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    Chemistry

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    Also known as: 169293-50-9, Nebivolol hcl, 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethanol) hydrochloride, 152520-56-4, Rac nebivolol hydrochloride, R 065824 hydrochloride
    Molecular Formula
    C22H26ClF2NO4
    Molecular Weight
    441.9  g/mol
    InChI Key
    JWEXHQAEWHKGCW-UHFFFAOYSA-N
    Nebivolol
    A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
    1 2D Structure

    Nebivolol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol;hydrochloride
    2.1.2 InChI
    InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H
    2.1.3 InChI Key
    JWEXHQAEWHKGCW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 67555, R

    2. Alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2h-1-benzopyran-2-methanol

    3. Bystolic

    4. Hydrochloride, Nebivolol

    5. Lobivon

    6. Nebilet

    7. Nebivolol

    8. R 67555

    9. R-67555

    10. R67555

    11. Silostar

    2.2.2 Depositor-Supplied Synonyms

    1. 169293-50-9

    2. Nebivolol Hcl

    3. 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethanol) Hydrochloride

    4. 152520-56-4

    5. Rac Nebivolol Hydrochloride

    6. R 065824 Hydrochloride

    7. Nebilox

    8. Rac-nebivolol Hcl

    9. R-067555

    10. Schembl514784

    11. N-phenyliminodiaceticacid

    12. Chembl1201731

    13. Akos016006035

    14. Ac-4233

    15. Ac-5636

    16. Ccg-214847

    17. Ro67555

    18. As-12100

    19. Cs-0362720

    20. Ft-0652243

    21. Ft-0655833

    22. 520n564

    23. W-60374

    24. J-010524

    25. 1-(6-fluoro-3,4-dihydro-2h-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2h-chromen-2-yl)-2-hydroxyethyl]amino]ethanol;hydrochloride

    26. 2h-1-benzopyran-2-methanol,a,a'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride(1:1)

    27. Alpha,alpha'[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2h-1-benzopyran-2-methanol]hydrochloride

    2.3 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 441.9 g/mol
    Molecular Formula C22H26ClF2NO4
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count6
    Exact Mass441.1518423 g/mol
    Monoisotopic Mass441.1518423 g/mol
    Topological Polar Surface Area71 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity483
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count4
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic beta-1 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Agonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

    API Reference Price

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MAHARASHTRA","supplier":"ZHEJIANG AUSUN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","customer":"GLENMARK PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"205.00","actualQuantity":"205","unit":"KGS","unitRateFc":"1820","totalValueFC":"376271.8","currency":"USD","unitRateINR":"153429.1","date":"10-Jul-2024","totalValueINR":"31452963","totalValueInUsd":"376271.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29329990","bill_no":"1005050","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","supplierAddress":"NO.5 DONGHAI 4TH AVENUE,ZHEJIANGCHE MICAL MATERIALS BASE LINHAIZONE,ZHE","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724610600,"product":"NEBIVOLOL HYDROCHLORIDE","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"ZHEJIANG AUSUN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GLENMARK PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"58.00","actualQuantity":"58","unit":"KGS","unitRateFc":"1811.2","totalValueFC":"106267.1","currency":"USD","unitRateINR":"153681.5","date":"26-Aug-2024","totalValueINR":"8913526","totalValueInUsd":"106267.1","indian_port":"Indore-EPZ\/SEZ","hs_no":"29329990","bill_no":"1006181","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724697000,"product":"NEBIVOLOL HYDROCHLORIDE","address":"98, GOVT.INDUSTRIAL AREA,","city":"MUMBAI.","supplier":"XXEJIXXG AXXUN XXARMXXEUTXXAL XXLTX","supplierCountry":"CHINA","foreign_port":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","customer":"AJANTA PHARMA LTD","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"2310","totalValueFC":"18694","currency":"USD","unitRateINR":"196003.5","date":"27-Aug-2024","totalValueINR":"1568028","totalValueInUsd":"18694","indian_port":"Dahez-SEZ","hs_no":"29329990","bill_no":"1004233","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","supplierAddress":"N\/A","customerAddress":"98, GOVT.INDUSTRIAL AREA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733941800,"product":"NEBIVOLOL HCL IH BATCH NO.NE23110028 & NE23110029 (INV NO.:SI3623123594 DT.29.11.2023)NEBIVOLOL HCL IH","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"MARCYRL PHARMACEUTICAL INDUSTRIES","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"HETERO DRUGS LTD","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"1355.9","totalValueFC":"102507.6","currency":"USD","unitRateINR":"116132.9","date":"12-Dec-2024","totalValueINR":"8709970.5","totalValueInUsd":"102507.6","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"7201054","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAIRO","supplierAddress":"THE WEST EXTENSION BLOCK 20005 OBOU R CITY, EGYPT OBOUR, Egypt SDNF Egypt","customerAddress":"7-2-A2, HETERO CORPORATE,"}]
    04-Jan-2022
    29-May-2025
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    DOSAGE - TABLET;ORAL - EQ 5MG BASE;80MG

    USFDA APPLICATION NUMBER - 206302

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    DOSAGE - TABLET;ORAL - EQ 10MG BASE

    USFDA APPLICATION NUMBER - 21742

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    DOSAGE - TABLET;ORAL - EQ 20MG BASE

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    DOSAGE - TABLET;ORAL - EQ 5MG BASE

    USFDA APPLICATION NUMBER - 21742

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    ABOUT THIS PAGE

    Looking for 152520-56-4 / Nebivolol API manufacturers, exporters & distributors?

    Nebivolol manufacturers, exporters & distributors 1

    38

    PharmaCompass offers a list of Nebivolol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nebivolol manufacturer or Nebivolol supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nebivolol manufacturer or Nebivolol supplier.

    PharmaCompass also assists you with knowing the Nebivolol API Price utilized in the formulation of products. Nebivolol API Price is not always fixed or binding as the Nebivolol Price is obtained through a variety of data sources. The Nebivolol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Nebivolol

    Synonyms

    169293-50-9, Nebivolol hcl, 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethanol) hydrochloride, 152520-56-4, Rac nebivolol hydrochloride, R 065824 hydrochloride

    Cas Number

    152520-56-4

    About Nebivolol

    A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

    Menarini brand of nebivolol hydrochloride Manufacturers

    A Menarini brand of nebivolol hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Menarini brand of nebivolol hydrochloride, including repackagers and relabelers. The FDA regulates Menarini brand of nebivolol hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Menarini brand of nebivolol hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Menarini brand of nebivolol hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Menarini brand of nebivolol hydrochloride Suppliers

    A Menarini brand of nebivolol hydrochloride supplier is an individual or a company that provides Menarini brand of nebivolol hydrochloride active pharmaceutical ingredient (API) or Menarini brand of nebivolol hydrochloride finished formulations upon request. The Menarini brand of nebivolol hydrochloride suppliers may include Menarini brand of nebivolol hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Menarini brand of nebivolol hydrochloride USDMF

    A Menarini brand of nebivolol hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Menarini brand of nebivolol hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Menarini brand of nebivolol hydrochloride DMFs exist exist since differing nations have different regulations, such as Menarini brand of nebivolol hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Menarini brand of nebivolol hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Menarini brand of nebivolol hydrochloride USDMF includes data on Menarini brand of nebivolol hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Menarini brand of nebivolol hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with USDMF on PharmaCompass.

    Menarini brand of nebivolol hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Menarini brand of nebivolol hydrochloride Drug Master File in Korea (Menarini brand of nebivolol hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Menarini brand of nebivolol hydrochloride. The MFDS reviews the Menarini brand of nebivolol hydrochloride KDMF as part of the drug registration process and uses the information provided in the Menarini brand of nebivolol hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Menarini brand of nebivolol hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Menarini brand of nebivolol hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with KDMF on PharmaCompass.

    Menarini brand of nebivolol hydrochloride CEP

    A Menarini brand of nebivolol hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Menarini brand of nebivolol hydrochloride Certificate of Suitability (COS). The purpose of a Menarini brand of nebivolol hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Menarini brand of nebivolol hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Menarini brand of nebivolol hydrochloride to their clients by showing that a Menarini brand of nebivolol hydrochloride CEP has been issued for it. The manufacturer submits a Menarini brand of nebivolol hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Menarini brand of nebivolol hydrochloride CEP holder for the record. Additionally, the data presented in the Menarini brand of nebivolol hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Menarini brand of nebivolol hydrochloride DMF.

    A Menarini brand of nebivolol hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Menarini brand of nebivolol hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Menarini brand of nebivolol hydrochloride WC

    A Menarini brand of nebivolol hydrochloride written confirmation (Menarini brand of nebivolol hydrochloride WC) is an official document issued by a regulatory agency to a Menarini brand of nebivolol hydrochloride manufacturer, verifying that the manufacturing facility of a Menarini brand of nebivolol hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Menarini brand of nebivolol hydrochloride APIs or Menarini brand of nebivolol hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Menarini brand of nebivolol hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Menarini brand of nebivolol hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Menarini brand of nebivolol hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Menarini brand of nebivolol hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Menarini brand of nebivolol hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Menarini brand of nebivolol hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Menarini brand of nebivolol hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Menarini brand of nebivolol hydrochloride suppliers with NDC on PharmaCompass.

    Menarini brand of nebivolol hydrochloride GMP

    Menarini brand of nebivolol hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Menarini brand of nebivolol hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Menarini brand of nebivolol hydrochloride GMP manufacturer or Menarini brand of nebivolol hydrochloride GMP API supplier for your needs.

    Menarini brand of nebivolol hydrochloride CoA

    A Menarini brand of nebivolol hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Menarini brand of nebivolol hydrochloride's compliance with Menarini brand of nebivolol hydrochloride specifications and serves as a tool for batch-level quality control.

    Menarini brand of nebivolol hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Menarini brand of nebivolol hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Menarini brand of nebivolol hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Menarini brand of nebivolol hydrochloride EP), Menarini brand of nebivolol hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Menarini brand of nebivolol hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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