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Chemistry

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Also known as: 969-33-5, Cyproheptadine hcl, Periactin hydrochloride, Anarexol, Cipractin, Nuran
Molecular Formula
C21H22ClN
Molecular Weight
323.9  g/mol
InChI Key
ZPMVNZLARAEGHB-UHFFFAOYSA-N
FDA UNII
0S9323MCT0

Cyproheptadine Hydrochloride
A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
1 2D Structure

Cyproheptadine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride
2.1.2 InChI
InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H
2.1.3 InChI Key
ZPMVNZLARAEGHB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl
2.2 Other Identifiers
2.2.1 UNII
0S9323MCT0
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Antergan

2. Cyproheptadine

3. Dihexazin

4. Periactin

5. Peritol

6. Viternum

2.3.2 Depositor-Supplied Synonyms

1. 969-33-5

2. Cyproheptadine Hcl

3. Periactin Hydrochloride

4. Anarexol

5. Cipractin

6. Nuran

7. Antegan

8. Peritol

9. Periactin Syrup

10. Component Of Dronactin

11. Cyproheptadine (hydrochloride)

12. Cyproheptadine Hydrochloride Anhydrous

13. Cyproheptadiene Hydrochloride

14. 41354-29-4

15. Nsc-169911

16. Cyproheptadine Hydrochloride Sesquihydrate

17. Cyproheptadine Hydrochloride (anhydrous)

18. Cpd000058431

19. Mls000028462

20. Chebi:59695

21. 0s9323mct0

22. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine Hydrochloride

23. Periactine

24. Nsc-759282

25. Smr000058431

26. 4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

27. Cyproheptadine (hydrochloride Sesquihydrate)

28. 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

29. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

30. Periactinol (van)

31. Contrallerg

32. Kulinet

33. Kyliver

34. Sialotin

35. Vinorex

36. Istam

37. Periactinol Hydrochloride

38. Cyproheptadine Chlorhydrate

39. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

40. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine Hydrochloride

41. Cycloheptadine Hydrochloride

42. Cyproheptadine Hydrochloride Hydrate

43. Vufb3511

44. Sr-01000003077

45. Einecs 213-535-1

46. Nsc 169911

47. C21h21n.hcl

48. Unii-0s9323mct0

49. 4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

50. Ai3-26940

51. 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

52. 4-(dibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride

53. Cycloheptadine Hcl

54. Prestwick_139

55. Opera_id_383

56. Cypoheptadine Hydrochloride

57. Cyproheptadine-hydrochloride

58. Piperidine, 4-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

59. Chembl1716

60. Schembl41842

61. Mls001077277

62. Mls001424281

63. Mls002222173

64. Regid_for_cid_13770

65. Cyproptadine Hydrochloride,(s)

66. Dtxsid5042586

67. Hy-b0366a

68. Hms1568e08

69. Hms3414j05

70. Hms3678j03

71. Pharmakon1600-01505973

72. Bcp34399

73. Cyproheptadine Hydrochloride (anh.)

74. Tox21_500246

75. Anhydrous Cyproheptadine Hydrochloride

76. Mfcd00012538

77. Nsc169911

78. Nsc759282

79. S2044

80. Akos015905305

81. Ccg-101144

82. Lp00246

83. Nc00394

84. Cyproheptadine Hydrochloride (periactin)

85. Ncgc00093708-01

86. Ncgc00093708-02

87. Ncgc00260931-01

88. Ac-15790

89. As-14697

90. Cyproheptadine Hydrochloride [who-dd]

91. Eu-0100246

92. Ft-0603147

93. Sw196450-4

94. C 6022

95. C77331

96. Wln: L C676 Byj Bu- Dt6n Dytj A1 &gh

97. Sr-01000003077-2

98. Sr-01000003077-4

99. Sr-01000003077-9

100. W-106308

101. Cyproheptadine Hydrochloride 100 Microg/ml In Methanol

102. Q27126856

103. Piperidine,d]cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

104. 4-(5h-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

105. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidinehydrochloride

106. 4-(5h-dibenzo[a,d]cyclohepten-5-yli Dine)-methylpiperidine Hydrochloride

107. 1-methyl-4-(2-tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

108. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 323.9 g/mol
Molecular Formula C21H22ClN
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass323.1440774 g/mol
Monoisotopic Mass323.1440774 g/mol
Topological Polar Surface Area3.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity423
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCyproheptadine hydrochloride
PubMed HealthCyproheptadine Hydrochloride (By mouth)
Drug ClassesRespiratory Agent
Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
Active IngredientCyproheptadine hydrochloride
Dosage FormTablet; Syrup
RouteOral
Strength4mg; 2mg/5ml
Market StatusPrescription
CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

2 of 2  
Drug NameCyproheptadine hydrochloride
PubMed HealthCyproheptadine Hydrochloride (By mouth)
Drug ClassesRespiratory Agent
Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
Active IngredientCyproheptadine hydrochloride
Dosage FormTablet; Syrup
RouteOral
Strength4mg; 2mg/5ml
Market StatusPrescription
CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


Gastrointestinal Agents

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)


Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)


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04-Jan-2021
27-Mar-2025
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ABOUT THIS PAGE

Looking for 969-33-5 / Cyproheptadine Hydrochloride API manufacturers, exporters & distributors?

Cyproheptadine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cyproheptadine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cyproheptadine Hydrochloride manufacturer or Cyproheptadine Hydrochloride supplier for your needs.

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PharmaCompass also assists you with knowing the Cyproheptadine Hydrochloride API Price utilized in the formulation of products. Cyproheptadine Hydrochloride API Price is not always fixed or binding as the Cyproheptadine Hydrochloride Price is obtained through a variety of data sources. The Cyproheptadine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cyproheptadine Hydrochloride

Synonyms

969-33-5, Cyproheptadine hcl, Periactin hydrochloride, Anarexol, Cipractin, Nuran

Cas Number

969-33-5

Unique Ingredient Identifier (UNII)

0S9323MCT0

About Cyproheptadine Hydrochloride

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

Periactin syrup Manufacturers

A Periactin syrup manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Periactin syrup, including repackagers and relabelers. The FDA regulates Periactin syrup manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Periactin syrup API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Periactin syrup manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Periactin syrup Suppliers

A Periactin syrup supplier is an individual or a company that provides Periactin syrup active pharmaceutical ingredient (API) or Periactin syrup finished formulations upon request. The Periactin syrup suppliers may include Periactin syrup API manufacturers, exporters, distributors and traders.

click here to find a list of Periactin syrup suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Periactin syrup USDMF

A Periactin syrup DMF (Drug Master File) is a document detailing the whole manufacturing process of Periactin syrup active pharmaceutical ingredient (API) in detail. Different forms of Periactin syrup DMFs exist exist since differing nations have different regulations, such as Periactin syrup USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Periactin syrup DMF submitted to regulatory agencies in the US is known as a USDMF. Periactin syrup USDMF includes data on Periactin syrup's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Periactin syrup USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Periactin syrup suppliers with USDMF on PharmaCompass.

Periactin syrup JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Periactin syrup Drug Master File in Japan (Periactin syrup JDMF) empowers Periactin syrup API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Periactin syrup JDMF during the approval evaluation for pharmaceutical products. At the time of Periactin syrup JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Periactin syrup suppliers with JDMF on PharmaCompass.

Periactin syrup CEP

A Periactin syrup CEP of the European Pharmacopoeia monograph is often referred to as a Periactin syrup Certificate of Suitability (COS). The purpose of a Periactin syrup CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Periactin syrup EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Periactin syrup to their clients by showing that a Periactin syrup CEP has been issued for it. The manufacturer submits a Periactin syrup CEP (COS) as part of the market authorization procedure, and it takes on the role of a Periactin syrup CEP holder for the record. Additionally, the data presented in the Periactin syrup CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Periactin syrup DMF.

A Periactin syrup CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Periactin syrup CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Periactin syrup suppliers with CEP (COS) on PharmaCompass.

Periactin syrup WC

A Periactin syrup written confirmation (Periactin syrup WC) is an official document issued by a regulatory agency to a Periactin syrup manufacturer, verifying that the manufacturing facility of a Periactin syrup active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Periactin syrup APIs or Periactin syrup finished pharmaceutical products to another nation, regulatory agencies frequently require a Periactin syrup WC (written confirmation) as part of the regulatory process.

click here to find a list of Periactin syrup suppliers with Written Confirmation (WC) on PharmaCompass.

Periactin syrup NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Periactin syrup as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Periactin syrup API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Periactin syrup as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Periactin syrup and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Periactin syrup NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Periactin syrup suppliers with NDC on PharmaCompass.

Periactin syrup GMP

Periactin syrup Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Periactin syrup GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Periactin syrup GMP manufacturer or Periactin syrup GMP API supplier for your needs.

Periactin syrup CoA

A Periactin syrup CoA (Certificate of Analysis) is a formal document that attests to Periactin syrup's compliance with Periactin syrup specifications and serves as a tool for batch-level quality control.

Periactin syrup CoA mostly includes findings from lab analyses of a specific batch. For each Periactin syrup CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Periactin syrup may be tested according to a variety of international standards, such as European Pharmacopoeia (Periactin syrup EP), Periactin syrup JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Periactin syrup USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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