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Synopsis

Chemistry

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Also known as: 79559-97-0, Sertraline hcl, Zoloft, Gladem, Lustral, Serad
Molecular Formula
C17H18Cl3N
Molecular Weight
342.7  g/mol
InChI Key
BLFQGGGGFNSJKA-XHXSRVRCSA-N
FDA UNII
UTI8907Y6X

Sertraline Hydrochloride
A selective serotonin uptake inhibitor that is used in the treatment of depression.
1 2D Structure

Sertraline Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
2.1.3 InChI Key
BLFQGGGGFNSJKA-XHXSRVRCSA-N
2.1.4 Canonical SMILES
CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
2.1.5 Isomeric SMILES
CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
UTI8907Y6X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Altruline

2. Apo Sertraline

3. Apo-sertraline

4. Aremis

5. Besitran

6. Gen Sertraline

7. Gen-sertraline

8. Gladem

9. Hydrochloride, Sertraline

10. Lustral

11. Novo Sertraline

12. Novo-sertraline

13. Ratio Sertraline

14. Ratio-sertraline

15. Rhoxal Sertraline

16. Rhoxal-sertraline

17. Sealdin

18. Sertraline

19. Sertraline Hydrochloride (1s-cis)-isomer

20. Zoloft

2.3.2 Depositor-Supplied Synonyms

1. 79559-97-0

2. Sertraline Hcl

3. Zoloft

4. Gladem

5. Lustral

6. Serad

7. (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride

8. Rac-cis-sertraline Hydrochloride

9. Sertraline.hcl

10. Sertraline (hydrochloride)

11. 79617-95-1

12. Nsc-746308

13. Nsc-758948

14. (+)-sertraline Hydrochloride

15. Sertraline (as Hydrochloride)

16. Sertraline Hydrechloride

17. (1s,4s)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenamine Hydrochloride

18. Chebi:9124

19. Uti8907y6x

20. Cp-51974-1

21. (+/-)-sertraline Hydrochloride

22. Cp 51,974-1

23. (1s,4s)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthylamine Hydrochloride

24. Atruline

25. Tresleen

26. Cp-51,974-1

27. Tatig

28. Dsstox_cid_20243

29. Dsstox_rid_79456

30. Dsstox_gsid_40243

31. 1-naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-, Hydrochloride, (1s-cis)-

32. Adjuvin

33. Aremis

34. Mls001401398

35. Mfcd00895772

36. (+)-cis-(1s,4s)-1-methylamino-4-(3,4-dichlorophenyl)tetralin Hydrochloride

37. (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-aminium Chloride

38. (1s-cis)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride

39. Cis-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenaminehydrochloride

40. Cas-79559-97-0

41. Sertraline Hydrochloride [usan]

42. Ncgc00092386-03

43. Smr000466298

44. C17h17cl2n.hcl

45. Unii-uti8907y6x

46. Serlift

47. Sertraline, Hcl

48. Sertraline Hydrochloride [usan:usp]

49. Zoloft (tn)

50. (1s,4s)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-4-(methylamino)naphthalene Hydrochloride

51. Cpd000466298

52. (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride

53. Sertraline Impurity G Hcl

54. Chembl1709

55. Schembl23230

56. Mls000758929

57. Spectrum1505262

58. Sertraline Hydrochloride- Bio-x

59. Dtxsid1040243

60. Hy-b0176a

61. Sertraline For System Suitability

62. (1r,4s)-sertraline Hcl

63. Sertraline For Peak Identification

64. Cp-51974-1 Hcl

65. Hms1922p09

66. Pharmakon1600-01505262

67. (1r,4s)-sertraline Hydrochloride

68. (1rs,4sr)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride

69. Sertraline Hydrochloride (jan/usp)

70. Tox21_111199

71. Tox21_500870

72. Ac-740

73. Ccg-39575

74. Nsc746308

75. Nsc758948

76. Sertraline Hydrochloride [mi]

77. Sertraline Hydrochloride [jan]

78. Akos005267232

79. Akos015846322

80. Tox21_111199_1

81. Cs-2052

82. Ks-1111

83. Lp00870

84. Nc00198

85. Nc00726

86. Nsc 746308

87. Nsc 758948

88. (1s-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenamine Hydrochloride

89. Sertraline Hydrochloride [mart.]

90. Sertraline Hydrochloride [vandf]

91. Ncgc00092386-01

92. Ncgc00092386-13

93. Ncgc00261555-01

94. Sertraline Hydrochloride [usp-rs]

95. Sertraline Hydrochloride [who-dd]

96. Bs164399

97. Sertraline Hydrochloride Impurity Standard

98. Sertraline Hydrochloride Related Compound A

99. Sertraline Hydrochloride, >=98% (hplc)

100. Cp-5197401

101. Eu-0100870

102. S4053

103. Sertraline Hydrochloride [ep Impurity]

104. Sertraline Hydrochloride [orange Book]

105. D00825

106. O12070

107. Sertraline Hydrochloride [ep Monograph]

108. Sertraline Hydrochloride [usp Monograph]

109. 559s970

110. A839713

111. Q27108281

112. Sertraline Hydrochloride 100 Microg/ml In Acetonitrile

113. Sertraline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

114. Sertraline Hydrochloride, British Pharmacopoeia (bp) Reference Standard

115. Sertraline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

116. (1s,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl(methyl)amine Hydrochloride

117. (1s,4s)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenaminehydrochloride

118. (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hcl

119. Sertraline For Peak Identification, European Pharmacopoeia (ep) Reference Standard

120. Sertraline For System Suitability, European Pharmacopoeia (ep) Reference Standard

121. Sertraline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

122. (1 S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphathalenamine Hydrochloride

123. (1s,4s)-4-(3,4-dichlorophenyl)-1,2, 3,4-tetrahydro-n-methyl-1-naphthalenamine Hydrochloride

124. (1s-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphathalenamine Hydrochloride

125. [(1s,4s)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine Hydrochloride

126. 1-naphthalenamine,?4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-, (1s,4s)-, Hydrochloride?(1:1)

127. Rac-sertraline Hydrochloride ((1rs,4rs)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride)

128. Sertraline Hydrochloride Racemic Mixture, United States Pharmacopeia (usp) Reference Standard

129. Sertraline Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 342.7 g/mol
Molecular Formula C17H18Cl3N
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass341.050483 g/mol
Monoisotopic Mass341.050483 g/mol
Topological Polar Surface Area12 Ų
Heavy Atom Count21
Formal Charge0
Complexity322
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameSertraline hydrochloride
PubMed HealthSertraline (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelSertraline is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtha...
Active IngredientSertraline hydrochloride
Dosage FormTablet; Concentrate
Routeoral; Oral
Strengtheq 100mg base; 200mg; eq 50mg base; 150mg; eq 150mg base; eq 200mg base; eq 20mg base/ml; eq 25mg base
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Wockhardt; Ranbaxy; Sun Pharm Inds (in); Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Lupin; Prosam Labs; Invagen Pharms; Cipla; Hikma Pharms; Watson Labs; Austarpharma; Zydus Pharms Usa; Mylan

2 of 4  
Drug NameZoloft
Drug LabelZOLOFT (sertraline hydrochloride) is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetr...
Active IngredientSertraline hydrochloride
Dosage FormTablet; Concentrate
RouteOral
Strengtheq 100mg base; eq 50mg base; eq 20mg base/ml; eq 25mg base
Market StatusPrescription
CompanyPfizer

3 of 4  
Drug NameSertraline hydrochloride
PubMed HealthSertraline (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelSertraline is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtha...
Active IngredientSertraline hydrochloride
Dosage FormTablet; Concentrate
Routeoral; Oral
Strengtheq 100mg base; 200mg; eq 50mg base; 150mg; eq 150mg base; eq 200mg base; eq 20mg base/ml; eq 25mg base
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Wockhardt; Ranbaxy; Sun Pharm Inds (in); Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Lupin; Prosam Labs; Invagen Pharms; Cipla; Hikma Pharms; Watson Labs; Austarpharma; Zydus Pharms Usa; Mylan

4 of 4  
Drug NameZoloft
Drug LabelZOLOFT (sertraline hydrochloride) is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetr...
Active IngredientSertraline hydrochloride
Dosage FormTablet; Concentrate
RouteOral
Strengtheq 100mg base; eq 50mg base; eq 20mg base/ml; eq 25mg base
Market StatusPrescription
CompanyPfizer

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)


Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Serotonin Reuptake Inhibitor [EPC]; Serotonin Uptake Inhibitors [MoA]; Cytochrome P450 2D6 Inhibitors [MoA]; Serotonin Reuptake Inhibitor [EPC]

API Reference Price

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03-Jan-2022
28-Feb-2026
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ABOUT THIS PAGE

Looking for 79559-97-0 / Sertraline Hydrochloride API manufacturers, exporters & distributors?

Sertraline Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sertraline Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sertraline Hydrochloride manufacturer or Sertraline Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sertraline Hydrochloride manufacturer or Sertraline Hydrochloride supplier.

PharmaCompass also assists you with knowing the Sertraline Hydrochloride API Price utilized in the formulation of products. Sertraline Hydrochloride API Price is not always fixed or binding as the Sertraline Hydrochloride Price is obtained through a variety of data sources. The Sertraline Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sertraline Hydrochloride

Synonyms

79559-97-0, Sertraline hcl, Zoloft, Gladem, Lustral, Serad

Cas Number

79559-97-0

Unique Ingredient Identifier (UNII)

UTI8907Y6X

About Sertraline Hydrochloride

A selective serotonin uptake inhibitor that is used in the treatment of depression.

Tresleen Manufacturers

A Tresleen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tresleen, including repackagers and relabelers. The FDA regulates Tresleen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tresleen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tresleen manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tresleen Suppliers

A Tresleen supplier is an individual or a company that provides Tresleen active pharmaceutical ingredient (API) or Tresleen finished formulations upon request. The Tresleen suppliers may include Tresleen API manufacturers, exporters, distributors and traders.

click here to find a list of Tresleen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tresleen USDMF

A Tresleen DMF (Drug Master File) is a document detailing the whole manufacturing process of Tresleen active pharmaceutical ingredient (API) in detail. Different forms of Tresleen DMFs exist exist since differing nations have different regulations, such as Tresleen USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tresleen DMF submitted to regulatory agencies in the US is known as a USDMF. Tresleen USDMF includes data on Tresleen's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tresleen USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tresleen suppliers with USDMF on PharmaCompass.

Tresleen JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Tresleen Drug Master File in Japan (Tresleen JDMF) empowers Tresleen API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Tresleen JDMF during the approval evaluation for pharmaceutical products. At the time of Tresleen JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Tresleen suppliers with JDMF on PharmaCompass.

Tresleen KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Tresleen Drug Master File in Korea (Tresleen KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Tresleen. The MFDS reviews the Tresleen KDMF as part of the drug registration process and uses the information provided in the Tresleen KDMF to evaluate the safety and efficacy of the drug.

After submitting a Tresleen KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Tresleen API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Tresleen suppliers with KDMF on PharmaCompass.

Tresleen CEP

A Tresleen CEP of the European Pharmacopoeia monograph is often referred to as a Tresleen Certificate of Suitability (COS). The purpose of a Tresleen CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Tresleen EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Tresleen to their clients by showing that a Tresleen CEP has been issued for it. The manufacturer submits a Tresleen CEP (COS) as part of the market authorization procedure, and it takes on the role of a Tresleen CEP holder for the record. Additionally, the data presented in the Tresleen CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Tresleen DMF.

A Tresleen CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Tresleen CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Tresleen suppliers with CEP (COS) on PharmaCompass.

Tresleen WC

A Tresleen written confirmation (Tresleen WC) is an official document issued by a regulatory agency to a Tresleen manufacturer, verifying that the manufacturing facility of a Tresleen active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tresleen APIs or Tresleen finished pharmaceutical products to another nation, regulatory agencies frequently require a Tresleen WC (written confirmation) as part of the regulatory process.

click here to find a list of Tresleen suppliers with Written Confirmation (WC) on PharmaCompass.

Tresleen NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Tresleen as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Tresleen API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Tresleen as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Tresleen and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Tresleen NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Tresleen suppliers with NDC on PharmaCompass.

Tresleen GMP

Tresleen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tresleen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tresleen GMP manufacturer or Tresleen GMP API supplier for your needs.

Tresleen CoA

A Tresleen CoA (Certificate of Analysis) is a formal document that attests to Tresleen's compliance with Tresleen specifications and serves as a tool for batch-level quality control.

Tresleen CoA mostly includes findings from lab analyses of a specific batch. For each Tresleen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tresleen may be tested according to a variety of international standards, such as European Pharmacopoeia (Tresleen EP), Tresleen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tresleen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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