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    Chemistry

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    Also known as: 969-33-5, Cyproheptadine hcl, Periactin hydrochloride, Anarexol, Cipractin, Nuran
    Molecular Formula
    C21H22ClN
    Molecular Weight
    323.9  g/mol
    InChI Key
    ZPMVNZLARAEGHB-UHFFFAOYSA-N
    FDA UNII
    0S9323MCT0
    Cyproheptadine Hydrochloride
    A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
    1 2D Structure

    Cyproheptadine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H
    2.1.3 InChI Key
    ZPMVNZLARAEGHB-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0S9323MCT0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Antergan

    2. Cyproheptadine

    3. Dihexazin

    4. Periactin

    5. Peritol

    6. Viternum

    2.3.2 Depositor-Supplied Synonyms

    1. 969-33-5

    2. Cyproheptadine Hcl

    3. Periactin Hydrochloride

    4. Anarexol

    5. Cipractin

    6. Nuran

    7. Antegan

    8. Peritol

    9. Periactin Syrup

    10. Component Of Dronactin

    11. Cyproheptadine (hydrochloride)

    12. Cyproheptadine Hydrochloride Anhydrous

    13. Cyproheptadiene Hydrochloride

    14. 41354-29-4

    15. Nsc-169911

    16. Cyproheptadine Hydrochloride Sesquihydrate

    17. Cyproheptadine Hydrochloride (anhydrous)

    18. Cpd000058431

    19. Mls000028462

    20. Chebi:59695

    21. 0s9323mct0

    22. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine Hydrochloride

    23. Periactine

    24. Nsc-759282

    25. Smr000058431

    26. 4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

    27. Cyproheptadine (hydrochloride Sesquihydrate)

    28. 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine Hydrochloride

    29. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

    30. Periactinol (van)

    31. Contrallerg

    32. Kulinet

    33. Kyliver

    34. Sialotin

    35. Vinorex

    36. Istam

    37. Periactinol Hydrochloride

    38. Cyproheptadine Chlorhydrate

    39. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

    40. 4-(5h-dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine Hydrochloride

    41. Cycloheptadine Hydrochloride

    42. Cyproheptadine Hydrochloride Hydrate

    43. Vufb3511

    44. Sr-01000003077

    45. Einecs 213-535-1

    46. Nsc 169911

    47. C21h21n.hcl

    48. Unii-0s9323mct0

    49. 4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

    50. Ai3-26940

    51. 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

    52. 4-(dibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride

    53. Cycloheptadine Hcl

    54. Prestwick_139

    55. Opera_id_383

    56. Cypoheptadine Hydrochloride

    57. Cyproheptadine-hydrochloride

    58. Piperidine, 4-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

    59. Chembl1716

    60. Schembl41842

    61. Mls001077277

    62. Mls001424281

    63. Mls002222173

    64. Regid_for_cid_13770

    65. Cyproptadine Hydrochloride,(s)

    66. Dtxsid5042586

    67. Hy-b0366a

    68. Hms1568e08

    69. Hms3414j05

    70. Hms3678j03

    71. Pharmakon1600-01505973

    72. Bcp34399

    73. Cyproheptadine Hydrochloride (anh.)

    74. Tox21_500246

    75. Anhydrous Cyproheptadine Hydrochloride

    76. Mfcd00012538

    77. Nsc169911

    78. Nsc759282

    79. S2044

    80. Akos015905305

    81. Ccg-101144

    82. Lp00246

    83. Nc00394

    84. Cyproheptadine Hydrochloride (periactin)

    85. Ncgc00093708-01

    86. Ncgc00093708-02

    87. Ncgc00260931-01

    88. Ac-15790

    89. As-14697

    90. Cyproheptadine Hydrochloride [who-dd]

    91. Eu-0100246

    92. Ft-0603147

    93. Sw196450-4

    94. C 6022

    95. C77331

    96. Wln: L C676 Byj Bu- Dt6n Dytj A1 &gh

    97. Sr-01000003077-2

    98. Sr-01000003077-4

    99. Sr-01000003077-9

    100. W-106308

    101. Cyproheptadine Hydrochloride 100 Microg/ml In Methanol

    102. Q27126856

    103. Piperidine,d]cyclohepten-5-ylidene)-1-methyl-, Hydrochloride

    104. 4-(5h-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

    105. 4-(5h-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidinehydrochloride

    106. 4-(5h-dibenzo[a,d]cyclohepten-5-yli Dine)-methylpiperidine Hydrochloride

    107. 1-methyl-4-(2-tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride

    108. 1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 323.9 g/mol
    Molecular Formula C21H22ClN
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass323.1440774 g/mol
    Monoisotopic Mass323.1440774 g/mol
    Topological Polar Surface Area3.2 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity423
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCyproheptadine hydrochloride
    PubMed HealthCyproheptadine Hydrochloride (By mouth)
    Drug ClassesRespiratory Agent
    Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
    Active IngredientCyproheptadine hydrochloride
    Dosage FormTablet; Syrup
    RouteOral
    Strength4mg; 2mg/5ml
    Market StatusPrescription
    CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

    2 of 2  
    Drug NameCyproheptadine hydrochloride
    PubMed HealthCyproheptadine Hydrochloride (By mouth)
    Drug ClassesRespiratory Agent
    Drug LabelCyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.Cyproheptadine hydrochloride USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, spa...
    Active IngredientCyproheptadine hydrochloride
    Dosage FormTablet; Syrup
    RouteOral
    Strength4mg; 2mg/5ml
    Market StatusPrescription
    CompanyLyne; Corepharma; Stason Pharms; Ivax Sub Teva Pharms; Pharm Assoc; Par Pharm

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Gastrointestinal Agents

    Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    API Reference Price

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    30-Apr-2025
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    ABOUT THIS PAGE

    Looking for 969-33-5 / Cyproheptadine Hydrochloride API manufacturers, exporters & distributors?

    Cyproheptadine Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Cyproheptadine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cyproheptadine Hydrochloride manufacturer or Cyproheptadine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cyproheptadine Hydrochloride manufacturer or Cyproheptadine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Cyproheptadine Hydrochloride API Price utilized in the formulation of products. Cyproheptadine Hydrochloride API Price is not always fixed or binding as the Cyproheptadine Hydrochloride Price is obtained through a variety of data sources. The Cyproheptadine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Cyproheptadine Hydrochloride

    Synonyms

    969-33-5, Cyproheptadine hcl, Periactin hydrochloride, Anarexol, Cipractin, Nuran

    Cas Number

    969-33-5

    Unique Ingredient Identifier (UNII)

    0S9323MCT0

    About Cyproheptadine Hydrochloride

    A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

    Cyproheptadine Hydrochloride Manufacturers

    A Cyproheptadine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cyproheptadine Hydrochloride, including repackagers and relabelers. The FDA regulates Cyproheptadine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cyproheptadine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Cyproheptadine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Cyproheptadine Hydrochloride Suppliers

    A Cyproheptadine Hydrochloride supplier is an individual or a company that provides Cyproheptadine Hydrochloride active pharmaceutical ingredient (API) or Cyproheptadine Hydrochloride finished formulations upon request. The Cyproheptadine Hydrochloride suppliers may include Cyproheptadine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Cyproheptadine Hydrochloride USDMF

    A Cyproheptadine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Cyproheptadine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Cyproheptadine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Cyproheptadine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Cyproheptadine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Cyproheptadine Hydrochloride USDMF includes data on Cyproheptadine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cyproheptadine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with USDMF on PharmaCompass.

    Cyproheptadine Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Cyproheptadine Hydrochloride Drug Master File in Japan (Cyproheptadine Hydrochloride JDMF) empowers Cyproheptadine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Cyproheptadine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Cyproheptadine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with JDMF on PharmaCompass.

    Cyproheptadine Hydrochloride CEP

    A Cyproheptadine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Cyproheptadine Hydrochloride Certificate of Suitability (COS). The purpose of a Cyproheptadine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cyproheptadine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cyproheptadine Hydrochloride to their clients by showing that a Cyproheptadine Hydrochloride CEP has been issued for it. The manufacturer submits a Cyproheptadine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cyproheptadine Hydrochloride CEP holder for the record. Additionally, the data presented in the Cyproheptadine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cyproheptadine Hydrochloride DMF.

    A Cyproheptadine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cyproheptadine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Cyproheptadine Hydrochloride WC

    A Cyproheptadine Hydrochloride written confirmation (Cyproheptadine Hydrochloride WC) is an official document issued by a regulatory agency to a Cyproheptadine Hydrochloride manufacturer, verifying that the manufacturing facility of a Cyproheptadine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cyproheptadine Hydrochloride APIs or Cyproheptadine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Cyproheptadine Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Cyproheptadine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cyproheptadine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Cyproheptadine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Cyproheptadine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Cyproheptadine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cyproheptadine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Cyproheptadine Hydrochloride suppliers with NDC on PharmaCompass.

    Cyproheptadine Hydrochloride GMP

    Cyproheptadine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Cyproheptadine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cyproheptadine Hydrochloride GMP manufacturer or Cyproheptadine Hydrochloride GMP API supplier for your needs.

    Cyproheptadine Hydrochloride CoA

    A Cyproheptadine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Cyproheptadine Hydrochloride's compliance with Cyproheptadine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Cyproheptadine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Cyproheptadine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Cyproheptadine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Cyproheptadine Hydrochloride EP), Cyproheptadine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cyproheptadine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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