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Also known as: 13171-25-0, 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, Trimetazidine hydrochloride, Kyurinett, Trimetazidine hcl, Trimetazidine 2hcl
Molecular Formula
C14H24Cl2N2O3
Molecular Weight
339.3  g/mol
InChI Key
VYFLPFGUVGMBEP-UHFFFAOYSA-N
FDA UNII
48V6723Z1P

Trimetazidine Hydrochloride
A vasodilator used in angina of effort or ischemic heart disease.
1 2D Structure

Trimetazidine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
2.1.2 InChI
InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H
2.1.3 InChI Key
VYFLPFGUVGMBEP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
48V6723Z1P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Centrophne

2. Dihydrochloride, Trimetazidine

3. Idaptan

4. Trimtazidine Irex

5. Trimetazidine

6. Vasartel

7. Vastarel

2.3.2 Depositor-Supplied Synonyms

1. 13171-25-0

2. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride

3. Trimetazidine Hydrochloride

4. Kyurinett

5. Trimetazidine Hcl

6. Trimetazidine 2hcl

7. Trimetazidine (dihydrochloride)

8. Yoshimilon

9. Vastarel F

10. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihydrochloride

11. Trimetazidine Di-hcl

12. Trimetazidine Hydrochloride [jan]

13. Trimetazidine Dihcl

14. Trimethazidine Dihydrochloride

15. Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, Dihydrochloride

16. Mfcd00243086

17. 48v6723z1p

18. Nsc-759317

19. Trimetajust

20. Lubomail

21. Vastarel

22. Yosimilon

23. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride

24. Dsstox_cid_25407

25. Dsstox_rid_80858

26. Dsstox_gsid_45407

27. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride

28. Adexor

29. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride (9ci)

30. Sr-01000781912

31. Ncgc00016697-01

32. Einecs 236-117-0

33. Cas-13171-25-0

34. Unii-48v6723z1p

35. S 4004

36. Kyurinett (tn)

37. Prestwick_871

38. Schembl580378

39. Chembl3561076

40. Dtxsid1045407

41. Chebi:32262

42. Piperazine, 1-(2,3,4-trimethoxybenzyl)-, Dihydrochloride

43. Hms1569n19

44. Bcp21402

45. Hy-b0968

46. Trimetazidine For System Suitability

47. Trimetazidine Hydrochloride (jp17)

48. Tox21_110568

49. S4543

50. Akos015895369

51. Tox21_110568_1

52. Ab05480

53. Ac-5896

54. Ccg-213960

55. Cs-4453

56. Ks-1125

57. Nsc 759317

58. Ncgc00016697-04

59. Trimetazidine Dihydrochloride [mi]

60. Trimetazidine Hydrochloride [mart.]

61. Trimetazidine Hydrochloride [who-dd]

62. Ft-0630397

63. T2726

64. A25088

65. D01606

66. P10117

67. 2,3,4-trimethoxybenzylpiperazine Dihydrochloride

68. 171t250

69. Sr-01000781912-3

70. Sr-01000781912-4

71. Trimetazidine Dihydrochloride [ep Monograph]

72. W-108326

73. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihcl

74. Q27259190

75. F2173-1142

76. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride, 97%

77. Trimetazidine Dihydrochloride 1.0 Mg/ml In Methanol (as Free Base)

78. Trimetazidine For System Suitability, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 339.3 g/mol
Molecular Formula C14H24Cl2N2O3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass338.1163980 g/mol
Monoisotopic Mass338.1163980 g/mol
Topological Polar Surface Area43 Ų
Heavy Atom Count21
Formal Charge0
Complexity259
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


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29-Apr-2025
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ABOUT THIS PAGE

Looking for 13171-25-0 / Trimetazidine API manufacturers, exporters & distributors?

Trimetazidine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Trimetazidine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Trimetazidine manufacturer or Trimetazidine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Trimetazidine manufacturer or Trimetazidine supplier.

PharmaCompass also assists you with knowing the Trimetazidine API Price utilized in the formulation of products. Trimetazidine API Price is not always fixed or binding as the Trimetazidine Price is obtained through a variety of data sources. The Trimetazidine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Trimetazidine

Synonyms

13171-25-0, 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, Trimetazidine hydrochloride, Kyurinett, Trimetazidine hcl, Trimetazidine 2hcl

Cas Number

13171-25-0

Unique Ingredient Identifier (UNII)

48V6723Z1P

About Trimetazidine

A vasodilator used in angina of effort or ischemic heart disease.

Trimetazidine Manufacturers

A Trimetazidine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trimetazidine, including repackagers and relabelers. The FDA regulates Trimetazidine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trimetazidine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trimetazidine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trimetazidine Suppliers

A Trimetazidine supplier is an individual or a company that provides Trimetazidine active pharmaceutical ingredient (API) or Trimetazidine finished formulations upon request. The Trimetazidine suppliers may include Trimetazidine API manufacturers, exporters, distributors and traders.

click here to find a list of Trimetazidine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trimetazidine USDMF

A Trimetazidine DMF (Drug Master File) is a document detailing the whole manufacturing process of Trimetazidine active pharmaceutical ingredient (API) in detail. Different forms of Trimetazidine DMFs exist exist since differing nations have different regulations, such as Trimetazidine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Trimetazidine DMF submitted to regulatory agencies in the US is known as a USDMF. Trimetazidine USDMF includes data on Trimetazidine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Trimetazidine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Trimetazidine suppliers with USDMF on PharmaCompass.

Trimetazidine JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Trimetazidine Drug Master File in Japan (Trimetazidine JDMF) empowers Trimetazidine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Trimetazidine JDMF during the approval evaluation for pharmaceutical products. At the time of Trimetazidine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Trimetazidine suppliers with JDMF on PharmaCompass.

Trimetazidine KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Trimetazidine Drug Master File in Korea (Trimetazidine KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Trimetazidine. The MFDS reviews the Trimetazidine KDMF as part of the drug registration process and uses the information provided in the Trimetazidine KDMF to evaluate the safety and efficacy of the drug.

After submitting a Trimetazidine KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Trimetazidine API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Trimetazidine suppliers with KDMF on PharmaCompass.

Trimetazidine CEP

A Trimetazidine CEP of the European Pharmacopoeia monograph is often referred to as a Trimetazidine Certificate of Suitability (COS). The purpose of a Trimetazidine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Trimetazidine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Trimetazidine to their clients by showing that a Trimetazidine CEP has been issued for it. The manufacturer submits a Trimetazidine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Trimetazidine CEP holder for the record. Additionally, the data presented in the Trimetazidine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Trimetazidine DMF.

A Trimetazidine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Trimetazidine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Trimetazidine suppliers with CEP (COS) on PharmaCompass.

Trimetazidine WC

A Trimetazidine written confirmation (Trimetazidine WC) is an official document issued by a regulatory agency to a Trimetazidine manufacturer, verifying that the manufacturing facility of a Trimetazidine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Trimetazidine APIs or Trimetazidine finished pharmaceutical products to another nation, regulatory agencies frequently require a Trimetazidine WC (written confirmation) as part of the regulatory process.

click here to find a list of Trimetazidine suppliers with Written Confirmation (WC) on PharmaCompass.

Trimetazidine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Trimetazidine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Trimetazidine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Trimetazidine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Trimetazidine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Trimetazidine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Trimetazidine suppliers with NDC on PharmaCompass.

Trimetazidine GMP

Trimetazidine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trimetazidine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trimetazidine GMP manufacturer or Trimetazidine GMP API supplier for your needs.

Trimetazidine CoA

A Trimetazidine CoA (Certificate of Analysis) is a formal document that attests to Trimetazidine's compliance with Trimetazidine specifications and serves as a tool for batch-level quality control.

Trimetazidine CoA mostly includes findings from lab analyses of a specific batch. For each Trimetazidine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trimetazidine may be tested according to a variety of international standards, such as European Pharmacopoeia (Trimetazidine EP), Trimetazidine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trimetazidine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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