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Chemistry

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Also known as: 93-60-7, Methyl pyridine-3-carboxylate, Nikomet, Methylnicotinate, Methyl-nicotinate, Nicometh
Molecular Formula
C7H7NO2
Molecular Weight
137.14  g/mol
InChI Key
YNBADRVTZLEFNH-UHFFFAOYSA-N
FDA UNII
7B1AVU9DJN

Methyl Nicotinate
heat spray is a natural product found in Chaenomeles speciosa, Coffea arabica, and other organisms with data available.
1 2D Structure

Methyl Nicotinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methyl pyridine-3-carboxylate
2.1.2 InChI
InChI=1S/C7H7NO2/c1-10-7(9)6-3-2-4-8-5-6/h2-5H,1H3
2.1.3 InChI Key
YNBADRVTZLEFNH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC(=O)C1=CN=CC=C1
2.2 Other Identifiers
2.2.1 UNII
7B1AVU9DJN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Methylnicotinate

2.3.2 Depositor-Supplied Synonyms

1. 93-60-7

2. Methyl Pyridine-3-carboxylate

3. Nikomet

4. Methylnicotinate

5. Methyl-nicotinate

6. Nicometh

7. Nicotinic Acid Methyl Ester

8. Methyl 3-pyridinecarboxylate

9. 3-(methoxycarbonyl)pyridine

10. 3-pyridinecarboxylic Acid, Methyl Ester

11. Heat Spray

12. Nicotinic Acid, Methyl Ester

13. 3-(carbomethoxy)pyridine

14. 3-picolinic Acid Methyl Ester

15. M-(methoxycarbonyl)pyridine

16. Fema No. 3709

17. Methyl Nicotinate [usan]

18. Nsc 13126

19. 3pyrcoome

20. 3-pyridinecarboxylic Acid Methyl Ester

21. Heat Spray (tn)

22. 3-carbomethoxypyridine

23. Nsc-13126

24. 7b1avu9djn

25. Methyl Nicotinate (usan)

26. Ncgc00159479-02

27. Methyl Ester Of Pyridine-3-carboxylic Acid

28. Wln: T6nj Cvo1

29. Dsstox_cid_24471

30. Dsstox_rid_80253

31. Dsstox_gsid_44471

32. Cas-93-60-7

33. Einecs 202-261-8

34. Unii-7b1avu9djn

35. Brn 0113951

36. Ai3-19241

37. Methyl Nicotinoate

38. Nicotinato De Metila

39. Nicotinato De Metilo

40. Nicotinato Di Metile

41. Mfcd00006388

42. Nicotinate De Methyle

43. Nicotinic Acid Methyl

44. Methyl Nicotinate, 99%

45. Methylpyridine-3-carboxylate

46. Schembl24566

47. 5-22-02-00059 (beilstein Handbook Reference)

48. Methyl Nicotinate [mi]

49. Chembl379845

50. Zinc1706

51. Dtxsid7044471

52. Methyl Nicotinate [fhfi]

53. Methyl Nicotinate [inci]

54. Fema 3709

55. Methyl Nicotinate [vandf]

56. Chebi:134761

57. Methyl Nicotinate [mart.]

58. Methyl Nicotinate, >=99%, Fg

59. Hms1775a18

60. Methyl Nicotinate [who-dd]

61. Cs-d1355

62. Hy-b1695

63. Nsc13126

64. Tox21_111702

65. Tox21_302038

66. Nsc403799

67. S6231

68. Stk803258

69. Methyl Nicotinate, Analytical Standard

70. Akos000119439

71. Tox21_111702_1

72. Db13882

73. Gs-3032

74. Nsc-403799

75. Methyl Nicotinate [ep Monograph]

76. Pyridine-3-carboxylic Acid Methyl Ester

77. Ncgc00159479-03

78. Ncgc00159479-05

79. Ncgc00255708-01

80. Ac-22482

81. Db-031973

82. Am20061626

83. Ft-0645164

84. N0086

85. Methyl Nicotinate Methyl 3-pyridinecarboxylate

86. Methyl Nicotinate, Puriss., >=99.0% (gc)

87. D04991

88. D87532

89. Ac-907/25014170

90. Sr-01000944497

91. Q-201381

92. Q3341206

93. Sr-01000944497-1

94. Methyl Nicotinate;methyl 3-pyridinecarboxylate

95. F0001-2240

96. Methyl Nicotinate, European Pharmacopoeia (ep) Reference Standard

97. Methyl Nicotinate, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 137.14 g/mol
Molecular Formula C7H7NO2
XLogP30.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass137.047678466 g/mol
Monoisotopic Mass137.047678466 g/mol
Topological Polar Surface Area39.2 Ų
Heavy Atom Count10
Formal Charge0
Complexity125
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Indicated for the temporary relief of aches and pains in muscles, tendons, and joints.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Following topical administration, methyl nicotinate acts as a peripheral vasodilator to enhance local blood flow at the site of application. It induced vasodilation of the peripheral blood capillaries which are located in the dermal papillae of upper dermis layers adjacent to the epidermisdermis junction. During tissue penetration at the dermis, methyl nicotinate is hydrolyzed to nicotinic acid. In human volunteers, topical administration of methyl nicotinate caused vasodilation-induced generalized cutaneous erythema.


5.2 Absorption, Distribution and Excretion

Absorption

The presence of methyl group facilitates the penetration of methyl nicotinate through the skin with good lipophilicity, allowing rapid absorption following topical administration. _In vitro_, about 80-90% of the polar compounds methyl nicotinate rapidly penetrated the skin. It was demonstrated in excised skin of hairless mice that methyl nicotinate can effectively bypass the stratum corneum layer of the skin. In humans, nicotinic acid and nicotinamide were shown to be rapidly absorbed from the stomach and intestine via a sodium carrier-mediated mechanism at low concentrations.


Route of Elimination

Following epicutaneous administration of small radiolabelled dose of methyl nicotinate in human volunteers, approximately 15% of the dose was recovered in the urine within 108 hours after treatment. The excretion of nicotinic acid mainly takes place in the kidneys.


Volume of Distribution

According to the animal studies, nicotinic acid is mainly concentrated in the liver, kidneys, and adipose tissue.


Clearance

No pharmacokinetic data available.


5.3 Metabolism/Metabolites

Methyl nicotinate undergoes ester hydrolysis to form nicotinic acid and methanol. The hydrolysis is thought to be mediated by nonspecific -naphthylacetate-esterase at the dermis layer of the skin.


5.4 Biological Half-Life

_In vitro_, the half-life of methyl nicotinate in the dermis was 3 to 10 minutes.


5.5 Mechanism of Action

While the mechanism of action of methyl nicotinate and other topically-administered nicotinic acid esters is not clear, it is thought that methyl nicotinate promotes the release of prostaglandin D2 that is strictly locally-acting due to its short half-life. It was demonstrated in human subjects that the local cutaneous vascular response to methyl nicotinic was suppressed by inhibitors of prostaglandin biosynthesis, indicating that the effect of methyl nicotinate on vascular smooth muscles may be mediated by the release of local prostaglandins. Prostaglandins released from the skin and blood vessels induce cutaneous vasodilation.


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ABOUT THIS PAGE

Looking for 93-60-7 / Methyl Nicotinate API manufacturers, exporters & distributors?

Methyl Nicotinate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Methyl Nicotinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Methyl Nicotinate manufacturer or Methyl Nicotinate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Methyl Nicotinate manufacturer or Methyl Nicotinate supplier.

API | Excipient name

Methyl Nicotinate

Synonyms

93-60-7, Methyl pyridine-3-carboxylate, Nikomet, Methylnicotinate, Methyl-nicotinate, Nicometh

Cas Number

93-60-7

Unique Ingredient Identifier (UNII)

7B1AVU9DJN

About Methyl Nicotinate

heat spray is a natural product found in Chaenomeles speciosa, Coffea arabica, and other organisms with data available.

Methyl Nicotinate Manufacturers

A Methyl Nicotinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methyl Nicotinate, including repackagers and relabelers. The FDA regulates Methyl Nicotinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methyl Nicotinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Methyl Nicotinate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

Methyl Nicotinate Suppliers

A Methyl Nicotinate supplier is an individual or a company that provides Methyl Nicotinate active pharmaceutical ingredient (API) or Methyl Nicotinate finished formulations upon request. The Methyl Nicotinate suppliers may include Methyl Nicotinate API manufacturers, exporters, distributors and traders.

click here to find a list of Methyl Nicotinate suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

Methyl Nicotinate WC

A Methyl Nicotinate written confirmation (Methyl Nicotinate WC) is an official document issued by a regulatory agency to a Methyl Nicotinate manufacturer, verifying that the manufacturing facility of a Methyl Nicotinate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Methyl Nicotinate APIs or Methyl Nicotinate finished pharmaceutical products to another nation, regulatory agencies frequently require a Methyl Nicotinate WC (written confirmation) as part of the regulatory process.

click here to find a list of Methyl Nicotinate suppliers with Written Confirmation (WC) on PharmaCompass.

Methyl Nicotinate GMP

Methyl Nicotinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Methyl Nicotinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Methyl Nicotinate GMP manufacturer or Methyl Nicotinate GMP API supplier for your needs.

Methyl Nicotinate CoA

A Methyl Nicotinate CoA (Certificate of Analysis) is a formal document that attests to Methyl Nicotinate's compliance with Methyl Nicotinate specifications and serves as a tool for batch-level quality control.

Methyl Nicotinate CoA mostly includes findings from lab analyses of a specific batch. For each Methyl Nicotinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Methyl Nicotinate may be tested according to a variety of international standards, such as European Pharmacopoeia (Methyl Nicotinate EP), Methyl Nicotinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methyl Nicotinate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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