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    Chemistry

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    Also known as:
    Molecular Formula
    C19H19N7O6
    Molecular Weight
    441.4  g/mol
    InChI Key
    OVBPIULPVIDEAO-LBPRGKRZSA-N
    Folic Acid
    1 2D Structure

    Folic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
    2.1.2 InChI
    InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
    2.1.3 InChI Key
    OVBPIULPVIDEAO-LBPRGKRZSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
    2.1.5 Isomeric SMILES
    C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
    2.2 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 441.4 g/mol
    Molecular Formula C19H19N7O6
    XLogP3-1.1
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count9
    Exact Mass441.13968135 g/mol
    Monoisotopic Mass441.13968135 g/mol
    Topological Polar Surface Area209 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity767
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFolic acid
    PubMed HealthFolic Acid
    Drug ClassesNutriceutical, Nutritive Agent
    Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
    Active IngredientFolic acid
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength1 mg; 1mg; 5mg/ml
    Market StatusPrescription
    CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

    2 of 2  
    Drug NameFolic acid
    PubMed HealthFolic Acid
    Drug ClassesNutriceutical, Nutritive Agent
    Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
    Active IngredientFolic acid
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength1 mg; 1mg; 5mg/ml
    Market StatusPrescription
    CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

    API Reference Price

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BLDG, PLOT","city":"NAVI MUMBAI, M.S.","supplier":"NINGBO HI TECH BIOCHEMICALS CO LTD","supplierCountry":"CHINA","foreign_port":"EZHOU HUAHU","customer":"ZEON HEALTH INDUSTRIES","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"38.6","totalValueFC":"19418.7","currency":"USD","unitRateINR":"3337.1","date":"05-Jun-2025","totalValueINR":"1668561.12","totalValueInUsd":"19418.7","indian_port":"Bombay Air","hs_no":"29362910","bill_no":"2484840","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"EZHOU HUAHU","supplierAddress":"Room 602,One Culture Plaza,No.1349 LiYuan North Road,Ningbo China SDNF China","customerAddress":"101, SAI SIDDHI BLDG, PLOT"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751481000,"product":"CHROMIUM PICOLINATE (CHROMIUM 12%) - USA FOLIC ACID PH - (FOR MEDICINAL USE)SWITZERLAND","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"DSM NUTRITIONAL PRODUCTS ASIA PACIFIC","supplierCountry":"UNITED STATES","foreign_port":"WARSAW","customer":"DSM NUTRITIONAL PRODUCTS INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"4266","totalValueFC":"17377.9","currency":"INR","unitRateINR":"373910.8","date":"03-Jul-2025","totalValueINR":"1495643","totalValueInUsd":"17377.9","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"3022966","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"WARSAW","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLE TREE BUSINESS CITY, Singapore - 117 440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1753122600,"product":"FOLIC ACID (FOR FOOD USE ONLY, NOT FOR MEDICINAL USE) FOLIC ACID (FOR FOOD USE ONLY, NOT FOR MEDICINAL USE)","address":"101 SHREE TOWER LINK.ROAD","city":"Mumbai","supplier":"JIANGSU GTIG HUATAI CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"CRYSTAL ORGOIMPEX LLP","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"46.8","totalValueFC":"2361.4","currency":"USD","unitRateINR":"4064.7","date":"22-Jul-2025","totalValueINR":"203232.8","totalValueInUsd":"2361.4","indian_port":"JNPT","hs_no":"29362910","bill_no":"3418491","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"15-16\/F HUACHANG ORIENTAL PLAZA, R ENMIN ROAD ZHANGJIAGANG CITY JIANG SU PROVINCE CHINA ., ., China China","customerAddress":"101 SHREE TOWER LINK.ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1753295400,"product":"FOLIC ACID (NOT FOR MEDICINAL USE) BATCH NO : FA25052505 FOLIC ACID NOT FOR MEDICINAL USE BATCH NO : FA25012004","address":"25 BUNDER STREET","city":"CHENNAI","supplier":"JIANGXI TIANXIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PANVO ORGANICS PRIVATE LTD","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"62.1","totalValueFC":"31291.3","currency":"USD","unitRateINR":"5386.2","date":"24-Jul-2025","totalValueINR":"2693119","totalValueInUsd":"31291.3","indian_port":"Madras Sea","hs_no":"29362910","bill_no":"3461810","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"LEPING INDUSTRIAL ZONE LEPING JIAN GXI 333300 CHINA, , CHINA SDNF CHINA","customerAddress":"25 BUNDER STREET"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1753900200,"product":"FOLIC ACID PELLETS 18\/25 FOLIC ACID PELLETS 18\/25","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"ESKAYEF PHARMACEUTICALS LTD","supplierCountry":"BANGLADESH","foreign_port":"DHAKA","customer":"MEDREICH LTD","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"23.5","totalValueFC":"592.5","currency":"USD","unitRateINR":"2039.8","date":"31-Jul-2025","totalValueINR":"50995","totalValueInUsd":"592.5","indian_port":"Bangalore Air","hs_no":"29362910","bill_no":"3611304","productDescription":"API","marketType":"","country":"BANGLADESH","selfForZScoreResived":"Pellets","supplierPort":"DHAKA","supplierAddress":"400, SQUIBB ROAD, TONGI INDUSTRIAL AREA TONGI GAZIPUR 1711 SDNF BANGLADESH","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1754505000,"product":"FOLIC ACID (FOOD GRADE). FOLIC ACID (FOOD GRADE).","address":"48, CHANDRA GUPTA ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"YOUYANG CO., LIMITED.","supplierCountry":"CAMBODIA","foreign_port":"PHNOM PENH","customer":"GORANG INTERNATIONAL","customerCountry":"INDIA","quantity":"2010.00","actualQuantity":"2010","unit":"KGS","unitRateFc":"36","totalValueFC":"71765","currency":"USD","unitRateINR":"3124.8","date":"07-Aug-2025","totalValueINR":"6280848","totalValueInUsd":"71765","indian_port":"JNPT","hs_no":"29362910","bill_no":"3749399","productDescription":"API","marketType":"","country":"CAMBODIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PHNOM PENH","supplierAddress":"UNIT 1002, 10\/F PERFECT COMM BLDG 2 0, AUSTIN AVENUE TSIM SHA TSUI HONG KONG ., ., Hong Kong Hong Kong","customerAddress":"48, CHANDRA GUPTA ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1757442600,"product":"FOLIC ACID NOT FOR MEDICINAL USE BATCH NO:FA25052026 FOLIC ACID NOT FOR MEDICINAL USE BATCH NO:FA25052026","address":"25 BUNDER STREET","city":"CHENNAI","supplier":"JIANGXI TIANXIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PANVO ORGANICS PRIVATE LTD","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"62.2","totalValueFC":"31342.8","currency":"USD","unitRateINR":"5533.2","date":"10-Sep-2025","totalValueINR":"2766599.34","totalValueInUsd":"31342.8","indian_port":"Madras Sea","hs_no":"29362910","bill_no":"4426539","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"LEPING , INDUSTRIAL ZONE, LEPING J IANGXI 333300 CHINA, , CHINA SDNF CHINA","customerAddress":"25 BUNDER STREET"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q4","strtotime":1762194600,"product":"FOLIC ACID VITAMIN B1 MONO(THIAMINE MONONITRATE)","address":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,","city":"CHENNAI, TAMIL NADU","supplier":"SINOCO CHEMICAL CO LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"HEXAGON NUTRITION EXPORTS PRIVATE LTD","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"43","totalValueFC":"171649.8","currency":"USD","unitRateINR":"3814.1","date":"04-Nov-2025","totalValueINR":"15256400","totalValueInUsd":"171649.8","indian_port":"Madras-EPZ\/SEZ","hs_no":"29362910","bill_no":"1","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"TRUST COMPANY COMPLEX AJELTAKE ROAD AJELTAKE ISLAND MAJURO MHL SDNF CHINA","customerAddress":"PLOT NO.B11, PHASE-1, MEPZ-SEZ,"}]
    18-Jan-2022
    27-Dec-2025
    KGS
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    Average Price (USD/KGS)

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    API Imports and Exports

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    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL...DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

    USFDA APPLICATION NUMBER - 18920

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

    USFDA APPLICATION NUMBER - 21625

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    DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006...DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

    USFDA APPLICATION NUMBER - 8809

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    ABOUT THIS PAGE

    Looking for / Folic Acid API manufacturers, exporters & distributors?

    Folic Acid manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Folic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Folic Acid manufacturer or Folic Acid supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Folic Acid manufacturer or Folic Acid supplier.

    PharmaCompass also assists you with knowing the Folic Acid API Price utilized in the formulation of products. Folic Acid API Price is not always fixed or binding as the Folic Acid Price is obtained through a variety of data sources. The Folic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Folic Acid

    FOL Manufacturers

    A FOL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of FOL, including repackagers and relabelers. The FDA regulates FOL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. FOL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of FOL manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    FOL Suppliers

    A FOL supplier is an individual or a company that provides FOL active pharmaceutical ingredient (API) or FOL finished formulations upon request. The FOL suppliers may include FOL API manufacturers, exporters, distributors and traders.

    click here to find a list of FOL suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    FOL USDMF

    A FOL DMF (Drug Master File) is a document detailing the whole manufacturing process of FOL active pharmaceutical ingredient (API) in detail. Different forms of FOL DMFs exist exist since differing nations have different regulations, such as FOL USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A FOL DMF submitted to regulatory agencies in the US is known as a USDMF. FOL USDMF includes data on FOL's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The FOL USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of FOL suppliers with USDMF on PharmaCompass.

    FOL JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The FOL Drug Master File in Japan (FOL JDMF) empowers FOL API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the FOL JDMF during the approval evaluation for pharmaceutical products. At the time of FOL JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of FOL suppliers with JDMF on PharmaCompass.

    FOL CEP

    A FOL CEP of the European Pharmacopoeia monograph is often referred to as a FOL Certificate of Suitability (COS). The purpose of a FOL CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of FOL EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of FOL to their clients by showing that a FOL CEP has been issued for it. The manufacturer submits a FOL CEP (COS) as part of the market authorization procedure, and it takes on the role of a FOL CEP holder for the record. Additionally, the data presented in the FOL CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the FOL DMF.

    A FOL CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. FOL CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of FOL suppliers with CEP (COS) on PharmaCompass.

    FOL WC

    A FOL written confirmation (FOL WC) is an official document issued by a regulatory agency to a FOL manufacturer, verifying that the manufacturing facility of a FOL active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting FOL APIs or FOL finished pharmaceutical products to another nation, regulatory agencies frequently require a FOL WC (written confirmation) as part of the regulatory process.

    click here to find a list of FOL suppliers with Written Confirmation (WC) on PharmaCompass.

    FOL NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing FOL as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for FOL API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture FOL as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain FOL and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a FOL NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of FOL suppliers with NDC on PharmaCompass.

    FOL GMP

    FOL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of FOL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right FOL GMP manufacturer or FOL GMP API supplier for your needs.

    FOL CoA

    A FOL CoA (Certificate of Analysis) is a formal document that attests to FOL's compliance with FOL specifications and serves as a tool for batch-level quality control.

    FOL CoA mostly includes findings from lab analyses of a specific batch. For each FOL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    FOL may be tested according to a variety of international standards, such as European Pharmacopoeia (FOL EP), FOL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (FOL USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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