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Chemistry

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Also known as: Coltramyl, Thiocolchicine glycoside, Coltrax, Miorel, N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide, Nsc624673
Molecular Formula
C27H33NO10S
Molecular Weight
563.6  g/mol
InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N

Thiocolchicoside
1 2D Structure

Thiocolchicoside

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
2.1.2 InChI
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16?,19-,22-,23+,24-,27-/m1/s1
2.1.3 InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N
2.1.4 Canonical SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC4C(C(C(C(O4)CO)O)O)O
2.1.5 Isomeric SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2,14-di-(demethoxy)-2-glucosidoxy-14- Methylthiocolchicine

2. Coltramyl

3. Miorel

4. Myoplge

5. Thiocolchicoside

2.2.2 Depositor-Supplied Synonyms

1. Coltramyl

2. Thiocolchicine Glycoside

3. Coltrax

4. Miorel

5. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

6. Nsc624673

7. 2-demethoxy-2-glucosidoxythiocolchicine

8. Nsc-147755

9. Thiocolchicoside-d3

10. Prestwick_875

11. Prestwick0_000539

12. Prestwick1_000539

13. Prestwick2_000539

14. Prestwick3_000539

15. Bspbio_000557

16. Mls002153865

17. 602-41-5 (unlabeled)

18. Schembl719194

19. Spbio_002478

20. Bpbio1_000613

21. Chembl1705373

22. Chebi:91529

23. Hms1569l19

24. Hms2096l19

25. Hms2234k08

26. Bdbm50248250

27. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

28. Smr001233221

29. Sr-01000841233

30. Q1165293

31. Sr-01000841233-2

32. Brd-a11605036-001-03-2

33. N-(3-(hexopyranosyloxy)-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

2.3 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 563.6 g/mol
Molecular Formula C27H33NO10S
XLogP3-0.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass563.18251742 g/mol
Monoisotopic Mass563.18251742 g/mol
Topological Polar Surface Area189 Ų
Heavy Atom Count39
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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07-Jan-2021
23-Apr-2025
KGS
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Looking for / Thiocolchicoside API manufacturers, exporters & distributors?

Thiocolchicoside manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Thiocolchicoside API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Thiocolchicoside manufacturer or Thiocolchicoside supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Thiocolchicoside manufacturer or Thiocolchicoside supplier.

PharmaCompass also assists you with knowing the Thiocolchicoside API Price utilized in the formulation of products. Thiocolchicoside API Price is not always fixed or binding as the Thiocolchicoside Price is obtained through a variety of data sources. The Thiocolchicoside Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Thiocolchicoside

Synonyms

Coltramyl, Thiocolchicine glycoside, Coltrax, Miorel, N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide, Nsc624673

Tiocolchicosido Manufacturers

A Tiocolchicosido manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tiocolchicosido, including repackagers and relabelers. The FDA regulates Tiocolchicosido manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tiocolchicosido API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tiocolchicosido manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tiocolchicosido Suppliers

A Tiocolchicosido supplier is an individual or a company that provides Tiocolchicosido active pharmaceutical ingredient (API) or Tiocolchicosido finished formulations upon request. The Tiocolchicosido suppliers may include Tiocolchicosido API manufacturers, exporters, distributors and traders.

click here to find a list of Tiocolchicosido suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tiocolchicosido USDMF

A Tiocolchicosido DMF (Drug Master File) is a document detailing the whole manufacturing process of Tiocolchicosido active pharmaceutical ingredient (API) in detail. Different forms of Tiocolchicosido DMFs exist exist since differing nations have different regulations, such as Tiocolchicosido USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tiocolchicosido DMF submitted to regulatory agencies in the US is known as a USDMF. Tiocolchicosido USDMF includes data on Tiocolchicosido's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tiocolchicosido USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tiocolchicosido suppliers with USDMF on PharmaCompass.

Tiocolchicosido CEP

A Tiocolchicosido CEP of the European Pharmacopoeia monograph is often referred to as a Tiocolchicosido Certificate of Suitability (COS). The purpose of a Tiocolchicosido CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Tiocolchicosido EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Tiocolchicosido to their clients by showing that a Tiocolchicosido CEP has been issued for it. The manufacturer submits a Tiocolchicosido CEP (COS) as part of the market authorization procedure, and it takes on the role of a Tiocolchicosido CEP holder for the record. Additionally, the data presented in the Tiocolchicosido CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Tiocolchicosido DMF.

A Tiocolchicosido CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Tiocolchicosido CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Tiocolchicosido suppliers with CEP (COS) on PharmaCompass.

Tiocolchicosido WC

A Tiocolchicosido written confirmation (Tiocolchicosido WC) is an official document issued by a regulatory agency to a Tiocolchicosido manufacturer, verifying that the manufacturing facility of a Tiocolchicosido active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tiocolchicosido APIs or Tiocolchicosido finished pharmaceutical products to another nation, regulatory agencies frequently require a Tiocolchicosido WC (written confirmation) as part of the regulatory process.

click here to find a list of Tiocolchicosido suppliers with Written Confirmation (WC) on PharmaCompass.

Tiocolchicosido GMP

Tiocolchicosido Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tiocolchicosido GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tiocolchicosido GMP manufacturer or Tiocolchicosido GMP API supplier for your needs.

Tiocolchicosido CoA

A Tiocolchicosido CoA (Certificate of Analysis) is a formal document that attests to Tiocolchicosido's compliance with Tiocolchicosido specifications and serves as a tool for batch-level quality control.

Tiocolchicosido CoA mostly includes findings from lab analyses of a specific batch. For each Tiocolchicosido CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tiocolchicosido may be tested according to a variety of international standards, such as European Pharmacopoeia (Tiocolchicosido EP), Tiocolchicosido JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tiocolchicosido USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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