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    Chemistry

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    Also known as: 123441-03-2, Exelon, Ena 713 free base, Prometax, Rivastigmine teva, Nimvastid
    Molecular Formula
    C14H22N2O2
    Molecular Weight
    250.34  g/mol
    InChI Key
    XSVMFMHYUFZWBK-NSHDSACASA-N
    FDA UNII
    PKI06M3IW0
    Rivastigmine
    A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE.
    Rivastigmine is a Cholinesterase Inhibitor. The mechanism of action of rivastigmine is as a Cholinesterase Inhibitor.
    1 2D Structure

    Rivastigmine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
    2.1.2 InChI
    InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
    2.1.3 InChI Key
    XSVMFMHYUFZWBK-NSHDSACASA-N
    2.1.4 Canonical SMILES
    CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
    2.1.5 Isomeric SMILES
    CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    PKI06M3IW0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (s)-n-ethyl-3-((1-dimethyl-amino)ethyl)-n-methylphenylcarbamate

    2. 713, Ena

    3. 713, Sdz Ena

    4. Ena 713

    5. Ena 713, Sdz

    6. Ena-713

    7. Ena713

    8. Exelon

    9. Hydrogen Tartrate, Rivastigmine

    10. Rivastigmine Hydrogen Tartrate

    11. Rivastigminetartrate

    12. Sdz Ena 713

    13. Tartrate, Rivastigmine Hydrogen

    2.3.2 Depositor-Supplied Synonyms

    1. 123441-03-2

    2. Exelon

    3. Ena 713 Free Base

    4. Prometax

    5. Rivastigmine Teva

    6. Nimvastid

    7. S-rivastigmine

    8. Rivastigmine Hexal

    9. (s)-rivastigmine

    10. (s)-3-(1-(dimethylamino)ethyl)phenyl Ethyl(methyl)carbamate

    11. Rivastigmine Sandoz

    12. Sdz-ena-713

    13. Sdz-212-713

    14. [3-[(1s)-1-(dimethylamino)ethyl]phenyl] N-ethyl-n-methylcarbamate

    15. M-((s)-1-(dimethylamino)ethyl)phenyl Ethylmethylcarbamate

    16. (s)-3-(1-(dimethylamino)ethyl)phenyl Ethylmethylcarbamate

    17. Chembl636

    18. 3-[(1s)-1-(dimethylamino)ethyl]phenyl N-ethyl-n-methylcarbamate

    19. Pki06m3iw0

    20. Chebi:8874

    21. Ena-713d

    22. Ono-2540

    23. Sdz-212713

    24. 3-[(1s)-1-(dimethylamino)ethyl]phenyl Ethyl(methyl)carbamate

    25. Exelon Patch

    26. Ethylmethylcarbamic Acid 3-[(1s)-1-(dimethylamino)ethyl]phenyl Ester

    27. Sr-05000001475

    28. Unii-pki06m3iw0

    29. Sdz 212-713

    30. Rivastigmine Transdermal System

    31. Prometax (tn)

    32. Rivastigmine [usan:inn:ban:jan]

    33. Rivastigmine.tartrate

    34. Rivastigmine Impurity D

    35. 3-((1s)-1-(dimethylamino)ethyl)phenyl Ethylmethylcarbamate

    36. Rivastigmine [mi]

    37. Rivastigmine [inn]

    38. Rivastigmine [jan]

    39. Carbamic Acid, Ethylmethyl-, 3-((1s)-1-(dimethylamino)ethyl)phenyl Ester

    40. Rivastigmine [usan]

    41. Schembl2764

    42. Rivastigmine [vandf]

    43. Rivastigmine [mart.]

    44. Ethylmethylcarbamic Acid 3-[1-(dimethylamino)ethyl]phenyl Ester

    45. Mls003876822

    46. Bidd:gt0316

    47. Rivastigmine [usp-rs]

    48. Rivastigmine [who-dd]

    49. Rivastigmine (jan/usp/inn)

    50. Gtpl6602

    51. Zinc4413

    52. Rivastigmine [ema Epar]

    53. Rivastigmine 1 A Pharma

    54. Dtxsid7023564

    55. Bdbm10620

    56. Bdbm11682

    57. Amy3808

    58. Hms2089h18

    59. Hms3715p15

    60. Hms3885b18

    61. Rivastigmine [orange Book]

    62. Rivastigmine [ep Monograph]

    63. Rivastigmine [usp Monograph]

    64. Mfcd00871496

    65. Akos015896334

    66. Carbamic Acid, Ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl Ester, (s)-

    67. Ac-8250

    68. Ccg-221197

    69. Cs-0946

    70. Db00989

    71. Rivastigmine 3m Health Care Ltd

    72. Ncgc00167531-03

    73. Ncgc00167531-17

    74. As-73448

    75. Hy-17368

    76. Smr002203623

    77. R0250

    78. S4687

    79. (r)-rivastigmine (rivastigmine Ep Impurity D)

    80. D03822

    81. D82061

    82. F10108

    83. Ab01275472-01

    84. Ab01275472_02

    85. Ab01275472_03

    86. 101r548

    87. Q411887

    88. Sr-05000001475-1

    89. Sr-05000001475-2

    90. W-200966

    91. (s)-3-[1-(dimethylamino)ethyl]phenyl N-ethyl-n-methylcarbamate

    92. [3-[(1s)-1-dimethylaminoethyl]phenyl] N-ethyl-n-methylcarbamate

    93. 3-((1s)-1-(dimethylamino)ethyl)phenyl N-ethyl N-methyl Carbamate

    94. Ethyl-methyl-carbamic Acid 3-(1-dimethylamino-ethyl)-phenyl Ester

    95. Ethyl-methyl-carbamic Acid 3-((r)-1-dimethylamino-ethyl)-phenyl Ester

    96. Ethyl-methyl-carbamic Acid 3-((s)-1-dimethylamino-ethyl)-phenyl Ester

    97. Carbamic Acid, N-ethyl-n-methyl-, 3-[(1s)-1-(dimethylamino)ethyl]phenyl Ester

    98. 2,3-dihydroxybutanedioic Acid; 3-[(1s)-1-(dimethylamino)ethyl]phenyl N-ethyl-n-methylcarbamate

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 250.34 g/mol
    Molecular Formula C14H22N2O2
    XLogP32.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass250.168127949 g/mol
    Monoisotopic Mass250.168127949 g/mol
    Topological Polar Surface Area32.8 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity269
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameRivastigmine
    PubMed HealthRivastigmine
    Drug ClassesCentral Nervous System Agent
    Drug LabelRivastigmine tartrate is a reversible cholinesterase inhibitor and is known chemically as (S)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]-phenyl carbamate hydrogen-(2R,3R)-tartrate. Rivastigmine tartrate is commonly referred to in the pharmacological...
    Active IngredientRivastigmine tartrate
    Dosage FormSolution
    Routeoral
    Strength2mg/ml
    Market StatusTentative Approval
    CompanyRanbaxy

    2 of 2  
    Drug NameRivastigmine
    PubMed HealthRivastigmine
    Drug ClassesCentral Nervous System Agent
    Drug LabelRivastigmine tartrate is a reversible cholinesterase inhibitor and is known chemically as (S)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]-phenyl carbamate hydrogen-(2R,3R)-tartrate. Rivastigmine tartrate is commonly referred to in the pharmacological...
    Active IngredientRivastigmine tartrate
    Dosage FormSolution
    Routeoral
    Strength2mg/ml
    Market StatusTentative Approval
    CompanyRanbaxy

    4.2 Drug Indication

    For the treatment of mild to moderate dementia associated with Parkinson's disease or of the Alzheimer's type.

    FDA Label

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

    Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

    Treatment of dementia

    Treatment of dementia

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Rivastigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. While the precise mechanism of rivastigmine's action is unknown, it is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase. If this proposed mechanism is correct, rivastigmine's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact.

    5.2 MeSH Pharmacological Classification

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    Cholinesterase Inhibitors

    Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    RIVASTIGMINE
    5.3.2 FDA UNII
    PKI06M3IW0
    5.3.3 Pharmacological Classes
    Cholinesterase Inhibitors [MoA]; Cholinesterase Inhibitor [EPC]
    5.4 ATC Code

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    N06DA03

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N06 - Psychoanaleptics

    N06D - Anti-dementia drugs

    N06DA - Anticholinesterases

    N06DA03 - Rivastigmine

    5.5 Absorption, Distribution and Excretion

    Route of Elimination

    Rivastigmine is extensively metabolized primarily via cholinesterase-mediated hydrolysis to the decarbamylated metabolite NAP226-90. Renal excretion of the metabolites is the major route of elimination. Less than 1% of the administered dose is excreted in the feces.

    Volume of Distribution

    1.8 to 2.7 L/kg

    Clearance

    renal cl=2.1-2.8 L/hr

    5.6 Metabolism/Metabolites

    Rivastigmine is rapidly metabolized by cholinesterase-mediated hydrolysis.

    5.7 Biological Half-Life

    1.5 hours

    5.8 Mechanism of Action

    Rivastigmine is a carbamate derivative that is structurally related to physostigmine, but not to donepezil and tacrine. The precise mechanism of rivastigmine has not been fully determined, but it is suggested that rivastigmine binds reversibly with and inactivates chlolinesterase (eg. acetylcholinesterase, butyrylcholinesterase), preventing the hydrolysis of acetycholine, and thus leading to an increased concentration of acetylcholine at cholinergic synapses. The anticholinesterase activity of rivastigmine is relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues.

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TELANGANA,? 500096, N\/A","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745433000,"product":"WE INTEND TO CLAIM REWARDS UNDER MERCHANDISE EXPORT INDIA SCHEME RIVASTIGMINE","address":"D\/607 SAHAR PLAZA, BLDG-3, A TO H,","city":"ANDHERI EAST,MAHARASHTRA","supplier":"OCEANIC PHARMACHEM PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"INDUSTRIAL BANK OF KOREA","customerCountry":"KOREA, REPUBLIC OF","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"2950","totalValueFC":"582820.9","currency":"USD","unitRateINR":249452.53375,"date":"24-Apr-2025","totalValueINR":"49890506.75","totalValueInUsd":"582820.9","indian_port":"Bombay Air","hs_no":"29242990","bill_no":"1241652","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"D\/607 SAHAR PLAZA, BLDG-3, A TO H,, ANDHERI EAST,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1747161000,"product":"RIVASTIGMINE (PH.EUR)","address":"PLOT NO. 705, ADITYA TRADE CENTRE","city":"HYDERABAD ANDHRA PRADESH","supplier":"SHODHANA LABORATORIES PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"MADRID","customer":"LABORATORIOS,S.A.","customerCountry":"SPAIN","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"4000","totalValueFC":"3783.2","currency":"USD","unitRateINR":322335,"date":"14-May-2025","totalValueINR":"322335","totalValueInUsd":"3783.2","indian_port":"Hyderabad Air","hs_no":"29242990","bill_no":"1787828","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO. 705, ADITYA TRADE CENTRE, HYDERABAD ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1663525800,"product":"RIVASTIGMINE BASE.(RE-IMPORT MATERIAL VIDE SB NO-4000131 DT:09.02.2021.RID NO-252100430934)","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"NOVARTIS PHARMA AG","supplierCountry":"SWITZERLAND","foreign_port":"BASEL","customer":"HETERO DRUGS LTD UNIT IX","customerCountry":"INDIA","quantity":"101.00","actualQuantity":"101","unit":"KGS","unitRateFc":"833.7","totalValueFC":"84475.5","currency":"USD","unitRateINR":"67029.2","date":"19-Sep-2022","totalValueINR":"6769954","totalValueInUsd":"84475.5","indian_port":"Vizag-HIPL SEZ","hs_no":"29242990","bill_no":"1000400","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BASEL","supplierAddress":"LICHTSTRASSE 35 CH 4056 BASEL SWITZERLAND","customerAddress":"7-2-A2, HETERO CORPORATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688149800,"product":"RE IMPORT - RIVASTIGMINE BASE ( S.B. NO.3621856 DT.20.08.2022)","address":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,","city":"HYDERABAD,TELANGANA","supplier":"MYLAN TECHNOLOGIES INC","supplierCountry":"INDIA","foreign_port":"NA","customer":"MYLAN LABORATORIES LTD","customerCountry":"INDIA","quantity":"28.89","actualQuantity":"28.886","unit":"KGS","unitRateFc":"2190","totalValueFC":"65192.5","currency":"USD","unitRateINR":"185492.4","date":"01-Jul-2023","totalValueINR":"5358138.387","totalValueInUsd":"65192.5","indian_port":"MADRAS AIR","hs_no":"29071990","bill_no":"0","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721932200,"product":"RIVASTIGMINE H. TARTRATE\/DS 18","address":"SANDOZ HOUSE,8TH FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMA AG BASEL","supplierCountry":"SWITZERLAND","foreign_port":"BASLE","customer":"NOVARTIS HEALTHCARE PRIVATE LTD","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"300","unit":"GMS","unitRateFc":"87.6","totalValueFC":"30729.1","currency":"CHF","unitRateINR":"8562.3","date":"26-Jul-2024","totalValueINR":"2568677.89","totalValueInUsd":"30729.1","indian_port":"Hyderabad Air","hs_no":"29242990","bill_no":"4715293","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"LICHSTRASE 35CH-4002 BASELSWITZERLAND CH","customerAddress":"SANDOZ HOUSE,8TH FLOOR,"}]
    07-Feb-2022
    14-May-2025
    KGS
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    Health Canada Patents

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    01

    Gowlings

    Rivastigmine
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    EPS
    Not Confirmed

    Gowlings

    Canada
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    EPS
    Not Confirmed

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

    Rivastigmine

    Brand Name : EXELON PATCH 5

    Patent Number : 2315784

    Filing Date : 1999-01-08

    Strength per Unit : 9.0mg / 5cm

    Dosage Form : Patch

    Human Or VET : Human

    Route of Administration : Transdermal

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

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    02

    Gowlings

    Rivastigmine
    arrow
    EPS
    Not Confirmed

    Gowlings

    Canada
    arrow
    EPS
    Not Confirmed

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

    Rivastigmine

    Brand Name : EXELON PATCH 10

    Patent Number : 2315784

    Filing Date : 1999-01-08

    Strength per Unit : 18.0mg / 10cm

    Dosage Form : Patch

    Human Or VET : Human

    Route of Administration : Transdermal

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    03

    Gowlings

    Rivastigmine
    arrow
    EPS
    Not Confirmed

    Gowlings

    Canada
    arrow
    EPS
    Not Confirmed

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

    Rivastigmine

    Brand Name : EXELON PATCH 15

    Patent Number : 2315784

    Filing Date : 1999-01-08

    Strength per Unit : 27.0 mg / 15 cm

    Dosage Form : PATCH

    Human Or VET : Human

    Route of Administration : TRANSDERMAL

    Patent Expiration Date : 2019-01-08

    Date Granted : 2006-06-27

    blank

    Portfolio PDF

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    Virtual Booth

    Digital Content

    Website

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    04

    Rivastigmine
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    Patent Expiration Date : 2008-05-28

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    Rivastigmine

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    Patent Number : 1284501

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    Patent Expiration Date : 2009-09-01

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    Rivastigmine

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    Patent Number : 1302853

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    Patent Expiration Date : 2009-09-01

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    Rivastigmine

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    Patent Number : 1307003

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    ABOUT THIS PAGE

    Looking for 123441-03-2 / Rivastigmine API manufacturers, exporters & distributors?

    Rivastigmine manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Rivastigmine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rivastigmine manufacturer or Rivastigmine supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rivastigmine manufacturer or Rivastigmine supplier.

    PharmaCompass also assists you with knowing the Rivastigmine API Price utilized in the formulation of products. Rivastigmine API Price is not always fixed or binding as the Rivastigmine Price is obtained through a variety of data sources. The Rivastigmine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Rivastigmine

    Synonyms

    123441-03-2, Exelon, Ena 713 free base, Prometax, Rivastigmine teva, Nimvastid

    Cas Number

    123441-03-2

    Unique Ingredient Identifier (UNII)

    PKI06M3IW0

    About Rivastigmine

    A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE.

    Rivastigmine (transdermal patch) Manufacturers

    A Rivastigmine (transdermal patch) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rivastigmine (transdermal patch), including repackagers and relabelers. The FDA regulates Rivastigmine (transdermal patch) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rivastigmine (transdermal patch) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Rivastigmine (transdermal patch) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Rivastigmine (transdermal patch) Suppliers

    A Rivastigmine (transdermal patch) supplier is an individual or a company that provides Rivastigmine (transdermal patch) active pharmaceutical ingredient (API) or Rivastigmine (transdermal patch) finished formulations upon request. The Rivastigmine (transdermal patch) suppliers may include Rivastigmine (transdermal patch) API manufacturers, exporters, distributors and traders.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Rivastigmine (transdermal patch) USDMF

    A Rivastigmine (transdermal patch) DMF (Drug Master File) is a document detailing the whole manufacturing process of Rivastigmine (transdermal patch) active pharmaceutical ingredient (API) in detail. Different forms of Rivastigmine (transdermal patch) DMFs exist exist since differing nations have different regulations, such as Rivastigmine (transdermal patch) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Rivastigmine (transdermal patch) DMF submitted to regulatory agencies in the US is known as a USDMF. Rivastigmine (transdermal patch) USDMF includes data on Rivastigmine (transdermal patch)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rivastigmine (transdermal patch) USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with USDMF on PharmaCompass.

    Rivastigmine (transdermal patch) JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Rivastigmine (transdermal patch) Drug Master File in Japan (Rivastigmine (transdermal patch) JDMF) empowers Rivastigmine (transdermal patch) API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Rivastigmine (transdermal patch) JDMF during the approval evaluation for pharmaceutical products. At the time of Rivastigmine (transdermal patch) JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with JDMF on PharmaCompass.

    Rivastigmine (transdermal patch) KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Rivastigmine (transdermal patch) Drug Master File in Korea (Rivastigmine (transdermal patch) KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Rivastigmine (transdermal patch). The MFDS reviews the Rivastigmine (transdermal patch) KDMF as part of the drug registration process and uses the information provided in the Rivastigmine (transdermal patch) KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Rivastigmine (transdermal patch) KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Rivastigmine (transdermal patch) API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Rivastigmine (transdermal patch) suppliers with KDMF on PharmaCompass.

    Rivastigmine (transdermal patch) CEP

    A Rivastigmine (transdermal patch) CEP of the European Pharmacopoeia monograph is often referred to as a Rivastigmine (transdermal patch) Certificate of Suitability (COS). The purpose of a Rivastigmine (transdermal patch) CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Rivastigmine (transdermal patch) EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Rivastigmine (transdermal patch) to their clients by showing that a Rivastigmine (transdermal patch) CEP has been issued for it. The manufacturer submits a Rivastigmine (transdermal patch) CEP (COS) as part of the market authorization procedure, and it takes on the role of a Rivastigmine (transdermal patch) CEP holder for the record. Additionally, the data presented in the Rivastigmine (transdermal patch) CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Rivastigmine (transdermal patch) DMF.

    A Rivastigmine (transdermal patch) CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Rivastigmine (transdermal patch) CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with CEP (COS) on PharmaCompass.

    Rivastigmine (transdermal patch) WC

    A Rivastigmine (transdermal patch) written confirmation (Rivastigmine (transdermal patch) WC) is an official document issued by a regulatory agency to a Rivastigmine (transdermal patch) manufacturer, verifying that the manufacturing facility of a Rivastigmine (transdermal patch) active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Rivastigmine (transdermal patch) APIs or Rivastigmine (transdermal patch) finished pharmaceutical products to another nation, regulatory agencies frequently require a Rivastigmine (transdermal patch) WC (written confirmation) as part of the regulatory process.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with Written Confirmation (WC) on PharmaCompass.

    Rivastigmine (transdermal patch) NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Rivastigmine (transdermal patch) as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Rivastigmine (transdermal patch) API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Rivastigmine (transdermal patch) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Rivastigmine (transdermal patch) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Rivastigmine (transdermal patch) NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Rivastigmine (transdermal patch) suppliers with NDC on PharmaCompass.

    Rivastigmine (transdermal patch) GMP

    Rivastigmine (transdermal patch) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Rivastigmine (transdermal patch) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rivastigmine (transdermal patch) GMP manufacturer or Rivastigmine (transdermal patch) GMP API supplier for your needs.

    Rivastigmine (transdermal patch) CoA

    A Rivastigmine (transdermal patch) CoA (Certificate of Analysis) is a formal document that attests to Rivastigmine (transdermal patch)'s compliance with Rivastigmine (transdermal patch) specifications and serves as a tool for batch-level quality control.

    Rivastigmine (transdermal patch) CoA mostly includes findings from lab analyses of a specific batch. For each Rivastigmine (transdermal patch) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Rivastigmine (transdermal patch) may be tested according to a variety of international standards, such as European Pharmacopoeia (Rivastigmine (transdermal patch) EP), Rivastigmine (transdermal patch) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rivastigmine (transdermal patch) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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