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    Also known as: 25316-40-9, Doxorubicin hcl, Rubex, Adriacin, Adriblastina, Caelyx
    Molecular Formula
    C27H30ClNO11
    Molecular Weight
    580.0  g/mol
    InChI Key
    MWWSFMDVAYGXBV-RUELKSSGSA-N
    FDA UNII
    82F2G7BL4E
    Doxorubicin Hydrochloride
    Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
    1 2D Structure

    Doxorubicin Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
    2.1.2 InChI
    InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
    2.1.3 InChI Key
    MWWSFMDVAYGXBV-RUELKSSGSA-N
    2.1.4 Canonical SMILES
    CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl
    2.1.5 Isomeric SMILES
    C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    82F2G7BL4E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Adriablastin

    2. Adriablastine

    3. Adriamycin

    4. Adriblastin

    5. Adriblastina

    6. Adriblastine

    7. Adrimedac

    8. Doxo Cell

    9. Doxo-cell

    10. Doxolem

    11. Doxorubicin

    12. Doxorubicin Hexal

    13. Doxorubicin Nc

    14. Doxorubicina Ferrer Farm

    15. Doxorubicina Funk

    16. Doxorubicina Tedec

    17. Doxorubicine Baxter

    18. Doxotec

    19. Farmiblastina

    20. Hydrochloride, Doxorubicin

    21. Myocet

    22. Onkodox

    23. Ribodoxo

    24. Rubex

    25. Urokit Doxo Cell

    26. Urokit Doxo-cell

    2.3.2 Depositor-Supplied Synonyms

    1. 25316-40-9

    2. Doxorubicin Hcl

    3. Rubex

    4. Adriacin

    5. Adriblastina

    6. Caelyx

    7. Doxil

    8. Adriamycin Hydrochloride

    9. Doxorubicin (adriamycin) Hcl

    10. Adriamycin, Hydrochloride

    11. Doxorubicin (hydrochloride)

    12. Hydroxydaunorubicin Hydrochloride

    13. Adriablastina Cs

    14. Adriblastin

    15. Nsc 123127

    16. Hydroxydaunomycin Hydrochloride

    17. Mls001401460

    18. 82f2g7bl4e

    19. Adm Hydrochloride

    20. Lipodox

    21. Smr000058570

    22. Adriamycin Pfs

    23. Adriamycin Rdf

    24. Dsstox_cid_10636

    25. Dsstox_rid_78854

    26. Dsstox_rid_80678

    27. Dsstox_gsid_30636

    28. Dsstox_gsid_45111

    29. (8s,10s)-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

    30. (8s,10s)-10-{[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione Hydrochloride

    31. Adrosal

    32. Duxocin

    33. Doxorubicin Citric Acid Salt

    34. Adriamycin Hydrochloride-dna Complex

    35. Mls000028393

    36. Mfcd00077757

    37. Lipo-dox

    38. Fi 6804

    39. (7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;hydrochloride

    40. (8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione Hydrochloride

    41. Nsc-123127

    42. Sr-01000003049

    43. Kw-125

    44. Unii-82f2g7bl4e

    45. Resmycin

    46. Ccris 740

    47. Doxorubicin.hcl

    48. Doxorubicin Hydrochloride [jan]

    49. Doxorubicin, Hcl

    50. Adriamycin (tn)

    51. Adriacin (tn)

    52. (1s,3s)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-l-lyxo-hexopyranoside Hydrochloride

    53. (8s,10s)-10-((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

    54. (8s-cis)-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione Hydrochloride

    55. Prestwick_188

    56. Einecs 246-818-3

    57. Doxorubicin Hydrochloride [usp:jan]

    58. Doxil (tn)

    59. Rubex (tn)

    60. Cpd000058570

    61. Adriblastina Hydrochloride

    62. (8s,10s)-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracen

    63. Dox

    64. Adriamycin [iarc]

    65. Doxorubicini Hydrochloridum

    66. Ncgc00163543-01

    67. Schembl3242

    68. Cas-25316-40-9

    69. Mls000049969

    70. Mls000049970

    71. Mls000049971

    72. Mls000070047

    73. Mls000392861

    74. Mls000392871

    75. Mls000392881

    76. Mls000392891

    77. Mls000392901

    78. Mls000759533

    79. Mls001055359

    80. Doxorubicin Hydrochloride,(s)

    81. Chembl359744

    82. Dtxsid3030636

    83. Chebi:31522

    84. Doxorubicin Hydrochloride- Bio-x

    85. Doxorubicin Hydrochloride Solution

    86. Liposomal Doxorubicin Hydrochloride

    87. Bcpp000429

    88. Hms1569g18

    89. Kuc110341c

    90. Ex-a1337

    91. Tox21_110050

    92. Tox21_112061

    93. Tox21_202483

    94. Adriamycin (doxorubicin Hydrochloride

    95. S1208

    96. Akos007930231

    97. Akos015920241

    98. Doxorubicin Hydrochloride (jp17/usp)

    99. Tox21_110050_1

    100. Bcp9000237

    101. Ccg-100975

    102. Cs-1239

    103. Nc00225

    104. 2-chloro-4-fluorobenzenesulphonylchloride

    105. Doxorubicin Hydrochloride [mart.]

    106. Doxorubicin Hydrochloride [vandf]

    107. Doxorubicin Hydrochloride Liposome

    108. Ncgc00014486-01

    109. Ncgc00024415-33

    110. Ncgc00024415-36

    111. Ncgc00260032-01

    112. Ncgc00263918-03

    113. (8s,10s)-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride

    114. As-31687

    115. Bd164391

    116. Doxorubicin Hydrochloride [usp-rs]

    117. Doxorubicin Hydrochloride [who-dd]

    118. Doxorubicin Hydrochloride [who-ip]

    119. Hy-15142

    120. Ksc-230-184-1

    121. Doxorubicin Hydrochloride [ema Epar]

    122. D01275

    123. Doxorubicin Hydrochloride [ep Monograph]

    124. Doxorubicin Hydrochloride [orange Book]

    125. Doxorubicin Hydrochloride [usp Monograph]

    126. 316d409

    127. A817779

    128. Doxorubicin Hydrochloride Liposome [vandf]

    129. Doxorubicin Liposomal Complex Of The Hydrochloride

    130. Doxorubicini Hydrochloridum [who-ip Latin]

    131. Doxorubicin Hydrochloride, 98.0-102.0% (hplc)

    132. Imx-110 Component Doxorubicin Hydrochloride

    133. Liposomal Doxorubicin Hydrochloride [who-dd]

    134. Sr-01000003049-5

    135. Q27032359

    136. Sr-01000003049-10

    137. Z1557399790

    138. Doxorubicin Liposomal Complex Of The Hydrochloride [mi]

    139. Doxorubicin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    140. Doxorubicin Hydrochloride, Suitable For Fluorescence, 98.0-102.0% (hplc)

    141. Doxorubicin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    142. Doxorubicin Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    143. (8s,10s)-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride

    144. (8s,10s)-10-((3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride

    145. 10-[(3-amino-2,3,6-trideoxy-?-l-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione Hydrochloride

    146. 5,12-naphthacenedione, 10-((3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxylacetyl)-1-methoxy-, Hydrochloride (8s-cis)-

    147. 5,12-naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, Hydrochloride, (8s,10s)-

    148. 5,12-naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, Hydrochloride, (8s-cis)-

    149. 5,12-naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxylacetyl)-1-methoxy-, Hydrochloride (8s-cis)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 580.0 g/mol
    Molecular Formula C27H30ClNO11
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count5
    Exact Mass579.1507385 g/mol
    Monoisotopic Mass579.1507385 g/mol
    Topological Polar Surface Area206 Ų
    Heavy Atom Count40
    Formal Charge0
    Complexity977
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameDoxorubicin hydrochloride
    PubMed HealthDoxorubicin Hydrochloride Liposome (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin consists of a naphthacenequinone nucleus linked through a glycosidic bond at ring atom 7 to an amino sugar, daunosamine. Ch...
    Active IngredientDoxorubicin hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml; 10mg/vial; 200mg/100ml; 50mg/vial; 20mg/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Pharmachemie Bv; Onco Therapies; Sun Pharm Inds; Teva Pharms Usa; Sagent Pharms; Eurohlth Intl; Alvogen; Sandoz; Actavis

    2 of 2  
    Drug NameDoxorubicin hydrochloride
    PubMed HealthDoxorubicin Hydrochloride Liposome (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin consists of a naphthacenequinone nucleus linked through a glycosidic bond at ring atom 7 to an amino sugar, daunosamine. Ch...
    Active IngredientDoxorubicin hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml; 10mg/vial; 200mg/100ml; 50mg/vial; 20mg/vial
    Market StatusPrescription
    CompanyFresenius Kabi Usa; Pharmachemie Bv; Onco Therapies; Sun Pharm Inds; Teva Pharms Usa; Sagent Pharms; Eurohlth Intl; Alvogen; Sandoz; Actavis

    4.2 Drug Indication

    Myocet liposomal, in combination with cyclophosphamide, is indicated for the first-line treatment of metastatic breast cancer in adult women.

    Caelyx pegylated liposomal is indicated:

    - as monotherapy for patients with metastatic breast cancer , where there is an increased cardiac risk;

    - for treatment of advanced ovarian cancer in women who have failed a first-line platinum-based chemotherapy regimen;

    - in combination with bortezomib for the treatment of progressive multiple myeloma in patients who have received at least one prior therapy and who have already undergone or are unsuitable for bone marrow transplant;

    - for treatment of AIDS-related Kaposis sarcoma (KS) in patients with low CD4 counts (< 200 CD4 lymphocytes/mm3) and extensive mucocutaneous or visceral disease.

    Caelyx pegylated liposomal may be used as first-line systemic chemotherapy, or as second line chemotherapy in AIDS-KS patients with disease that has progressed with, or in patients intolerant to, prior combination systemic chemotherapy comprising at least two of the following agents: a vinca alkaloid, bleomycin and standarddoxorubicin (or other anthracycline).

    Treatment of breast and ovarian cancer .

    Treatment of hepatocellular carcinoma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

    Antibiotics, Antineoplastic

    Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Anthracyclines [CS]; Topoisomerase Inhibitors [MoA]; Anthracycline Topoisomerase Inhibitor [EPC]
    5.3 ATC Code

    L01DB01

    L01DB

    L01DB01

    API Reference Price

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    08-Feb-2022
    19-Apr-2025
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    Drugs in Development

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    HighField Files INDs for Two ADCplex Liposomes with Novel Payloads

    Details:

    HF158K1 is an investigational HER2-targeted immunoliposome therapy designed to deliver the chemotherapy drug doxorubicin to HER2-expressing tumor cells.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: HF158K1

    Study Phase: Phase IProduct Type: Cytotoxic Drug

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable April 21, 2025

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    01

    HighField Biopharmaceuticals

    China
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    HighField Biopharmaceuticals

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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    HighField Files INDs for Two ADCplex Liposomes with Novel Payloads

    Details : HF158K1 is an investigational HER2-targeted immunoliposome therapy designed to deliver the chemotherapy drug doxorubicin to HER2-expressing tumor cells.

    Product Name : HF158K1

    Product Type : Cytotoxic Drug

    Upfront Cash : Inapplicable

    April 21, 2025

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    Medicus’ SKNJCT-003 Shows Positive Interim Data in Basal Cell Carcinoma

    Details:

    D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 06, 2025

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    02

    Medicus Pharma

    Canada
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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Medicus’ SKNJCT-003 Shows Positive Interim Data in Basal Cell Carcinoma

    Details : D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Inapplicable

    March 06, 2025

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    Medicus Pharma Submits Phase 2 SKNJCT-004 Design for UAE BCC Treatment

    Details:

    D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable February 27, 2025

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    03

    Medicus Pharma

    Canada
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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Medicus Pharma Submits Phase 2 SKNJCT-004 Design for UAE BCC Treatment

    Details : D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Inapplicable

    February 27, 2025

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    Medicus Updates SKNJCT-003 Phase 2 Study for Nodular Basal Cell Carcinoma

    Details:

    D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable February 14, 2025

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    Medicus Pharma

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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Medicus Updates SKNJCT-003 Phase 2 Study for Nodular Basal Cell Carcinoma

    Details : D-MNA (doxorubicin) is a dissolvable transdermal patch featuring cellulose-based microneedle arrays loaded with doxorubicin. It is being evaluated for the treatment of nodular basal cell carcinoma.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Inapplicable

    February 14, 2025

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    Medicus Pharma Expands Phase 2 Study Collaboration in Asia Pacific

    Details:

    The collaboration aims to explore expansion of Phase 2 clinical study evaluating D-MNA, microneedle arrays containing doxorubicin for treatment of Basal Cell Carcinoma in the Asia-pacific region.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Swanielle Inc

    Deal Size: Undisclosed Upfront Cash: Undisclosed

    Deal Type: Collaboration December 02, 2024

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    Medicus Pharma

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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Swanielle Inc

    Deal Size : Undisclosed

    Deal Type : Collaboration

    DEALS_DEV arrow-down

    Medicus Pharma Expands Phase 2 Study Collaboration in Asia Pacific

    Details : The collaboration aims to explore expansion of Phase 2 clinical study evaluating D-MNA, microneedle arrays containing doxorubicin for treatment of Basal Cell Carcinoma in the Asia-pacific region.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Undisclosed

    December 02, 2024

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    Medicus Pharma Raises $4.0M Through Initial Public Offering in the United States

    Details:

    The Company intends to use the proceeds to fund its Phase 2 proof of concept trial for basal cell carcinoma using its doxorubicin tip loaded dissolvable microarray needle skinpatch, D-MNA.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Maxim Group LLC

    Deal Size: $4.0 million Upfront Cash: Undisclosed

    Deal Type: Public Offering November 19, 2024

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    Medicus Pharma

    Canada
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    Medicus Pharma Raises $4.0M Through Initial Public Offering in the United States

    Details : The Company intends to use the proceeds to fund its Phase 2 proof of concept trial for basal cell carcinoma using its doxorubicin tip loaded dissolvable microarray needle skinpatch, D-MNA.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Undisclosed

    November 19, 2024

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    Medicus Pharma Raises $4.0M in U.S. Initial Public Offering for Pipeline Growth

    Details:

    The Company intends to use the proceeds to fund its Phase 2 proof of concept trial for basal cell carcinoma using its doxorubicin tip loaded dissolvable microarray needle skinpatch, D-MNA.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: D-MNA

    Study Phase: Phase IIProduct Type: Cytotoxic Drug

    Sponsor: Maxim Group LLC

    Deal Size: $4.0 million Upfront Cash: Undisclosed

    Deal Type: Public Offering November 13, 2024

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    Medicus Pharma

    Canada
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    Global DDF Summit
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    Medicus Pharma

    Canada
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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Maxim Group LLC

    Deal Size : $4.0 million

    Deal Type : Public Offering

    DEALS_DEV arrow-down

    Medicus Pharma Raises $4.0M in U.S. Initial Public Offering for Pipeline Growth

    Details : The Company intends to use the proceeds to fund its Phase 2 proof of concept trial for basal cell carcinoma using its doxorubicin tip loaded dissolvable microarray needle skinpatch, D-MNA.

    Product Name : D-MNA

    Product Type : Cytotoxic Drug

    Upfront Cash : Undisclosed

    November 13, 2024

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    Lupin Introduces Doxorubicin Hydrochloride Liposome Injection in US

    Details:

    Doxorubicin hydrochloride is a DNA Topoisomerase-II inhibitor, indicated for the treatment of ovarian cancer, AIDS-related Kaposi’s sarcoma, and multiple myeloma.


    Lead Product(s): Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: Doxil-Generic

    Study Phase: Approved FDFProduct Type: Cytotoxic Drug

    Sponsor: ForDoz

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable August 29, 2024

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    Lupin Ltd

    India
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    Global DDF Summit
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    Lead Product(s) : Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : ForDoz

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Lupin Introduces Doxorubicin Hydrochloride Liposome Injection in US

    Details : Doxorubicin hydrochloride is a DNA Topoisomerase-II inhibitor, indicated for the treatment of ovarian cancer, AIDS-related Kaposi’s sarcoma, and multiple myeloma.

    Product Name : Doxil-Generic

    Product Type : Cytotoxic Drug

    Upfront Cash : Inapplicable

    August 29, 2024

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    Ordspono™ Approved in EU for Relapsed/Refractory Lymphoma Treatment

    Details:

    Ordspono (odronextamab) is a novel, CD20×CD3 bispecific antibody, which is being evaluated for the treatment of relapsed/refractory follicular lymphoma and in R/R diffuse large B-cell lymphoma.


    Lead Product(s): Odronextamab,Cyclophosphamide,Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: REGN1979

    Study Phase: Approved FDFProduct Type: Antibody

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable August 26, 2024

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    Regeneron Pharmaceuticals

    U.S.A
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    Global DDF Summit
    Not Confirmed

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    U.S.A
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    Not Confirmed
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    Lead Product(s) : Odronextamab,Cyclophosphamide,Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Ordspono™ Approved in EU for Relapsed/Refractory Lymphoma Treatment

    Details : Ordspono (odronextamab) is a novel, CD20×CD3 bispecific antibody, which is being evaluated for the treatment of relapsed/refractory follicular lymphoma and in R/R diffuse large B-cell lymphoma.

    Product Name : REGN1979

    Product Type : Antibody

    Upfront Cash : Inapplicable

    August 26, 2024

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    Odronextamab Recommended for EU Approval to Treat Relapsed/Refractory Lymphoma

    Details:

    REGN1979 (odronextamab) is a novel, CD20×CD3 bispecific antibody, which is being evaluated for the treatment of relapsed/refractory follicular lymphoma and in R/R diffuse large B-cell lymphoma.


    Lead Product(s): Odronextamab,Cyclophosphamide,Doxorubicin Hydrochloride

    Therapeutic Area: Oncology Brand Name: REGN1979

    Study Phase: Phase IIIProduct Type: Antibody

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 28, 2024

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    Regeneron Pharmaceuticals

    U.S.A
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    Global DDF Summit
    Not Confirmed

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    U.S.A
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    Not Confirmed
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    Lead Product(s) : Odronextamab,Cyclophosphamide,Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Odronextamab Recommended for EU Approval to Treat Relapsed/Refractory Lymphoma

    Details : REGN1979 (odronextamab) is a novel, CD20×CD3 bispecific antibody, which is being evaluated for the treatment of relapsed/refractory follicular lymphoma and in R/R diffuse large B-cell lymphoma.

    Product Name : REGN1979

    Product Type : Antibody

    Upfront Cash : Inapplicable

    June 28, 2024

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    01

    DR REDDYS

    India
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    CPhI China
    Booth #E1H28
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    RLD : No

    TE Code : AB

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

    Dosage Form : INJECTABLE, LIPOSOMAL;INJECTION

    Dosage Strength : 20MG/10ML (2MG/ML)

    Approval Date : 2017-05-15

    Application Number : 208657

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    02

    DR REDDYS

    India
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    CPhI China
    Booth #E1H28
    • fda
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    RLD : No

    TE Code : AB

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

    Dosage Form : INJECTABLE, LIPOSOMAL;INJECTION

    Dosage Strength : 50MG/25ML (2MG/ML)

    Approval Date : 2017-05-15

    Application Number : 208657

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    03

    AYANA PHARMA LTD

    Israel
    Global DDF Summit
    Not Confirmed
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    AYANA PHARMA LTD

    Israel
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    Global DDF Summit
    Not Confirmed
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    RLD : No

    TE Code : AB

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

    Dosage Form : INJECTABLE, LIPOSOMAL;INJECTION

    Dosage Strength : 50MG/25ML (2MG/ML)

    Approval Date : 2021-10-12

    Application Number : 207228

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    04

    BRISTOL MYERS SQUIBB

    U.S.A
    Global DDF Summit
    Not Confirmed
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    BRISTOL MYERS SQUIBB

    U.S.A
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    Global DDF Summit
    Not Confirmed
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    RLD : No

    TE Code :

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : RUBEX

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 10MG/VIAL

    Approval Date : 1989-04-13

    Application Number : 62926

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    05

    BRISTOL MYERS SQUIBB

    U.S.A
    Global DDF Summit
    Not Confirmed
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    BRISTOL MYERS SQUIBB

    U.S.A
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    Not Confirmed
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    RLD : No

    TE Code :

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : RUBEX

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 50MG/VIAL

    Approval Date : 1989-04-13

    Application Number : 62926

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    06

    HLTHCARE

    Bangladesh
    Global DDF Summit
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    HLTHCARE

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    Global DDF Summit
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    RLD : No

    TE Code :

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 2MG/ML

    Approval Date : 2012-07-18

    Application Number : 200146

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    07

    LUPIN

    India
    Global DDF Summit
    Not Confirmed
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    LUPIN

    India
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    Global DDF Summit
    Not Confirmed
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    RLD : No

    TE Code : AB

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

    Dosage Form : INJECTABLE, LIPOSOMAL;INJECTION

    Dosage Strength : 20MG/10ML (2MG/ML)

    Approval Date : 2024-07-16

    Application Number : 215178

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    PFIZER

    U.S.A
    Global DDF Summit
    Not Confirmed
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    PFIZER

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    RLD : No

    TE Code :

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 50MG/VIAL

    Approval Date : 1982-01-01

    Application Number : 50467

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    PFIZER

    U.S.A
    Global DDF Summit
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    PFIZER

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    RLD : No

    TE Code :

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 20MG/VIAL

    Approval Date : 1985-05-20

    Application Number : 50467

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    SAGENT PHARMS

    U.S.A
    Global DDF Summit
    Not Confirmed
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    SAGENT PHARMS

    U.S.A
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    RLD : No

    TE Code : AP

    DOXORUBICIN HYDROCHLORIDE

    Brand Name : DOXORUBICIN HYDROCHLORIDE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 2MG/ML

    Approval Date : 2013-03-18

    Application Number : 91495

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    DRUG PRODUCT COMPOSITIONS

    Do you need Business Intel? Ask us

    DOSAGE - INJECTABLE;INJECTION - 150MG/75ML

    USFDA APPLICATION NUMBER - 50629

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    DOSAGE - INJECTABLE;INJECTION - 200MG/100ML

    USFDA APPLICATION NUMBER - 50629

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    DOSAGE - INJECTABLE;INJECTION - 2MG/ML

    USFDA APPLICATION NUMBER - 50629

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    DOSAGE - INJECTABLE, LIPOSOMAL;INJECTION - 20...DOSAGE - INJECTABLE, LIPOSOMAL;INJECTION - 20MG/10ML (2MG/ML)

    USFDA APPLICATION NUMBER - 50718

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    DOSAGE - INJECTABLE, LIPOSOMAL;INJECTION - 50...DOSAGE - INJECTABLE, LIPOSOMAL;INJECTION - 50MG/25ML (2MG/ML)

    USFDA APPLICATION NUMBER - 50718

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    EDQM

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    01

    EDQM, Council of Europe

    Epirubicin hydrochloride

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    Europ. Pharma Outsourcing
    Not Confirmed

    01

    EDQM, Council of Europe

    France
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    Europ. Pharma Outsourcing
    Not Confirmed

    Epirubicin hydrochloride

    CAS Number : 56390-09-1

    Quantity Per Vial : 100 mg

    Sale Unit : 1

    Order Code : E0550000

    Batch No : 6

    Price (€) : 79

    Storage : -20°C ± 5°C

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    EDQM, Council of Europe

    Doxorubicin hydrochloride

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    EDQM, Council of Europe

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    Not Confirmed

    Doxorubicin hydrochloride

    CAS Number : 25316-40-9

    Quantity Per Vial : 150 mg

    Sale Unit : 1

    Order Code : D2975000

    Batch No : 7

    Price (€) : 79

    Storage : -20°C ± 5°C

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    ABOUT THIS PAGE

    Looking for 25316-40-9 / Doxorubicin Hydrochloride API manufacturers, exporters & distributors?

    Doxorubicin Hydrochloride manufacturers, exporters & distributors 1

    63

    PharmaCompass offers a list of Doxorubicin Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Doxorubicin Hydrochloride manufacturer or Doxorubicin Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Doxorubicin Hydrochloride manufacturer or Doxorubicin Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Doxorubicin Hydrochloride API Price utilized in the formulation of products. Doxorubicin Hydrochloride API Price is not always fixed or binding as the Doxorubicin Hydrochloride Price is obtained through a variety of data sources. The Doxorubicin Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Doxorubicin Hydrochloride

    Synonyms

    25316-40-9, Doxorubicin hcl, Rubex, Adriacin, Adriblastina, Caelyx

    Cas Number

    25316-40-9

    Unique Ingredient Identifier (UNII)

    82F2G7BL4E

    About Doxorubicin Hydrochloride

    Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

    Myocet Manufacturers

    A Myocet manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Myocet, including repackagers and relabelers. The FDA regulates Myocet manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Myocet API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

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    Myocet USDMF

    A Myocet DMF (Drug Master File) is a document detailing the whole manufacturing process of Myocet active pharmaceutical ingredient (API) in detail. Different forms of Myocet DMFs exist exist since differing nations have different regulations, such as Myocet USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Myocet DMF submitted to regulatory agencies in the US is known as a USDMF. Myocet USDMF includes data on Myocet's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Myocet USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Myocet suppliers with USDMF on PharmaCompass.

    Myocet JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Myocet Drug Master File in Japan (Myocet JDMF) empowers Myocet API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Myocet JDMF during the approval evaluation for pharmaceutical products. At the time of Myocet JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Myocet suppliers with JDMF on PharmaCompass.

    Myocet KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Myocet Drug Master File in Korea (Myocet KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Myocet. The MFDS reviews the Myocet KDMF as part of the drug registration process and uses the information provided in the Myocet KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Myocet KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Myocet API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Myocet suppliers with KDMF on PharmaCompass.

    Myocet CEP

    A Myocet CEP of the European Pharmacopoeia monograph is often referred to as a Myocet Certificate of Suitability (COS). The purpose of a Myocet CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Myocet EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Myocet to their clients by showing that a Myocet CEP has been issued for it. The manufacturer submits a Myocet CEP (COS) as part of the market authorization procedure, and it takes on the role of a Myocet CEP holder for the record. Additionally, the data presented in the Myocet CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Myocet DMF.

    A Myocet CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Myocet CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Myocet suppliers with CEP (COS) on PharmaCompass.

    Myocet WC

    A Myocet written confirmation (Myocet WC) is an official document issued by a regulatory agency to a Myocet manufacturer, verifying that the manufacturing facility of a Myocet active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Myocet APIs or Myocet finished pharmaceutical products to another nation, regulatory agencies frequently require a Myocet WC (written confirmation) as part of the regulatory process.

    click here to find a list of Myocet suppliers with Written Confirmation (WC) on PharmaCompass.

    Myocet NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Myocet as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Myocet API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Myocet as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Myocet and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Myocet NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Myocet suppliers with NDC on PharmaCompass.

    Myocet GMP

    Myocet Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Myocet GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Myocet GMP manufacturer or Myocet GMP API supplier for your needs.

    Myocet CoA

    A Myocet CoA (Certificate of Analysis) is a formal document that attests to Myocet's compliance with Myocet specifications and serves as a tool for batch-level quality control.

    Myocet CoA mostly includes findings from lab analyses of a specific batch. For each Myocet CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Myocet may be tested according to a variety of international standards, such as European Pharmacopoeia (Myocet EP), Myocet JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Myocet USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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