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    Chemistry

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    Also known as: Ethanoic acid, 64-19-7, Glacial acetic acid, Ethylic acid, Vinegar acid, Acetic acid, glacial
    Molecular Formula
    C2H4O2
    Molecular Weight
    60.05  g/mol
    InChI Key
    QTBSBXVTEAMEQO-UHFFFAOYSA-N
    FDA UNII
    Q40Q9N063P
    Acetic Acid
    Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
    1 2D Structure

    Acetic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    acetic acid
    2.1.2 InChI
    InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
    2.1.3 InChI Key
    QTBSBXVTEAMEQO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    Q40Q9N063P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acetic Acid Glacial

    2. Acetic Acid, Glacial

    3. Glacial Acetic Acid

    4. Glacial, Acetic Acid

    5. Vinegar

    2.3.2 Depositor-Supplied Synonyms

    1. Ethanoic Acid

    2. 64-19-7

    3. Glacial Acetic Acid

    4. Ethylic Acid

    5. Vinegar Acid

    6. Acetic Acid, Glacial

    7. Acetic Acid Glacial

    8. Methanecarboxylic Acid

    9. Acetasol

    10. Essigsaeure

    11. Acide Acetique

    12. Vinegar

    13. Aci-jel

    14. Azijnzuur

    15. Aceticum Acidum

    16. Acido Acetico

    17. Kyselina Octova

    18. Octowy Kwas

    19. Pyroligneous Acid

    20. Hoac

    21. Azijnzuur [dutch]

    22. Ethanoic Acid Monomer

    23. Acetyl Alcohol

    24. Essigsaeure [german]

    25. Ethoic Acid

    26. Caswell No. 003

    27. Otic Tridesilon

    28. Octowy Kwas [polish]

    29. Otic Domeboro

    30. Acetic Acid (natural)

    31. Acide Acetique [french]

    32. Acido Acetico [italian]

    33. Fema No. 2006

    34. Kyselina Octova [czech]

    35. Acoh

    36. Acetic Acid, Water Solutions

    37. Acetic Acid-

    38. Carboxylic Acids, C2-3

    39. Ethanoate

    40. Un2789

    41. Un2790

    42. Mecooh

    43. Epa Pesticide Chemical Code 044001

    44. Nsc 132953

    45. Brn 0506007

    46. Acetic Acid, Diluted

    47. Acetic Acid [jan]

    48. Ai3-02394

    49. Ch3cooh

    50. Acidum Aceticum Glaciale

    51. Ch3-cooh

    52. Ch3co2h

    53. 10.methanecarboxylic Acid

    54. Chembl539

    55. Nsc-132953

    56. Nsc-406306

    57. Ins No.260

    58. E-260

    59. Chebi:15366

    60. Ins-260

    61. Q40q9n063p

    62. Ethanoat

    63. Shotgun

    64. Mfcd00036152

    65. Acetic Acid, Of A Concentration Of More Than 10 Per Cent, By Weight, Of Acetic Acid

    66. Nsc-111201

    67. Nsc-112209

    68. Nsc-115870

    69. Nsc-127175

    70. 68475-71-8

    71. C2:0

    72. Perchloric Acid Solution

    73. Orlex

    74. Vosol

    75. Wln: Qv1

    76. Acetic Acid Solution, Not Less Than 50% But More Than 80% Acid, By Mass [un2790] [corrosive]

    77. Acetic Acid Solution, With More Than 10% And Less Than 50% Acid, By Mass [un2790] [corrosive]

    78. Acetic Acid, Glacial Or Acetic Acid Solution, >80% Acid, By Mass [un2789] [corrosive]

    79. Acetic Acid, >=99.7%

    80. Acetic Acid, Aqueous Solution

    81. Fema Number 2006

    82. Acetic Acid, Acs Reagent, >=99.7%

    83. Acy

    84. Hsdb 40

    85. Ccris 5952

    86. Methane Carboxylic Acid

    87. Einecs 200-580-7

    88. Acetic Acid 0.25% In Plastic Container

    89. Ethylate

    90. Acetic Aicd

    91. Acetic-acid

    92. Acidum Aceticum

    93. Glacial Acetate

    94. Acetic Cid

    95. Actic Acid

    96. Unii-q40q9n063p

    97. Acetic -acid

    98. Distilled Vinegar

    99. Methanecarboxylate

    100. Acetic Acid, Glacial [usp:jan]

    101. Nat. Acetic Acid

    102. Acetasol (tn)

    103. Acetic Acid,glacial

    104. Acetic Acid Natural

    105. Vinegar (salt/mix)

    106. Acetic Acid, Propionic Acid Distillate

    107. Meco2h

    108. Undiluted Acetic Acid

    109. 63459-47-2

    110. Oxytocin Identification

    111. 3,3'-(1,4-phenylene)dipropiolic Acid

    112. Hoocch3

    113. Acetic Acid (recovered)

    114. 546-67-8

    115. Acetic Acid Lc/ms Grade

    116. E 260

    117. Acetic Acid [ii]

    118. Acetic Acid [mi]

    119. Acetic Acid, Acs Reagent

    120. Dsstox_cid_4394

    121. Acetic Acid Solution, 1n

    122. Acetic Acid-[13c,d3]

    123. Bmse000191

    124. Bmse000817

    125. Bmse000857

    126. Otic Domeboro (salt/mix)

    127. Ec 200-580-7

    128. Acetic Acid (jp17/nf)

    129. Acetic Acid [fhfi]

    130. Acetic Acid [inci]

    131. Acetic Acid [for Lc-ms]

    132. Acetic Acid [vandf]

    133. Dsstox_rid_77386

    134. Nciopen2_000659

    135. Nciopen2_000682

    136. Dsstox_gsid_24394

    137. Acetic Acid [mart.]

    138. Acetic Acid, Glacial (usp)

    139. Buffer Solution, Ph 4.64

    140. 4-02-00-00094 (beilstein Handbook Reference)

    141. Glacial Acetic Acid (jp17)

    142. Un 2790 (salt/mix)

    143. Acetic Acid [who-dd]

    144. Acetic Acid [who-ip]

    145. Aceticum Acidum [hpus]

    146. Ins No. 260

    147. Gtpl1058

    148. Acetic Acid Glacial Hplc Grade

    149. Acetic Acid Solution, For Hplc

    150. Acetic Acid, Analytical Standard

    151. Acetic Acid, Glacial Usp Grade

    152. Dtxsid5024394

    153. Acetic Acid, Puriss., >=80%

    154. Acetic Acid, 99.8%, Anhydrous

    155. Acetic Acid, Ar, >=99.8%

    156. Acetic Acid, Lr, >=99.5%

    157. Acetic Acid, Glacial Reagent Acs

    158. Acetic Acid Solution, 1 N, 1 M

    159. Acetic Acid, Extra Pure, 99.8%

    160. Acetic Acid, 99.5-100.0%

    161. Acetic Acid, Glacial, Acs Reagent

    162. Str00276

    163. Zinc5224164

    164. Acetic Acid, Puriss., 99-100%

    165. Tox21_301453

    166. Acetic Acid, Glacial, >=99.85%

    167. Bdbm50074329

    168. Lmfa01010002

    169. Nsc132953

    170. Nsc406306

    171. Stl264240

    172. Tclp Extraction Fluid 2 (salt/mix)

    173. Acetic Acid, 1% V/v Aqueous Solution

    174. Acetic Acid, 4% V/v Aqueous Solution

    175. Acetic Acid, Environmental Grade Plus

    176. Acetic Acid, For Hplc, >=99.8%

    177. Akos000268789

    178. Acidum Aceticum [who-ip Latin]

    179. Buffer Solution (acetate), Ph 4.01

    180. Db03166

    181. Un 2789

    182. Acetic Acid, >=99.5%, Fcc, Fg

    183. Acetic Acid, Natural, >=99.5%, Fg

    184. Acetic Acid, Reagentplus(r), >=99%

    185. Cas-64-19-7

    186. Acetic Acid, Usp, 99.5-100.5%

    187. Ncgc00255303-01

    188. Acetic Acid 1000 Microg/ml In Methanol

    189. Acetic Acid Solution, 25% W/w, Aqueous

    190. Acetic Acid Solution, 56% W/w, Aqueous

    191. Acetic Acid Solution, 60% W/w, Aqueous

    192. Acetic Acid Solution, 84% W/w, Aqueous

    193. Acetic Acid, 0.1n Standardized Solution

    194. Acetic Acid, 1.0n Standardized Solution

    195. Acetic Acid, Saj First Grade, >=99.0%

    196. Buffer Solution (acetate), Ph 4.0-4.6

    197. Db-085748

    198. Acetic Acid 1000 Microg/ml In Acetonitrile

    199. Acetic Acid, >=99.99% Trace Metals Basis

    200. Acetic Acid, Jis Special Grade, >=99.7%

    201. Acetic Acid, Purified By Double-distillation

    202. Ft-0621735

    203. Ft-0621743

    204. Ft-0621764

    205. Ft-0661109

    206. Ft-0661110

    207. Acetic Acid, Uv Hplc Spectroscopic, 99.9%

    208. Acetic Acid, Vetec(tm) Reagent Grade, >=99%

    209. Bifido Selective Supplement B, For Microbiology

    210. C00033

    211. D00010

    212. Orlex Hc Component Acetic Acid, Glacial

    213. Q47512

    214. Vosol Hc Component Acetic Acid, Glacial

    215. Acetic Acid, Glacial, Electronic Grade, 99.7%

    216. Tridesilon Component Acetic Acid, Glacial

    217. A834671

    218. Acetasol Hc Component Acetic Acid, Glacial

    219. Acetic Acid, >=99.7%, Saj Super Special Grade

    220. Acetic Acid, Glacial Component Of Borofair

    221. Acetic Acid, Glacial Component Of Orlex Hc

    222. Acetic Acid, Glacial Component Of Vosol Hc

    223. Sr-01000944354

    224. Acetic Acid, Glacial Component Of Tridesilon

    225. Sr-01000944354-1

    226. Acetic Acid Solution, Saj First Grade, 27.0-33.0%

    227. Acetic Acid, Glacial Component Of Acetasol Hc

    228. Glacial Acetic Acid, Meets Usp Testing Specifications

    229. Acetic Acid, >=99.7%, Suitable For Amino Acid Analysis

    230. Acetic Acid, >=99.7%, For Titration In Non-aqueous Medium

    231. Acetic Acid, For Luminescence, Bioultra, >=99.5% (gc)

    232. Acetic Acid, Glacial Or Acetic Acid Solution, >80% Acid, By Mass

    233. Acetic Acid Solution, Not Less Than 50% But More Than 80% Acid, By Mass

    234. Acetic Acid Solution, With More Than 10% And Less Than 50% Acid, By Mass

    235. Acetic Acid, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.8%

    236. Acetic Acid, Semiconductor Grade Mos Puranal(tm) (honeywell 17926)

    237. Glacial Acetic Acid, United States Pharmacopeia (usp) Reference Standard

    238. Acetic Acid, Acculute Standard Volumetric Solution, Final Concentration 1.0n

    239. Acetic Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.8%

    240. Glacial Acetic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

    241. 158461-04-2

    242. Acetic Acid, Glacial, Pharmagrade, Usp, Jp, Ph Eur, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production.

    243. Acetic Acid, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, Fcc, 99.8-100.5%

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 60.05 g/mol
    Molecular Formula C2H4O2
    XLogP3-0.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass60.021129366 g/mol
    Monoisotopic Mass60.021129366 g/mol
    Topological Polar Surface Area37.3 Ų
    Heavy Atom Count4
    Formal Charge0
    Complexity31
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameAcetic acid
    PubMed HealthAcetic Acid (Inside the bladder)
    Drug ClassesBladder Irrigant
    Drug LabelEach 100 mL contains:Glacial Acetic Acid USP 0.25 gWater for Injection USP qspH: 3.1 (2.83.4)Calculated Osmolarity: 42 mOsmol/literThe formula of the active ingredient is:IngredientMolecular FormulaMolecular WeightGlacial Acetic Acid USPCH3COO...
    Active IngredientAcetic acid, glacial
    Dosage FormSolution/drops
    RouteOtic
    Strength2%
    Market StatusPrescription
    CompanyWockhardt; Vintage; Taro

    2 of 6  
    Drug NameChirhostim
    PubMed HealthSecretin (Injection)
    Drug ClassesDiagnostic Agent, Pancreatic Function, Endocrine-Metabolic Agent
    Active IngredientSecretin synthetic human
    Dosage FormFor solution
    RouteIntravenous
    Strength40mcg/vial; 16mcg/vial
    Market StatusPrescription
    CompanyChirhoclin

    3 of 6  
    Drug NameVosol
    PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
    Drug ClassesAnti-Infective/Anti-Inflammatory Combination
    Active IngredientAcetic acid, glacial
    Dosage FormSolution/drops
    RouteOtic
    Strength2%
    Market StatusPrescription
    CompanyHi Tech Pharma

    4 of 6  
    Drug NameAcetic acid
    PubMed HealthAcetic Acid (Inside the bladder)
    Drug ClassesBladder Irrigant
    Drug LabelEach 100 mL contains:Glacial Acetic Acid USP 0.25 gWater for Injection USP qspH: 3.1 (2.83.4)Calculated Osmolarity: 42 mOsmol/literThe formula of the active ingredient is:IngredientMolecular FormulaMolecular WeightGlacial Acetic Acid USPCH3COO...
    Active IngredientAcetic acid, glacial
    Dosage FormSolution/drops
    RouteOtic
    Strength2%
    Market StatusPrescription
    CompanyWockhardt; Vintage; Taro

    5 of 6  
    Drug NameChirhostim
    PubMed HealthSecretin (Injection)
    Drug ClassesDiagnostic Agent, Pancreatic Function, Endocrine-Metabolic Agent
    Active IngredientSecretin synthetic human
    Dosage FormFor solution
    RouteIntravenous
    Strength40mcg/vial; 16mcg/vial
    Market StatusPrescription
    CompanyChirhoclin

    6 of 6  
    Drug NameVosol
    PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
    Drug ClassesAnti-Infective/Anti-Inflammatory Combination
    Active IngredientAcetic acid, glacial
    Dosage FormSolution/drops
    RouteOtic
    Strength2%
    Market StatusPrescription
    CompanyHi Tech Pharma

    4.2 Therapeutic Uses

    BACKGROUND: Ultrasound (US)-guided percutaneous acetic acid injection therapy (PAIT) is effective for patients with hepatocellular carcinoma (HCC). This study aimed to determine the occurrence and predictive value of persistent intra-tumoral retention of acetic acid after PAIT. METHODS: /The trial/ prospectively studied 60 (52 M, mean age 68 +/- 10 years) patients with 72 HCC nodules (45 < or = 3 cm) treated with PAIT. The presence of post-treatment persistent retention of acetic acid, defined as a homogeneous and highly hyperechoid mass in US appearance 3 days after completion of the treatment, was correlated with the treatment response. RESULTS: The mean size of the treated tumor was 2.9 +/- 1.0 cm (range 1.5-5 cm). Thirty (42%) HCC nodules showed complete tumor necrosis demonstrated by contrast-enhanced dynamic CT. Complete response was found in 22 (69%) of 32 nodules showing persistent intra-tumoral retention of acetic acid (P < 0.001). Small (< or = 3 cm) tumor size was also significantly associated with complete tumor necrosis (P = 0.001). There were no significant differences of the injection volume and treatment sessions between those with and without complete tumor necrosis in either small or large (> 3 cm) HCC (P > 0.1). Multivariate logistic regression analysis showed that persistent retention of acetic acid (odds ratio (OR) 10.4, 95% confidence interval (CI) 3.1-34.7; P < 0.001) and tumor size < or = 3 cm (OR 6.8, 95%, CI 1.8-25.8; P = 0.002) were independent factors predicting complete tumor necrosis. CONCLUSIONS: The presence of persistent retention of acetic acid is associated with a favorable response and may predict complete tumor necrosis after PAIT.

    PMID:15000280 Huo TI et al; Scand J Gastroenterol. 39(2):168-73 (2004).

    EXPL THER BACKGROUND AND AIM: Application of acetic acid topically to the mucosal or serosal side of the stomach has been well used to create a chronic gastric ulcer model. The aim of the present study was to apply it as a new cytoreductive approach in a mouse model of gastric cancer. METHODS: A total of 43 genetically engineered mice, the so-called (INS-GAS) mice that develop spontaneously gastric cancer at 10-14 months of age, were included. Acetic acid-induced ulcer method was applied to mice under isofluran anesthesia. The ulcer at the cancer side was made by exposing either the anterior serosal or posterior mucosal side of gastric wall to 0.1 mL of 60% or 100% acetic acid for 30 or 60 s with a cylindrical metal mold (4 mm ID). Route to the serosal side was intra-abdominal and one to the mucosal side was through a small hole made in the forestomach. The opposite side of gastric wall (no treatment with acetic acid) was used as the corresponding control. After the mice were sacrificed, the stomachs were collected 1, 3, 6 hrs or 1, 3 and 7 days, postoperatively, and evaluated by visual inspection and histology. RESULTS: Gastric cancer was found in both the anterior and posterior walls of the corpus in all 43 mice. Intraluminal pH value was between 11 and 13. Severe necrosis in the cancer was observed in the side exposing to acetic acid, but not in the control side, shortly after the treatment (i.e. within 30 or 60 min). The muscularis mucosa and muscle layers were less damaged, regardless of the side of the treatment. Ulcer formation in the cancer took place 1, 3 or 7 days later. The ulcer depth was sometimes at the muscularis mucosa and muscle layers. At 3 and 7 days, regeneration of epithelial cells was clearly observed in the ulcer margin in the stomach of mice. CONCLUSIONS: Topical application of acetic acid either from mucosal or serosal surface promptly caused the necrosis of tumor, suggesting the potential approach of this simple and reliable method as a cytoreductive treatment of gastric cancer in patients through endoscopy or laparoscopy.

    PMID:22486870 Okabe S et al; J Gastroenterol Hepatol. 27 Suppl 3:40-8 (2012).

    MEDICATION (Vet): Vesicant, caustic, destructive of warts.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 11

    EXPL THER OBJECTIVE: To investigate whether enhancing vaginal acidity improves the success of medical abortions in the midtrimester. METHODS: A double-blind, randomized, placebo-controlled trial was conducted with 48 women with missed midtrimester abortions. Twice daily, the study participants (n=24) were treated with a 3% acetic acid gel and the controls (n=24) with a placebo gel, starting 2 days prior to initiating the misoprostol treatment. The primary outcome measures were the rates of successful abortion within 24 and 48 hours. Secondary measures included gel tolerability and adverse effects of the misoprostol treatment. RESULTS: The success rates were higher in the study group, within both 24 hours (11/23 vs 3/24; P=0.011) and 48 hours (18/23 vs 6/24; P<0.001). Among the women with a vaginal pH of 5 or higher at baseline, acidic gel was also associated with higher success rates within 24 hours (8/13 vs 2/15; P<0.01) and 48 hours (13/13 vs 3/15; P<0,001). The vaginal gels were well tolerated and the misoprostol treatment produced no serious adverse effects. CONCLUSION: A 3% acetic acid gel appears to be an effective and safe preparatory adjuvant to vaginal misoprostol treatment for midtrimester medical abortions, especially in women with a vaginal pH of 5 or higher...

    PMID:22980429 Abd-El-Maeboud KH et al; Int J Gynaecol Obstet. 119(3):248-52 (2012).

    ... Thirty-five patients with histologically confirmed high-grade squamous intraepithelial lesions of the cervix entered the study. ...Telomerase activity was detectable in 27 of 35 (77.1%) fresh tissue samples, 15 of 35 (42.9%) tissue samples swabbed with 5% acetic acid, and 0 of 10 (0%) normal cervical tissue samples, respectively. Twelve samples became telomerase negative after 5% acetic acid applied. Among the 15 telomerase-positive tissue samples swabbed with 5% acetic acid, 12 had relative weak telomerase activity compared to corresponding fresh tissue samples, the other 3 remained the same.

    PMID:9784327 ChangChien CC, et al; Gynecol Oncol 71 (1): 99-103 (1998)

    4.3 Drug Warning

    ... Glacial acetic acid is widely used as a substitute for chemical peeling because it is readily ... available and affordable. However, its use can result in a number of serious complications. A 28-year-old female patient was admitted to /the/ hospital with deep second-degree chemical burns on her face caused by the application of a mixture of glacial acetic acid and flour for chemical peeling. During a 6-month follow-up, hypertrophic scarring developed on the both nasolabial folds despite scar management. Glacial acetic acid is a concentrated form of the organic acid, which gives vinegar its sour taste and pungent smell, and it is also an important reagent during the production of organic compounds. Unfortunately, misleading information regarding the use of glacial acetic acid for chemical peeling is causing serious chemical burns. Furthermore, there is high possibility of a poor prognosis, which includes inflammation, hypertrophic scar formation and pigmentation associated with its misuse. ...

    PMID:20708991 Yoo JH et al; . J Plast Reconstr Aesthet Surg. 63(12):e829-31 (2010).

    The enhanced toxicity of acid instilled directly into the rectum, without benefit of dilution and neutralization in the upper intestine, is evident in a case of acetic acid intoxication by accidental rectal administration of 50 mL of 9% acetic acid to a 5-yr-old boy. The complications included necrosis of the colon, acute renal failure, acute liver dysfunction, disseminated intravascular coagulopathy (DIC) and sepsis.

    PMID:8007044 Kawamata M et al; J Toxicol Clin Toxicol 32 (3): 333-36 (1994)

    In two patients, accidental application of acetic acid to the eyes followed very quickly by irrigation with water resulted in immediate corneal opacification. ... Regeneration of the epithelium took many months, but corneal anesthesia and opacity were permanent.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 703

    4.4 Drug Indication

    Used to treat infections in the ear canal.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Indicators and Reagents

    Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)

    5.2 ATC Code

    G - Genito urinary system and sex hormones

    G01 - Gynecological antiinfectives and antiseptics

    G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

    G01AD - Organic acids

    G01AD02 - Acetic acid

    S - Sensory organs

    S02 - Otologicals

    S02A - Antiinfectives

    S02AA - Antiinfectives

    S02AA10 - Acetic acid

    5.3 Absorption, Distribution and Excretion

    Acetic acid is absorbed from the GI tract and through the lung.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 701

    5.4 Metabolism/Metabolites

    Acetic acid ... is readily metabolized by most tissues and may give rise to the production of ketone bodies as intermediates. In vitro, acetate is incorporated into phospholipids, neutral lipids, steroids, sterols, and saturated and unsaturated fatty acids in a variety of human and animal tissue preparations. ...Metabolism of 14(C) acetate in mice results in radioactivity associated with the protein fractions of plasma and most major tissues.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 701

    In the body, acetic acid is partially converted into formic acid.

    Sheftel, V.O.; Indirect Food Additives and Polymers. Migration and Toxicology. Lewis Publishers, Boca Raton, FL. 2000., p. 650

    When dogs were administered large doses (1-2 g/kg ip or sc) of sodium acetate, only small amounts appeared in the urine, which is evidence of the rapid utilization of acetic acid.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 701

    Acetic Acid is a known human metabolite of acetaldehyde.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.5 Mechanism of Action

    Although acetic acid has been shown to induce apoptosis in yeast, the exact apoptotic mechanisms remain unknown. Here, /the study examined/ the effects of acetic acid treatment on yeast cells by 2-DE, revealing alterations in the levels of proteins directly or indirectly linked with the target of rapamycin (TOR) pathway: amino-acid biosynthesis, transcription/translation machinery, carbohydrate metabolism, nucleotide biosynthesis, stress response, protein turnover and cell cycle. The increased levels of proteins involved in amino-acid biosynthesis presented a counteracting response to a severe intracellular amino-acid starvation induced by acetic acid. Deletion of GCN4 and GCN2 encoding key players of general amino-acid control (GAAC) system caused a higher resistance to acetic acid indicating an involvement of Gcn4p/Gcn2p in the apoptotic signaling. Involvement of the TOR pathway in acetic acid-induced apoptosis was also reflected by the higher survival rates associated to a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-negative phenotype and lower reactive oxygen species levels of Deltator1 cells. In addition, deletion mutants for several downstream mediators of the TOR pathway revealed that apoptotic signaling involves the phosphatases Pph21p and Pph22p but not Sit4p. Altogether, /these/ results indicate that GAAC and TOR pathways (Tor1p) are involved in the signaling of acetic acid-induced apoptosis.

    PMID:19137548 Almeida B et al; Proteomics. 9(3):720-32 (2009).

    Acetic acid was found to have actions on urinary bladder smooth muscle in /the/ routine ion channel screening assays. Numerous studies have examined the mechanisms of bladder irritation by acetic acid; however, the direct effect of acetic acid on ion channels in detrusor smooth muscle cells has not been evaluated. /The study/ used whole-cell patch-clamp techniques to examine the effect of acetic acid on large-conductance Ca2+-activated K+ channels (BKCa) from guinea pig detrusor smooth muscle cells and CHO cells expressing recombinant human BKCaalphabeta1 (CHO BKCaalphabeta1) and human BKCaalpha (CHO BKCaalpha). Acetic acid activated BKCa currents in a concentration-dependent (0.01% to 0.05% v/v) manner in all the cell systems studied. Acetic acid (0.05%) increased BKCa current at +30 mV by 2764 +/- 918% (n=8) in guinea pig detrusor smooth muscle cells. Acetic acid (0.03%) shifted the V1/2 of conductance-voltage curve by 64 +/- 14 (n=5), 128 +/- 14 (n=5), and 126 +/- 12 mV (n=4) in CHO BKCaalpha, CHO BKCaalphabeta1 and detrusor smooth muscle cells, respectively. This effect of acetic acid was found to be independent of pH and was also not produced by its salt form, sodium acetate. Automated patch-clamp experiments also showed similar activation of CHO BKCaalphabeta1 by acetic acid. In conclusion, acetic acid directly activates BKCa channels in detrusor smooth muscle cells. This novel study necessitates caution while interpreting the results from acetic acid bladder irritation model.

    PMID:17382925 Ghatta S et al; Eur J Pharmacol. 563(1-3):203-8 (2007).

    /It was/ previously shown that acetic acid activates a mitochondria-dependent death process in Saccharomyces cerevisiae and that the ADP/ATP carrier (AAC) is required for mitochondrial outer membrane permeabilization and cytochrome c release. Mitochondrial fragmentation and degradation have also been shown in response to this death stimulus. Herein, /the study/ show that autophagy is not active in cells undergoing acetic acid-induced apoptosis and is therefore not responsible for mitochondrial degradation. Furthermore, /the study/ found that the vacuolar protease Pep4p and the AAC proteins have a role in mitochondrial degradation using yeast genetic approaches. Depletion and overexpression of Pep4p, an orthologue of human cathepsin D, delays and enhances mitochondrial degradation respectively. Moreover, Pep4p is released from the vacuole into the cytosol in response to acetic acid treatment. AAC-deleted cells also show a decrease in mitochondrial degradation in response to acetic acid and are not defective in Pep4p release. Therefore, AAC proteins seem to affect mitochondrial degradation at a step subsequent to Pep4p release, possibly triggering degradation through their involvement in mitochondrial permeabilization. The finding that both mitochondrial AAC proteins and the vacuolar Pep4p interfere with mitochondrial degradation suggests a complex regulation and interplay between mitochondria and the vacuole in yeast programmed cell death.

    PMID:20345665 Pereira C et al ; Mol Microbiol. 76(6):1398-410 (2010).

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CHINA","customerAddress":"Fifth Floor, B-506,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748543400,"product":"VINYL ACETATE MONOMER HQ14-17PPM (AIFTA NO.20255060190 DT. 26.05.2025 )VINYL ACETATE MONOMER HQ14-17PPM","address":"105,BAJAJ BHAVAN,10 TH FLOOR,,NARI","city":"MUMBAI,MAHARASHTRA","supplier":"CELANESE PTE LTD","supplierCountry":"SINGAPORE","foreign_port":"SINGAPORE","customer":"C J SHAH CO","customerCountry":"INDIA","quantity":"300000.00","actualQuantity":"300","unit":"MTS","unitRateFc":"840","totalValueFC":"255547.4","currency":"USD","unitRateINR":"72576","date":"30-May-2025","totalValueINR":"21772800","totalValueInUsd":"255547.4","indian_port":"JNPT","hs_no":"29153200","bill_no":"2367729","productDescription":"API","marketType":"","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"70 ANSON ROAD,#21-01\/02 HUB SYNERGY POINT SINGAPORE 079905 Singapore, SINGAPORE, Singapore Singapore","customerAddress":"105,BAJAJ BHAVAN,10 TH FLOOR,,NARI"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748543400,"product":"VINYL ACETATE MONOMER HQ14-17 PPM IN BULK (AIFTA NO. 20255060186 DT. 26.05.2025 )VINYL ACETATE MONOMER HQ14-17 PPM IN BULK","address":"REGENT CHAMBERS 7TH FLOOR","city":"MUMBAI,MAHARASHTRA","supplier":"CELANESE PTE LTD","supplierCountry":"SINGAPORE","foreign_port":"SINGAPORE","customer":"VINYL CHEMICALS INDIA LTD","customerCountry":"INDIA","quantity":"999595.00","actualQuantity":"999.595","unit":"MTS","unitRateFc":"840","totalValueFC":"851479.5","currency":"USD","unitRateINR":"72576","date":"30-May-2025","totalValueINR":"72546606.72","totalValueInUsd":"851479.5","indian_port":"JNPT","hs_no":"29153200","bill_no":"2368892","productDescription":"API","marketType":"","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"70 ANSON ROAD HUB SYNERGY POINT #21 -01\/002 SINGAPORE 079905 ., , Singa pore Singapore","customerAddress":"REGENT CHAMBERS 7TH FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748629800,"product":"CYANO ACETIC ACID 70% CYANO ACETIC ACID","address":"4, PRABHU PARK NO.2,","city":"","supplier":"HEBEI CHENGXIN SKYTOP PHARMCHEM CO","supplierCountry":"CHINA","foreign_port":"XINGANG","customer":"BEST VALUE CHEM PRIVATE LTD","customerCountry":"INDIA","quantity":"22500.00","actualQuantity":"22500","unit":"KGS","unitRateFc":"1.2","totalValueFC":"27836.4","currency":"N\/A","unitRateINR":"105.4","date":"31-May-2025","totalValueINR":"2371680","totalValueInUsd":"27836.4","indian_port":"JNPT","hs_no":"29269090","bill_no":"2399640","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XINGANG","supplierAddress":",LTD CHENGNAN AREA, INDUSTRIAL ZONE OF SHIJIAZHUANG SOUTH, YUANSHI COUN TY SHIJIAZHUANG CITY, HEBEI PROVINC CHINA","customerAddress":"4, PRABHU PARK NO.2,"}]
    01-Jan-2022
    31-May-2025
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    DOSAGE - SOLUTION/DROPS;OTIC - 2% **Federal R...DOSAGE - SOLUTION/DROPS;OTIC - 2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12179

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    DOSAGE - SOLUTION;IRRIGATION, URETHRAL - 250M...DOSAGE - SOLUTION;IRRIGATION, URETHRAL - 250MG/100ML

    USFDA APPLICATION NUMBER - 17656

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    ABOUT THIS PAGE

    Looking for 64-19-7 / Acetic Acid API manufacturers, exporters & distributors?

    Acetic Acid manufacturers, exporters & distributors 1

    74

    PharmaCompass offers a list of Acetic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Acetic Acid manufacturer or Acetic Acid supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Acetic Acid manufacturer or Acetic Acid supplier.

    PharmaCompass also assists you with knowing the Acetic Acid API Price utilized in the formulation of products. Acetic Acid API Price is not always fixed or binding as the Acetic Acid Price is obtained through a variety of data sources. The Acetic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Acetic Acid

    Synonyms

    Ethanoic acid, 64-19-7, Glacial acetic acid, Ethylic acid, Vinegar acid, Acetic acid, glacial

    Cas Number

    64-19-7

    Unique Ingredient Identifier (UNII)

    Q40Q9N063P

    About Acetic Acid

    Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)

    Ethylic acid Manufacturers

    A Ethylic acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ethylic acid, including repackagers and relabelers. The FDA regulates Ethylic acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ethylic acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ethylic acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ethylic acid Suppliers

    A Ethylic acid supplier is an individual or a company that provides Ethylic acid active pharmaceutical ingredient (API) or Ethylic acid finished formulations upon request. The Ethylic acid suppliers may include Ethylic acid API manufacturers, exporters, distributors and traders.

    click here to find a list of Ethylic acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ethylic acid USDMF

    A Ethylic acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Ethylic acid active pharmaceutical ingredient (API) in detail. Different forms of Ethylic acid DMFs exist exist since differing nations have different regulations, such as Ethylic acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ethylic acid DMF submitted to regulatory agencies in the US is known as a USDMF. Ethylic acid USDMF includes data on Ethylic acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ethylic acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ethylic acid suppliers with USDMF on PharmaCompass.

    Ethylic acid GMP

    Ethylic acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ethylic acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ethylic acid GMP manufacturer or Ethylic acid GMP API supplier for your needs.

    Ethylic acid CoA

    A Ethylic acid CoA (Certificate of Analysis) is a formal document that attests to Ethylic acid's compliance with Ethylic acid specifications and serves as a tool for batch-level quality control.

    Ethylic acid CoA mostly includes findings from lab analyses of a specific batch. For each Ethylic acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ethylic acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Ethylic acid EP), Ethylic acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ethylic acid USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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