4,11-diethyl-4-hydroxy-3,4-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl Ester, Monohydrochloride, (s)-

    56. Ac-28335

    57. As-13304

    58. I0714

    59. Irinotecan Hydrochloride Anhydrous [mi]

    60. Irinotecan Hydrochloride, Topoisomerase Inhibitor

    61. 286i906

    62. A897508

    63. Sr-01000763864

    64. Q-100016

    65. Sr-01000763864-3

    66. Q27106952

    67. Z1550648758

    68. (+)-7-ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, Monohydrochloride

    69. (1,4'-bipiperidine)-1'-carboxylic Acid, (4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl Ester, Hydrochloride (1:1)

    70. (19s)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate Hydrochloride

    71. (4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic Acid Ester Hydrochloride

    72. (4s)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate Hydrochloride

    73. (s)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylatehydrochloride

    74. [(19s)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate Hydrochloride

    75. [1, 4,11-diethyl-3,4,12, 14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7] Indolizino[1,2-b]quinolin-9-yl Ester, Monohydrochloride (s)-

    76. [1,4'-bipiperidine]-1'-carboxylic Acid,(4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester, Monohydrochloride

    77. 1-[1-({[(4s)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium Chloride

    2.3.3 Other Synonyms

    1. Camptosar

    2. Campto

    3. Irinotecan

    4. Hy-16562

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 623.1 g/mol
    Molecular Formula C33H39ClN4O6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass622.2558127 g/mol
    Monoisotopic Mass622.2558127 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count44
    Formal Charge0
    Complexity1200
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameIrinotecan hydrochloride
    Drug LabelIrinotecan hydrochloride injection is an antineoplastic agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically investigated as CPT-11. Irinotecan hydrochloride injection is supplied as a sterile, pale yellow, clear, aqu...
    Active IngredientIrinotecan hydrochloride
    Dosage FormInjectable
    Routeinjection; Injection
    Strength20mg/ml; 100mg/5ml (20mg/ml); 500mg/25ml (20mg/ml); 100mg/5ml; 40mg/2ml (20mg/ml)
    Market StatusPrescription
    CompanyPliva Lachema; Hospira; Teva Parenteral; Fresenius Kabi Oncol; Accord Hlthcare; Jiangsu Hengrui Med; Hikma Farmaceutica; Teva Pharms Usa; Cipla; Hisun Pharm Hangzhou; Sun Pharma Global; Actavis Elizabeth; Emcure Pharms; Mustafa Nevzat Ilac; Fresenius Kabi

    2 of 2  
    Drug NameIrinotecan hydrochloride
    Drug LabelIrinotecan hydrochloride injection is an antineoplastic agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically investigated as CPT-11. Irinotecan hydrochloride injection is supplied as a sterile, pale yellow, clear, aqu...
    Active IngredientIrinotecan hydrochloride
    Dosage FormInjectable
    Routeinjection; Injection
    Strength20mg/ml; 100mg/5ml (20mg/ml); 500mg/25ml (20mg/ml); 100mg/5ml; 40mg/2ml (20mg/ml)
    Market StatusPrescription
    CompanyPliva Lachema; Hospira; Teva Parenteral; Fresenius Kabi Oncol; Accord Hlthcare; Jiangsu Hengrui Med; Hikma Farmaceutica; Teva Pharms Usa; Cipla; Hisun Pharm Hangzhou; Sun Pharma Global; Actavis Elizabeth; Emcure Pharms; Mustafa Nevzat Ilac; Fresenius Kabi

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Topoisomerase I Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Topoisomerase Inhibitors [MoA]; Topoisomerase Inhibitor [EPC]
    Post Enquiry
    POST ENQUIRY