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Chemistry

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Also known as: 146986-50-7, Y-27632, Y27632, Y 27632, Cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, trans-, 4-[(1r)-1-aminoethyl]-n-pyridin-4-ylcyclohexane-1-carboxamide
Molecular Formula
C14H21N3O
Molecular Weight
247.34  g/mol
InChI Key
IYOZTVGMEWJPKR-VOMCLLRMSA-N
FDA UNII
0X370ROP6H

Y27632
Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.
1 2D Structure

Y27632

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
2.1.2 InChI
InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1
2.1.3 InChI Key
IYOZTVGMEWJPKR-VOMCLLRMSA-N
2.1.4 Canonical SMILES
CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
2.1.5 Isomeric SMILES
C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
2.2 Other Identifiers
2.2.1 UNII
0X370ROP6H
2.3 Synonyms
2.3.1 MeSH Synonyms

1. N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide

2. Y 27632

3. Y 27632, (4(r)-trans)-isomer

4. Y 27632, (4(s)-trans)-isomer

5. Y 27632, (trans)-isomer

6. Y 27632, Dihydrochloride, (4(r)-trans)-isomer

7. Y-27632

8. Y27632

2.3.2 Depositor-Supplied Synonyms

1. 146986-50-7

2. Y-27632

3. Y27632

4. Y 27632

5. Cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, Trans-

6. 4-[(1r)-1-aminoethyl]-n-pyridin-4-ylcyclohexane-1-carboxamide

7. Y-27632, Free Base

8. 4-[(1r)-1-aminoethyl]-n-(pyridin-4-yl)cyclohexane-1-carboxamide

9. 0x370rop6h

10. Chebi:75393

11. (r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) Cyclohexanecarboxamide

12. 521059-79-0

13. (1r,4r)-4-((r)-1-aminoethyl)-n-(pyridin-4-yl)cyclohexanecarboxamide

14. (r)-(+)-trans-n-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide

15. Ximelegatran

16. (r)-4-(1-aminoethyl)-n-(pyridin-4-yl)cyclohexanecarboxamide

17. Trans-4-((r)-1-aminoethyl)-n-(pyridin-4-yl)cyclohexanecarboxamide

18. Y27

19. Unii-0x370rop6h

20. (+)-(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl)cyclohexanecarboxamide

21. [+]-[r]-trans-4-[1-aminoethyl]-n-[4-pyridyl]cyclohexanecarboxamide

22. Cyclohexanecarboxamide, 4-(1-aminoethyl)-n-4-pyridinyl-, [4(r)-trans]-

23. 2etr

24. 2gnf

25. 2gnj

26. Cyclohexanecarboxamide, 4-((1r)-1-aminoethyl)-n-4-pyridinyl-, Trans-

27. Cyclohexanecarboxamide, 4-(1-aminoethyl)-n-4-pyridinyl-, (4(r)-trans)-

28. Iyoztvgmewjpkr-vomcllrmsa-n

29. 1q8t

30. Biomolki_000071

31. Y27632 Dihydrochloride

32. Biomolki2_000075

33. Cbiol_001962

34. Bspbio_001234

35. Kbiogr_000574

36. Kbioss_000574

37. Schembl598993

38. Chembl559147

39. Gtpl5290

40. Rock Inhibitor, Y-27632

41. Schembl1980406

42. Schembl7804373

43. Chembl1083134

44. Chembl1188380

45. Dtxsid7043740

46. Schembl13970844

47. Schembl18935698

48. Y-27632dihydrochloride

49. Bdbm14029

50. Bdbm86729

51. Chebi:92773

52. Kbio2_000574

53. Kbio2_003142

54. Kbio2_005710

55. Kbio3_001027

56. Kbio3_001028

57. 4-[(1r)-1-aminoethyl]-n-(4-pyridyl)cyclohexanecarboxamide

58. Bcpp000008

59. Bio1_000248

60. Bio1_000737

61. Bio1_001226

62. Bio2_000457

63. Bio2_000937

64. Hms1362n15

65. Hms1792n15

66. Hms1990n15

67. Hms3403n15

68. Y 27632 [who-dd]

69. Bdbm50319631

70. Nsc751297

71. S6390

72. (1r,4r)-4-[(1r)-1-aminoethyl]-n-(pyridin-4-yl)cyclohexane-1-carboxamide

73. Akos026750241

74. Akos028109253

75. Am81233

76. Ccg-204428

77. Cs-0131

78. Db08756

79. Nsc-751297

80. Idi1_002212

81. Smp2_000199

82. Ncgc00092276-02

83. Ncgc00092276-03

84. Ncgc00092276-04

85. Ncgc00092276-05

86. Ncgc00092276-06

87. Ncgc00092276-07

88. Ncgc00092276-08

89. Ncgc00092276-09

90. Ncgc00092276-10

91. Ncgc00387412-04

92. As-77772

93. Hy-10071

94. J888.082d

95. Cas_146986-50-7

96. Ns00073644

97. A25646

98. J-008296

99. J-525164

100. Q6584634

101. Brd-k44084986-001-03-9

102. Brd-k44084986-300-02-7

103. (r)-trans-4-(1-aminoethyl)-n-(4-pyridyl)cyclohexanecarboxamide

104. Trans-4-[(1r)-1-aminoethyl]-n-(pyridin-4-yl)cyclohexanecarboxamide

105. Trans-4-[(1r)-1-aminoethyl]-n-pyridin-4-ylcyclohexanecarboxamide

106. (1r,4r)-4-((r)-1-aminoethyl)-n-(pyridin-4-yl)cyclohexane-1-carboxamide

107. (r)-(+)-trans-4-(1-aminoethyl)-n-(4-pyridyl)cyclohexanecarboxamide

108. 4.beta.-((1r)-1-aminoethyl)-n-(4-pyridinyl)cyclohexane-1.alpha.-carboxamide

109. Cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, Trans- (9ci)

110. Trans-4-[(1r)-1-aminoethyl]-n-4-pyridinylcyclohexanecar Boxamide Dihydrochloride

2.4 Create Date
2005-06-08
3 Chemical and Physical Properties
Molecular Weight 247.34 g/mol
Molecular Formula C14H21N3O
XLogP30.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area68
Heavy Atom Count18
Formal Charge0
Complexity268
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


ABOUT THIS PAGE

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Y27632 manufacturers, exporters & distributors 1

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Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Y27632 manufacturer or Y27632 supplier.

PharmaCompass also assists you with knowing the Y27632 API Price utilized in the formulation of products. Y27632 API Price is not always fixed or binding as the Y27632 Price is obtained through a variety of data sources. The Y27632 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Y27632

Synonyms

146986-50-7, Y-27632, Y 27632, Cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, trans-, 4-[(1r)-1-aminoethyl]-n-pyridin-4-ylcyclohexane-1-carboxamide, Y-27632, free base

Cas Number

146986-50-7

Unique Ingredient Identifier (UNII)

0X370ROP6H

About Y27632

Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.

Y27632 Manufacturers

A Y27632 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Y27632, including repackagers and relabelers. The FDA regulates Y27632 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Y27632 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Y27632 Suppliers

A Y27632 supplier is an individual or a company that provides Y27632 active pharmaceutical ingredient (API) or Y27632 finished formulations upon request. The Y27632 suppliers may include Y27632 API manufacturers, exporters, distributors and traders.

Y27632 GMP

Y27632 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Y27632 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Y27632 GMP manufacturer or Y27632 GMP API supplier for your needs.

Y27632 CoA

A Y27632 CoA (Certificate of Analysis) is a formal document that attests to Y27632's compliance with Y27632 specifications and serves as a tool for batch-level quality control.

Y27632 CoA mostly includes findings from lab analyses of a specific batch. For each Y27632 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Y27632 may be tested according to a variety of international standards, such as European Pharmacopoeia (Y27632 EP), Y27632 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Y27632 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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