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Chemistry

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Also known as:
Molecular Formula
C19H19N7O6
Molecular Weight
441.4  g/mol
InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N

Folic Acid
1 2D Structure

Folic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
2.1.2 InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
2.1.3 InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
2.1.5 Isomeric SMILES
C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
2.2 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 441.4 g/mol
Molecular Formula C19H19N7O6
XLogP3-1.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass441.13968135 g/mol
Monoisotopic Mass441.13968135 g/mol
Topological Polar Surface Area209 Ų
Heavy Atom Count32
Formal Charge0
Complexity767
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFolic acid
PubMed HealthFolic Acid
Drug ClassesNutriceutical, Nutritive Agent
Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active IngredientFolic acid
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength1 mg; 1mg; 5mg/ml
Market StatusPrescription
CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

2 of 2  
Drug NameFolic acid
PubMed HealthFolic Acid
Drug ClassesNutriceutical, Nutritive Agent
Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active IngredientFolic acid
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength1 mg; 1mg; 5mg/ml
Market StatusPrescription
CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

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SWITZERLAND FOLIC ACID PH - SWITZERLAND","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"DSM NUTRITIONAL PRODUCTS ASIA PACIFIC","supplierCountry":"SWITZERLAND","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"DSM NUTRITIONAL PRODUCTS INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"157.2","totalValueFC":"635.2","currency":"INR","unitRateINR":"13693.1","date":"17-Jan-2025","totalValueINR":"54772.52","totalValueInUsd":"635.2","indian_port":"Bombay Air","hs_no":"29362910","bill_no":"7828478","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLE TREE BUSINESS CITY, Singapore - 117 440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737570600,"product":"FOLIC ACID FOLIC ACID","address":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,","city":"CHENNAI, TAMIL NADU","supplier":"SINOCO CHEMICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"HEXAGON NUTRITION EXPORTS PRIVATE LTD","customerCountry":"INDIA","quantity":"2500.00","actualQuantity":"2500","unit":"KGS","unitRateFc":"50","totalValueFC":"126262.3","currency":"USD","unitRateINR":"4355","date":"23-Jan-2025","totalValueINR":"10887500","totalValueInUsd":"126262.3","indian_port":"Madras-EPZ\/SEZ","hs_no":"29362910","bill_no":"7942853","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"TRUST COMPANY COMPLEX AJELTAKE ROAD AJELTAKE ISLAND MAJURO MHL","customerAddress":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738002600,"product":"FOLIC ACID","address":"A\/403,ANJANI COMPLEX","city":"ANDHERI (EAST),MUMBAI","supplier":"NINGBO HITECH BIOCHEMICALS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MC COY DRUGS PVT LTD","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"44","totalValueFC":"44423","currency":"USD","unitRateINR":"3830.6","date":"28-Jan-2025","totalValueINR":"3830561","totalValueInUsd":"44423","indian_port":"Surat-EPZ\/SEZ","hs_no":"29362910","bill_no":"1000282","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"A\/403,ANJANI COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744741800,"product":"FOLIC ACID NOT FOR MEDICINAL USE BATCH NO : FA25022009 FOLIC ACID NOT FOR MEDICINAL USE","address":"25 BUNDER STREET","city":"CHENNAI","supplier":"JIANGXI TIANXIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"NANJING","customer":"PANVO ORGANICS PRIVATE LTD","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"33.3","totalValueFC":"16833.5","currency":"USD","unitRateINR":"2882","date":"16-Apr-2025","totalValueINR":"1440979","totalValueInUsd":"16833.5","indian_port":"Madras Air","hs_no":"29362910","bill_no":"9513270","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANJING","supplierAddress":"LEPING INDUSTRIAL ZONE LEPING JIAN GXI 333300 CHINA, , CHINA SDNF CHINA","customerAddress":"25 BUNDER STREET"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748025000,"product":"FOLIC ACID VITAMIN K1 5% POWDER","address":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,","city":"CHENNAI, TAMIL NADU","supplier":"SINCO CHEMICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"HEXAGON NUTRITION EXPORTS PRIVATE LTD","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"44.5","totalValueFC":"135379.3","currency":"USD","unitRateINR":"3844.8","date":"24-May-2025","totalValueINR":"11534400","totalValueInUsd":"135379.3","indian_port":"Madras-EPZ\/SEZ","hs_no":"29362910","bill_no":"2257286","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"TRUST COMPANY COMPLEX AJELTAKE ROAD AJELTAKE ISLAND MAJURO MHL SDNF CHINA","customerAddress":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,"}]
01-Jan-2022
24-May-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL...DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

USFDA APPLICATION NUMBER - 18920

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DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

USFDA APPLICATION NUMBER - 21163

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DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

USFDA APPLICATION NUMBER - 21163

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DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

USFDA APPLICATION NUMBER - 21625

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DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006...DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

USFDA APPLICATION NUMBER - 8809

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ABOUT THIS PAGE

Looking for / Folic Acid API manufacturers, exporters & distributors?

Folic Acid manufacturers, exporters & distributors 1

25

PharmaCompass offers a list of Folic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Folic Acid manufacturer or Folic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Folic Acid manufacturer or Folic Acid supplier.

PharmaCompass also assists you with knowing the Folic Acid API Price utilized in the formulation of products. Folic Acid API Price is not always fixed or binding as the Folic Acid Price is obtained through a variety of data sources. The Folic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Folic Acid

Folvite Manufacturers

A Folvite manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Folvite, including repackagers and relabelers. The FDA regulates Folvite manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Folvite API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Folvite manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Folvite Suppliers

A Folvite supplier is an individual or a company that provides Folvite active pharmaceutical ingredient (API) or Folvite finished formulations upon request. The Folvite suppliers may include Folvite API manufacturers, exporters, distributors and traders.

click here to find a list of Folvite suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Folvite USDMF

A Folvite DMF (Drug Master File) is a document detailing the whole manufacturing process of Folvite active pharmaceutical ingredient (API) in detail. Different forms of Folvite DMFs exist exist since differing nations have different regulations, such as Folvite USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Folvite DMF submitted to regulatory agencies in the US is known as a USDMF. Folvite USDMF includes data on Folvite's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Folvite USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Folvite suppliers with USDMF on PharmaCompass.

Folvite JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Folvite Drug Master File in Japan (Folvite JDMF) empowers Folvite API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Folvite JDMF during the approval evaluation for pharmaceutical products. At the time of Folvite JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Folvite suppliers with JDMF on PharmaCompass.

Folvite CEP

A Folvite CEP of the European Pharmacopoeia monograph is often referred to as a Folvite Certificate of Suitability (COS). The purpose of a Folvite CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Folvite EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Folvite to their clients by showing that a Folvite CEP has been issued for it. The manufacturer submits a Folvite CEP (COS) as part of the market authorization procedure, and it takes on the role of a Folvite CEP holder for the record. Additionally, the data presented in the Folvite CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Folvite DMF.

A Folvite CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Folvite CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Folvite suppliers with CEP (COS) on PharmaCompass.

Folvite WC

A Folvite written confirmation (Folvite WC) is an official document issued by a regulatory agency to a Folvite manufacturer, verifying that the manufacturing facility of a Folvite active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Folvite APIs or Folvite finished pharmaceutical products to another nation, regulatory agencies frequently require a Folvite WC (written confirmation) as part of the regulatory process.

click here to find a list of Folvite suppliers with Written Confirmation (WC) on PharmaCompass.

Folvite NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Folvite as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Folvite API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Folvite as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Folvite and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Folvite NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Folvite suppliers with NDC on PharmaCompass.

Folvite GMP

Folvite Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Folvite GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Folvite GMP manufacturer or Folvite GMP API supplier for your needs.

Folvite CoA

A Folvite CoA (Certificate of Analysis) is a formal document that attests to Folvite's compliance with Folvite specifications and serves as a tool for batch-level quality control.

Folvite CoA mostly includes findings from lab analyses of a specific batch. For each Folvite CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Folvite may be tested according to a variety of international standards, such as European Pharmacopoeia (Folvite EP), Folvite JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Folvite USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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