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Chemistry

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Also known as:
Molecular Formula
C18H19ClN4
Molecular Weight
326.8  g/mol
InChI Key
ZUXABONWMNSFBN-UHFFFAOYSA-N

Clozapine
1 2D Structure

Clozapine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
2.1.2 InChI
InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
2.1.3 InChI Key
ZUXABONWMNSFBN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
2.1.5 Isomeric SMILES
CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
2.2 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 326.8 g/mol
Molecular Formula C18H19ClN4
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass326.1298243 g/mol
Monoisotopic Mass326.1298243 g/mol
Topological Polar Surface Area30.9 A^2
Heavy Atom Count23
Formal Charge0
Complexity584
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameClozapine
PubMed HealthClozapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelVERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active IngredientClozapine
Dosage FormTablet
RouteOral
Strength200mg; 100mg; 25mg; 50mg; 12.5mg
Market StatusPrescription
CompanyIvax Sub Teva Pharms; Sun Pharm Inds; Mylan

2 of 6  
Drug NameClozaril
PubMed HealthClozapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelCLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active IngredientClozapine
Dosage FormTablet
RouteOral
Strength100mg; 25mg
Market StatusPrescription
CompanyNovartis

3 of 6  
Drug NameFazaclo odt
Active IngredientClozapine
Dosage FormTablet, orally disintegrating
RouteOral
Strength200mg; 100mg; 25mg; 150mg; 12.5mg
Market StatusPrescription
CompanyJazz Pharms Iii

4 of 6  
Drug NameClozapine
PubMed HealthClozapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelVERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
Active IngredientClozapine
Dosage FormTablet
RouteOral
Strength200mg; 100mg; 25mg; 50mg; 12.5mg
Market StatusPrescription
CompanyIvax Sub Teva Pharms; Sun Pharm Inds; Mylan

5 of 6  
Drug NameClozaril
PubMed HealthClozapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelCLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
Active IngredientClozapine
Dosage FormTablet
RouteOral
Strength100mg; 25mg
Market StatusPrescription
CompanyNovartis

6 of 6  
Drug NameFazaclo odt
Active IngredientClozapine
Dosage FormTablet, orally disintegrating
RouteOral
Strength200mg; 100mg; 25mg; 150mg; 12.5mg
Market StatusPrescription
CompanyJazz Pharms Iii

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GUJARAT","supplier":"SUZHOU SOPHAR CO LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"TORRENT PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"60.00","actualQuantity":"60","unit":"KGS","unitRateFc":"123","totalValueFC":"8070.9","currency":"USD","unitRateINR":"11272.5","date":"05-Sep-2024","totalValueINR":"676350","totalValueInUsd":"8070.9","indian_port":"JNPT","hs_no":"29335990","bill_no":"5430291","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"HOUCHENG WENXING ROAD, JINGANG TOWN , ZHANGJIAGANG CITY, JIANGSU PROV., CHINA CHINA CHINA","customerAddress":"TORRENT HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725474600,"product":"CLOZAPINE BP 2024 (PHARMACEUTICAL RAW MATERIAL)","address":"TORRENT HOUSE,","city":"AHMEDABAD. GUJARAT","supplier":"SUZHOU SOPHAR CO LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"TORRENT PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"431.62","actualQuantity":"431.62","unit":"KGS","unitRateFc":"127.2","totalValueFC":"58059.3","currency":"USD","unitRateINR":"11272.5","date":"05-Sep-2024","totalValueINR":"4865436.45","totalValueInUsd":"58059.3","indian_port":"JNPT","hs_no":"29335990","bill_no":"5431368","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"HOUCHENG WENXING ROAD, JINGANG TOWN , ZHANGJIAGANG CITY, JIANGSU PROV., CHINA CHINA CHINA","customerAddress":"TORRENT HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737397800,"product":"CLOZAPINE (FOR PHARMACEUTICAL USE ONLY) CLOZAPINE (FOR PHARMACEUTICAL USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MEDICHEM SA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"MYLAN LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"591.80","actualQuantity":"591.8","unit":"KGS","unitRateFc":"250","totalValueFC":"149444.1","currency":"USD","unitRateINR":"21775","date":"21-Jan-2025","totalValueINR":"12886445","totalValueInUsd":"149444.1","indian_port":"JNPT","hs_no":"29339990","bill_no":"7912583","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"FRUCTUOS GELABERT, 6,08970 SANT JOA N DESPIBARCELONA SDNF","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738089000,"product":"CLOZAPINE USP","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"MEDICHEM SA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALEMBIC PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"275","totalValueFC":"27777.7","currency":"USD","unitRateINR":"23952.5","date":"29-Jan-2025","totalValueINR":"2395250","totalValueInUsd":"27777.7","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"8078202","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"Fructus Gelabert, 6-8, planta 8089 70, Sant Joan Desp,Barcelona SDNF","customerAddress":"ALEMBIC ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740076200,"product":"CLOZAPINE USP CLOZAPINE USP","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"SINOBRIGHT PHARMACEUTICAL INDUSTRIES","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"70.00","actualQuantity":"70","unit":"KGS","unitRateFc":"88","totalValueFC":"6215.7","currency":"USD","unitRateINR":"7722","date":"21-Feb-2025","totalValueINR":"540540","totalValueInUsd":"6215.7","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"8488629","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"LIMITED.,OFFICE F,32\/F PLAZA 88 NO 88 YEUNG UK ROAD, TSUEN WAN NT,HONG KONG CN","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742754600,"product":"CLOZAPINE IP\/BP\/USP CLOZAPINE IP\/BP\/USP","address":"13,VITHALDAS ROAD,BULAKHIDAS","city":"MUMBAI,MAHARASHTRA","supplier":"BRILLIANT PHARMACEUTICAL LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"MEDI PHARMA DRUG HOUSE","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"70.5","totalValueFC":"35532.8","currency":"USD","unitRateINR":"6155.5","date":"24-Mar-2025","totalValueINR":"3077761.5","totalValueInUsd":"35532.8","indian_port":"JNPT","hs_no":"29339990","bill_no":"9071811","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"OFFICE F 32\/F PLAZA 88 NO 88 YEUNG UK ROAD TSUEN WAN NT HONG KONG, SDNF CHINA","customerAddress":"13,VITHALDAS ROAD,BULAKHIDAS"}]
12-Jan-2022
14-Apr-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 19758

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DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 19758

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DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 19758

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DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 19758

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DOSAGE - SUSPENSION;ORAL - 50MG/ML

USFDA APPLICATION NUMBER - 203479

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21590

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21590

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21590

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21590

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21590

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ABOUT THIS PAGE

Looking for / Clozapine API manufacturers, exporters & distributors?

Clozapine manufacturers, exporters & distributors 1

19

PharmaCompass offers a list of Clozapine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Clozapine manufacturer or Clozapine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Clozapine manufacturer or Clozapine supplier.

PharmaCompass also assists you with knowing the Clozapine API Price utilized in the formulation of products. Clozapine API Price is not always fixed or binding as the Clozapine Price is obtained through a variety of data sources. The Clozapine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Clozapine

Zapine Manufacturers

A Zapine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zapine, including repackagers and relabelers. The FDA regulates Zapine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zapine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Zapine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Zapine Suppliers

A Zapine supplier is an individual or a company that provides Zapine active pharmaceutical ingredient (API) or Zapine finished formulations upon request. The Zapine suppliers may include Zapine API manufacturers, exporters, distributors and traders.

click here to find a list of Zapine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Zapine USDMF

A Zapine DMF (Drug Master File) is a document detailing the whole manufacturing process of Zapine active pharmaceutical ingredient (API) in detail. Different forms of Zapine DMFs exist exist since differing nations have different regulations, such as Zapine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Zapine DMF submitted to regulatory agencies in the US is known as a USDMF. Zapine USDMF includes data on Zapine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Zapine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Zapine suppliers with USDMF on PharmaCompass.

Zapine JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Zapine Drug Master File in Japan (Zapine JDMF) empowers Zapine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Zapine JDMF during the approval evaluation for pharmaceutical products. At the time of Zapine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Zapine suppliers with JDMF on PharmaCompass.

Zapine KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Zapine Drug Master File in Korea (Zapine KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Zapine. The MFDS reviews the Zapine KDMF as part of the drug registration process and uses the information provided in the Zapine KDMF to evaluate the safety and efficacy of the drug.

After submitting a Zapine KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Zapine API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Zapine suppliers with KDMF on PharmaCompass.

Zapine CEP

A Zapine CEP of the European Pharmacopoeia monograph is often referred to as a Zapine Certificate of Suitability (COS). The purpose of a Zapine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Zapine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Zapine to their clients by showing that a Zapine CEP has been issued for it. The manufacturer submits a Zapine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Zapine CEP holder for the record. Additionally, the data presented in the Zapine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Zapine DMF.

A Zapine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Zapine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Zapine suppliers with CEP (COS) on PharmaCompass.

Zapine WC

A Zapine written confirmation (Zapine WC) is an official document issued by a regulatory agency to a Zapine manufacturer, verifying that the manufacturing facility of a Zapine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Zapine APIs or Zapine finished pharmaceutical products to another nation, regulatory agencies frequently require a Zapine WC (written confirmation) as part of the regulatory process.

click here to find a list of Zapine suppliers with Written Confirmation (WC) on PharmaCompass.

Zapine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Zapine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Zapine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Zapine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Zapine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Zapine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Zapine suppliers with NDC on PharmaCompass.

Zapine GMP

Zapine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zapine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zapine GMP manufacturer or Zapine GMP API supplier for your needs.

Zapine CoA

A Zapine CoA (Certificate of Analysis) is a formal document that attests to Zapine's compliance with Zapine specifications and serves as a tool for batch-level quality control.

Zapine CoA mostly includes findings from lab analyses of a specific batch. For each Zapine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zapine may be tested according to a variety of international standards, such as European Pharmacopoeia (Zapine EP), Zapine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zapine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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