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    Chemistry

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    Also known as:
    Molecular Formula
    C23H33ClN6O4S
    Molecular Weight
    525.1  g/mol
    InChI Key
    XCMULUAPJXCOHI-UHFFFAOYSA-N
    Vardenafil Hydrochloride
    1 2D Structure

    Vardenafil Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C23H32N6O4S.ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H
    2.1.3 InChI Key
    XCMULUAPJXCOHI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
    2.1.5 Isomeric SMILES
    CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
    2.2 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 525.1 g/mol
    Molecular Formula C23H33ClN6O4S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count8
    Exact Mass524.1972524 g/mol
    Monoisotopic Mass524.1972524 g/mol
    Topological Polar Surface Area118 A^2
    Heavy Atom Count35
    Formal Charge0
    Complexity854
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameVardenafil hydrochloride
    Drug LabelLEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
    Active IngredientVardenafil hydrochloride
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyTeva Pharms

    2 of 2  
    Drug NameVardenafil hydrochloride
    Drug LabelLEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
    Active IngredientVardenafil hydrochloride
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyTeva Pharms

    API Reference Price

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    04-Jan-2022
    31-May-2025
    KGS
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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 200179

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    DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    Looking for / Vardenafil Hydrochloride API manufacturers, exporters & distributors?

    Vardenafil Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Vardenafil Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vardenafil Hydrochloride manufacturer or Vardenafil Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vardenafil Hydrochloride manufacturer or Vardenafil Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Vardenafil Hydrochloride API Price utilized in the formulation of products. Vardenafil Hydrochloride API Price is not always fixed or binding as the Vardenafil Hydrochloride Price is obtained through a variety of data sources. The Vardenafil Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Vardenafil Hydrochloride

    Vardenafil Hydrochloride Manufacturers

    A Vardenafil Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vardenafil Hydrochloride, including repackagers and relabelers. The FDA regulates Vardenafil Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vardenafil Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Vardenafil Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Vardenafil Hydrochloride Suppliers

    A Vardenafil Hydrochloride supplier is an individual or a company that provides Vardenafil Hydrochloride active pharmaceutical ingredient (API) or Vardenafil Hydrochloride finished formulations upon request. The Vardenafil Hydrochloride suppliers may include Vardenafil Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Vardenafil Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Vardenafil Hydrochloride USDMF

    A Vardenafil Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Vardenafil Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Vardenafil Hydrochloride DMFs exist exist since differing nations have different regulations, such as Vardenafil Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Vardenafil Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Vardenafil Hydrochloride USDMF includes data on Vardenafil Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Vardenafil Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Vardenafil Hydrochloride suppliers with USDMF on PharmaCompass.

    Vardenafil Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Vardenafil Hydrochloride Drug Master File in Japan (Vardenafil Hydrochloride JDMF) empowers Vardenafil Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Vardenafil Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Vardenafil Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Vardenafil Hydrochloride suppliers with JDMF on PharmaCompass.

    Vardenafil Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Vardenafil Hydrochloride Drug Master File in Korea (Vardenafil Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Vardenafil Hydrochloride. The MFDS reviews the Vardenafil Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Vardenafil Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Vardenafil Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Vardenafil Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Vardenafil Hydrochloride suppliers with KDMF on PharmaCompass.

    Vardenafil Hydrochloride CEP

    A Vardenafil Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Vardenafil Hydrochloride Certificate of Suitability (COS). The purpose of a Vardenafil Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Vardenafil Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Vardenafil Hydrochloride to their clients by showing that a Vardenafil Hydrochloride CEP has been issued for it. The manufacturer submits a Vardenafil Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Vardenafil Hydrochloride CEP holder for the record. Additionally, the data presented in the Vardenafil Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Vardenafil Hydrochloride DMF.

    A Vardenafil Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Vardenafil Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Vardenafil Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Vardenafil Hydrochloride WC

    A Vardenafil Hydrochloride written confirmation (Vardenafil Hydrochloride WC) is an official document issued by a regulatory agency to a Vardenafil Hydrochloride manufacturer, verifying that the manufacturing facility of a Vardenafil Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Vardenafil Hydrochloride APIs or Vardenafil Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Vardenafil Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Vardenafil Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Vardenafil Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Vardenafil Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Vardenafil Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Vardenafil Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Vardenafil Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Vardenafil Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Vardenafil Hydrochloride suppliers with NDC on PharmaCompass.

    Vardenafil Hydrochloride GMP

    Vardenafil Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Vardenafil Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vardenafil Hydrochloride GMP manufacturer or Vardenafil Hydrochloride GMP API supplier for your needs.

    Vardenafil Hydrochloride CoA

    A Vardenafil Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Vardenafil Hydrochloride's compliance with Vardenafil Hydrochloride specifications and serves as a tool for batch-level quality control.

    Vardenafil Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Vardenafil Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Vardenafil Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Vardenafil Hydrochloride EP), Vardenafil Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vardenafil Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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