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    Chemistry

    Click the arrow to open the dropdown
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    Also known as: 98319-26-7, Proscar, Propecia, Finastid, Prostide, Chibro-proscar
    Molecular Formula
    C23H36N2O2
    Molecular Weight
    372.5  g/mol
    InChI Key
    DBEPLOCGEIEOCV-WSBQPABSSA-N
    FDA UNII
    57GNO57U7G
    Finasteride
    An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
    Finasteride is a 5-alpha Reductase Inhibitor. The mechanism of action of finasteride is as a 5-alpha Reductase Inhibitor.
    1 2D Structure

    Finasteride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
    2.1.2 InChI
    InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
    2.1.3 InChI Key
    DBEPLOCGEIEOCV-WSBQPABSSA-N
    2.1.4 Canonical SMILES
    CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C
    2.1.5 Isomeric SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C
    2.2 Other Identifiers
    2.2.1 UNII
    57GNO57U7G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chibro Proscar

    2. Chibro-proscar

    3. Eucoprost

    4. Mk 906

    5. Mk-906

    6. Mk906

    7. Propecia

    8. Propeshia

    9. Proscar

    2.3.2 Depositor-Supplied Synonyms

    1. 98319-26-7

    2. Proscar

    3. Propecia

    4. Finastid

    5. Prostide

    6. Chibro-proscar

    7. Mk-906

    8. Finpecia

    9. Finasterida

    10. Finasteridum

    11. Mk 906

    12. (5alpha,17beta)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

    13. (4ar,4bs,6as,7s,9as,9bs,11ar)-n-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxamide

    14. Chembl710

    15. Nsc-741485

    16. N-tert-butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

    17. 57gno57u7g

    18. Chebi:5062

    19. (1s,3as,3bs,5ar,9ar,9bs,11as)-n-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide

    20. (4ar,4bs,6as,7s,9as,9bs,11ar)-n-(tert-butyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxamide

    21. Nsc-759318

    22. Finasteridum [inn-latin]

    23. Finasterida [inn-spanish]

    24. Dsstox_cid_625

    25. Dsstox_rid_75699

    26. Dsstox_gsid_20625

    27. (4ar,4bs,6as,7s,9as,9bs,11ar)-n-(1,1-dimethylethyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxamide

    28. N-tert-butyl-3-oxo-4-aza-5alpha-androst-1-en-17beta-carboxamide

    29. Andozac

    30. 4-azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-

    31. Propecia (tn)

    32. Smr000466304

    33. Proscar (tn)

    34. Mk 0906

    35. Mk-0906

    36. Ccris 7438

    37. Hsdb 6793

    38. Mk906

    39. Sr-01000759414

    40. Brn 4269024

    41. Unii-57gno57u7g

    42. L-652,931

    43. 17beta-(n-tert-butylcarbamoyl)-4-aza-5 Alpha-androst-1-en-3-one

    44. Ncgc00016965-01

    45. Finasteride [usan:usp:inn:ban]

    46. N-(2-methyl-2-propyl)-3-oxo-4-aza-5-alpha-androst-1-ene-17-beta-carboxamide

    47. Cas-98319-26-7

    48. Mfcd00869737

    49. Ym-152

    50. Ks-1058

    51. Finasteride (proscar)

    52. Finasteride [mi]

    53. Prestwick0_000717

    54. Prestwick1_000717

    55. Prestwick2_000717

    56. Prestwick3_000717

    57. Finasteride [inn]

    58. Finasteride [jan]

    59. Finasteride [usan]

    60. Finasteride [vandf]

    61. Schembl5509

    62. Finasteride [mart.]

    63. Bspbio_000933

    64. Finasteride [who-dd]

    65. Mls000759404

    66. Mls001165768

    67. Mls001424046

    68. Finasteride (jan/usp/inn)

    69. Spbio_002854

    70. Bpbio1_001027

    71. Gtpl6818

    72. Dtxsid3020625

    73. N-tert-butyl-3-oxo-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide

    74. Finasteride [ep Impurity]

    75. Finasteride [orange Book]

    76. 4-azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5.alpha.,17.beta.)-

    77. Bcpp000229

    78. Finasteride [ep Monograph]

    79. Finasteride [usp Impurity]

    80. Hms1570o15

    81. Hms2051f09

    82. Hms2090g22

    83. Hms2097o15

    84. Hms2235l23

    85. Hms3714o15

    86. Finasteride [usp Monograph]

    87. 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    88. Act02599

    89. Entadfi Component Finasteride

    90. Ex-a1951

    91. Zinc3782599

    92. Tox21_110717

    93. Tox21_201506

    94. Tox21_302744

    95. Bdbm50334788

    96. Nsc741485

    97. Nsc757443

    98. S1197

    99. Akos015894916

    100. Tox21_110717_1

    101. Bcp9000685

    102. Ccg-100937

    103. Cs-1767

    104. Db01216

    105. Finasteride Component Of Entadfi

    106. Finasteride, >=98% (hplc), Powder

    107. Nc00187

    108. Nsc 741485

    109. Nsc 759318

    110. Nsc-757443

    111. Ncgc00093560-05

    112. Ncgc00256334-01

    113. Ncgc00259057-01

    114. 140375-21-9

    115. Bf164456

    116. Cpd000466304

    117. Hy-13635

    118. Bcp0726000222

    119. Ab00513901

    120. D00321

    121. Ab00513901-07

    122. Ab00513901-08

    123. Ab00513901_09

    124. Finasteride, Vetranal(tm), Analytical Standard

    125. 319f267

    126. A845840

    127. Q424167

    128. Sr-01000759414-4

    129. Sr-01000759414-6

    130. Brd-k01095011-001-03-5

    131. Brd-k01095011-001-15-9

    132. Finasteride, British Pharmacopoeia (bp) Reference Standard

    133. Finasteride, European Pharmacopoeia (ep) Reference Standard

    134. ([1-phenyl-meth-(e)-ylidene]-amino)-aceticacidethylester

    135. (17beta-(n-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one

    136. Finasteride, United States Pharmacopeia (usp) Reference Standard

    137. (5?,17?)-n-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

    138. 4-azaandrost-1-ene-17-carboxamide,1-dimethylethyl)-3-oxo-, (5.alpha., 17.beta.)-

    139. Finasteride For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    140. (1s,2r,7r,10s,11s,14s,15s)-n-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide

    141. (1s,3as,3bs,5ar,9ar,9bs,11as)-n-isobutyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide

    142. (1s,3as,3bs,5ar,9ar,9bs,11as)-n-isobutyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide;finasteride

    143. (4ar,4bs,6as,7s,9as,9bs,11ar)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    144. (4ar,4bs,6as,9as,9bs,11ar)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    145. (4ar,6as)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    146. (4ar,6as,11ar)-4a,6a-dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    147. (4ar,6as,7s)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    148. (4ar,6as,7s,11ar)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    149. (r)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide

    150. 1h-indeno[5,4-f]quinoline-7-carboxamide, N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4ar,4bs,6as,7s,9as,9bs,11ar)-

    151. 4a,6a,9a-trimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid (finasteride)

    152. 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-indeno[5,4-f]quinoline-7-carboxylic Acid Tert-butylamide(finasteride)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 372.5 g/mol
    Molecular Formula C23H36N2O2
    XLogP33
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass372.277678395 g/mol
    Monoisotopic Mass372.277678395 g/mol
    Topological Polar Surface Area58.2 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity678
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameFinasteride
    PubMed HealthFinasteride (By mouth)
    Drug ClassesAlopecia Agent, Benign Prostatic Hypertrophy Agent
    Drug LabelFinasteride, USP, a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone into 5-dihydrotestosterone (DHT).Finasteride is 4-Azaandrost-1-ene-17-car...
    Active IngredientFinasteride
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 1mg
    Market StatusTentative Approval; Prescription
    CompanyWatson Labs; Mylan Pharms; Actavis Elizabeth; Teva; Accord Hlthcare; Hetero Labs Ltd Iii; Aurobindo Pharma; Zydus Pharms Usa; Dr Reddys Labs; Gedeon Richter Usa; Sun Pharma Global; Mylan

    2 of 6  
    Drug NamePropecia
    PubMed HealthFinasteride (By mouth)
    Drug ClassesAlopecia Agent, Benign Prostatic Hypertrophy Agent
    Drug LabelPROPECIA (finasteride) tablets contain finasteride as the active ingredient. Finasteride, a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone int...
    Active IngredientFinasteride
    Dosage FormTablet
    RouteOral
    Strength1mg
    Market StatusPrescription
    CompanyMerck

    3 of 6  
    Drug NameProscar
    Drug LabelPROSCAR (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone into 5-dihydrotestosterone (DHT).Finasteride is 4-azaandrost-1-ene-1...
    Active IngredientFinasteride
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyMerck

    4 of 6  
    Drug NameFinasteride
    PubMed HealthFinasteride (By mouth)
    Drug ClassesAlopecia Agent, Benign Prostatic Hypertrophy Agent
    Drug LabelFinasteride, USP, a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone into 5-dihydrotestosterone (DHT).Finasteride is 4-Azaandrost-1-ene-17-car...
    Active IngredientFinasteride
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 1mg
    Market StatusTentative Approval; Prescription
    CompanyWatson Labs; Mylan Pharms; Actavis Elizabeth; Teva; Accord Hlthcare; Hetero Labs Ltd Iii; Aurobindo Pharma; Zydus Pharms Usa; Dr Reddys Labs; Gedeon Richter Usa; Sun Pharma Global; Mylan

    5 of 6  
    Drug NamePropecia
    PubMed HealthFinasteride (By mouth)
    Drug ClassesAlopecia Agent, Benign Prostatic Hypertrophy Agent
    Drug LabelPROPECIA (finasteride) tablets contain finasteride as the active ingredient. Finasteride, a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone int...
    Active IngredientFinasteride
    Dosage FormTablet
    RouteOral
    Strength1mg
    Market StatusPrescription
    CompanyMerck

    6 of 6  
    Drug NameProscar
    Drug LabelPROSCAR (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone into 5-dihydrotestosterone (DHT).Finasteride is 4-azaandrost-1-ene-1...
    Active IngredientFinasteride
    Dosage FormTablet
    RouteOral
    Strength5mg
    Market StatusPrescription
    CompanyMerck

    4.2 Therapeutic Uses

    Enzyme Inhibitors

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Treatment of benign prostatic hypertrophy

    Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1250

    Antiandrogen therapy appears to produce a 30 to 40% decrease in the volume of the hyperplastic prostate after 3 to 6 months of therapy. Longer treatment may result in further prostatic regression, although this remains to be seen. Biopsy studies suggest that epithelial regression occurs to a much more significant degree than does stromal regression, but this finding may simply reflect the relatively longer turnover of the stromal cell population. The significant placebo effect of oral medication in patients with benign prostatic hyperplasia makes interpretation of clinical symptomatology and uro-flow data difficult. Analysis of symptom improvement is further complicated by the relatively slow improvement of patients on antiandrogen therapy, in contrast to surgery, in which relief is immediate. In addition to limited stromal involution and inadequate treatment duration, other biologic factors may limit the clinical efficacy of antiandrogen therapy. Most importantly, prostatic involution may not necessarily decrease urethral resistance. In addition, obstruction induced detrusor dysfunction may persist after relief of outflow obstruction in some patients, as it does after surgery. Incomplete antiandrogen action of the compounds, as well as compliance issues, may likewise limit efficacy. Although there are no data to suggest that the 5 alpha-reductase inhibitor finasteride will be more effective than other antiandrogen compounds in the treatment of benign prostatic hyperplasia, preliminary studies suggest that it has less toxicity. If long-term studies validate a modest but significant clinical response rate and preservation of sexual function, then finasteride therapy may well be acceptable to a subgroup of men presenting with the symptoms of benign prostatic hyperplasia.

    PMID:1695786 McConnell JD; Urol Clin North Am 17 (3): 661-70 (1990)

    4.3 Drug Indication

    Finasteride is indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms, reduce the risk of acute urinary retention, and reduce the risk of the need for surgery including transurethral resection of the prostate (TURP) and prostatectomy. A combination product with [tadalafil] is also used for the symptomatic treatment of BPH for up to 26 weeks. Finasteride is also indicated for the treatment of male pattern hair loss (androgenetic alopecia, hereditary alopecia, or common male baldness) in male patients.

    Treatment of androgenetic alopecia

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Finasteride is an antiandrogenic compound that works by suppressing the production of serum and intraprostatic dihydrotestosterone (DHT) in men via inhibiting the enzyme responsible for the biosynthesis of DHT. The maximum effect of a rapid reduction in serum DHT concentration is expected to be observed 8 hours following administration of the first dose. In a single man receiving a single oral dose of 5 mg finasteride for up to 4 years, there was a reduction in the serum DHT concentrations by approximately 70% and the median circulating level of testosterone increased by approximately 10-20% within the physiologic range. In a double-blind, placebo-controlled study, finasteride reduced intraprostatic DHT level by 91.4% but finasteride is not expected to decrease the DHT levels to castrate levels since circulating testosterone is also converted to DHT by the type 1 isoenzyme expressed in other tissues. It is expected that DHT levels return to normal within 14 days upon discontinuation of the drug. In a study of male patients with benign prostatic hyperplasia prior to prostatectomy, the treatment with finasteride resulted in an approximate 80% lower DHT content was measured in prostatic tissue removed at surgery compared to placebo. While finasteride reduces the size of the prostate gland by 20%, this may not correlate well with improvement in symptoms. The effects of finasteride are reported to be more pronounced in male patients with enlarged prostates (>25 mL) who are at the greatest risk of disease progression. In phase III clinical studies, oral administration of finasteride in male patients with male pattern hair loss promoted hair growth and prevented further hair loss by 66% and 83% of the subjects, respectively, which lasted during two years' treatment. The incidences of these effects in treatment groups were significantly higher than that of the group receiving a placebo. Following finasteride administration, the levels of DHT in the scalp skin was shown to be reduced by more than 60%, indicating that the DHT found in scalp is derived from both local DHT production and circulating DHT. The effect of finasteride on scalp DHT is likely seen because of its effect on both local follicular DHT levels as well as serum DHT levels.. There is evidence from early clinical observations and controlled studies that finasteride may reduce bleeding of prostatic origin.

    5.2 MeSH Pharmacological Classification

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    5-alpha Reductase Inhibitors

    Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE. (See all compounds classified as 5-alpha Reductase Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    FINASTERIDE
    5.3.2 FDA UNII
    57GNO57U7G
    5.3.3 Pharmacological Classes
    5-alpha Reductase Inhibitors [MoA]; 5-alpha Reductase Inhibitor [EPC]
    5.4 ATC Code

    G04CB01

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    D - Dermatologicals

    D11 - Other dermatological preparations

    D11A - Other dermatological preparations

    D11AX - Other dermatologicals

    D11AX10 - Finasteride

    G - Genito urinary system and sex hormones

    G04 - Urologicals

    G04C - Drugs used in benign prostatic hypertrophy

    G04CB - Testosterone-5-alpha reductase inhibitors

    G04CB01 - Finasteride

    5.5 Absorption, Distribution and Excretion

    Absorption

    Finasteride is well absorbed following oral administration and displays a slow accumulation phase after multiple dosing.[lablel] In healthy male subjects receiving oral finasteride, the mean oral bioavailability was 65% for 1 mg finasteride and 63% for 5 mg finasteride, and the values ranged from 26 to 170% for 1 mg dose and from 34 to 108% for 5 mg dose, respectively. It is reported that food intake does not affect the oral bioavailability of the drug. The peak plasma concentrations (Cmax) averaged 37 ng/mL (range, 27-49 ng/mL) and was reached 1-2 hours post administration. The AUC(0-24 hr) was 53 ngxhr/mL (range, 20-154 ngxhr/mL). The plasma concentrations and AUC are reported to be higher in elderly male patients aged 70 years or older.

    Route of Elimination

    In healthy subjects, about 32-46% of total oral dose of finasteride was excreted in the urine in the form of metabolites while about 51-64% of the dose was excreted in the feces. In patients with renal impairment, the extent of urinary excretion of finasteride is expected to be decreased while the fecal excretion is increased.

    Volume of Distribution

    The volume of distribution is 76 L at steady state, ranging from 44 to 96 L. Finasteride has been shown to cross the blood brain barrier but does not appear to distribute preferentially to the CSF. It is not known whether finasteride is excreted in human milk.

    Clearance

    In healthy young subjects (n=15), the mean plasma clearance of finasteride was 165 mL/min with the range between 70 and 279 mL/min.

    5.6 Metabolism/Metabolites

    Finasteride undergoes extensive hepatic metabolism predominantly mediated by the cytochrome P450 3A4 (CYP3A4) enzyme to form the t-butyl side chain monohydroxylated and monocarboxylic acid metabolites. Theses metabolites retain less than 20% of the pharmacological activity of the parent compound.

    Finasteride has known human metabolites that include N-(1-Hydroxy-2-methylpropan-2-yl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    In healthy young subjects receiving finasteride, the mean elimination half-life in plasma was 6 hours ranging from 3 to 16 hours. In elderly patients over the age of 70 years, the half-life is prolonged to 8 hours.

    5.8 Mechanism of Action

    Finasteride acts as a competitive and specific inhibitor of Type II 5-reductase, a nuclear-bound steroid intracellular enzyme primarily located in the prostatic stromal cell that converts the androgen testosterone into the more active metabolite, 5-dihydrotestosterone (DHT). DHT is considered to be the primary androgen playing a role in the development and enlargement of the prostate gland. It serves as the hormonal mediator for the hyperplasia upon accumulation within the prostate gland. DHT displays a higher affinity towards androgen receptors in the prostate gland compared to testosterone and by acting on the androgen receptors, DHT modulates genes that are responsible for cell proliferation. Responsible for the production of DHT together with type I 5-reductase, the type II 5-reductase isozyme is primarily found in the prostate, seminal vesicles, epididymides, and hair follicles as well as liver. Although finasteride is 100-fold more selective for type II 5-reductase than for the type I isoenzyme, chronic treatment with this drug may have some effect on type I 5-reductase, which is predominantly expressed in sebaceous glands of most regions of skin, including the scalp, and liver. It is proposed that the type I 5-reductase and type II 5-reductase is responsible for the production of one-third and two-thirds of circulating DHT, respectively. The mechanism of action of Finasteride is based on its preferential inhibition of Type II 5-reductase through the formation of a stable complex with the enzyme _in vitro_ and _in vivo_. Finasteride works selectively, where it preferentially displays a 100-fold selectivity for the human Type II 5-reductase over type I enzyme. Inhibition of Type II 5-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT concentrations, minimal to moderate increase in serum testosterone concentrations, and substantial increases in prostatic testosterone concentrations. As DHT appears to be the principal androgen responsible for stimulation of prostatic growth, a decrease in DHT concentrations will result in a decrease in prostatic volume (approximately 20-30% after 6-24 months of continued therapy). It is suggested that increased levels of DHT can lead to potentiated transcription of prostaglandin D2, which promotes the proliferation of prostate cancer cells. In men with androgenic alopecia, the mechanism of action has not been fully determined, but finasteride has shown to decrease scalp DHT concentration to the levels found in the hairy scalp, reduce serum DHT, increase hair regrowth, and slow hair loss. Another study suggests that finasteride may work to reduce bleeding of prostatic origin by inhibiting vascular endothelial growth factor (VEGF) in the prostate, leading to atrophy and programmed cell death. This may bestow the drug therapeutic benefits in patients idiopathic prostatic bleeding, bleeding during anticoagulation, or bleeding after instrumentation.

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VAISHNODE","city":"AHMEDABAD","supplier":"HUBEI GEDIAN HUMANWELL PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"0.60","actualQuantity":"0.6","unit":"KGS","unitRateFc":"2800","totalValueFC":"1677","currency":"USD","unitRateINR":"216020","date":"02-May-2022","totalValueINR":"129612","totalValueInUsd":"1677","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"8520652","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662057000,"product":"FINASTERIDE (TEST LIC : TL\/AZ\/22\/000110) FOR R&D PURPOSE NOTFOR SALE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"HUBEI GEDIAN HUMANWELL PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"2800","totalValueFC":"1405.4","currency":"USD","unitRateINR":"225260","date":"02-Sep-2022","totalValueINR":"112630","totalValueInUsd":"1405.4","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"2275495","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1667932200,"product":"FINASTERIDE","address":"502 JOLLY BHAVAN 2, 7 NEW MARINE, LINES CHURCHGATE MUMBAI","city":"MUMBAI,MAHARASHTRA","supplier":"WUHAN JIULONG PHARMACEUTICAL ","supplierCountry":"CHINA","foreign_port":"NA","customer":"B.M. CHEMIE","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"1700","totalValueFC":"26183.4","currency":"USD","unitRateINR":"142460","date":"09-Nov-2022","totalValueINR":"2136900","totalValueInUsd":"26183.4","indian_port":"BOMBAY AIR","hs_no":"29379090","bill_no":"3221855","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"502 JOLLY BHAVAN 2, 7 NEW MARINE, LINES CHURCHGATE MUMBAI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1684434600,"product":"FINASTERIDE","address":"1,GR. FLOOR, KIRITIDHAM COMPLEX, NR. DINESH HALL, INCOME TAX","city":"AHMEDABAD","supplier":"M S YUANFANG CHEMICAL LIMITED","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"27.00","actualQuantity":"27","unit":"KGS","unitRateFc":"1070","totalValueFC":"29246.6","currency":"USD","unitRateINR":"89131","date":"19-May-2023","totalValueINR":"2406537","totalValueInUsd":"29246.6","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"China","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"","customerAddress":"1,GR. FLOOR, KIRITIDHAM COMPLEX, NR. DINESH HALL, INCOME TAX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1692210600,"product":"FINASTERIDE USP\/IP","address":"108, MARINE CHEMBERS, 43, NEW ,MARINE LINES, BEHIND SNDT COLLEGE, ,","city":"Mumbai","supplier":"WUHAN JIULONG PHARMACEUTICAL CO LIMITED","supplierCountry":"CHINA","foreign_port":"NA","customer":"B M CHEMIE","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1350","totalValueFC":"136217.3","currency":"USD","unitRateINR":"111709.1","date":"17-Aug-2023","totalValueINR":"11283742.8","totalValueInUsd":"136217.3","indian_port":"SAHAR AIR","hs_no":"29379090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"108, MARINE CHEMBERS, 43, NEW ,MARINE LINES, BEHIND SNDT COLLEGE, ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735151400,"product":"FINASTERIDE IP\/USP FINASTERIDE IP\/USP","address":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020","city":"","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1350","totalValueFC":"27311.7","currency":"USD","unitRateINR":"116032.5","date":"26-Dec-2024","totalValueINR":"2320650","totalValueInUsd":"27311.7","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"7453588","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737916200,"product":"FINASTERIDE IP\/USP FINASTERIDE IP\/USP","address":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020","city":"","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1100","totalValueFC":"22222.2","currency":"USD","unitRateINR":"95810","date":"27-Jan-2025","totalValueINR":"1916200","totalValueInUsd":"22222.2","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"8017090","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742149800,"product":"FINASTERIDE EP11\/IP2022\/USP2024 FINASTERIDE EP11\/IP2022\/USP2024","address":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020","city":"","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1350","totalValueFC":"27368.6","currency":"USD","unitRateINR":"118530","date":"17-Mar-2025","totalValueINR":"2370600","totalValueInUsd":"27368.6","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"8925810","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742149800,"product":"FINASTERIDE IP\/USP FINASTERIDE IP\/USP","address":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020","city":"","supplier":"WUHAN JIULONG PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"WUHAN","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"1350","totalValueFC":"20526.4","currency":"USD","unitRateINR":"118530","date":"17-Mar-2025","totalValueINR":"1777950","totalValueInUsd":"20526.4","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"8925810","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"WUHAN","supplierAddress":"NO.77, OPTICS VALLEY SEVENTH ROAD, EAST LAKE HIGH-TECH DISTRICT, WHUHA N 430206 HUBEI, , CHINA CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"}]
    13-Jan-2021
    27-Mar-2025
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 5MG

    USFDA APPLICATION NUMBER - 20180

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    DOSAGE - TABLET;ORAL - 1MG

    USFDA APPLICATION NUMBER - 20788

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    ABOUT THIS PAGE

    Looking for 98319-26-7 / Finasteride API manufacturers, exporters & distributors?

    Finasteride manufacturers, exporters & distributors 1

    77

    PharmaCompass offers a list of Finasteride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Finasteride manufacturer or Finasteride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Finasteride manufacturer or Finasteride supplier.

    PharmaCompass also assists you with knowing the Finasteride API Price utilized in the formulation of products. Finasteride API Price is not always fixed or binding as the Finasteride Price is obtained through a variety of data sources. The Finasteride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Finasteride

    Synonyms

    98319-26-7, Proscar, Propecia, Finastid, Prostide, Chibro-proscar

    Cas Number

    98319-26-7

    Unique Ingredient Identifier (UNII)

    57GNO57U7G

    About Finasteride

    An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.

    Propeshia Manufacturers

    A Propeshia manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Propeshia, including repackagers and relabelers. The FDA regulates Propeshia manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Propeshia API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Propeshia manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Propeshia Suppliers

    A Propeshia supplier is an individual or a company that provides Propeshia active pharmaceutical ingredient (API) or Propeshia finished formulations upon request. The Propeshia suppliers may include Propeshia API manufacturers, exporters, distributors and traders.

    click here to find a list of Propeshia suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Propeshia USDMF

    A Propeshia DMF (Drug Master File) is a document detailing the whole manufacturing process of Propeshia active pharmaceutical ingredient (API) in detail. Different forms of Propeshia DMFs exist exist since differing nations have different regulations, such as Propeshia USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Propeshia DMF submitted to regulatory agencies in the US is known as a USDMF. Propeshia USDMF includes data on Propeshia's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Propeshia USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Propeshia suppliers with USDMF on PharmaCompass.

    Propeshia JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Propeshia Drug Master File in Japan (Propeshia JDMF) empowers Propeshia API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Propeshia JDMF during the approval evaluation for pharmaceutical products. At the time of Propeshia JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Propeshia suppliers with JDMF on PharmaCompass.

    Propeshia KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Propeshia Drug Master File in Korea (Propeshia KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Propeshia. The MFDS reviews the Propeshia KDMF as part of the drug registration process and uses the information provided in the Propeshia KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Propeshia KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Propeshia API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Propeshia suppliers with KDMF on PharmaCompass.

    Propeshia CEP

    A Propeshia CEP of the European Pharmacopoeia monograph is often referred to as a Propeshia Certificate of Suitability (COS). The purpose of a Propeshia CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Propeshia EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Propeshia to their clients by showing that a Propeshia CEP has been issued for it. The manufacturer submits a Propeshia CEP (COS) as part of the market authorization procedure, and it takes on the role of a Propeshia CEP holder for the record. Additionally, the data presented in the Propeshia CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Propeshia DMF.

    A Propeshia CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Propeshia CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Propeshia suppliers with CEP (COS) on PharmaCompass.

    Propeshia WC

    A Propeshia written confirmation (Propeshia WC) is an official document issued by a regulatory agency to a Propeshia manufacturer, verifying that the manufacturing facility of a Propeshia active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Propeshia APIs or Propeshia finished pharmaceutical products to another nation, regulatory agencies frequently require a Propeshia WC (written confirmation) as part of the regulatory process.

    click here to find a list of Propeshia suppliers with Written Confirmation (WC) on PharmaCompass.

    Propeshia NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Propeshia as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Propeshia API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Propeshia as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Propeshia and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Propeshia NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Propeshia suppliers with NDC on PharmaCompass.

    Propeshia GMP

    Propeshia Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Propeshia GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Propeshia GMP manufacturer or Propeshia GMP API supplier for your needs.

    Propeshia CoA

    A Propeshia CoA (Certificate of Analysis) is a formal document that attests to Propeshia's compliance with Propeshia specifications and serves as a tool for batch-level quality control.

    Propeshia CoA mostly includes findings from lab analyses of a specific batch. For each Propeshia CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Propeshia may be tested according to a variety of international standards, such as European Pharmacopoeia (Propeshia EP), Propeshia JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Propeshia USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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