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    Chemistry

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    Also known as: 163521-08-2, Vilazodone hcl, Viibryd, Vilazodone (hydrochloride), Emd-68843, Emd 68 843
    Molecular Formula
    C26H28ClN5O2
    Molecular Weight
    478.0  g/mol
    InChI Key
    RPZBRGFNBNQSOP-UHFFFAOYSA-N
    FDA UNII
    U8HTX2GK8J
    Vilazodone Hydrochloride
    A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT.
    1 2D Structure

    Vilazodone Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H
    2.1.3 InChI Key
    RPZBRGFNBNQSOP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    U8HTX2GK8J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)-1-piperazinyl)-, Hydrochloride (1:1)

    2. 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide

    3. 68843, Emd

    4. Emb 68843

    5. Emb-68843

    6. Emb68843

    7. Emd 68843

    8. Hcl, Vilazodone

    9. Hydrochloride, Vilazodone

    10. Viibryd

    11. Vilazodone

    12. Vilazodone Hcl

    2.3.2 Depositor-Supplied Synonyms

    1. 163521-08-2

    2. Vilazodone Hcl

    3. Viibryd

    4. Vilazodone (hydrochloride)

    5. Emd-68843

    6. Emd 68 843

    7. Vilazodone Hydrochloride [usan]

    8. 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide Hydrochloride

    9. Emd 68843

    10. U8htx2gk8j

    11. Sb659746-a

    12. 163521-08-2 (hcl)

    13. Chebi:70705

    14. Sb659746a

    15. 5-[4-[4-(5-cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide Hydrochloride

    16. Sb 659746a

    17. Sb-659746a

    18. Sb-659746-a

    19. Vilazodone Hydrochloride (usan)

    20. 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide, Hydrochloride

    21. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide Hydrochloride

    22. 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)-1-piperazinyl)-, Hydrochloride (1:1)

    23. 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide Monohydrochloride

    24. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride

    25. 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide Hydrochloride

    26. Unii-u8htx2gk8j

    27. Vilazodonei

    28. 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-, Hydrochloride (1:1)

    29. Viibryd (tn)

    30. Vilazodonehydrochloride

    31. Vilazodone Monohydrochloride

    32. Schembl867358

    33. Chembl1615374

    34. Dtxsid80936833

    35. Bcp11496

    36. Emd68843

    37. Mfcd00940014

    38. S4259

    39. Vilazodone Hydrochloride [mi]

    40. Akos024464039

    41. Ccg-213313

    42. Cs-0549

    43. Vilazodone Hydrochloride [mart.]

    44. Vilazodone Hydrochloride [vandf]

    45. Vilazodone Hydrochloride [who-dd]

    46. 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboximidic Acid--hydrogen Chloride (1/1)

    47. Ac-25885

    48. As-74699

    49. Emd 68843;sb659746a

    50. Hy-14261

    51. Vilazodone Hydrochloride, >=98% (hplc)

    52. A3919

    53. Sw219887-1

    54. V0149

    55. Vilazodone Hydrochloride [orange Book]

    56. D09699

    57. 521v128

    58. J-525160

    59. Q27139037

    60. 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine Hydrochloride

    61. 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)piperazine Hydrochloride

    62. 1-[4-(5-cyanoindol-3-yl)butyl]4-(2-carbamoyl-benzofuran-5-yl)-piperazine Hydrochloride

    63. 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2carboxamide Hydrochloride

    64. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide Hydrochloride

    65. 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-ium Chloride

    66. Vilazodone Hydrochloride Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 478.0 g/mol
    Molecular Formula C26H28ClN5O2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass477.1931528 g/mol
    Monoisotopic Mass477.1931528 g/mol
    Topological Polar Surface Area102 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity729
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameViibryd
    PubMed HealthVilazodone (By mouth)
    Drug ClassesAntidepressant
    Drug LabelVIIBRYD Tablets for oral administration contain polymorph Form IV vilazodone hydrochloride (HCl), a selective serotonin reuptake inhibitor and a 5HT1A receptor partial agonist.Vilazodone HCl is 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)...
    Active IngredientVilazodone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyForest Labs

    2 of 2  
    Drug NameViibryd
    PubMed HealthVilazodone (By mouth)
    Drug ClassesAntidepressant
    Drug LabelVIIBRYD Tablets for oral administration contain polymorph Form IV vilazodone hydrochloride (HCl), a selective serotonin reuptake inhibitor and a 5HT1A receptor partial agonist.Vilazodone HCl is 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)...
    Active IngredientVilazodone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyForest Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antidepressive Agents

    Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

    Selective Serotonin Reuptake Inhibitors

    Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)

    Serotonin 5-HT1 Receptor Agonists

    Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes. (See all compounds classified as Serotonin 5-HT1 Receptor Agonists.)

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    04-Mar-2022
    23-May-2025
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    DOSAGE - TABLET;ORAL - 10MG

    USFDA APPLICATION NUMBER - 22567

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    USFDA APPLICATION NUMBER - 22567

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    ABOUT THIS PAGE

    Looking for 163521-08-2 / Vilazodone Hydrochloride API manufacturers, exporters & distributors?

    Vilazodone Hydrochloride manufacturers, exporters & distributors 1

    90

    PharmaCompass offers a list of Vilazodone Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vilazodone Hydrochloride manufacturer or Vilazodone Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vilazodone Hydrochloride manufacturer or Vilazodone Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Vilazodone Hydrochloride API Price utilized in the formulation of products. Vilazodone Hydrochloride API Price is not always fixed or binding as the Vilazodone Hydrochloride Price is obtained through a variety of data sources. The Vilazodone Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Vilazodone Hydrochloride

    Synonyms

    163521-08-2, Vilazodone hcl, Viibryd, Vilazodone (hydrochloride), Emd-68843, Emd 68 843

    Cas Number

    163521-08-2

    Unique Ingredient Identifier (UNII)

    U8HTX2GK8J

    About Vilazodone Hydrochloride

    A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT.

    EMD-68843 Manufacturers

    A EMD-68843 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of EMD-68843, including repackagers and relabelers. The FDA regulates EMD-68843 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. EMD-68843 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of EMD-68843 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    EMD-68843 Suppliers

    A EMD-68843 supplier is an individual or a company that provides EMD-68843 active pharmaceutical ingredient (API) or EMD-68843 finished formulations upon request. The EMD-68843 suppliers may include EMD-68843 API manufacturers, exporters, distributors and traders.

    click here to find a list of EMD-68843 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    EMD-68843 USDMF

    A EMD-68843 DMF (Drug Master File) is a document detailing the whole manufacturing process of EMD-68843 active pharmaceutical ingredient (API) in detail. Different forms of EMD-68843 DMFs exist exist since differing nations have different regulations, such as EMD-68843 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A EMD-68843 DMF submitted to regulatory agencies in the US is known as a USDMF. EMD-68843 USDMF includes data on EMD-68843's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The EMD-68843 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of EMD-68843 suppliers with USDMF on PharmaCompass.

    EMD-68843 WC

    A EMD-68843 written confirmation (EMD-68843 WC) is an official document issued by a regulatory agency to a EMD-68843 manufacturer, verifying that the manufacturing facility of a EMD-68843 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting EMD-68843 APIs or EMD-68843 finished pharmaceutical products to another nation, regulatory agencies frequently require a EMD-68843 WC (written confirmation) as part of the regulatory process.

    click here to find a list of EMD-68843 suppliers with Written Confirmation (WC) on PharmaCompass.

    EMD-68843 NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing EMD-68843 as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for EMD-68843 API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture EMD-68843 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain EMD-68843 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a EMD-68843 NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of EMD-68843 suppliers with NDC on PharmaCompass.

    EMD-68843 GMP

    EMD-68843 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of EMD-68843 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right EMD-68843 GMP manufacturer or EMD-68843 GMP API supplier for your needs.

    EMD-68843 CoA

    A EMD-68843 CoA (Certificate of Analysis) is a formal document that attests to EMD-68843's compliance with EMD-68843 specifications and serves as a tool for batch-level quality control.

    EMD-68843 CoA mostly includes findings from lab analyses of a specific batch. For each EMD-68843 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    EMD-68843 may be tested according to a variety of international standards, such as European Pharmacopoeia (EMD-68843 EP), EMD-68843 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (EMD-68843 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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