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Chemistry

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Also known as: 1236699-92-5, As703026, As-703026, Pimasertib (as-703026), As 703026, Msc1936369b
Molecular Formula
C15H15FIN3O3
Molecular Weight
431.20  g/mol
InChI Key
VIUAUNHCRHHYNE-JTQLQIEISA-N
FDA UNII
6ON9RK82AL

Pimasertib
Pimasertib is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
1 2D Structure

Pimasertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide
2.1.2 InChI
InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1
2.1.3 InChI Key
VIUAUNHCRHHYNE-JTQLQIEISA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O
2.1.5 Isomeric SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O
2.2 Other Identifiers
2.2.1 UNII
6ON9RK82AL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. As 703026

2. As-703026

3. As703026

4. Msc-1236369b

5. N-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide

2.3.2 Depositor-Supplied Synonyms

1. 1236699-92-5

2. As703026

3. As-703026

4. Pimasertib (as-703026)

5. As 703026

6. Msc1936369b

7. 1204531-26-9

8. Msc-1936369

9. 6on9rk82al

10. Msc1936369a

11. Msc-1936369a

12. Sar 245509

13. Emd 1036239

14. Emd-1036239

15. (s)-n-(2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)isonicotinamide

16. 4-pyridinecarboxamide, N-((2s)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)-

17. N-((2s)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)pyridine-4-carboxamide

18. N-[(2s)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodo-anilino)pyridine-4-carboxamide

19. N-[(2s)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide

20. G-02443714

21. (s)-n-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylamino)isonicotinamide

22. (s)-n-(2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)isonicotinamide.

23. 4-pyridinecarboxamide, N-[(2s)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-

24. Pimasertib [inn]

25. Pimasertib [usan:inn]

26. Unii-6on9rk82al

27. N-[(2s)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide

28. Pimasertib (usan/inn)

29. Pimasertib [usan]

30. Pimasertib; As703026

31. N-[(2s)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide

32. Pimasertib [who-dd]

33. Mls006010177

34. Gtpl7872

35. Schembl2720659

36. Chembl2107832

37. Chebi:94793

38. Dtxsid40152870

39. Ex-a403

40. Bcpp000386

41. Bcp02094

42. Bdbm50014412

43. Nsc755763

44. Nsc800854

45. Zinc38226009

46. Akos022186348

47. Bcp9000325

48. Ccg-269018

49. Cs-0198

50. Db14904

51. Nsc-755763

52. Nsc-800854

53. Ncgc00346530-01

54. Ac-32862

55. As-16324

56. Hy-12042

57. Smr004701285

58. As703026,msc1936369b

59. Sw219691-1

60. C71933

61. D10426

62. A857420

63. J-523298

64. Brd-k89014967-001-01-9

65. Q27088393

66. As7030261236699-92-5

67. As-703026;n-[(2s)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;as-703026

2.4 Create Date
2009-09-14
3 Chemical and Physical Properties
Molecular Weight 431.20 g/mol
Molecular Formula C15H15FIN3O3
XLogP31.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass431.01422 g/mol
Monoisotopic Mass431.01422 g/mol
Topological Polar Surface Area94.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity391
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1236699-92-5 / Pimasertib API manufacturers, exporters & distributors?

Pimasertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Pimasertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pimasertib manufacturer or Pimasertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pimasertib manufacturer or Pimasertib supplier.

PharmaCompass also assists you with knowing the Pimasertib API Price utilized in the formulation of products. Pimasertib API Price is not always fixed or binding as the Pimasertib Price is obtained through a variety of data sources. The Pimasertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Pimasertib

Synonyms

1236699-92-5, As703026, As-703026, Pimasertib (as-703026), As 703026, Msc1936369b

Cas Number

1236699-92-5

Unique Ingredient Identifier (UNII)

6ON9RK82AL

About Pimasertib

Pimasertib is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Pimasertib (AS-703026) Manufacturers

A Pimasertib (AS-703026) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pimasertib (AS-703026), including repackagers and relabelers. The FDA regulates Pimasertib (AS-703026) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pimasertib (AS-703026) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Pimasertib (AS-703026) Suppliers

A Pimasertib (AS-703026) supplier is an individual or a company that provides Pimasertib (AS-703026) active pharmaceutical ingredient (API) or Pimasertib (AS-703026) finished formulations upon request. The Pimasertib (AS-703026) suppliers may include Pimasertib (AS-703026) API manufacturers, exporters, distributors and traders.

Pimasertib (AS-703026) GMP

Pimasertib (AS-703026) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pimasertib (AS-703026) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pimasertib (AS-703026) GMP manufacturer or Pimasertib (AS-703026) GMP API supplier for your needs.

Pimasertib (AS-703026) CoA

A Pimasertib (AS-703026) CoA (Certificate of Analysis) is a formal document that attests to Pimasertib (AS-703026)'s compliance with Pimasertib (AS-703026) specifications and serves as a tool for batch-level quality control.

Pimasertib (AS-703026) CoA mostly includes findings from lab analyses of a specific batch. For each Pimasertib (AS-703026) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pimasertib (AS-703026) may be tested according to a variety of international standards, such as European Pharmacopoeia (Pimasertib (AS-703026) EP), Pimasertib (AS-703026) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pimasertib (AS-703026) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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