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Chemistry

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Also known as: 60560-33-0, Pinacidil anhydrous, (r,s)-pinacidil, Pinacidil [inn], P 1134, (+/-)-pinacidil
Molecular Formula
C13H19N5
Molecular Weight
245.32  g/mol
InChI Key
IVVNZDGDKPTYHK-UHFFFAOYSA-N
FDA UNII
BB4UGO5K0D

Pinacidil
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
1 2D Structure

Pinacidil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine
2.1.2 InChI
InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
2.1.3 InChI Key
IVVNZDGDKPTYHK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
2.2 Other Identifiers
2.2.1 UNII
BB4UGO5K0D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anhydrous, Pinacidil

2. Pinacidil Anhydrous

3. Pindac

2.3.2 Depositor-Supplied Synonyms

1. 60560-33-0

2. Pinacidil Anhydrous

3. (r,s)-pinacidil

4. Pinacidil [inn]

5. P 1134

6. (+/-)-pinacidil

7. S-1230

8. N-cyano-n'-4-pyridinyl-n''-(1,2,2-trimethylpropyl)guanidine

9. 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine

10. Bb4ugo5k0d

11. Guanidine, N-cyano-n'-4-pyridinyl-n''-(1,2,2-trimethylpropyl)-

12. Chembl1159

13. Mls000069377

14. (+-)-pinacidil

15. Pinacidilum

16. Smr000058360

17. (z)-2-cyano-1-(3,3-dimethylbutan-2-yl)-3-(pyridin-4-yl)guanidine

18. P-1134;s-1230

19. Pinacidilum [inn-latin]

20. P-154

21. 1-(3,3-dimethylbutan-2-yl)-2-cyano-3-(pyridin-4-yl)guanidine

22. Sr-01000075340

23. Sr-05000001757

24. Ncgc00025188-04

25. Einecs 262-294-9

26. Unii-bb4ugo5k0d

27. S 1230

28. P-1134

29. 2-cyano-3-(4-pyridinyl)-1-(1,2,2-trimethylpropyl)guanidine

30. Prestwick_396

31. Spectrum_000387

32. Specplus_000759

33. Pinacidil [mi]

34. Opera_id_1844

35. Prestwick0_000246

36. Prestwick1_000246

37. Prestwick2_000246

38. Prestwick3_000246

39. Spectrum2_001739

40. Spectrum5_001372

41. Pinacidil [who-dd]

42. Cbiol_001878

43. Lopac0_001037

44. Schembl65787

45. Bspbio_000032

46. Bspbio_001461

47. Bspbio_002360

48. Kbiogr_000181

49. Kbioss_000181

50. Kbioss_000867

51. Mls002154248

52. Divk1c_006855

53. Spectrum2300270

54. Spbio_001818

55. Spbio_002251

56. Bpbio1_000036

57. Gtpl2412

58. Schembl9260276

59. Dtxsid7048249

60. Bcbcmap01_000050

61. Bdbm86245

62. Chebi:91706

63. Kbio1_001799

64. Kbio2_000181

65. Kbio2_000867

66. Kbio2_002749

67. Kbio2_003435

68. Kbio2_005317

69. Kbio2_006003

70. Kbio3_000361

71. Kbio3_000362

72. Bio1_000164

73. Bio1_000653

74. Bio1_001142

75. Bio2_000181

76. Bio2_000661

77. Hms1361j03

78. Hms1568b14

79. Hms1791j03

80. Hms1922l10

81. Hms1989j03

82. Hms2089c19

83. Hms2094g21

84. Hms2095b14

85. Hms2234f10

86. Hms3263o15

87. Hms3267p10

88. Hms3371h14

89. Hms3402j03

90. Hms3712b14

91. Pharmakon1600-02300270

92. Nsc_4826

93. Tox21_501037

94. Bdbm50103517

95. Bdbm50240750

96. Ccg-39493

97. Nsc759588

98. Akos001637331

99. Akos025394868

100. Ccg-205115

101. Ccg-222341

102. Db06762

103. Lp01037

104. Sdccgsbi-0051008.p005

105. Idi1_033931

106. Ncgc00015787-02

107. Ncgc00015787-03

108. Ncgc00015787-04

109. Ncgc00015787-05

110. Ncgc00015787-06

111. Ncgc00015787-09

112. Ncgc00025188-02

113. Ncgc00025188-03

114. Ncgc00025188-05

115. Ncgc00025188-06

116. Ncgc00025188-07

117. Ncgc00025188-08

118. Ncgc00025188-10

119. Ncgc00095199-01

120. Ncgc00095199-02

121. Ncgc00095199-03

122. Ncgc00095199-04

123. Ncgc00188958-01

124. Ncgc00247667-01

125. Ncgc00261722-01

126. Hy-14290

127. Sbi-0051008.p004

128. Cas_85371-64-8

129. Cs-0003257

130. Eu-0101037

131. Ft-0630932

132. Sw197742-2

133. F77807

134. Ab00052442-04

135. Ab00052442_05

136. Ab00052442_06

137. 371p648

138. 560p330

139. Q821869

140. Sr-01000075340-1

141. Sr-01000075340-3

142. Sr-05000001757-1

143. Sr-05000001757-2

144. Brd-a43882281-001-06-4

145. Brd-a43882281-001-11-4

146. Brd-a58207013-001-01-2

147. 3-cyano-2-(3,3-dimethylbutan-2-yl)-1-pyridin-4-ylguanidine

148. N-cyano-n'-(4-pyridyl)-n''-(1,2,2-trimethylpropyl)guanidine

149. N''''-cyano-n-pyridin-4-yl-n''-(1,2,2-trimethylpropyl)guanidine

150. N'-cyano-n''-(3,3-dimethylbutan-2-yl)-n-(pyridin-4-yl)guanidine

151. ()-n-cyano-n''-4-pyridinyl-n''''-(1,2,2-trimethylpropyl)guanidine

152. 4n-cyanoimino(1,2,2-trimethylpropylamino)methyl-4-pyridinamine(pinacidil)

153. 4n-cyanoimino[1,2,2-trimethyl-(1r)-propylamino]methyl-4-pyridinamine

154. 4n-cyanoimino[1,2,2-trimethyl-(1s)-propylamino]methyl-4-pyridinamine

155. N''''-cyano-n-pyridin-4-yl-n''-[(1r)-1,2,2-trimethylpropyl]guanidine

156. N''''-cyano-n-pyridin-4-yl-n''-[(1s)-1,2,2-trimethylpropyl]guanidine

157. N-pyridin-4-yl-n''-(1,2,2-trimethyl-propyl)-cyanoguanidine (pinacidil)

158. ( Inverted Question Mark)-n-cyano-n'-4-pyridinyl-n''-(1,2,2-trimethylpropyl)-guanidine

159. Guanidine, N''-cyano-n-4-pyridinyl-n'-(1,2,2-trimethylpropyl)-,(+/-)-

160. N''''-cyano-n-pyridin-4-yl-n''-(1,2,2-trimethylpropyl)guanidine ((+)-pinacidil)

161. N''''-cyano-n-pyridin-4-yl-n''-(1,2,2-trimethylpropyl)guanidine (pinacidil)

162. 113563-69-2

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 245.32 g/mol
Molecular Formula C13H19N5
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass245.16404563 g/mol
Monoisotopic Mass245.16404563 g/mol
Topological Polar Surface Area73.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity327
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Membrane Transport Modulators

Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS. (See all compounds classified as Membrane Transport Modulators.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


4.2 ATC Code

C - Cardiovascular system

C02 - Antihypertensives

C02D - Arteriolar smooth muscle, agents acting on

C02DG - Guanidine derivatives

C02DG01 - Pinacidil


ABOUT THIS PAGE

Looking for 113563-69-2 / Pinacidil API manufacturers, exporters & distributors?

Pinacidil manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Pinacidil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pinacidil manufacturer or Pinacidil supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pinacidil manufacturer or Pinacidil supplier.

PharmaCompass also assists you with knowing the Pinacidil API Price utilized in the formulation of products. Pinacidil API Price is not always fixed or binding as the Pinacidil Price is obtained through a variety of data sources. The Pinacidil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Pinacidil

Synonyms

60560-33-0, Pinacidil anhydrous, (r,s)-pinacidil, Pinacidil [inn], P 1134, (+/-)-pinacidil

Cas Number

113563-69-2

Unique Ingredient Identifier (UNII)

BB4UGO5K0D

About Pinacidil

A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Pinacidil Manufacturers

A Pinacidil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pinacidil, including repackagers and relabelers. The FDA regulates Pinacidil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pinacidil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Pinacidil Suppliers

A Pinacidil supplier is an individual or a company that provides Pinacidil active pharmaceutical ingredient (API) or Pinacidil finished formulations upon request. The Pinacidil suppliers may include Pinacidil API manufacturers, exporters, distributors and traders.

Pinacidil GMP

Pinacidil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pinacidil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pinacidil GMP manufacturer or Pinacidil GMP API supplier for your needs.

Pinacidil CoA

A Pinacidil CoA (Certificate of Analysis) is a formal document that attests to Pinacidil's compliance with Pinacidil specifications and serves as a tool for batch-level quality control.

Pinacidil CoA mostly includes findings from lab analyses of a specific batch. For each Pinacidil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pinacidil may be tested according to a variety of international standards, such as European Pharmacopoeia (Pinacidil EP), Pinacidil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pinacidil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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