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    Also known as: Flector, Diclofenac hydroxyethylpyrrolidine, Diep, Dhep, Diclofenac epolaminum, Diclofenac-epolamine
    Molecular Formula
    C20H24Cl2N2O3
    Molecular Weight
    411.3  g/mol
    InChI Key
    DCERVXIINVUMKU-UHFFFAOYSA-N
    FDA UNII
    X5F8EKL9ZG
    Diclofenac Epolamine
    1 2D Structure

    Diclofenac Epolamine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-(2,6-dichloroanilino)phenyl]acetic acid;2-pyrrolidin-1-ylethanol
    2.1.2 InChI
    InChI=1S/C14H11Cl2NO2.C6H13NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;8-6-5-7-3-1-2-4-7/h1-7,17H,8H2,(H,18,19);8H,1-6H2
    2.1.3 InChI Key
    DCERVXIINVUMKU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCN(C1)CCO.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    X5F8EKL9ZG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dhep

    2. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

    3. Diclofenac Hydroxyethylpyrrolidine

    4. Diclofenac-epolamine

    5. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

    6. Diep

    7. Flector

    8. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

    2.3.2 Depositor-Supplied Synonyms

    1. Flector

    2. Diclofenac Hydroxyethylpyrrolidine

    3. Diep

    4. Dhep

    5. Diclofenac Epolaminum

    6. Diclofenac-epolamine

    7. X5f8ekl9zg

    8. 2-[2-(2,6-dichloroanilino)phenyl]acetic Acid;2-pyrrolidin-1-ylethanol

    9. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

    10. 2-((2,6-dichlorophenyl)amino)benzeneacetic Acid, Compd. With 1-pyrrolidineethanol (1:1)

    11. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

    12. Dhep Plaster

    13. Benzeneacetic Acid, 2-((2,6-dichlorophenyl)amino)-, Compd. With 1-pyrrolidineethanol (1:1)

    14. Chebi:48296

    15. Unii-x5f8ekl9zg

    16. Flector (tn)

    17. Licart

    18. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

    19. Schembl1006944

    20. Chembl1201180

    21. Dtxsid80152531

    22. Diclofenac Epolamine [vandf]

    23. Diclofenac Epolamine [mart.]

    24. S5737

    25. Diclofenac Epolamine [who-dd]

    26. Diclofenac Hydroxyethylpirrolidine

    27. Diclofenac Epolamine [orange Book]

    28. D07818

    29. 528d502

    30. Diclofenac Acid N-(2-hydroxyetheyl) Pyrrolidine Salt

    31. Q27121125

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 411.3 g/mol
    Molecular Formula C20H24Cl2N2O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass410.1163980 g/mol
    Monoisotopic Mass410.1163980 g/mol
    Topological Polar Surface Area72.8 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity363
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFlector
    PubMed HealthDiclofenac
    Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
    Drug LabelFlector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
    Active IngredientDiclofenac epolamine
    Dosage FormPatch
    RouteTopical
    Strength1.3%
    Market StatusPrescription
    CompanyInst Biochem

    2 of 2  
    Drug NameFlector
    PubMed HealthDiclofenac
    Drug ClassesAnalgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
    Drug LabelFlector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
    Active IngredientDiclofenac epolamine
    Dosage FormPatch
    RouteTopical
    Strength1.3%
    Market StatusPrescription
    CompanyInst Biochem

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cyclooxygenase Inhibitors [MoA]; Decreased Prostaglandin Production [PE]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]

    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696962600,"product":"HARMLESS BULK DRUG HS CODE- 29420090 DICLOFENAC EPOLAMINE\/APOLAMINE (*LUT ARN NO. AD240423002553N)","address":"PLOT NO. 322\/4 B G.I.D.C.","city":"GUJARAT","supplier":"AMOLI ORGANICS","supplierCountry":"INDIA","foreign_port":"SHANGHAI","customer":"TO THE ORDER OF","customerCountry":"CHINA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"500","totalValueFC":"2462.3","currency":"USD","unitRateINR":41000,"date":"11-Oct-2023","totalValueINR":"205000","totalValueInUsd":"2462.3","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4556800","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. 322\/4 B G.I.D.C., GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719772200,"product":"HARMLESS BULK DRUG HS CODE- 29420090 DICLOFENAC EPOLAMINE\/APOLAMINE (*LUT ARN NO. AD2403241438355)","address":"PLOT NO. 221, G.I.D.C.,","city":"GUJARAT","supplier":"AMOLI ORGANICS","supplierCountry":"INDIA","foreign_port":"TUNIS","customer":"TO THE ORDER OF","customerCountry":"TUNISIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"300","totalValueFC":"5815.2","currency":"USD","unitRateINR":24145.349999999999,"date":"01-Jul-2024","totalValueINR":"482907","totalValueInUsd":"5815.2","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"2104833","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TUNISIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. 221, G.I.D.C.,, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"HARMLESS BULK DRUG HS CODE- 29420090 DICLOFENAC EPOLAMINE\/APOLAMINE (LUT ARN NOAD2403241438355)","address":"PLOT NO. 221, G.I.D.C.,","city":"GUJARAT","supplier":"AMOLI ORGANICS","supplierCountry":"INDIA","foreign_port":"MONTEVIDEO -","customer":"TO THE ORDER OF","customerCountry":"URUGUAY","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"300","totalValueFC":"4229.5","currency":"USD","unitRateINR":23415,"date":"14-Aug-2024","totalValueINR":"351225","totalValueInUsd":"4229.5","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3195353","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"URUGUAY","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. 221, G.I.D.C.,, GUJARAT","customerAddress":""}]
    11-Oct-2023
    14-Aug-2024
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