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Chemistry

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Also known as: 63-91-2, 3-phenyl-l-alanine, (2s)-2-amino-3-phenylpropanoic acid, (s)-2-amino-3-phenylpropanoic acid, (s)-phenylalanine, (s)-2-amino-3-phenylpropionic acid
Molecular Formula
C9H11NO2
Molecular Weight
165.19  g/mol
InChI Key
COLNVLDHVKWLRT-QMMMGPOBSA-N
FDA UNII
47E5O17Y3R

Phenylalanine
An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
1 2D Structure

Phenylalanine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-amino-3-phenylpropanoic acid
2.1.2 InChI
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
2.1.3 InChI Key
COLNVLDHVKWLRT-QMMMGPOBSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)O)N
2.1.5 Isomeric SMILES
C1=CC=C(C=C1)C[C@@H](C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
47E5O17Y3R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Endorphenyl

2. L-isomer Phenylalanine

3. Phenylalanine, L Isomer

4. Phenylalanine, L-isomer

2.3.2 Depositor-Supplied Synonyms

1. 63-91-2

2. 3-phenyl-l-alanine

3. (2s)-2-amino-3-phenylpropanoic Acid

4. (s)-2-amino-3-phenylpropanoic Acid

5. (s)-phenylalanine

6. (s)-2-amino-3-phenylpropionic Acid

7. Beta-phenyl-l-alanine

8. (l)-phenylalanine

9. 3-phenylalanine

10. H-phe-oh

11. Antibiotic Fn 1636

12. L-alanine, Phenyl-

13. Alanine, 3-phenyl-

14. L-antibiotic Fn 1636

15. (s)-alpha-amino-beta-phenylpropionic Acid

16. L-alanine, 3-phenyl-

17. Phenylalanine (van)

18. Fenilalanina [spanish]

19. Phenylalaninum [latin]

20. (s)-alpha-aminohydrocinnamic Acid

21. Alanine, Phenyl-, L-

22. Fema No. 3585

23. (s)-(-)-phenylalanine

24. Beta-phenylalnine, (-)-

25. (s)-alpha-amino-benzenepropanoic Acid

26. Phenylalanine, L-

27. Hydrocinnamic Acid, Alpha-amino-

28. 2-amino-3-phenylpropionic Acid, L-

29. Phenylalanine [usan:inn:jan]

30. Hsdb 1825

31. Alpha-aminohydrocinnamic Acid, L-

32. Alpha-amino-beta-phenylpropionic Acid, L-

33. Benzenepropanoic Acid, Alpha-amino-, (s)-

34. Fenilalanina

35. Phe

36. Alpha-aminohydrocinnamic Acid

37. Endophenyl

38. Nsc 79477

39. L-phe

40. Laevo-phenyl Alanine

41. 67675-33-6

42. L-phenylalinine

43. Chembl301523

44. Chebi:17295

45. 47e5o17y3r

46. Nsc-79477

47. Phenylalaninum

48. Mfcd00064227

49. Phenylalamine

50. Phenylalanine (l-phenylalanine)

51. Alanine, Phenyl-

52. .beta.-phenylalanine

53. Phenyl-.alpha.-alanine

54. L-.beta.-phenylalanine

55. .beta.-phenyl-l-alanine

56. (-)-.beta.-phenylalanine

57. Einecs 200-568-1

58. .alpha.-aminohydrocinnamic Acid

59. .beta.-phenyl-.alpha.-alanine

60. Phenylalanine (usp/inn)

61. L-phenylaniline

62. Hydrocinnamic Acid, .alpha.-amino-

63. Unii-47e5o17y3r

64. Ccris 4254

65. .beta.-phenyl-.alpha.-alanine, L-

66. L-phenyl Alanine

67. Pheoh

68. 1usi

69. Nci9959

70. (-)-phenylalanine

71. .alpha.-amino-.beta.-phenylpropionic Acid

72. Racemic Phenylalanine

73. Phenylalanine [usan:usp:inn:jan]

74. 1f2p

75. Alpha-aminohydrocinnamate

76. (-)-beta-phenylalanine

77. L-phenylalanine, 99%

78. Beta-phenyl-alpha-alanine

79. L-phenylalanine (jp17)

80. Phenylalanine [ii]

81. Phenylalanine [mi]

82. Bmse000045

83. Bmse000900

84. Bmse000921

85. Bmse001016

86. Phenylalanine [inn]

87. Schembl8119

88. Ncistruc1_000204

89. Ncistruc2_000248

90. H-phe-2-chlorotrityl Resin

91. Phenylalanine [hsdb]

92. Phenylalanine [inci]

93. Phenylalanine [usan]

94. L-(-)-phenylalanine

95. Phenylalanine [vandf]

96. (s)-alpha-aminohydrocinnamate

97. L-phenylalanine (h-phe-oh)

98. L-phenylalanine [fcc]

99. L-phenylalanine [jan]

100. Phenylalanine [mart.]

101. L-2-amino-3-phenylpropionate

102. L-phenylalanine [fhfi]

103. L-phenylalanine, 99%, Fcc

104. Phenylalanine [who-dd]

105. Gtpl3313

106. (s)-alpha-aminobenzenepropanoate

107. 3-amino-4-phenyl-butanoic Acid

108. Dtxsid4040763

109. (s)-2-amino-3-phenylpropanoate

110. Bdbm18073

111. (s)-2-amino-3-phenylpropionate

112. 1f9436b3-8b0d-4ac6-a004-4249b0bda436

113. L-phenylalanine [usp-rs]

114. L-phenylalanine Non-animal Source

115. (s)-alpha-amino-benzenepropanoate

116. L-2-amino-3-phenylpropionic Acid

117. Zinc105196

118. Hy-n0215

119. L-2-amino-3-phenyl-propionic Acid

120. Phenylalanine [ep Monograph]

121. (s)-alpha-aminobenzenepropanoic Acid

122. Ac8117

123. Ccg-37572

124. Ncgc00013103

125. Phenylalanine [usp Monograph]

126. L-[2,3,4,5,6-3h]phenylalanine

127. (s)-alpha-amino-beta-phenylpropionate

128. Akos010373257

129. Akos015853585

130. (s)-.alpha.-aminobenzenepropanoic Acid

131. Db00120

132. L-phenylalanine, Vetec(tm), 98.5%

133. L-phenylalanine, Reagent Grade, >=98%

134. Leucine Impurity C [ep Impurity]

135. Ncgc00013103-02

136. Ncgc00013103-03

137. Ncgc00013103-04

138. Ncgc00013103-05

139. Ncgc00095047-01

140. Ncgc00095047-02

141. Ncgc00095047-03

142. Ncgc00095047-04

143. Ac-22417

144. As-14129

145. Bp-20538

146. Tyrosine Impurity A [ep Impurity]

147. Db-029978

148. L-phenylalanine, 99%, Natural, Fcc, Fg

149. Am20060774

150. Nateglinide Impurity D [ep Impurity]

151. P0134

152. Benzenepropanoic Acid, .alpha.-amino-, (s)-

153. L-phenylalanine, Bioultra, >=99.0% (nt)

154. 63p912

155. A20654

156. C00079

157. D00021

158. M02961

159. L-phenylalanine, Saj Special Grade, >=99.0%

160. Q170545

161. L-.alpha.-amino-.beta.-phenylpropionic Acid

162. L-phenylalanine, Vetec(tm) Reagent Grade, >=98%

163. Q-201326

164. L-phenylalanine, Cell Culture Reagent (h-l-phe-oh)

165. Lysine Hydrochloride Impurity B [ep Impurity]

166. F0001-2360

167. Z1258578341

168. L-phenylalanine, Certified Reference Material, Tracecert(r)

169. Phenylalanine, European Pharmacopoeia (ep) Reference Standard

170. 3-(2-aminoethyl)-1,3-thiazolidine-2,4-dionehydrochloride

171. L-phenylalanine, United States Pharmacopeia (usp) Reference Standard

172. L(-)-phenylalanine; Beta-phenylalanine;dl-2-amino-3-phenylpropanoic Acid;

173. L-phenylalanine, Analytical Standard, For Nitrogen Determination According To Kjeldahl Method

174. L-phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material

175. L-phenylalanine, From Non-animal Source, Meets Ep, Jp, Usp Testing Specifications, Suitable For Cell Culture, 98.5-101.0%

176. L-phenylalanine, Pharmagrade, Ajinomoto, Ep, Jp, Usp, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production, Suitable For Cell Culture

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 165.19 g/mol
Molecular Formula C9H11NO2
XLogP3-1.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass165.078978594 g/mol
Monoisotopic Mass165.078978594 g/mol
Topological Polar Surface Area63.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity153
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


/EXPTL TREATMENT/ There is no totally effective treatment for vitiligo (localised hypopigmentation). Oral or topical photochemotherapy with psoralens is generally considered to be the best available treatment, but experimental therapy includes UVA phototherapy with phenylalanine. Use of phenylalanine in oral doses of up to 100 mg/kg with UVA/sunlight led to beneficial results in more than 90% of 200 patients with vitiligo. Greatest benefit was noted in early disease, but prolonged use still induced repigmentation in long-standing cases. Repigmentation occurred mainly in areas rich in follicles. Such therapy is contra-indicated in phenylketonuria and in pregnancy. Similarly a further open study reported responses in 94 of 149 patients receiving 50 to 100 mg/kg daily of phenylalanine plus twice weekly UVA treatment. However, only 22% of responders had repigmentation in more than 60% of the affected area. Higher doses did not seem to be more effective than 50 mg/kg daily. Another group reported on 6 years of experience of treatment of vitiligo using 50 or 100 mg/kg daily of phenylalanine, with application of 10% phenylalanine gel and daily sun exposure. Although not ideal, they considered the treatment useful, especially for its ability to rapidly repigment the face. The same group performed an open study, adding topical 0.025% clobetasol propionate, and ultraviolet exposure during autumn and winter; 65.5% of patients achieved 100% repigmentation on the face.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1960.


/Experimental Therapy/ L-Phenylalanine (Phe), is a potent releaser of the satiety hormone, cholecystokinin (CCK) and previous studies, conducted primarily in men, show that ingestion of Phe reduces energy intake. The objective of the current study was to test the effects of Phe on energy intake in overweight and obese women. Subjects (n =3 2) received three treatments (high-dose (10 g Phe), low-dose (5 g Phe and 5 g glucose) or control (10 g glucose)) 20 min before an ad libitum lunch and dinner meal in a within-subjects', counterbalanced, double-blind study. No effect of Phe was found; however, interactions with dietary restraint status were detected in post-hoc analyses.

PMID:18342398 Pohle-Krauza RJ, et al; Appetite 51 (1): 111-9 (2008).


/Experimental Therapy/ L-phenylalanine in combination with 0.025% clobetasol propionate and sunlight during sunny months or UVA lamps in winter, appears to improve evolutive vitiligo without side effects, and therefore is especially recommended on the face or for children.

PMID:12847735 Camacho F, Mazuecos J; J Drugs Dermatol 1 (2): 127-31 (2002).


For more Therapeutic Uses (Complete) data for (L)-Phenylalanine (7 total), please visit the HSDB record page.


4.2 Drug Warning

Overweight and obese women (n = 32) received three treatments (high-dose (10 g Phe), low-dose (5 g Phe and 5 g glucose) or control (10 g glucose)) 20 min before an ad libitum lunch and dinner meal. High-dose Phe increased ratings of nausea.

PMID:18342398 Pohle-Krauza RJ, et al; Appetite 51 (1): 111-9 (2008).


4.3 Drug Indication

L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Used by the brain to produce Norepinephrine, a chemical that transmits signals between nerve cells and the brain; keeps you awake and alert; reduces hunger pains; functions as an antidepressant and helps improve memory.


5.2 Absorption, Distribution and Excretion

Absorption

Absorbed from the small intestine by a sodium dependent active transport process.


... It diffuses across placental membrane reaching higher fetal than maternal levels. In rhesus monkey when serum maternal levels are 1-2 mg/100 mL near full term there is an approx 1.5:1 diffusion rate, but when maternal levels ... high (25 mg/100 mL) fetal serum ... reach 45 mg/100 mL to detriment of fetus. /Phenylalanine/

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 448


Although the free amino acids dissolved in the body fluids are only a very small proportion of the body's total mass of amino acids, they are very important for the nutritional and metabolic control of the body's proteins. ... Although the plasma compartment is most easily sampled, the concentration of most amino acids is higher in tissue intracellular pools. Typically, large neutral amino acids, such as leucine and phenylalanine, are essentially in equilibrium with the plasma. Others, notably glutamine, glutamic acid, and glycine, are 10- to 50-fold more concentrated in the intracellular pool. Dietary variations or pathological conditions can result in substantial changes in the concentrations of the individual free amino acids in both the plasma and tissue pools.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). National Academy Press, Washington, D.C., pg. 596, 2009. Available from, as of March 10, 2010: https://www.nap.edu/catalog/10490.html


Table: Comparison of the Pool Sizes of Free and Protein-Bound Amino Acids in Rat Muscle [Table#3670]

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). National Academy Press, Washington, D.C., pg. 597, 2009. Available from, as of March 10, 2010: https://www.nap.edu/catalog/10490.html


[Table#3670]


After ingestion, proteins are denatured by the acid in the stomach, where they are also cleaved into smaller peptides by the enzyme pepsin, which is activated by the increase in stomach acidity that occurs on feeding. The proteins and peptides then pass into the small intestine, where the peptide bonds are hydrolyzed by a variety of enzymes. These bondspecific enzymes originate in the pancreas and include trypsin, chymotrypsins, elastase, and carboxypeptidases. The resultant mixture of free amino acids and small peptides is then transported into the mucosal cells by a number of carrier systems for specific amino acids and for di- and tri-peptides, each specific for a limited range of peptide substrates. After intracellular hydrolysis of the absorbed peptides, the free amino acids are then secreted into the portal blood by other specific carrier systems in the mucosal cell or are further metabolized within the cell itself. Absorbed amino acids pass into the liver, where a portion of the amino acids are taken up and used; the remainder pass through into the systemic circulation and are utilized by the peripheral tissues. /Amino acids/

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). National Academy Press, Washington, D.C., pg. 599, 2009. Available from, as of March 10, 2010: https://www.nap.edu/catalog/10490.html


For more Absorption, Distribution and Excretion (Complete) data for (L)-Phenylalanine (13 total), please visit the HSDB record page.


5.3 Metabolism/Metabolites

Hepatic. L-phenylalanine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body, where it undergoes metabolic reactions similar to those that take place in the liver.


Pathways of amino acid metabolism- L-phenylalanine; product of oxidative deamination or transamination: phenylpyruvic acid. Product of decarboxylation: phenylethylamine. Phenylalanine to tyrosine.

Fenaroli's Handbook of Flavor Ingredients. Volume 2. Edited, translated, and revised by T.E. Furia and N. Bellanca. 2nd ed. Cleveland: The Chemical Rubber Co., 1975., p. 831


L-Phenylalanine yields in man: N-acetyl-L-phenylalanine; benzoic acid; probably in man, 2,5-dihydroxy-L-phenylalanine. /From table/

Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 15


L-Phenylalanine yields in man: phenethylamine; phenylpyruvic acid; L-tyrosine. /From table/

Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 16


L-Phenylalanine yields L-m-tyrosine in rat. /From table/

Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 16


For more Metabolism/Metabolites (Complete) data for (L)-Phenylalanine (12 total), please visit the HSDB record page.


5.4 Mechanism of Action

The supposed antidepressant effects of L-phenylalanine may be due to its role as a precursor in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
The mechanism of L-phenylalanine's possible antivitiligo activity is not well understood. It is thought that L-phenylalanine may stimulate the production of melanin in the affected skin


Amino acids are selected for protein synthesis by binding with transfer RNA (tRNA) in the cell cytoplasm. The information on the amino acid sequence of each individual protein is contained in the sequence of nucleotides in the messenger RNA (mRNA) molecules, which are synthesized in the nucleus from regions of DNA by the process of transcription. The mRNA molecules then interact with various tRNA molecules attached to specific amino acids in the cytoplasm to synthesize the specific protein by linking together individual amino acids; this process, known as translation, is regulated by amino acids (e.g., leucine), and hormones. Which specific proteins are expressed in any particular cell and the relative rates at which the different cellular proteins are synthesized, are determined by the relative abundances of the different mRNAs and the availability of specific tRNA-amino acid combinations, and hence by the rate of transcription and the stability of the messages. From a nutritional and metabolic point of view, it is important to recognize that protein synthesis is a continuing process that takes place in most cells of the body. In a steady state, when neither net growth nor protein loss is occurring, protein synthesis is balanced by an equal amount of protein degradation. The major consequence of inadequate protein intakes, or diets low or lacking in specific indispensable amino acids relative to other amino acids (often termed limiting amino acids), is a shift in this balance so that rates of synthesis of some body proteins decrease while protein degradation continues, thus providing an endogenous source of those amino acids most in need. /Amino acids/

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). National Academy Press, Washington, D.C., pg. 601-602, 2009. Available from, as of March 10, 2010: https://www.nap.edu/catalog/10490.html


The mechanism of intracellular protein degradation, by which protein is hydrolyzed to free amino acids, is more complex and is not as well characterized at the mechanistic level as that of synthesis. A wide variety of different enzymes that are capable of splitting peptide bonds are present in cells. However, the bulk of cellular proteolysis seems to be shared between two multienzyme systems: the lysosomal and proteasomal systems. The lysosome is a membrane-enclosed vesicle inside the cell that contains a variety of proteolytic enzymes and operates mostly at acid pH. Volumes of the cytoplasm are engulfed (autophagy) and are then subjected to the action of the protease enzymes at high concentration. This system is thought to be relatively unselective in most cases, although it can also degrade specific intracellular proteins. The system is highly regulated by hormones such as insulin and glucocorticoids, and by amino acids. The second system is the ATP-dependent ubiquitin-proteasome system, which is present in the cytoplasm. The first step is to join molecules of ubiquitin, a basic 76-amino acid peptide, to lysine residues in the target protein. Several enzymes are involved in this process, which selectively targets proteins for degradation by a second component, the proteasome. /Amino acids/

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). National Academy Press, Washington, D.C., pg. 602, 2009. Available from, as of March 10, 2010: https://www.nap.edu/catalog/10490.html


API Reference Price

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CHINA SDNF China","customerAddress":"5TH FLOOR , CLARIS CORPORATE HQ"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741285800,"product":"L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE","address":"2ND FLOOR, SERENE CHAMBERS,,ROAD N","city":"HYDEABAD,TELANGANA","supplier":"SICHUAN TONGSHENG BIOPHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"LAURUS LABS LIMITED","customerCountry":"INDIA","quantity":"18.00","actualQuantity":"18","unit":"KGS","unitRateFc":"100","totalValueFC":"1824.6","currency":"USD","unitRateINR":"8780","date":"07-Mar-2025","totalValueINR":"158040","totalValueInUsd":"1824.6","indian_port":"Hyderabad Air","hs_no":"29225090","bill_no":"8757642","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"NO, 23 OF YONGDINGHE WEST ROAD, TIA NYUAN DEVELOPMENT ZONE, DEYANG, 618 000 SICHUAN, CHINA China","customerAddress":"2ND FLOOR, SERENE CHAMBERS,,ROAD N"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741977000,"product":"ALPHA-KETOPHENYLALANINE CALCIUM ALPHA-KETOPHENYLALANINE CALCIUM","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"HEBEI YIPIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SUN PHARMA LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"35","totalValueFC":"6386","currency":"USD","unitRateINR":"3073","date":"15-Mar-2025","totalValueINR":"553140","totalValueInUsd":"6386","indian_port":"JNPT","hs_no":"29222990","bill_no":"8902943","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"SANXIA ROAD, ECONOMY TECHNOLOGY ARE A OF SHIJIAZHUANG HEBEI, CHINA Hebe i, , China China","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742236200,"product":"P5482-BULK L-PHENYLALANINE MEETS EP, JP, & (LABORATORY CHEMICALS) (520 MG)P5482-BULK L-PHENYLALANINE MEETS EP, JP, & (LABORATORY CHEMI","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK","city":"BANGALORE","supplier":"SIGMA ALDRICH MANUFACTURING LLC","supplierCountry":"JAPAN","foreign_port":"CHICAGO, IL","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.52","actualQuantity":"0.52","unit":"KGS","unitRateFc":"60.5","totalValueFC":"31.9","currency":"USD","unitRateINR":"5314.2","date":"18-Mar-2025","totalValueINR":"2763.36","totalValueInUsd":"31.9","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"8952549","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO, IL","supplierAddress":"3050 SPRUCE STREET ST.LOUIS, MO,631 03 United States, , United States SDNF United States","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1743791400,"product":"L-PHENYLALANINE L-PHENYLALANINE","address":"PLOT No 74 B J N PHARMA CITY","city":"Visakhapatnam","supplier":"NANJING GREENWAY LIFESCIENCE CO LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"LAURUS SYNTHESIS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"213","totalValueFC":"215.5","currency":"USD","unitRateINR":"18445.8","date":"05-Apr-2025","totalValueINR":"18445.8","totalValueInUsd":"215.5","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"9312445","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ROOM 501,BUILDING 9TH,NO.6 JINMA RO AD,MAQUN QIXIA,NANJING,JIANGSU,2100 49 CHINA. China","customerAddress":"PLOT No 74 B J N PHARMA CITY"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1743964200,"product":"BOC-2,6-DIMETHYL-4-CARBOXAMIDO-L-PHENYLALANINE BOC-2,6-DIMETHYL-4-CARBOXAMIDO-L","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"CHIRAL QUEST (SUZHOU) CO LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"PIRAMAL PHARMA LIMITED","customerCountry":"INDIA","quantity":"1660.00","actualQuantity":"1660","unit":"KGS","unitRateFc":"1198.3","totalValueFC":"2012426.7","currency":"USD","unitRateINR":"103775.5","date":"07-Apr-2025","totalValueINR":"172267307.2","totalValueInUsd":"2012426.7","indian_port":"Hyderabad Air","hs_no":"29242990","bill_no":"9348977","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"Room 509, Building A1 south, 218 Xinghu Street,SIP, Suzhou,Jiangsu 215123, China CHINA","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744569000,"product":"BOC-L-HOMOPHENYLALANINE BOC-L-HOMOPHENYLALANINE","address":"2ND FLOOR, SERENE CHAMBERS,","city":"","supplier":"LEVACHEM COLTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"LAURUS LABS LIMITED","customerCountry":"INDIA","quantity":"18.00","actualQuantity":"18","unit":"KGS","unitRateFc":"310","totalValueFC":"5645.1","currency":"USD","unitRateINR":"26846","date":"14-Apr-2025","totalValueINR":"483228","totalValueInUsd":"5645.1","indian_port":"Hyderabad Air","hs_no":"29242990","bill_no":"9474784","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"SUNING UNIVERSAL MANSION, 188 GUANG ZHOU ROAD, NANJING 210024,CHINA SDNF China","customerAddress":"2ND FLOOR, SERENE CHAMBERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744828200,"product":"ALPHA-KETOPHENYLALANINE CALCIUM ALPHA-KETOPHENYLALANINE CALCIUM","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"HEBEI YIPIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SUN PHARMA LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"80.00","actualQuantity":"80","unit":"KGS","unitRateFc":"35","totalValueFC":"2832.7","currency":"USD","unitRateINR":"3031","date":"17-Apr-2025","totalValueINR":"242480","totalValueInUsd":"2832.7","indian_port":"JNPT","hs_no":"29222990","bill_no":"9534494","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"SANXIA ROAD, ECONOMY TECHNOLOGY ARE A OF SHIJIAZHUANG HEBEI, CHINA Hebe i, , China China","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744828200,"product":"D-PHENYLALANINE - (PO NO.1510970104) D-PHENYLALANINE","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"SICHUAN TONGSHENG BIOPHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"DIVI\\'S LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"150","totalValueFC":"303.5","currency":"USD","unitRateINR":"12990","date":"17-Apr-2025","totalValueINR":"25980","totalValueInUsd":"303.5","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"9534655","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"CO LTD NO.23 OF YONGDINGHE WEST ROA D, TIANYUAN DEVELOPMENT ZONE, DEYAN G 618000 SICHUAN CHINA","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"}]
08-Jan-2022
17-Apr-2025
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ABOUT THIS PAGE

Looking for 63-91-2 / Phenylalanine API manufacturers, exporters & distributors?

Phenylalanine manufacturers, exporters & distributors 1

34

PharmaCompass offers a list of Phenylalanine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Phenylalanine manufacturer or Phenylalanine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Phenylalanine manufacturer or Phenylalanine supplier.

PharmaCompass also assists you with knowing the Phenylalanine API Price utilized in the formulation of products. Phenylalanine API Price is not always fixed or binding as the Phenylalanine Price is obtained through a variety of data sources. The Phenylalanine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Phenylalanine

Synonyms

L-phenylalanine, 63-91-2, 3-phenyl-l-alanine, (2s)-2-amino-3-phenylpropanoic acid, (s)-2-amino-3-phenylpropanoic acid, (s)-phenylalanine

Cas Number

63-91-2

Unique Ingredient Identifier (UNII)

47E5O17Y3R

About Phenylalanine

An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.

LS-1515 Manufacturers

A LS-1515 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LS-1515, including repackagers and relabelers. The FDA regulates LS-1515 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LS-1515 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of LS-1515 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

LS-1515 Suppliers

A LS-1515 supplier is an individual or a company that provides LS-1515 active pharmaceutical ingredient (API) or LS-1515 finished formulations upon request. The LS-1515 suppliers may include LS-1515 API manufacturers, exporters, distributors and traders.

click here to find a list of LS-1515 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

LS-1515 USDMF

A LS-1515 DMF (Drug Master File) is a document detailing the whole manufacturing process of LS-1515 active pharmaceutical ingredient (API) in detail. Different forms of LS-1515 DMFs exist exist since differing nations have different regulations, such as LS-1515 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A LS-1515 DMF submitted to regulatory agencies in the US is known as a USDMF. LS-1515 USDMF includes data on LS-1515's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The LS-1515 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of LS-1515 suppliers with USDMF on PharmaCompass.

LS-1515 JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The LS-1515 Drug Master File in Japan (LS-1515 JDMF) empowers LS-1515 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the LS-1515 JDMF during the approval evaluation for pharmaceutical products. At the time of LS-1515 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of LS-1515 suppliers with JDMF on PharmaCompass.

LS-1515 CEP

A LS-1515 CEP of the European Pharmacopoeia monograph is often referred to as a LS-1515 Certificate of Suitability (COS). The purpose of a LS-1515 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of LS-1515 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of LS-1515 to their clients by showing that a LS-1515 CEP has been issued for it. The manufacturer submits a LS-1515 CEP (COS) as part of the market authorization procedure, and it takes on the role of a LS-1515 CEP holder for the record. Additionally, the data presented in the LS-1515 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the LS-1515 DMF.

A LS-1515 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. LS-1515 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of LS-1515 suppliers with CEP (COS) on PharmaCompass.

LS-1515 NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing LS-1515 as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for LS-1515 API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture LS-1515 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain LS-1515 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a LS-1515 NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of LS-1515 suppliers with NDC on PharmaCompass.

LS-1515 GMP

LS-1515 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of LS-1515 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right LS-1515 GMP manufacturer or LS-1515 GMP API supplier for your needs.

LS-1515 CoA

A LS-1515 CoA (Certificate of Analysis) is a formal document that attests to LS-1515's compliance with LS-1515 specifications and serves as a tool for batch-level quality control.

LS-1515 CoA mostly includes findings from lab analyses of a specific batch. For each LS-1515 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

LS-1515 may be tested according to a variety of international standards, such as European Pharmacopoeia (LS-1515 EP), LS-1515 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LS-1515 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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