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Chemistry

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Also known as: 630-93-3, 5,5-diphenylhydantoin sodium salt, Dilantin sodium, Diphenylhydantoin sodium, Diphantoine, Tacosal
Molecular Formula
C15H11N2NaO2
Molecular Weight
274.25  g/mol
InChI Key
FJPYVLNWWICYDW-UHFFFAOYSA-M
FDA UNII
4182431BJH

Phenytoin Sodium
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
1 2D Structure

Phenytoin Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;5,5-diphenylimidazolidin-3-ide-2,4-dione
2.1.2 InChI
InChI=1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
2.1.3 InChI Key
FJPYVLNWWICYDW-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC=C(C=C1)C2(C(=O)[N-]C(=O)N2)C3=CC=CC=C3.[Na+]
2.2 Other Identifiers
2.2.1 UNII
4182431BJH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5,5-diphenylhydantoin

2. 5,5-diphenylimidazolidine-2,4-dione

3. Antisacer

4. Difenin

5. Dihydan

6. Dilantin

7. Diphenylhydantoin

8. Diphenylhydantoinate, Sodium

9. Epamin

10. Epanutin

11. Fenitoin

12. Hydantol

13. Phenhydan

14. Phenytoin

15. Sodium Diphenylhydantoinate

2.3.2 Depositor-Supplied Synonyms

1. 630-93-3

2. 5,5-diphenylhydantoin Sodium Salt

3. Dilantin Sodium

4. Diphenylhydantoin Sodium

5. Diphantoine

6. Tacosal

7. Antisacer

8. Phenytoin Sodium Salt

9. Diphentoin

10. Epanutin

11. Solantoin

12. Solantyl

13. Eptoin

14. Sodium Phenytoin

15. Diphenylan Sodium

16. Sodium 2,5-dioxo-4,4-diphenylimidazolidin-1-ide

17. Phenytek

18. Sodium Diphenylhydantoin

19. 5,5-diphenylhydantoin Sodium

20. Mls000554076

21. 2,4-imidazolidinedione, 5,5-diphenyl-, Monosodium Salt

22. 4182431bjh

23. Citrullamon

24. Fenidantoin

25. Novodiphenyl

26. Aladdin

27. Alepsin

28. Cumatil

29. Decatona

30. Dihydan

31. Ditomed

32. Enkefal

33. Epdantoin

34. Epileptin

35. Epsolin

36. Eptolin

37. Fenigramon

38. Fenitron

39. Fenytoin

40. Hidantin

41. Phenilep

42. Smr000146393

43. Ditoin

44. Episar

45. Muldis

46. Fenitoin Sodium

47. Hidantal Sodium

48. Lepitoin Sodium

49. Denyl Sodium

50. Aleviatin Sodium

51. Diphenine Sodium

52. Epilantin-e

53. Fenitoina Sodica

54. Soluble Phenytoin

55. Dilantin Infatabs

56. Metinal Idantoina

57. Di-len

58. Dilantin Injection

59. Dilantin Suspension

60. Om-hydantoine Sodium

61. Sdph

62. Prompt Phenytoin Sodium

63. Sodium;5,5-diphenylimidazolidin-3-ide-2,4-dione

64. Mls000028562

65. Sodium Diphenyl Hydantoinate

66. Diphenylhydantoin Sodium Salt

67. Sodium 5,5-diphenylhydantoinate

68. Phenytoin, Sodium Salt

69. Sodium 5,5-diphenyl Hydantoinate

70. Nsc-757274

71. Extended Phenytoin Sodium

72. Smr000058987

73. Einecs 211-148-2

74. Mfcd00069674

75. Hydantoin, 5,5-diphenyl-, Sodium Salt

76. Phenytoin Sodium [usp:jan]

77. Sodium 5,5-diphenylhydantoin

78. Diphenylhydantoin, Sodium Salt

79. Sodium 5,5-diphenyl-2,4-imidazolidinedione

80. Unii-4182431bjh

81. Hydantoin, 5,5-diphenyl-, Monosodium Salt

82. Opera_id_1233

83. Dsstox_cid_3775

84. Dsstox_rid_77190

85. Dsstox_gsid_23775

86. Spectrum1500485

87. Schembl3051683

88. Dtxsid2023775

89. Phenytoin Sodium [vandf]

90. Hms501j09

91. 5,5-diphenylhydatoin Sodium Salt

92. Phenytoin Sodium [mart.]

93. Phenytoin Sodium [usp-rs]

94. Phenytoin Sodium [who-dd]

95. Phenytoin Sodium [who-ip]

96. Hms1920h10

97. Hms2091p14

98. Hms2233k24

99. Hms3259h11

100. Hms3373o11

101. Phenytoin Sodium Salt [mi]

102. Tox21_302338

103. Ccg-39219

104. Akos003273947

105. Akos015951389

106. Akos025310163

107. Phenytoin Sodium [ep Impurity]

108. Phenytoin Sodium [orange Book]

109. Nc00642

110. Nsc 757274

111. Phenytoin Sodium [ep Monograph]

112. 5,5-diphenylhydantoin Sodium Sigmaultra

113. Phenytoin Sodium [usp Monograph]

114. Ncgc00094758-01

115. Ncgc00094758-02

116. Ncgc00164434-01

117. Ncgc00255285-01

118. As-13308

119. Cas-630-93-3

120. 5,5-diphenylhydantoin Sodium Salt, >=99%

121. Phenytoinum Natricum [who-ip Latin]

122. D1331

123. Diphenylhydantoin Sodium [green Book]

124. Phenytoin Sodium For Injection [jan]

125. En300-49847

126. H12023

127. A834211

128. Sr-05000001698

129. Q-201564

130. Sr-05000001698-1

131. Q27258415

132. 2,4-imidazolidinedione, 5,5-diphenyl-, Sodium Salt (1:1)

133. Phenytoin Sodium, European Pharmacopoeia (ep) Reference Standard

134. Phenytoin Sodium, United States Pharmacopeia (usp) Reference Standard

135. Phenytoin Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

2.3.3 Other Synonyms

1. Phenylhydantoin

2.4 Create Date
2005-06-29
3 Chemical and Physical Properties
Molecular Weight 274.25 g/mol
Molecular Formula C15H11N2NaO2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass274.07182188 g/mol
Monoisotopic Mass274.07182188 g/mol
Topological Polar Surface Area47.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NamePhenytoin sodium
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormInjectable
RouteInjection
Strength50mg/ml
Market StatusPrescription
CompanyHospira; Hikma Maple; X-gen Pharms; Luitpold

2 of 2  
Drug NamePhenytoin sodium
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormInjectable
RouteInjection
Strength50mg/ml
Market StatusPrescription
CompanyHospira; Hikma Maple; X-gen Pharms; Luitpold

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


Cytochrome P-450 CYP1A2 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inducers.)


Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cytochrome P450 1A2 Inducers [MoA]; Cytochrome P450 2B6 Inducers [MoA]; Cytochrome P450 2C19 Inducers [MoA]; Cytochrome P450 2C8 Inducers [MoA]; Cytochrome P450 2C9 Inducers [MoA]; Cytochrome P450 2D6 Inducers [MoA]; Cytochrome P450 3A Inducers [MoA]; Decreased Central Nervous System Disorganized Electrical Activity [PE]; Anti-epileptic Agent [EPC]

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Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1758220200,"product":"HISY-FSPH-Y037-N FOSPHENYTOIN SODIUM HISY-FSPH-Y037-N FOSPHENYTOIN SODIUM","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"CHEMWERTH INC","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"INTAS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"6.20","actualQuantity":"6200","unit":"GMS","unitRateFc":"4.8","totalValueFC":"30096.8","currency":"USD","unitRateINR":"428.5","date":"19-Sep-2025","totalValueINR":"2656615","totalValueInUsd":"30096.8","indian_port":"Ahmedabad Air","hs_no":"29332100","bill_no":"4599344","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"1764 LITCHFIELD TURNPIKE SUITE 202 WOODBRIDGE SDNF United States Of America","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"}]
24-Jan-2022
19-Sep-2025
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DOSAGE - INJECTABLE;INJECTION - 50MG/ML

USFDA APPLICATION NUMBER - 84307

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DOSAGE - CAPSULE;ORAL - 100MG EXTENDED

USFDA APPLICATION NUMBER - 84349

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DOSAGE - CAPSULE;ORAL - 30MG EXTENDED

USFDA APPLICATION NUMBER - 84349

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ABOUT THIS PAGE

Looking for 630-93-3 / Phenytoin Sodium API manufacturers, exporters & distributors?

Phenytoin Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Phenytoin Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Phenytoin Sodium manufacturer or Phenytoin Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Phenytoin Sodium manufacturer or Phenytoin Sodium supplier.

PharmaCompass also assists you with knowing the Phenytoin Sodium API Price utilized in the formulation of products. Phenytoin Sodium API Price is not always fixed or binding as the Phenytoin Sodium Price is obtained through a variety of data sources. The Phenytoin Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Phenytoin Sodium

Synonyms

630-93-3, 5,5-diphenylhydantoin sodium salt, Dilantin sodium, Diphenylhydantoin sodium, Diphantoine, Tacosal

Cas Number

630-93-3

Unique Ingredient Identifier (UNII)

4182431BJH

About Phenytoin Sodium

An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

Epamin Manufacturers

A Epamin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Epamin, including repackagers and relabelers. The FDA regulates Epamin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Epamin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Epamin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Epamin Suppliers

A Epamin supplier is an individual or a company that provides Epamin active pharmaceutical ingredient (API) or Epamin finished formulations upon request. The Epamin suppliers may include Epamin API manufacturers, exporters, distributors and traders.

click here to find a list of Epamin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Epamin USDMF

A Epamin DMF (Drug Master File) is a document detailing the whole manufacturing process of Epamin active pharmaceutical ingredient (API) in detail. Different forms of Epamin DMFs exist exist since differing nations have different regulations, such as Epamin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Epamin DMF submitted to regulatory agencies in the US is known as a USDMF. Epamin USDMF includes data on Epamin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Epamin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Epamin suppliers with USDMF on PharmaCompass.

Epamin CEP

A Epamin CEP of the European Pharmacopoeia monograph is often referred to as a Epamin Certificate of Suitability (COS). The purpose of a Epamin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Epamin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Epamin to their clients by showing that a Epamin CEP has been issued for it. The manufacturer submits a Epamin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Epamin CEP holder for the record. Additionally, the data presented in the Epamin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Epamin DMF.

A Epamin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Epamin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Epamin suppliers with CEP (COS) on PharmaCompass.

Epamin WC

A Epamin written confirmation (Epamin WC) is an official document issued by a regulatory agency to a Epamin manufacturer, verifying that the manufacturing facility of a Epamin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Epamin APIs or Epamin finished pharmaceutical products to another nation, regulatory agencies frequently require a Epamin WC (written confirmation) as part of the regulatory process.

click here to find a list of Epamin suppliers with Written Confirmation (WC) on PharmaCompass.

Epamin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Epamin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Epamin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Epamin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Epamin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Epamin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Epamin suppliers with NDC on PharmaCompass.

Epamin GMP

Epamin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Epamin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Epamin GMP manufacturer or Epamin GMP API supplier for your needs.

Epamin CoA

A Epamin CoA (Certificate of Analysis) is a formal document that attests to Epamin's compliance with Epamin specifications and serves as a tool for batch-level quality control.

Epamin CoA mostly includes findings from lab analyses of a specific batch. For each Epamin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Epamin may be tested according to a variety of international standards, such as European Pharmacopoeia (Epamin EP), Epamin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Epamin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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