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Chemistry

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Also known as: 12650-69-0, Pseudomonic acid, Bactroban, Mupirocine, Centany, Pseudomonic acid a
Molecular Formula
C26H44O9
Molecular Weight
500.6  g/mol
InChI Key
MINDHVHHQZYEEK-HBBNESRFSA-N
FDA UNII
D0GX863OA5

Mupirocin
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Mupirocin is a RNA Synthetase Inhibitor Antibacterial. The mechanism of action of mupirocin is as a RNA Synthetase Inhibitor.
1 2D Structure

Mupirocin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
2.1.2 InChI
InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
2.1.3 InChI Key
MINDHVHHQZYEEK-HBBNESRFSA-N
2.1.4 Canonical SMILES
CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O
2.1.5 Isomeric SMILES
C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
2.2 Other Identifiers
2.2.1 UNII
D0GX863OA5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 14c-labeled Mupirocin

2. Bactroban

3. Brl 4910a

4. Brl-4910a

5. Brl4910a

6. Mupirocin Calcium

7. Mupirocin, 14c Labeled

8. Mupirocin, 14c-labeled

9. Mupirocin, Calcium Salt (2:1)

10. Mupirocin, Calcium Salt (2:1), Dihydrate

11. Mupirocin, Lithium Salt

12. Mupirocin, Sodium Salt

13. Pseudomonic Acid

14. Pseudomonic Acid A

2.3.2 Depositor-Supplied Synonyms

1. 12650-69-0

2. Pseudomonic Acid

3. Bactroban

4. Mupirocine

5. Centany

6. Pseudomonic Acid A

7. Bactoderm

8. Mupirocina

9. Mupirocinum

10. Turixin

11. Brl 4910a

12. Brl-4910a

13. Trans-pseudomonic Acid

14. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic Acid

15. Bactroban (tn)

16. Chembl719

17. Nsc-759182

18. Chebi:7025

19. D0gx863oa5

20. Mrc

21. Ncgc00164554-03

22. Plasimine

23. 80558-54-9

24. L-talo-non-2-enonic Acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2s,3s)-3-[(1s,2s)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl Ester, (2e)-

25. Mupirocine [french]

26. Mupirocinum [latin]

27. Mupirocina [spanish]

28. Bactroban Ointment

29. 9-(((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoic Acid

30. Centany (tn)

31. Mupirocin Neo-sensitabs

32. Mupirocin (usp/inn)

33. Sr-05000001947

34. Unii-d0gx863oa5

35. 1jzs

36. Mupirocin [usan:usp:inn:ban]

37. Mupirocin,(s)

38. 9-((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

39. Mfcd01711620

40. Cpd000471888

41. Mupirocin [inn]

42. Mupirocin [mi]

43. Mupirocin [usan]

44. Mupirocin [vandf]

45. Mupirocin [mart.]

46. Mupirocin [usp-rs]

47. Mupirocin [who-dd]

48. Schembl3291

49. Dsstox_cid_26438

50. Dsstox_rid_81614

51. Dsstox_gsid_46438

52. 8-carboxyoctyl (e)-4-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxytetrahydro-2h-pyran-2-yl)-3-methylcrotonat

53. Mls001074711

54. Bidd:gt0320

55. Mupirocin, Pseudomonic Acid A

56. Mupirocin [green Book]

57. Cid_446596

58. Schembl1027618

59. Mupirocin [orange Book]

60. Dtxsid0046438

61. Mupirocin [ep Monograph]

62. Mupirocin [usp Impurity]

63. Chebi:94519

64. Gtpl10916

65. Mupirocin [usp Monograph]

66. Hms2234e20

67. Hms3259l05

68. Hms3712k03

69. Pharmakon1600-01505706

70. Hy-b0958

71. Zinc4102194

72. Tox21_112183

73. Bdbm50290686

74. Nsc759182

75. Nsc815348

76. Akos015994756

77. Mupirocin, >=92% (hplc), Powder

78. Ccg-213522

79. Db00410

80. Fd12069

81. Ks-5137

82. Nc00620

83. Nsc 759182

84. Nsc-815348

85. Ncgc00164554-05

86. Ncgc00164554-06

87. (e)-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-beta-methyl-2h-pyran-2-crotonic Acid, Ester With 9-hydroxynonanoic Acid

88. As-11580

89. Smr000471888

90. Sbi-0206892.p001

91. Cas-12650-69-0

92. M2955

93. S4297

94. D01076

95. M-8680

96. Ab01563109_01

97. Mupirocin, Antibiotic For Culture Media Use Only

98. Q413578

99. Sr-05000001947-1

100. Sr-05000001947-2

101. Brd-k15262564-001-06-9

102. Mupirocin, United States Pharmacopeia (usp) Reference Standard

103. (2e)-5,9-anhydro-2,3,4,8-tetradeoxy-8-(((2s,3s)-3-((1s,2s)-2-hydroxy-1-methylpropyl)oxiranyl)methyl)-3-methyl-l-talo-non-2-enonic Acid, 8-carboxyoctyl Ester

104. (e)-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-.beta.-methyl-2h-pyran-2-crotonic Acid, Ester With 9-hydroxynonanoic Acid

105. 9-((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)-tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

106. 9-((e)-4-{(2s,3r,4r,5s)-3,4-dihydroxy-5-[(2s,3s)-3-((1s,2s)-2-hydroxy-1-methyl-propyl)-oxiranylmethyl]-tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)-nonanoic Acid

107. 9-({(2e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-({(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)tetrahydro-2h-pyran-2-yl]-3-methylbut-2-enoyl}oxy)nonanoic Acid

108. 9-(4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)-tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

109. 9-(4-{3,4-dihydroxy-5-[3-(2-hydroxy-1-methyl-propyl)-oxiranylmethyl]-tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)-nonanoic Acid (mupirocin)

110. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3- [(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] Oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic Acid

111. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3-[(1s,2s)-2-hydroxy-1-methyl-propyl]oxiran-2-yl]methyl]tetrahydropyran-2-yl]-3-methyl-but-2-enoyl]oxynonanoic Acid

112. 9-{[(2e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-{[(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic Acid

113. Nonanoic Acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2h-pyran-2-yl)-2-butenyl)oxy)-, (2s-(2.alpha.(e),3.beta.,4.beta.,5.alpha.(2r*,3r*(1r*,2r*))))-

114. Nonanoic Acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2h-pyran-2-yl)-2-butenyl)oxy)-, (2s-(2alpha(e),3beta,4beta,5alpha(2r*,3r*(1r*,2r*))))-

115. Rel-9-(((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoic Acid

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 500.6 g/mol
Molecular Formula C26H44O9
XLogP33
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count17
Exact Mass500.29853298 g/mol
Monoisotopic Mass500.29853298 g/mol
Topological Polar Surface Area146 Ų
Heavy Atom Count35
Formal Charge0
Complexity694
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameBactroban
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin calcium; Mupirocin
Dosage FormOintment; Cream
RouteNasal; Topical
Strength2%; eq 2% base
Market StatusPrescription
CompanyGlaxosmithkline

2 of 6  
Drug NameCentany
PubMed HealthMupirocin (On the skin)
Drug ClassesAntibacterial
Drug LabelEach gram of Centany (mupirocin ointment),2% contains 20 mg mupirocin in a soft white ointment base consisting of castor oil, oleyl alcohol, hard fat (Softisan 378) and propylene glycol monostearate. Mupirocin is a naturally occurring antibiotic. T...
Active IngredientMupirocin
Dosage FormOintment
RouteTopical
Strength2%
Market StatusPrescription
CompanyPerrigo New York

3 of 6  
Drug NameMupirocin
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin; Mupirocin calcium
Dosage FormOintment; Cream
RouteTopical
Strengtheq 2% base; 2%
Market StatusPrescription
CompanyGlenmark Pharms; Teva; Taro; Glenmark Generics; Fougera Pharms; Perrigo New York

4 of 6  
Drug NameBactroban
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin calcium; Mupirocin
Dosage FormOintment; Cream
RouteNasal; Topical
Strength2%; eq 2% base
Market StatusPrescription
CompanyGlaxosmithkline

5 of 6  
Drug NameCentany
PubMed HealthMupirocin (On the skin)
Drug ClassesAntibacterial
Drug LabelEach gram of Centany (mupirocin ointment),2% contains 20 mg mupirocin in a soft white ointment base consisting of castor oil, oleyl alcohol, hard fat (Softisan 378) and propylene glycol monostearate. Mupirocin is a naturally occurring antibiotic. T...
Active IngredientMupirocin
Dosage FormOintment
RouteTopical
Strength2%
Market StatusPrescription
CompanyPerrigo New York

6 of 6  
Drug NameMupirocin
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin; Mupirocin calcium
Dosage FormOintment; Cream
RouteTopical
Strengtheq 2% base; 2%
Market StatusPrescription
CompanyGlenmark Pharms; Teva; Taro; Glenmark Generics; Fougera Pharms; Perrigo New York

4.2 Drug Indication

Indicated for the treatment of impetigo and secondary skin infections, leading to traumatic skin lesions, due to _Staphylococcus aureus_ and _Streptococcus pyogenes_.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Mupirocin is reported to be active against susceptible aerobic gram-positive cocci, such as _Staphylococcus aureus_, _Staphylococcus epidermidis_, and other beta-hemolytic streptococci_Streptococcus pyogenes_. It mediates its antibacterial activity by inhibiting the bacterial protein synthesis and formation of bacterial proteins essential for survival. The minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC). In one clinical study investigating the therapeutic effectiveness of topical mupirocin in impetigo, the therapeutic response rate was about 94 to 98% after one week following the end of therapy. In clinical studies of patients with primary and secondary skin infections, both elimination of the bacterial pathogen and clinical cure or improvement hav been demonstrated in over 90% of patients receiving topical mupirocin. Mupirocin resistance as high as 81% has been reported previously. Resistance to mupirocin, which occurs more frequently in methicillin-resistant than methicillin-susceptible staphylococci, may occur with the production of a modified isoleucyl-tRNA synthetase, or the acquisition of, by genetic transfer, a plasmid mediating a new isoleucyl-tRNA synthetase.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
MUPIROCIN
5.3.2 FDA UNII
D0GX863OA5
5.3.3 Pharmacological Classes
RNA Synthetase Inhibitors [MoA]; RNA Synthetase Inhibitor Antibacterial [EPC]
5.4 ATC Code

D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AX - Other antibiotics for topical use

D06AX09 - Mupirocin


R - Respiratory system

R01 - Nasal preparations

R01A - Decongestants and other nasal preparations for topical use

R01AX - Other nasal preparations

R01AX06 - Mupirocin


5.5 Absorption, Distribution and Excretion

Absorption

Systemic or percutaneous absorption of mupirocin following dermal application is expected to be minimal in adults and children. Occlusive dressings do not significantly enhance drug absorption, but damaged skin may allow enhanced penetration of the drug across the skin barrier.


Route of Elimination

Any mupirocin reaching the systemic circulation is rapidly metabolized to form the inactive monic acid, which is eliminated by renal excretion. Following the application of Centany (mupirocin ointment),2% to a 400 cm2 area on the back of 23 healthy volunteers once daily for 7 days, the mean (range) cumulative urinary excretion of monic acid over 24 hrs following the last administration was 1.25% (0.2% to 3.0%) of the administered dose of mupirocin.


Volume of Distribution

No information available.


Clearance

No information available.


5.6 Metabolism/Metabolites

Following intravenous or oral administration, mupirocin undergoes rapid hepatic metabolism to form the principal metabolite monic acid, which has no antibacterial activity.


5.7 Biological Half-Life

In healthy male volunteers, the elimination half-life of mupirocin was about 20 to 40 minutes following intravenous administration. The elimination half-life of monic acid was about 30 to 80 minutes.


5.8 Mechanism of Action

Mupirocin specifically and reversibly binds to bacterial isoleucyl transfer-RNA (tRNA) synthetase, which is an enzyme that promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Inhibition of this enzyme subsequently leads to the inhibition of the bacterial protein and RNA synthesis. Mupirocin is bacteriostatic at lower concentrations but it exerts bactericidal effects with prolonged exposure, killing 90-99% of susceptible bacteria over a 24 hour period.


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LIMITED","customerCountry":"INDIA","quantity":"160.00","actualQuantity":"160","unit":"KGS","unitRateFc":"957","totalValueFC":"154625.1","currency":"USD","unitRateINR":"80675.1","date":"28-Jun-2024","totalValueINR":"12908016","totalValueInUsd":"154625.1","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"4222774","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719513000,"product":"MUPIROCIN IP","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"260.00","actualQuantity":"260","unit":"KGS","unitRateFc":"957","totalValueFC":"251265.8","currency":"USD","unitRateINR":"80675.1","date":"28-Jun-2024","totalValueINR":"20975526","totalValueInUsd":"251265.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"4229256","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720981800,"product":"MUPIROCIN USP (MUPIROCIN P) BATCH NO.80210100623","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLENMARK PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"2000","totalValueFC":"404110.1","currency":"USD","unitRateINR":"168900","date":"15-Jul-2024","totalValueINR":"33780000","totalValueInUsd":"404110.1","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"4509278","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING,PIET HEINKADE107,1019 GM AMSTERDAM.SDNF NETHERLANDS","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"MUPIROCIN USP (BATCH NO.230519MP\/15 KGS,230608MP\/115 KGS,230611MP\/135 KGS,230616MP\/135 KGS)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"CENTURY PHARMACEUTICALS LIMITED","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"GLENMARK PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"965","totalValueFC":"390470.5","currency":"USD","unitRateINR":"81880.3","date":"24-Aug-2024","totalValueINR":"32752100","totalValueInUsd":"390470.5","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5227858","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"801-2, 8\/F,EASEY COMMERCIALBUILDING,253-261 HENNESSY ROAD,WANCHAI,SDNF HONG KONG","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"MUPIROCIN IP","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"957","totalValueFC":"96808.4","currency":"USD","unitRateINR":"81201.5","date":"31-Aug-2024","totalValueINR":"8120145","totalValueInUsd":"96808.4","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5345310","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725215400,"product":"MUPIROCIN CALCIUM MICRONIZED","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"22.00","actualQuantity":"22","unit":"KGS","unitRateFc":"2125","totalValueFC":"47335.1","currency":"USD","unitRateINR":"180306.3","date":"02-Sep-2024","totalValueINR":"3966737.5","totalValueInUsd":"47335.1","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5374452","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Micronized","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1 07 1019 GM AMSTERDAM THE NETHERLAND S Netherlands Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"MUPIROCIN CALCIUM USP (MUPIROCIN CALCIUM MICRONIZED) (BATCHNO.83200300224)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLENMARK PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"7500","totalValueFC":"151429.8","currency":"USD","unitRateINR":"634500","date":"28-Sep-2024","totalValueINR":"12690000","totalValueInUsd":"151429.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5855324","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Micronized","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING,PIET HEINKADE107 ,1019 GM AMSTERDAM. SDNF NETHERLANDS","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"MUPIROCIN IP","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TEVA API BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"957","totalValueFC":"193224.4","currency":"USD","unitRateINR":"80962.2","date":"28-Sep-2024","totalValueINR":"16192440","totalValueInUsd":"193224.4","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5852756","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1 07 1019 GM AMSTERDAM THE NETHERLAND S Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733337000,"product":"MUPIROCIN IP","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TAPI NL BV","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"97.40","actualQuantity":"97.4","unit":"KGS","unitRateFc":"957","totalValueFC":"93629.8","currency":"USD","unitRateINR":"81680","date":"05-Dec-2024","totalValueINR":"7955627.13","totalValueInUsd":"93629.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"7065925","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEINKADE 55 1019 GM AMSTERDAM THE NETHERLANDS Amsterdam, , Nether lands Netherlands","customerAddress":"DR ANNIE BESANT ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737138600,"product":"MUPIROCIN IP MUPIROCIN IP","address":"DR ANNIE BESANT ROAD","city":"MUMBAI ,MAHARASHTRA","supplier":"TAPI NL BV","supplierCountry":"HUNGARY","foreign_port":"WILHELMSHAVEN","customer":"GLAXOSMITHKLINE PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"737.50","actualQuantity":"737.5","unit":"KGS","unitRateFc":"850","totalValueFC":"633205.6","currency":"USD","unitRateINR":"74035","date":"18-Jan-2025","totalValueINR":"54600812.5","totalValueInUsd":"633205.6","indian_port":"JNPT","hs_no":"29419090","bill_no":"7860282","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"WILHELMSHAVEN","supplierAddress":"PIET HEINKADE 55 1019 GM AMSTERDAM THE NETHERLANDS SDNF Netherlands","customerAddress":"DR ANNIE BESANT ROAD"}]
06-Jan-2022
25-Apr-2025
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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API Imports and Exports

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Average Price
(USD/KGS)
Number of Transactions

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FDF Dossiers

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01

Mupirocin

Brand Name : Banogon Ointment

Dosage Form : OIN

Dosage Strength : 2g/100g

Packaging : 15X1g/100g

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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02

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  • EDQM
  • WHO-GMP

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Regulatory Info :

Registration Country : India

Mupirocin; Fluticasone Propionate

Brand Name : Mupirocin; Fluticasone Propionate

Dosage Form : Ointment

Dosage Strength : 2%; 0.005%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

Octavius Pharma

03

IOPC
Not Confirmed
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IOPC
Not Confirmed

MUPIROCIN

Brand Name : MUPIROCIN

Dosage Form : OINTMENT;TOPICAL

Dosage Strength : 2%

Packaging :

Approval Date : 2005-11-30

Application Number : 65192

Regulatory Info : RX

Registration Country : USA

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04

IOPC
Not Confirmed
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IOPC
Not Confirmed

Mupirocin

Brand Name : Supiroban

Dosage Form : OIN

Dosage Strength : 20mg/g

Packaging : 14X1mg/g

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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05

GSK

United Kingdom
IOPC
Not Confirmed
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GSK

United Kingdom
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IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban

Dosage Form :

Dosage Strength : Cream Derm 15 G 2%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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06

GSK

United Kingdom
IOPC
Not Confirmed
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GSK

United Kingdom
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban Topical

Dosage Form : OIN

Dosage Strength : 2g/100g

Packaging : 10X1g/100g

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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07

IOPC
Not Confirmed
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IOPC
Not Confirmed

Mupirocin; Mometasone Furoate

Brand Name : Glorocin-M

Dosage Form : Ointment

Dosage Strength : 2%; 0.1%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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08

IOPC
Not Confirmed
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IOPC
Not Confirmed

Mupirocin

Brand Name : Medicianz Mupirocin Ointment

Dosage Form : ointment

Dosage Strength : 2%

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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09

IOPC
Not Confirmed
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IOPC
Not Confirmed

Mupirocin

Brand Name : Mupobel

Dosage Form : Ointment

Dosage Strength : 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Turkey

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10

IOPC
Not Confirmed
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IOPC
Not Confirmed

MUPIROCIN

Brand Name : MUPIROCIN

Dosage Form : OINTMENT;TOPICAL

Dosage Strength : 2%

Packaging :

Approval Date : 2003-11-07

Application Number : 65085

Regulatory Info : RX

Registration Country : USA

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Europe

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01

GlaxoSmithKline

United Kingdom
IOPC
Not Confirmed
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GlaxoSmithKline

United Kingdom
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IOPC
Not Confirmed

mupirocin

Brand Name : Bactroban

Dosage Form : OINTMENT

Dosage Strength : 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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02

GLAXOSMITHKLINE SpA

United Kingdom
IOPC
Not Confirmed
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GLAXOSMITHKLINE SpA

United Kingdom
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban

Dosage Form :

Dosage Strength : Ung Derm 15 G 2%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

GLAXOSMITHKLINE SpA

United Kingdom
IOPC
Not Confirmed
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GLAXOSMITHKLINE SpA

United Kingdom
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban

Dosage Form :

Dosage Strength : Cream Derm 15 G 2%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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04

IOPC
Not Confirmed
arrow
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Mupobel

Dosage Form : Cream

Dosage Strength : 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Turkey

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05

IOPC
Not Confirmed
arrow
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Mupobel

Dosage Form : Ointment

Dosage Strength : 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Turkey

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06

GLAXO ALLEN SpA

Country
IOPC
Not Confirmed
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GLAXO ALLEN SpA

Country
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Mupiskin

Dosage Form :

Dosage Strength : Ung Dern 15 G 2%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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07

Country
IOPC
Not Confirmed
arrow

Country
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Plasimine 20Mg/G 15G Ointment

Dosage Form : Ointment

Dosage Strength : 20 Mg/Ointment

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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08

Country
IOPC
Not Confirmed
arrow

Country
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Mupirocin Isdin 20Mg/G Ointment Tube 15G

Dosage Form : Ointment

Dosage Strength : 20 Mg/Ointment

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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09

Country
IOPC
Not Confirmed
arrow

Country
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban 20Mg/G 15G Ointment

Dosage Form : Ointment

Dosage Strength : 20 Mg/Ointment

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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10

Country
IOPC
Not Confirmed
arrow

Country
arrow
IOPC
Not Confirmed

Mupirocin

Brand Name : Bactroban 20Mg/G 30G Ointment

Dosage Form : Ointment

Dosage Strength : 20 Mg/Ointment

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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ABOUT THIS PAGE

Looking for 12650-69-0 / Mupirocin API manufacturers, exporters & distributors?

Mupirocin manufacturers, exporters & distributors 1

91

PharmaCompass offers a list of Mupirocin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mupirocin manufacturer or Mupirocin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Mupirocin manufacturer or Mupirocin supplier.

PharmaCompass also assists you with knowing the Mupirocin API Price utilized in the formulation of products. Mupirocin API Price is not always fixed or binding as the Mupirocin Price is obtained through a variety of data sources. The Mupirocin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Mupirocin

Synonyms

12650-69-0, Pseudomonic acid, Bactroban, Mupirocine, Centany, Pseudomonic acid a

Cas Number

12650-69-0

Unique Ingredient Identifier (UNII)

D0GX863OA5

About Mupirocin

A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.

Mupirocin Manufacturers

A Mupirocin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mupirocin, including repackagers and relabelers. The FDA regulates Mupirocin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mupirocin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Mupirocin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Mupirocin Suppliers

A Mupirocin supplier is an individual or a company that provides Mupirocin active pharmaceutical ingredient (API) or Mupirocin finished formulations upon request. The Mupirocin suppliers may include Mupirocin API manufacturers, exporters, distributors and traders.

click here to find a list of Mupirocin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Mupirocin USDMF

A Mupirocin DMF (Drug Master File) is a document detailing the whole manufacturing process of Mupirocin active pharmaceutical ingredient (API) in detail. Different forms of Mupirocin DMFs exist exist since differing nations have different regulations, such as Mupirocin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Mupirocin DMF submitted to regulatory agencies in the US is known as a USDMF. Mupirocin USDMF includes data on Mupirocin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Mupirocin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Mupirocin suppliers with USDMF on PharmaCompass.

Mupirocin KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Mupirocin Drug Master File in Korea (Mupirocin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Mupirocin. The MFDS reviews the Mupirocin KDMF as part of the drug registration process and uses the information provided in the Mupirocin KDMF to evaluate the safety and efficacy of the drug.

After submitting a Mupirocin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Mupirocin API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Mupirocin suppliers with KDMF on PharmaCompass.

Mupirocin CEP

A Mupirocin CEP of the European Pharmacopoeia monograph is often referred to as a Mupirocin Certificate of Suitability (COS). The purpose of a Mupirocin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Mupirocin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Mupirocin to their clients by showing that a Mupirocin CEP has been issued for it. The manufacturer submits a Mupirocin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Mupirocin CEP holder for the record. Additionally, the data presented in the Mupirocin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Mupirocin DMF.

A Mupirocin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Mupirocin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Mupirocin suppliers with CEP (COS) on PharmaCompass.

Mupirocin WC

A Mupirocin written confirmation (Mupirocin WC) is an official document issued by a regulatory agency to a Mupirocin manufacturer, verifying that the manufacturing facility of a Mupirocin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Mupirocin APIs or Mupirocin finished pharmaceutical products to another nation, regulatory agencies frequently require a Mupirocin WC (written confirmation) as part of the regulatory process.

click here to find a list of Mupirocin suppliers with Written Confirmation (WC) on PharmaCompass.

Mupirocin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Mupirocin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Mupirocin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Mupirocin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Mupirocin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Mupirocin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Mupirocin suppliers with NDC on PharmaCompass.

Mupirocin GMP

Mupirocin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mupirocin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mupirocin GMP manufacturer or Mupirocin GMP API supplier for your needs.

Mupirocin CoA

A Mupirocin CoA (Certificate of Analysis) is a formal document that attests to Mupirocin's compliance with Mupirocin specifications and serves as a tool for batch-level quality control.

Mupirocin CoA mostly includes findings from lab analyses of a specific batch. For each Mupirocin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mupirocin may be tested according to a variety of international standards, such as European Pharmacopoeia (Mupirocin EP), Mupirocin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mupirocin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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