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Chemistry

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Also known as: 49562-28-9, Procetofen, Lipantil, Tricor, Lipanthyl, Antara
Molecular Formula
C20H21ClO4
Molecular Weight
360.8  g/mol
InChI Key
YMTINGFKWWXKFG-UHFFFAOYSA-N
FDA UNII
U202363UOS

Fenofibrate
An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood.
Fenofibrate is a Peroxisome Proliferator Receptor alpha Agonist. The mechanism of action of fenofibrate is as a Peroxisome Proliferator-activated Receptor alpha Agonist.
1 2D Structure

Fenofibrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
2.1.2 InChI
InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
2.1.3 InChI Key
YMTINGFKWWXKFG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
2.2 Other Identifiers
2.2.1 UNII
U202363UOS
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Antara Micronized Procetofen

2. Apo Feno Micro

3. Apo Fenofibrate

4. Apo-feno-micro

5. Apo-fenofibrate

6. Azu, Fenofibrat

7. Cil

8. Controlip

9. Debat, Fnofibrate

10. Durafenat

11. Fnofibrate Debat

12. Fnofibrate Msd

13. Fenobeta

14. Fenofanton

15. Fenofibrat Abz

16. Fenofibrat Al

17. Fenofibrat Azu

18. Fenofibrat Fph

19. Fenofibrat Heumann

20. Fenofibrat Hexal

21. Fenofibrat Ratiopharm

22. Fenofibrat Stada

23. Fenofibrat Von Ct

24. Fenofibrat-ratiopharm

25. Gen Fenofibrate

26. Gen-fenofibrate

27. Heumann, Fenofibrat

28. Hexal, Fenofibrat

29. Lf 178

30. Lf-178

31. Lf178

32. Lipanthyl

33. Lipantil

34. Liparison

35. Lipidil

36. Lipidil Ter

37. Lipidil-ter

38. Livesan

39. Lofibra

40. Micronized Procetofen, Antara

41. Mtw Fenofibrat

42. Mtw-fenofibrat

43. Normalip

44. Novo Fenofibrate

45. Novo-fenofibrate

46. Nu Fenofibrate

47. Nu-fenofibrate

48. Phenofibrate

49. Pms Fenofibrate Micro

50. Pms-fenofibrate Micro

51. Procetofen

52. Procetofen, Antara Micronized

53. Procetofene

54. Secalip

55. Stada, Fenofibrat

56. Supralip

57. Tricor

2.3.2 Depositor-Supplied Synonyms

1. 49562-28-9

2. Procetofen

3. Lipantil

4. Tricor

5. Lipanthyl

6. Antara

7. Lipidil

8. Fenobrate

9. Secalip

10. Triglide

11. Fenoglide

12. Finofibrate

13. Lipoclar

14. Lipofene

15. Proctofene

16. Fenogal

17. Lipirex

18. Lipofen

19. Sedufen

20. Elasterin

21. Fenotard

22. Protolipan

23. Ankebin

24. Lipidex

25. Lipifen

26. Liposit

27. Lipsin

28. Nolipax

29. Fenofibratum [inn-latin]

30. Propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

31. Fenofibrato [inn-spanish]

32. Lipantil (tn)

33. Tricor (tn)

34. Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

35. Lf-178

36. Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate

37. 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic Acid 1-methylethyl Ester

38. Nsc 281319

39. Fenofibrate Micronized

40. Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate

41. Fnf

42. Propanoic Acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl Ester

43. Elasterate

44. Procetofene

45. Luxacor

46. Mfcd00133314

47. Fenofibrate Delayed Release

48. Chembl672

49. Mls000028515

50. Chebi:5001

51. Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate

52. Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

53. Lofibra

54. U202363uos

55. Propanoic Acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, 1-methylethyl Ester

56. Nsc-281319

57. Ncgc00015437-10

58. Fenofibrato

59. Fenofibratum

60. Smr000058299

61. Supralip

62. Cas-49562-28-9

63. Dsstox_cid_9874

64. Propan-2-yl 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate

65. Dsstox_rid_78828

66. Dsstox_gsid_29874

67. Tricor (micronized)

68. Antara (micronized)

69. Fenomax

70. Isopropyl 2-[p-(p-chlorobenzoyl)phenoxy]-2-methylpropionate

71. Pharmavit

72. Fenofibrate (micronized)

73. Fulcro

74. Cip-fenofibrate

75. 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic Acid 1-methylethyl Ester

76. Lcp-fenochol

77. Lcp-feno

78. Triglide (tn)

79. Fenofibrate Idd-p

80. Lipofen (tn)

81. Antara (tn)

82. Ccris 7282

83. Sr-01000000091

84. Einecs 256-376-3

85. Lf 178

86. Brn 2062462

87. Procetoken

88. Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionate

89. Unii-u202363uos

90. Hsdb 7736

91. Fenofibrate,(s)

92. Grs-027

93. Fenofibrate [usan:usp:inn:ban]

94. Prestwick_217

95. Spectrum_001250

96. Opera_id_328

97. Fenofibrate [mi]

98. Prestwick0_000275

99. Prestwick1_000275

100. Prestwick2_000275

101. Prestwick3_000275

102. Spectrum2_001390

103. Spectrum3_001431

104. Spectrum4_000413

105. Spectrum5_001479

106. Fenofibrate [inn]

107. Fenofibrate [jan]

108. Lopac-f-6020

109. Fenofibrate [hsdb]

110. Fenofibrate [usan]

111. Ec 256-376-3

112. F 6020

113. Fenofibrate [vandf]

114. Schembl4670

115. Fenofibrate [mart.]

116. Lopac0_000486

117. Bspbio_000150

118. Bspbio_003162

119. Fenofibrate [usp-rs]

120. Fenofibrate [who-dd]

121. Kbiogr_000706

122. Kbioss_001730

123. Mls001148191

124. Mls002548878

125. Bidd:gt0574

126. Divk1c_000557

127. Fenofibrate (jan/usp/inn)

128. Spectrum1501010

129. Spbio_001380

130. Spbio_002369

131. Fenofibrate [ema Epar]

132. Fenofibrate, >=99%, Powder

133. Bpbio1_000166

134. Fenofibrate (tricor, Trilipix)

135. Gtpl7186

136. Dtxsid2029874

137. Hms501l19

138. Kbio1_000557

139. Kbio2_001730

140. Kbio2_004298

141. Kbio2_006866

142. Kbio3_002382

143. Fenofibrate [orange Book]

144. Ninds_000557

145. Fenofibrate [ep Monograph]

146. Fenofibrate [usp Impurity]

147. Hms1568h12

148. Hms1921b17

149. Hms2090g20

150. Hms2092b05

151. Hms2095h12

152. Hms2231b14

153. Hms3259k03

154. Hms3261b13

155. Hms3369m13

156. Hms3649d20

157. Hms3655k12

158. Hms3712h12

159. Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoate

160. Pharmakon1600-01501010

161. Zinc584092

162. Fenofibrate [usp Monograph]

163. Albb-028958

164. Bcp21243

165. Tox21_110147

166. Tox21_300151

167. Tox21_500486

168. 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic Acid Isopropyl Ester

169. Bdbm50085042

170. Ccg-38996

171. Nsc281319

172. Nsc757822

173. S1794

174. Akos005107777

175. Tox21_110147_1

176. Ab03716

177. Ac-4227

178. Cs-0892

179. Db01039

180. Lp00486

181. Ms-2223

182. Nc00452

183. Nsc-757822

184. Sdccgsbi-0050470.p004

185. Idi1_000557

186. Ncgc00015437-01

187. Ncgc00015437-02

188. Ncgc00015437-03

189. Ncgc00015437-04

190. Ncgc00015437-05

191. Ncgc00015437-06

192. Ncgc00015437-07

193. Ncgc00015437-08

194. Ncgc00015437-09

195. Ncgc00015437-11

196. Ncgc00015437-12

197. Ncgc00015437-13

198. Ncgc00015437-14

199. Ncgc00015437-16

200. Ncgc00015437-17

201. Ncgc00015437-31

202. Ncgc00021475-03

203. Ncgc00021475-04

204. Ncgc00021475-05

205. Ncgc00021475-06

206. Ncgc00021475-07

207. Ncgc00021475-08

208. Ncgc00253945-01

209. Ncgc00261171-01

210. Fenofibrate (micronized) (fenofibrate

211. Fenofibrate, Analytical Reference Material

212. Hy-17356

213. Sy052561

214. Sbi-0050470.p003

215. Db-051642

216. Ab00052196

217. Eu-0100486

218. F0674

219. Ft-0626400

220. Ft-0654669

221. Sw196525-4

222. C07586

223. D00565

224. Ab00052196-15

225. Ab00052196-16

226. Ab00052196_17

227. Ab00052196_18

228. 562f289

229. A827746

230. Q419724

231. Q-201111

232. Sr-01000000091-2

233. Sr-01000000091-5

234. Sr-01000000091-6

235. Sr-01000000091-8

236. Brd-k50388907-001-05-6

237. Brd-k50388907-001-18-9

238. Brd-k50388907-001-20-5

239. Sr-01000000091-16

240. Z2768724415

241. Fenofibrate, European Pharmacopoeia (ep) Reference Standard

242. Isopropyl 2-(4-(4-chlorobenzoyl)-phenoxy)-2-methylpropanoate

243. 1-methylethyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

244. 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoicacidisopropylester

245. Fenofibrate, United States Pharmacopeia (usp) Reference Standard

246. Isopropyl (4''-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate

247. 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic Acid 1-methyl-ethyl Ester

248. 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic Acid Isopropyl Ester

249. Fenofibrate, Pharmaceutical Secondary Standard; Certified Reference Material

250. Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoate;fenofibrate

251. Propanoic Acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethylester

2.3.3 Other Synonyms

1. 42017-89-0

2. Fenofibric Acid

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 360.8 g/mol
Molecular Formula C20H21ClO4
XLogP35.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass360.1128368 g/mol
Monoisotopic Mass360.1128368 g/mol
Topological Polar Surface Area52.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity458
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 16  
Drug NameAntara
PubMed HealthFenofibrate (By mouth)
Drug ClassesAntihyperlipidemic
Drug LabelFenofibrate, is a lipid regulating agent available as tablets for oral administration. Each tablet contains 54 mg or 160 mg of fenofibrate, USP. The chemical name for fenofibrate is 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethy...
Active IngredientFenofibrate
Dosage FormCapsule
RouteOral
Strength43mg; 130mg; 30mg; 90mg
Market StatusPrescription
CompanyLupin Atlantis

2 of 16  
Drug NameFenofibrate
PubMed HealthFenofibrate (By mouth)
Drug ClassesAntihyperlipidemic
Active IngredientFenofibrate
Dosage FormCapsule
RouteOral
Strength43mg; 200mg; 130mg; 67mg; 134mg
Market StatusPrescription
CompanyMylan Pharms; Teva; Apotex; Dr Reddys Labs Sa; Impax Labs

3 of 16  
Drug NameFenofibrate
PubMed HealthFenofibric acid (By mouth)
Drug ClassesAntihyperlipidemic
Drug LabelFENOGLIDE (fenofibrate) Tablets, is a lipid regulating agent available as tablets for oral administration. Each tablet contains 40 mg or 120 mg fenofibrate. The chemical name for fenofibrate is 2-[4-(4-chlorobenzoyl) phenoxy]-2-methyl-propanoic acid,...
Active IngredientFenofibrate
Dosage FormTablet; Capsule
Routeoral; Oral
Strength43mg; 160mg; 54mg; 48mg; 130mg; 107mg; 145mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Ranbaxy; Valeant Intl; Teva; Lupin; Mylan; Impax Labs

4 of 16  
Drug NameFenoglide
Drug LabelLIPOFEN (fenofibrate capsules, USP), is a lipid regulating agent available as hard gelatin capsules for oral administration. Each hard gelatin capsule contains 50 or 150 mg of fenofibrate, USP. The chemical name for fenofibrate is 2-[4-(4-chloroben...
Active IngredientFenofibrate
Dosage FormTablet
RouteOral
Strength120mg; 40mg
Market StatusPrescription
CompanySantarus

5 of 16  
Drug NameFibricor
Drug LabelTRICOR (fenofibrate tablets), is a lipid regulating agent available as tablets for oral administration. Each tablet contains 48 mg or 145 mg of fenofibrate. The chemical name for fenofibrate is 2-[4-(4-chlorobenzoyl) phenoxy]-2-methyl-propanoic acid,...
Active IngredientFenofibric acid
Dosage FormTablet
RouteOral