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Chemistry

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Also known as: 64485-93-4, Cefotaxime sodium salt, Sodium cefotaxime, Hr 756, Cefotaxime, Ru 24756
Molecular Formula
C16H16N5NaO7S2
Molecular Weight
477.5  g/mol
InChI Key
AZZMGZXNTDTSME-JUZDKLSSSA-M
FDA UNII
258J72S7TZ

Cefotaxime
Semisynthetic broad-spectrum cephalosporin.
1 2D Structure

Cefotaxime

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
2.1.3 InChI Key
AZZMGZXNTDTSME-JUZDKLSSSA-M
2.1.4 Canonical SMILES
CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
258J72S7TZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Benaxima

2. Biosint

3. Cefotaxim

4. Cefotaxime

5. Cefradil

6. Cephotaxim

7. Claforan

8. Fotexina

9. Hr 756

10. Hr-756

11. Hr756

12. Kendrick

13. Klaforan

14. Primafen

15. Ru 24756

16. Ru-24756

17. Ru24756

18. Sodium, Cefotaxime

19. Taporin

2.3.2 Depositor-Supplied Synonyms

1. 64485-93-4

2. Cefotaxime Sodium Salt

3. Sodium Cefotaxime

4. Hr 756

5. Cefotaxime

6. Ru 24756

7. (+)-cefotaxime Sodium Salt

8. Hr-756

9. Cefotaxime (sodium)

10. Ru-24756

11. Mls000028559

12. Chebi:3498

13. 258j72s7tz

14. Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate

15. Cefotax

16. Nsc-756666

17. Sodium;(6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

18. Smr000058812

19. Tolycar

20. Pretor

21. Sodium (6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(z)-(o-methyloxime), Acetate (ester)

22. Sodium;(6r,7r)-3-(acetyloxymethyl)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

23. Cefotaxime (sodium Salt)

24. Ralopar

25. Tolycor

26. Zariviz

27. Claforan Sodium

28. Mls002222330

29. Cefotaxime Na-salt

30. Cefotaxime Sodium Salt (syn-isomer)

31. Smr001307269

32. Mfcd00079073

33. Unii-258j72s7tz

34. Cefotaxim Sodium

35. Claforan (tn)

36. Prestwick_823

37. Cefotaxime Sodium [usan:usp:jan]

38. Einecs 264-915-9

39. Cefotaxime, Sodium Salt

40. Opera_id_1945

41. Chembl1010

42. Schembl41092

43. Cefotaxime And Dextrose 2.4% In Plastic Container

44. Cefotaxime And Dextrose 3.9% In Plastic Container

45. Mls001077352

46. Mls001333684

47. Sym-methoxyimino Cephalosporin

48. Claforan In Dextrose 5% In Plastic Container

49. Cefotaxime Sodium [jan]

50. Cefotaxime Sodium (jp17/usp)

51. Cefotaxime Sodium [usan]

52. Dtxsid4046991

53. Cefotaxime Sodium [vandf]

54. Cefotaxime Sodium [mart.]

55. Claforan In Sodium Chloride 0.9% In Plastic Container

56. Hms1568k20

57. Hms2095k20

58. Hms2233j21

59. Hms3260h18

60. Hms3712k20

61. Cefotaxime Sodium [usp-rs]

62. Cefotaxime Sodium [who-dd]

63. Amy40166

64. Cefotaxime Sodium Salt [mi]

65. Hy-a0088

66. Tox21_500278

67. S4517

68. Akos015951272

69. Ccg-220139

70. Ccg-221582

71. Cefotaxime Sodium [ep Impurity]

72. Cefotaxime Sodium [orange Book]

73. Cs-4297

74. Ks-1416

75. Nsc 756666

76. Cefotaxime Sodium [usp Impurity]

77. Cefotaxime Sodium [usp Monograph]

78. Ncgc00093734-01

79. Ncgc00093734-02

80. Ncgc00260963-01

81. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, Monosodium Salt, (6r-(6alpha,7beta(z)))-

82. Smr000653480

83. Eu-0100278

84. A16005

85. C 7912

86. C08113

87. D00919

88. Cefadroxil, Antibiotic For Culture Media Use Only

89. Q-200807

90. Cefotaxime Sodium Salt, Potency: 916-964 Mug Per Mg

91. Cefotaxime Sodium, European Pharmacopoeia (ep) Reference Standard

92. Cefotaxime Sodium Salt, Plant Cell Culture Tested, Bioreagent, Powder

93. Cefotaxime Sodium, United States Pharmacopeia (usp) Reference Standard

94. Cefotaxime For Peak Identification, European Pharmacopoeia (ep) Reference Standard

95. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, Monosodium Salt, (6r-(6.alpha.,7.beta.(z)))-

96. Sodium (6r,7r)-3-(acetoxymethyl)-7-((e)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

97. Sodium (6r,7r)-3-(acetoxymethyl)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

98. Sodium (6r-(6alpha,7beta(z)))-3-(acetoxymethyl)-7-((2-aminothiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

99. Sodium 3-(acetoxymethyl)-7beta-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylate

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 477.5 g/mol
Molecular Formula C16H16N5NaO7S2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Exact Mass477.03888450 g/mol
Monoisotopic Mass477.03888450 g/mol
Topological Polar Surface Area230 Ų
Heavy Atom Count31
Formal Charge0
Complexity839
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameCefotaxime sodium
Drug LabelSterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-...
Active IngredientCefotaxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market StatusPrescription
CompanyWockhardt; Hospira; Lupin

2 of 4  
Drug NameClaforan
Drug LabelSterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-...
Active IngredientCefotaxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market StatusPrescription
CompanySanofi Aventis Us

3 of 4  
Drug NameCefotaxime sodium
Drug LabelSterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-...
Active IngredientCefotaxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market StatusPrescription
CompanyWockhardt; Hospira; Lupin

4 of 4  
Drug NameClaforan
Drug LabelSterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-...
Active IngredientCefotaxime sodium
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market StatusPrescription
CompanySanofi Aventis Us

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]
5.3 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD01 - Cefotaxime


API Reference Price

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05-Jan-2021
27-Mar-2025
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DOSAGE - INJECTABLE;INJECTION - EQ 500MG BASE...DOSAGE - INJECTABLE;INJECTION - EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50547

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Looking for 64485-93-4 / Cefotaxime API manufacturers, exporters & distributors?

Cefotaxime manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cefotaxime API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cefotaxime manufacturer or Cefotaxime supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cefotaxime manufacturer or Cefotaxime supplier.

PharmaCompass also assists you with knowing the Cefotaxime API Price utilized in the formulation of products. Cefotaxime API Price is not always fixed or binding as the Cefotaxime Price is obtained through a variety of data sources. The Cefotaxime Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cefotaxime

Synonyms

64485-93-4, Cefotaxime sodium salt, Sodium cefotaxime, Hr 756, Ru 24756, (+)-cefotaxime sodium salt

Cas Number

64485-93-4

Unique Ingredient Identifier (UNII)

258J72S7TZ

About Cefotaxime

Semisynthetic broad-spectrum cephalosporin.

Cefotaxime Sodium Manufacturers

A Cefotaxime Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefotaxime Sodium, including repackagers and relabelers. The FDA regulates Cefotaxime Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefotaxime Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cefotaxime Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cefotaxime Sodium Suppliers

A Cefotaxime Sodium supplier is an individual or a company that provides Cefotaxime Sodium active pharmaceutical ingredient (API) or Cefotaxime Sodium finished formulations upon request. The Cefotaxime Sodium suppliers may include Cefotaxime Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Cefotaxime Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cefotaxime Sodium USDMF

A Cefotaxime Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Cefotaxime Sodium active pharmaceutical ingredient (API) in detail. Different forms of Cefotaxime Sodium DMFs exist exist since differing nations have different regulations, such as Cefotaxime Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cefotaxime Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Cefotaxime Sodium USDMF includes data on Cefotaxime Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cefotaxime Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cefotaxime Sodium suppliers with USDMF on PharmaCompass.

Cefotaxime Sodium JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Cefotaxime Sodium Drug Master File in Japan (Cefotaxime Sodium JDMF) empowers Cefotaxime Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Cefotaxime Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Cefotaxime Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Cefotaxime Sodium suppliers with JDMF on PharmaCompass.

Cefotaxime Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Cefotaxime Sodium Drug Master File in Korea (Cefotaxime Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Cefotaxime Sodium. The MFDS reviews the Cefotaxime Sodium KDMF as part of the drug registration process and uses the information provided in the Cefotaxime Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Cefotaxime Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Cefotaxime Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Cefotaxime Sodium suppliers with KDMF on PharmaCompass.

Cefotaxime Sodium CEP

A Cefotaxime Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Cefotaxime Sodium Certificate of Suitability (COS). The purpose of a Cefotaxime Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cefotaxime Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cefotaxime Sodium to their clients by showing that a Cefotaxime Sodium CEP has been issued for it. The manufacturer submits a Cefotaxime Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cefotaxime Sodium CEP holder for the record. Additionally, the data presented in the Cefotaxime Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cefotaxime Sodium DMF.

A Cefotaxime Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cefotaxime Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Cefotaxime Sodium suppliers with CEP (COS) on PharmaCompass.

Cefotaxime Sodium WC

A Cefotaxime Sodium written confirmation (Cefotaxime Sodium WC) is an official document issued by a regulatory agency to a Cefotaxime Sodium manufacturer, verifying that the manufacturing facility of a Cefotaxime Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cefotaxime Sodium APIs or Cefotaxime Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Cefotaxime Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Cefotaxime Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Cefotaxime Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cefotaxime Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Cefotaxime Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Cefotaxime Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Cefotaxime Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cefotaxime Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Cefotaxime Sodium suppliers with NDC on PharmaCompass.

Cefotaxime Sodium GMP

Cefotaxime Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefotaxime Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefotaxime Sodium GMP manufacturer or Cefotaxime Sodium GMP API supplier for your needs.

Cefotaxime Sodium CoA

A Cefotaxime Sodium CoA (Certificate of Analysis) is a formal document that attests to Cefotaxime Sodium's compliance with Cefotaxime Sodium specifications and serves as a tool for batch-level quality control.

Cefotaxime Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Cefotaxime Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefotaxime Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefotaxime Sodium EP), Cefotaxime Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefotaxime Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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