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Chemistry

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Also known as: 22457-89-2, Benphothiamine, Betivina, Benzoylthiamine monophosphate, S-benzoylthiamine o-monophosphate, S-benzoylthiamine monophosphate
Molecular Formula
C19H23N4O6PS
Molecular Weight
466.4  g/mol
InChI Key
BTNNPSLJPBRMLZ-LGMDPLHJSA-N

Benfotiamine
Benfotiamine has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.
1 2D Structure

Benfotiamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate
2.1.2 InChI
InChI=1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13-
2.1.3 InChI Key
BTNNPSLJPBRMLZ-LGMDPLHJSA-N
2.1.4 Canonical SMILES
CC1=NC=C(C(=N1)N)CN(C=O)C(=C(CCOP(=O)(O)O)SC(=O)C2=CC=CC=C2)C
2.1.5 Isomeric SMILES
CC1=NC=C(C(=N1)N)CN(C=O)/C(=C(/CCOP(=O)(O)O)\SC(=O)C2=CC=CC=C2)/C
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Benfothiamine

2. Benphothiamine

3. Btmp-benfo

4. Milgamma

5. Neurostop

6. S-benzoylthiamine Monophosphate

2.2.2 Depositor-Supplied Synonyms

1. 22457-89-2

2. Benphothiamine

3. Betivina

4. Benzoylthiamine Monophosphate

5. S-benzoylthiamine O-monophosphate

6. S-benzoylthiamine Monophosphate

7. Benfotiamina

8. Benfotiaminum

9. 22457-89-2 (free Acid)

10. S-[(z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] Benzenecarbothioate

11. (z)-s-(2-(n-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-(phosphonooxy)pent-2-en-3-yl) Benzothioate

12. S-[2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-5-(phosphonooxy)pent-2-en-3-yl] Benzenecarbothioate

13. Sr-01000872627

14. N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate

15. Chebi:41039

16. Prestwick_68

17. Biotamin (tn)

18. Mfcd00057343

19. Prestwick2_000654

20. Prestwick3_000654

21. Benfotiamine (jan/inn)

22. Bspbio_000687

23. Schembl188070

24. Bpbio1_000757

25. Chembl4303665

26. Schembl19184708

27. Hms1570c09

28. Hms2097c09

29. Hms3714c09

30. Zinc2015559

31. Stl453586

32. Akos015920320

33. Ac-8280

34. Ccg-220654

35. Db11748

36. Ncgc00179477-01

37. (3z)-4-{n-[(4-amino-2-methylpyrimidin-5-yl)methyl]carbonylamino}-3-(phenylcarb Onylthio)pent-3-enyl Dihydrogen Phosphate

38. 57b892

39. A15020

40. D01255

41. Sr-01000872627-1

42. Sr-01000872627-2

43. 137-74-6

44. S-[(2z)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-5-(phosphonooxy)pent-2-en-3-yl] Benzenecarbothioate

45. S-{(1z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} Benzenecarbothioate

46. S-{(1z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino]-1-[2-(phosphonooxy)ethyl]-1-propenyl} Benzenecarbothioate, Aldrichcpr

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 466.4 g/mol
Molecular Formula C19H23N4O6PS
XLogP30.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass466.10759264 g/mol
Monoisotopic Mass466.10759264 g/mol
Topological Polar Surface Area181 Ų
Heavy Atom Count31
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)


Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


4.2 ATC Code

A - Alimentary tract and metabolism

A11 - Vitamins

A11D - Vitamin b1, plain and in combination with vitamin b6 and b12

A11DA - Vitamin b1, plain

A11DA03 - Benfotiamine


API Reference Price

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29-May-2025
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ABOUT THIS PAGE

Looking for 22457-89-2 / Benfotiamine API manufacturers, exporters & distributors?

Benfotiamine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Benfotiamine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Benfotiamine manufacturer or Benfotiamine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Benfotiamine manufacturer or Benfotiamine supplier.

PharmaCompass also assists you with knowing the Benfotiamine API Price utilized in the formulation of products. Benfotiamine API Price is not always fixed or binding as the Benfotiamine Price is obtained through a variety of data sources. The Benfotiamine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Benfotiamine

Synonyms

22457-89-2, Benphothiamine, Betivina, Benzoylthiamine monophosphate, S-benzoylthiamine o-monophosphate, S-benzoylthiamine monophosphate

Cas Number

22457-89-2

About Benfotiamine

Benfotiamine has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.

Vitanevril Manufacturers

A Vitanevril manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vitanevril, including repackagers and relabelers. The FDA regulates Vitanevril manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vitanevril API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Vitanevril manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Vitanevril Suppliers

A Vitanevril supplier is an individual or a company that provides Vitanevril active pharmaceutical ingredient (API) or Vitanevril finished formulations upon request. The Vitanevril suppliers may include Vitanevril API manufacturers, exporters, distributors and traders.

click here to find a list of Vitanevril suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Vitanevril USDMF

A Vitanevril DMF (Drug Master File) is a document detailing the whole manufacturing process of Vitanevril active pharmaceutical ingredient (API) in detail. Different forms of Vitanevril DMFs exist exist since differing nations have different regulations, such as Vitanevril USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Vitanevril DMF submitted to regulatory agencies in the US is known as a USDMF. Vitanevril USDMF includes data on Vitanevril's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Vitanevril USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Vitanevril suppliers with USDMF on PharmaCompass.

Vitanevril JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Vitanevril Drug Master File in Japan (Vitanevril JDMF) empowers Vitanevril API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Vitanevril JDMF during the approval evaluation for pharmaceutical products. At the time of Vitanevril JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Vitanevril suppliers with JDMF on PharmaCompass.

Vitanevril KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Vitanevril Drug Master File in Korea (Vitanevril KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Vitanevril. The MFDS reviews the Vitanevril KDMF as part of the drug registration process and uses the information provided in the Vitanevril KDMF to evaluate the safety and efficacy of the drug.

After submitting a Vitanevril KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Vitanevril API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Vitanevril suppliers with KDMF on PharmaCompass.

Vitanevril WC

A Vitanevril written confirmation (Vitanevril WC) is an official document issued by a regulatory agency to a Vitanevril manufacturer, verifying that the manufacturing facility of a Vitanevril active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Vitanevril APIs or Vitanevril finished pharmaceutical products to another nation, regulatory agencies frequently require a Vitanevril WC (written confirmation) as part of the regulatory process.

click here to find a list of Vitanevril suppliers with Written Confirmation (WC) on PharmaCompass.

Vitanevril GMP

Vitanevril Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vitanevril GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vitanevril GMP manufacturer or Vitanevril GMP API supplier for your needs.

Vitanevril CoA

A Vitanevril CoA (Certificate of Analysis) is a formal document that attests to Vitanevril's compliance with Vitanevril specifications and serves as a tool for batch-level quality control.

Vitanevril CoA mostly includes findings from lab analyses of a specific batch. For each Vitanevril CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vitanevril may be tested according to a variety of international standards, such as European Pharmacopoeia (Vitanevril EP), Vitanevril JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vitanevril USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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