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    EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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    Gonane Donepezil

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    Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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    Axplora- The partner of choice for complex APIs.

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    Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

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    Chemistry

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    Also known as: 120011-70-3, Donepezil hcl, Aricept, Bnag, 110119-84-1, 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one hydrochloride
    Molecular Formula
    C24H30ClNO3
    Molecular Weight
    416.0  g/mol
    InChI Key
    XWAIAVWHZJNZQQ-UHFFFAOYSA-N
    FDA UNII
    3O2T2PJ89D
    Donepezil
    An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
    1 2D Structure

    Donepezil

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
    2.1.3 InChI Key
    XWAIAVWHZJNZQQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    3O2T2PJ89D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride

    2. Aricept

    3. Donepezil

    4. Donepezilium Oxalate Trihydrate

    5. E 2020

    6. E-2020

    7. E2020

    8. Eranz

    2.3.2 Depositor-Supplied Synonyms

    1. 120011-70-3

    2. Donepezil Hcl

    3. Aricept

    4. Bnag

    5. 110119-84-1

    6. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride

    7. E2020

    8. Donepezilhcl

    9. E-2020

    10. Aricept Odt

    11. E 2020

    12. Donepezil (hydrochloride)

    13. Donepezil, Hcl

    14. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

    15. Nsc-737535

    16. Nsc-758882

    17. Chembl1678

    18. 3o2t2pj89d

    19. 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

    20. 2-(1-benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride

    21. 120011-70-3 (hcl)

    22. E2020;e-2020

    23. Dsstox_cid_26698

    24. Dsstox_rid_81832

    25. Dsstox_gsid_46698

    26. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, Hydrochloride (1:1)

    27. Eranz

    28. 2-(1-benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one Hydrochloride

    29. E 2020 (pharmaceutical)

    30. Smr000449292

    31. Cas-120011-70-3

    32. Donepezil Hydrochloride [usan]

    33. Nsc 737535

    34. Nsc 758882

    35. Ncgc00167537-01

    36. Unii-3o2t2pj89d

    37. Memorit

    38. Memac

    39. Aricept Evess

    40. Donepezil,hcl

    41. Aricept D

    42. (+/-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

    43. (+/-)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone Hydrochloride

    44. Aricept (tn)

    45. Donepezil Hydrochloride [usan:usp]

    46. Adlarity

    47. Donepezil, Hydrochloride

    48. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hcl

    49. Donepezil Hcl (aricept)

    50. Donepezil Hcl - Bio-x

    51. Schembl1815

    52. Donepezil Hydrochloride,(s)

    53. Mls000758276

    54. Mls001401387

    55. Chebi:4696

    56. Dtxsid0046698

    57. Pharmakon1600-01504403

    58. Act02683

    59. Amy40527

    60. Bcp02205

    61. Bcp24884

    62. Hy-b0034

    63. Donepezil Hydrochloride [mi]

    64. Tox21_112534

    65. Ac-913

    66. Donepezil Hydrochloride (jp17/usp)

    67. Donepezil Hydrochloride [jan]

    68. Mfcd00881312

    69. Nsc737535

    70. Nsc758882

    71. S2462

    72. Akos000277343

    73. Akos016340656

    74. Tox21_112534_1

    75. Ccg-101043

    76. Ccg-213309

    77. Cs-0863

    78. Donepezil Hydrochloride [mart.]

    79. Donepezil Hydrochloride [vandf]

    80. Ks-1051

    81. Nc00293

    82. (+-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

    83. Donepezil Hydrochloride [usp-rs]

    84. Donepezil Hydrochloride [who-dd]

    85. Ncgc00167537-02

    86. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, Hydrochloride

    87. Bd164380

    88. D4099

    89. Donepezil Hydrochloride [orange Book]

    90. Ft-0602354

    91. Ft-0625589

    92. Donepezil Hydrochloride [ep Monograph]

    93. D00670

    94. Donepezil Hydrochloride [usp Monograph]

    95. E-2022

    96. Namzaric Component Donepezil Hydrochloride

    97. 119d841

    98. A804411

    99. Donepezil Hydrochloride Component Of Namzaric

    100. Donepezil Hydrochloride Monohydrate, >=98% (hplc)

    101. Q-100096

    102. Q-201040

    103. Q27106438

    104. Donepezil Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    105. 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one Hcl

    106. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1h-inden-1-one

    107. (+-)-2,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

    108. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride 120014-06-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 416.0 g/mol
    Molecular Formula C24H30ClNO3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass415.1914215 g/mol
    Monoisotopic Mass415.1914215 g/mol
    Topological Polar Surface Area38.8 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity510
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAricept
    PubMed HealthDonepezil (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
    Active IngredientDonepezil hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 23mg; 10mg
    Market StatusPrescription
    CompanyEisai

    2 of 4  
    Drug NameDonepezil hydrochloride
    Drug LabelDonepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
    Active IngredientDonepezil hydrochloride
    Dosage FormTablet, orally disintegrating; Tablet
    Routeoral; Oral
    Strength5mg; 23mg; 10mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

    3 of 4  
    Drug NameAricept
    PubMed HealthDonepezil (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
    Active IngredientDonepezil hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 23mg; 10mg
    Market StatusPrescription
    CompanyEisai

    4 of 4  
    Drug NameDonepezil hydrochloride
    Drug LabelDonepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
    Active IngredientDonepezil hydrochloride
    Dosage FormTablet, orally disintegrating; Tablet
    Routeoral; Oral
    Strength5mg; 23mg; 10mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

    5 Pharmacology and Biochemistry