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    Chemistry

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    Also known as: 299-28-5, Calcium d-gluconate, Calglucon, D-gluconic acid, calcium salt (2:1), Gluconate calcium, Calcarea gluconica
    Molecular Formula
    C12H22CaO14
    Molecular Weight
    430.37  g/mol
    InChI Key
    NEEHYRZPVYRGPP-IYEMJOQQSA-L
    FDA UNII
    SQE6VB453K
    Calcium Gluconate
    The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
    1 2D Structure

    Calcium Gluconate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    2.1.2 InChI
    InChI=1S/2C6H12O7.Ca/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
    2.1.3 InChI Key
    NEEHYRZPVYRGPP-IYEMJOQQSA-L
    2.1.4 Canonical SMILES
    C(C(C(C(C(C(=O)[O-])O)O)O)O)O.C(C(C(C(C(C(=O)[O-])O)O)O)O)O.[Ca+2]
    2.1.5 Isomeric SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    SQE6VB453K
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Calciofon

    2. Calcipot

    3. Calcium Braun

    4. Calcivitol

    5. Calglucon

    6. Cbg

    7. Ebucin

    8. Flopak Plain

    9. Glucal

    10. Glucobiogen

    11. Gluconate De Calcium Lavoisier

    12. Gluconate, Calcium

    13. Gluconato Calc Fresenius

    2.3.2 Depositor-Supplied Synonyms

    1. 299-28-5

    2. Calcium D-gluconate

    3. Calglucon

    4. D-gluconic Acid, Calcium Salt (2:1)

    5. Gluconate Calcium

    6. Calcarea Gluconica

    7. Calcium Di-gluconate

    8. Calcium Gluconate Anhydrous

    9. Gluconic Acid Calcium Salt

    10. Calcium Gluconate, Anhydrous

    11. Glucobiogen

    12. Calciofon

    13. Sqe6vb453k

    14. Ins No.578

    15. Ebucin

    16. Gluconate De Calcium

    17. Ins-578

    18. Almora

    19. Nsc-744619

    20. 152772-65-1

    21. Calcium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

    22. Calcicol

    23. Calcipur

    24. Calglucol

    25. Dragocal

    26. Kalpren

    27. Novocal

    28. E-578

    29. Calcium (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

    30. Calcium Hexagluconate

    31. 2,3,4,5,6-pentahydroxycaproic Acid Hemicalcium Salt

    32. 18016-24-5

    33. Gluconato Di Calcio

    34. Calcium D-gluconate (1:2)

    35. Gluconate De Calcium [french]

    36. Gluconato Di Calcio [italian]

    37. Ccris 1336

    38. Hsdb 994

    39. Calcium Gluconate [usan:jan]

    40. Einecs 206-075-8

    41. Unii-sqe6vb453k

    42. Gluconic Acid, Calcium Salt

    43. Calcii Gluconas

    44. Gluconic Acid, Calcium Salt (2:1), D-

    45. Gluconic Acid, Calcium Salt, D-

    46. Mfcd00064209

    47. Calcium Bis(d-gluconate)

    48. Calcium Gluconate (usp)

    49. L-gluconic Acid Calcium Salt

    50. Schembl24132

    51. Gluconic Acid Hemicalcium Salt

    52. Calcium Gluconate [mi]

    53. Chebi:3309

    54. Calcium Gluconate [fcc]

    55. Boron Gluconate Blend 5% 40m

    56. Calcium Gluconate [hsdb]

    57. Calcium Gluconate [inci]

    58. Chembl2106119

    59. Dtxsid2029618

    60. Calcium Gluconate [vandf]

    61. Calcium Gluconate [who-dd]

    62. Calcium Gluconate [who-ip]

    63. Akos015895893

    64. Calcii Gluconas [who-ip Latin]

    65. Calcium Gluconate [orange Book]

    66. Db11126

    67. Nsc 744619

    68. Calcium Gluconate [usp Impurity]

    69. Calcium Gluconate [usp Monograph]

    70. As-80559

    71. Calcium Gluconate Anhydrous [usp-rs]

    72. G0037

    73. C08133

    74. D00935

    75. A876351

    76. Q413739

    77. Calcium Gluconate, Anhydrous [ep Monograph]

    78. W-202243

    79. Calcium D-gluconate Gel, 2.5% W/w Aqueous Solution

    80. Calcium Bis[(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate]

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 430.37 g/mol
    Molecular Formula C12H22CaO14
    Hydrogen Bond Donor Count10
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count8
    Exact Mass430.0635462 g/mol
    Monoisotopic Mass430.0635462 g/mol
    Topological Polar Surface Area283 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity165
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Some studies have shown that calcium supplementation begun in the second trimester may be effective in lowering blood pressure in pregnancy women with pregnancy-induced hypertension or pre-eclampsia, both of which may possibly be associated with increased calcium demand of the fetus during the last trimester. /Calcium supplements/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 698

    Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Due to increased needs, children and pregnancy women are at greatest risk. Pre- and postmenopausal women; adolescents, especially girls and the elderly may not receive adequate calcium in their diets. ... Calcium supplements are used as part of the prevention and treatment of osteoporosis in patients with an inadequate calcium intake. The use of calcium citrate may reduce the risk of kidney stones in susceptible patients. The use of water-soluble salts of calcium (ie, citrate, gluconate, and lactate) may be preferable to acid-soluble salts (ie, carbonate and phosphate) for patients with reduced stomach acid or patients taking acid-inhibiting medication, such as the histamine H2-receptor antagonists. /Calcium supplements; Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency oral calcium salts may be administered concomitantly with vitamin D analogs. /Calcium supplements; Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    Calcium chloride and parenteral calcium gluconate are used to decrease or reverse the cardiac depressant effects of hyperkalemia on electrocardiographic (ECG) function. /Calcium supplements; Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    For more Therapeutic Uses (Complete) data for CALCIUM GLUCONATE (27 total), please visit the HSDB record page.

    4.2 Drug Warning

    VET: ... Calcium gluconate ... if given by iv injection, should be admin slowly ... given rapidly ... may have toxic effect on heart.

    Clarke, E.G., and M. L. Clarke. Veterinary Toxicology. Baltimore, Maryland: The Williams and Wilkins Company, 1975., p. 47

    Calcium gluconate ... not recommended for im use because dose must be large and danger of sterile abscess formation is too great.

    Hayes, W.J., Jr., E.R. Laws Jr., (eds.). Handbook of Pesticide Toxicology Volume 1. General Principles. New York, NY: Academic Press, Inc., 1991., p. 398

    Many physicians recommend that pregnant women receive multivitamin and mineral supplements, especially those pregnant women who do not consume an adequate diet and those in high-risk categories )ie, women carrying more than one fetus, heavy cigarette smokers, and alcohol and drug abusers). Taking excessive amounts of a multivitamin and mineral supplement may be harmful to the mother and/or fetus and should be avoided. /Calcium supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    Side/adverse effects may be more likely to occur if oral calcium supplements are taken in much larger doses than recommended (greater than 2000 to 2500 mg a day), if they are taken for a longer period of time, or if they are taken by patients with renal function impairment or milk-alkali syndrome. /Calcium supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 744

    For more Drug Warnings (Complete) data for CALCIUM GLUCONATE (15 total), please visit the HSDB record page.

    4.3 Drug Indication

    Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Calcium Gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]
    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12A - Calcium

    A12AA - Calcium

    A12AA03 - Calcium gluconate

    D - Dermatologicals

    D11 - Other dermatological preparations

    D11A - Other dermatological preparations

    D11AX - Other dermatologicals

    D11AX03 - Calcium gluconate

    5.4 Absorption, Distribution and Excretion

    Absorption

    Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced.

    Route of Elimination

    Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted.

    Volume of Distribution

    Not available

    Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced. /Calcium supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    Elimination: Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted. /Calcium supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 742

    5.5 Metabolism/Metabolites

    Calcium gluconate does not require hepatic metabolism for the release of Ca++ and is as effective as calcium chloride in treating ionic hypocalcemia in the absence of hepatic function.

    5.6 Mechanism of Action

    Calcium is essential for the functional integrity of the nervous, muscular, and skeletal systems. It plays a role in normal cardiac function, renal function, respiration, blood coagulation, and cell membrane and capillary permeability. Also, calcium helps to regulate the release and storage of neurotransmitters and hormones, the uptake and binding of amino acids, absorption of vitamin B 12, and gastrin secretion. The major fraction (99%) of calcium is in the skeletal structure primarily as hydroxyapatite, Ca 10(PO 4) 6(OH) 2; small amounts of calcium carbonate and amorphous calcium phosphates are also present. The calcium of bone is in a constant exchange with the calcium of plasma. Since the metabolic functions of calcium are essential for life, when there is a disturbance in the calcium balance because of dietary deficiency or other causes, the stores of calcium in bone may be depleted to fill the body's more acute needs. Therefore, on a chronic basis, normal mineralization of bone depends on adequate amounts of total body calcium.

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    03-Jan-2022
    30-Apr-2025
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    Calcium Gluconate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Calcium Gluconate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Calcium Gluconate manufacturer or Calcium Gluconate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Calcium Gluconate manufacturer or Calcium Gluconate supplier.

    PharmaCompass also assists you with knowing the Calcium Gluconate API Price utilized in the formulation of products. Calcium Gluconate API Price is not always fixed or binding as the Calcium Gluconate Price is obtained through a variety of data sources. The Calcium Gluconate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Calcium Gluconate

    Synonyms

    299-28-5, Calcium d-gluconate, Calglucon, D-gluconic acid, calcium salt (2:1), Gluconate calcium, Calcarea gluconica

    Cas Number

    299-28-5

    Unique Ingredient Identifier (UNII)

    SQE6VB453K

    About Calcium Gluconate

    The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

    Calcium Gluconate Manufacturers

    A Calcium Gluconate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcium Gluconate, including repackagers and relabelers. The FDA regulates Calcium Gluconate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcium Gluconate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Calcium Gluconate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Calcium Gluconate Suppliers

    A Calcium Gluconate supplier is an individual or a company that provides Calcium Gluconate active pharmaceutical ingredient (API) or Calcium Gluconate finished formulations upon request. The Calcium Gluconate suppliers may include Calcium Gluconate API manufacturers, exporters, distributors and traders.

    click here to find a list of Calcium Gluconate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Calcium Gluconate USDMF

    A Calcium Gluconate DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcium Gluconate active pharmaceutical ingredient (API) in detail. Different forms of Calcium Gluconate DMFs exist exist since differing nations have different regulations, such as Calcium Gluconate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Calcium Gluconate DMF submitted to regulatory agencies in the US is known as a USDMF. Calcium Gluconate USDMF includes data on Calcium Gluconate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcium Gluconate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Calcium Gluconate suppliers with USDMF on PharmaCompass.

    Calcium Gluconate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Calcium Gluconate Drug Master File in Japan (Calcium Gluconate JDMF) empowers Calcium Gluconate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Calcium Gluconate JDMF during the approval evaluation for pharmaceutical products. At the time of Calcium Gluconate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Calcium Gluconate suppliers with JDMF on PharmaCompass.

    Calcium Gluconate CEP

    A Calcium Gluconate CEP of the European Pharmacopoeia monograph is often referred to as a Calcium Gluconate Certificate of Suitability (COS). The purpose of a Calcium Gluconate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Calcium Gluconate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Calcium Gluconate to their clients by showing that a Calcium Gluconate CEP has been issued for it. The manufacturer submits a Calcium Gluconate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Calcium Gluconate CEP holder for the record. Additionally, the data presented in the Calcium Gluconate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Calcium Gluconate DMF.

    A Calcium Gluconate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Calcium Gluconate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Calcium Gluconate suppliers with CEP (COS) on PharmaCompass.

    Calcium Gluconate WC

    A Calcium Gluconate written confirmation (Calcium Gluconate WC) is an official document issued by a regulatory agency to a Calcium Gluconate manufacturer, verifying that the manufacturing facility of a Calcium Gluconate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Calcium Gluconate APIs or Calcium Gluconate finished pharmaceutical products to another nation, regulatory agencies frequently require a Calcium Gluconate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Calcium Gluconate suppliers with Written Confirmation (WC) on PharmaCompass.

    Calcium Gluconate GMP

    Calcium Gluconate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Calcium Gluconate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcium Gluconate GMP manufacturer or Calcium Gluconate GMP API supplier for your needs.

    Calcium Gluconate CoA

    A Calcium Gluconate CoA (Certificate of Analysis) is a formal document that attests to Calcium Gluconate's compliance with Calcium Gluconate specifications and serves as a tool for batch-level quality control.

    Calcium Gluconate CoA mostly includes findings from lab analyses of a specific batch. For each Calcium Gluconate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Calcium Gluconate may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcium Gluconate EP), Calcium Gluconate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcium Gluconate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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